{"id":"https://openalex.org/W3093549337","doi":"https://doi.org/10.1016/j.regen.2020.100034","title":"Characterizing and overcoming innate immunity in beta-cell replacement therapy","display_name":"Characterizing and overcoming innate immunity in beta-cell replacement therapy","publication_year":2020,"publication_date":"2020-10-24","ids":{"openalex":"https://openalex.org/W3093549337","doi":"https://doi.org/10.1016/j.regen.2020.100034","mag":"3093549337"},"language":"en","primary_location":{"id":"doi:10.1016/j.regen.2020.100034","doi":"https://doi.org/10.1016/j.regen.2020.100034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.regen.2020.100034","pdf_url":null,"source":{"id":"https://openalex.org/S2898177172","display_name":"Journal of Immunology and Regenerative Medicine","issn_l":"2468-4988","issn":["2468-4988"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology and Regenerative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026663025","display_name":"Kenjiro Kumano","orcid":"https://orcid.org/0000-0001-5979-7454","observed_orcids":["https://orcid.org/0000-0001-5979-7454"]},"institutions":[{"id":"https://openalex.org/I4405274104","display_name":"Baylor Scott & White Research Institute","ror":"https://ror.org/012z4f430","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160418","https://openalex.org/I4405274104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenjiro Kumano","raw_affiliation_strings":["Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, USA"],"raw_orcid":"https://orcid.org/0000-0001-5979-7454","affiliations":[{"raw_affiliation_string":"Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, USA","institution_ids":["https://openalex.org/I4405274104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010536397","display_name":"Srividya Vasu","orcid":"https://orcid.org/0000-0002-6625-9184","observed_orcids":["https://orcid.org/0000-0002-6625-9184"]},"institutions":[{"id":"https://openalex.org/I4405274104","display_name":"Baylor Scott & White Research Institute","ror":"https://ror.org/012z4f430","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160418","https://openalex.org/I4405274104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srividya Vasu","raw_affiliation_strings":["Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-6625-9184","affiliations":[{"raw_affiliation_string":"Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, USA","institution_ids":["https://openalex.org/I4405274104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091230343","display_name":"Rehma Shabbir","orcid":"https://orcid.org/0000-0002-8365-1620","observed_orcids":["https://orcid.org/0000-0002-8365-1620"]},"institutions":[{"id":"https://openalex.org/I4405274104","display_name":"Baylor Scott & White Research Institute","ror":"https://ror.org/012z4f430","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160418","https://openalex.org/I4405274104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rehma Shabbir","raw_affiliation_strings":["Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, USA"],"raw_orcid":"https://orcid.org/0000-0002-8365-1620","affiliations":[{"raw_affiliation_string":"Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, USA","institution_ids":["https://openalex.org/I4405274104"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052634878","display_name":"Carly M. Darden","orcid":"https://orcid.org/0000-0002-0941-6403","observed_orcids":["https://orcid.org/0000-0002-0941-6403"]},"institutions":[{"id":"https://openalex.org/I157394403","display_name":"Baylor University","ror":"https://ror.org/005781934","country_code":"US","type":"education","lineage":["https://openalex.org/I157394403"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carly Darden","raw_affiliation_strings":["Institute of Biomedical Studies, Baylor University, Waco, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biomedical Studies, Baylor University, Waco, TX, USA","institution_ids":["https://openalex.org/I157394403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073369976","display_name":"Michael C. Lawrence","orcid":"https://orcid.org/0000-0003-1260-4621","observed_orcids":["https://orcid.org/0000-0003-1260-4621"]},"institutions":[{"id":"https://openalex.org/I4405274104","display_name":"Baylor Scott & White Research Institute","ror":"https://ror.org/012z4f430","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210160418","https://openalex.org/I4405274104"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Lawrence","raw_affiliation_strings":["Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Islet Cell Laboratory, Baylor Scott and White Research Institute, Dallas, TX, USA","institution_ids":["https://openalex.org/I4405274104"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017433482","display_name":"Bashoo Naziruddin","orcid":"https://orcid.org/0000-0002-0671-9572","observed_orcids":["https://orcid.org/0000-0002-0671-9572"]},"institutions":[{"id":"https://openalex.org/I2802366037","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802366037","https://openalex.org/I4210160418"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bashoo Naziruddin","raw_affiliation_strings":["Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX, USA","institution_ids":["https://openalex.org/I2802366037"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017433482"],"corresponding_institution_ids":["https://openalex.org/I2802366037"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":0.494,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.6206408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"10","issue":null,"first_page":"100034","last_page":"100034"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/islet-transplantation","display_name":"islet transplantation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.8320000171661377},{"id":"https://openalex.org/keywords/beta-cell-replacement-therapy","display_name":"beta cell replacement therapy","score":0.8920000195503235},{"id":"https://openalex.org/keywords/ischemia-reperfusion-injury","display_name":"ischemia-reperfusion injury","score":0.9079999923706055},{"id":"https://openalex.org/keywords/damage-associated-molecular-patterns","display_name":"damage-associated molecular patterns","score":0.9980000257492065},{"id":"https://openalex.org/keywords/instant-blood-mediated-inflammatory-reaction","display_name":"instant blood-mediated inflammatory reaction","score":0.9449999928474426},{"id":"https://openalex.org/keywords/insulitis","display_name":"insulitis","score":0.8240000009536743},{"id":"https://openalex.org/keywords/islet-encapsulation","display_name":"islet encapsulation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cytokine-signaling","display_name":"cytokine signaling","score":0.6129999756813049},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.7950000166893005},{"id":"https://openalex.org/keywords/islet-engraftment","display_name":"islet engraftment","score":0.8429999947547913},{"id":"https://openalex.org/keywords/anti-inflammatory-strategies","display_name":"anti-inflammatory strategies","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7146618962287903},{"id":"https://openalex.org/C2776174256","wikidata":"https://www.wikidata.org/wiki/Q830842","display_name":"BETA (programming language)","level":2,"score":0.5204934477806091},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5033108592033386},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.40452858805656433},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39077481627464294},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2294783890247345},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.1552596390247345},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.regen.2020.100034","doi":"https://doi.org/10.1016/j.regen.2020.100034","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.regen.2020.100034","pdf_url":null,"source":{"id":"https://openalex.org/S2898177172","display_name":"Journal of Immunology and Regenerative Medicine","issn_l":"2468-4988","issn":["2468-4988"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Immunology and Regenerative Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320333607","display_name":"Baylor University Medical Center","ror":"https://ror.org/03nxfhe13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":160,"referenced_works":["https://openalex.org/W53650203","https://openalex.org/W1576404915","https://openalex.org/W1696581921","https://openalex.org/W1896027017","https://openalex.org/W1939015906","https://openalex.org/W1959181807","https://openalex.org/W1963953904","https://openalex.org/W1964100264","https://openalex.org/W1965315257","https://openalex.org/W1965319363","https://openalex.org/W1968959177","https://openalex.org/W1971194431","https://openalex.org/W1972272933","https://openalex.org/W1973424799","https://openalex.org/W1974417451","https://openalex.org/W1974744116","https://openalex.org/W1975762253","https://openalex.org/W1977811548","https://openalex.org/W1978824708","https://openalex.org/W1979136847","https://openalex.org/W1982596096","https://openalex.org/W1985282777","https://openalex.org/W1987086068","https://openalex.org/W1988378648","https://openalex.org/W1989245068","https://openalex.org/W1998044534","https://openalex.org/W1999719081","https://openalex.org/W2001019228","https://openalex.org/W2001057008","https://openalex.org/W2004063914","https://openalex.org/W2005164022","https://openalex.org/W2007184943","https://openalex.org/W2017351024","https://openalex.org/W2018474575","https://openalex.org/W2020228231","https://openalex.org/W2021214934","https://openalex.org/W2022835497","https://openalex.org/W2024915434","https://openalex.org/W2025377941","https://openalex.org/W2026097978","https://openalex.org/W2027672602","https://openalex.org/W2028693640","https://openalex.org/W2032193600","https://openalex.org/W2035008308","https://openalex.org/W2035499146","https://openalex.org/W2040605985","https://openalex.org/W2043024227","https://openalex.org/W2046176025","https://openalex.org/W2048438191","https://openalex.org/W2048988294","https://openalex.org/W2049653750","https://openalex.org/W2050190427","https://openalex.org/W2050618841","https://openalex.org/W2056191911","https://openalex.org/W2065700597","https://openalex.org/W2066424656","https://openalex.org/W2067714284","https://openalex.org/W2069098685","https://openalex.org/W2070580293","https://openalex.org/W2070806097","https://openalex.org/W2071851448","https://openalex.org/W2076618616","https://openalex.org/W2076745823","https://openalex.org/W2088733561","https://openalex.org/W2090831802","https://openalex.org/W2091618147","https://openalex.org/W2095372191","https://openalex.org/W2102369007","https://openalex.org/W2103302057","https://openalex.org/W2103727761","https://openalex.org/W2106617659","https://openalex.org/W2107844390","https://openalex.org/W2108040825","https://openalex.org/W2111365775","https://openalex.org/W2116611386","https://openalex.org/W2119892564","https://openalex.org/W2121699757","https://openalex.org/W2122332000","https://openalex.org/W2125229121","https://openalex.org/W2125352391","https://openalex.org/W2125998432","https://openalex.org/W2126491715","https://openalex.org/W2128219297","https://openalex.org/W2129568900","https://openalex.org/W2132908857","https://openalex.org/W2135337547","https://openalex.org/W2136073712","https://openalex.org/W2136127635","https://openalex.org/W2137315507","https://openalex.org/W2137464815","https://openalex.org/W2139265907","https://openalex.org/W2141544811","https://openalex.org/W2144283470","https://openalex.org/W2145047873","https://openalex.org/W2146539838","https://openalex.org/W2158070939","https://openalex.org/W2159228347","https://openalex.org/W2161677103","https://openalex.org/W2162120036","https://openalex.org/W2163238496","https://openalex.org/W2168128391","https://openalex.org/W2173263243","https://openalex.org/W2217818916","https://openalex.org/W2234396308","https://openalex.org/W2264329642","https://openalex.org/W2312992015","https://openalex.org/W2318188273","https://openalex.org/W2321023578","https://openalex.org/W2328786770","https://openalex.org/W2340338776","https://openalex.org/W2408443895","https://openalex.org/W2411497190","https://openalex.org/W2411510178","https://openalex.org/W2472741975","https://openalex.org/W2474025349","https://openalex.org/W2510214416","https://openalex.org/W2513462790","https://openalex.org/W2523093820","https://openalex.org/W2534835884","https://openalex.org/W2554650020","https://openalex.org/W2562467566","https://openalex.org/W2569262272","https://openalex.org/W2606390916","https://openalex.org/W2615757630","https://openalex.org/W2733214856","https://openalex.org/W2752195988","https://openalex.org/W2752870502","https://openalex.org/W2756017353","https://openalex.org/W2774191793","https://openalex.org/W2777721344","https://openalex.org/W2779069198","https://openalex.org/W2789432975","https://openalex.org/W2791423015","https://openalex.org/W2795820530","https://openalex.org/W2801995202","https://openalex.org/W2803546694","https://openalex.org/W2803800121","https://openalex.org/W2805464772","https://openalex.org/W2888566681","https://openalex.org/W2895085875","https://openalex.org/W2896365107","https://openalex.org/W2901233057","https://openalex.org/W2921407860","https://openalex.org/W2943155462","https://openalex.org/W2943216263","https://openalex.org/W2946669448","https://openalex.org/W2948013344","https://openalex.org/W2950501366","https://openalex.org/W2953150194","https://openalex.org/W2966170525","https://openalex.org/W2967800723","https://openalex.org/W2969362013","https://openalex.org/W2971698073","https://openalex.org/W2977856631","https://openalex.org/W2979505766","https://openalex.org/W2981456926","https://openalex.org/W2985505599","https://openalex.org/W2996744432","https://openalex.org/W3004777863","https://openalex.org/W3018049514"],"related_works":["https://openalex.org/W2953150194","https://openalex.org/W2070806097","https://openalex.org/W2049776193","https://openalex.org/W2026793752","https://openalex.org/W2141574411","https://openalex.org/W2988119625","https://openalex.org/W2811363903","https://openalex.org/W562571480","https://openalex.org/W4392189892","https://openalex.org/W646832294"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2020-10-29T00:00:00"}
