{"id":"https://openalex.org/W3093536381","doi":"https://doi.org/10.3390/ijms21207758","title":"Saliva microRNA Biomarkers of Cumulative Concussion","display_name":"Saliva microRNA Biomarkers of Cumulative Concussion","publication_year":2020,"publication_date":"2020-10-20","ids":{"openalex":"https://openalex.org/W3093536381","doi":"https://doi.org/10.3390/ijms21207758","mag":"3093536381","pmid":"https://pubmed.ncbi.nlm.nih.gov/33092191","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7589940"},"language":"en","primary_location":{"id":"doi:10.3390/ijms21207758","doi":"https://doi.org/10.3390/ijms21207758","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21207758","pdf_url":"https://www.mdpi.com/1422-0067/21/20/7758/pdf?version=1603260440","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/21/20/7758/pdf?version=1603260440","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058606960","display_name":"Steven D. Hicks","orcid":"https://orcid.org/0000-0002-9579-6798","observed_orcids":["https://orcid.org/0000-0002-9579-6798"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Steven D. Hicks","raw_affiliation_strings":["Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0002-9579-6798","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077805827","display_name":"Robert P. Olympia","orcid":"https://orcid.org/0000-0002-1115-4473","observed_orcids":["https://orcid.org/0000-0002-1115-4473","https://orcid.org/0000-0001-5625-7567"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Olympia","raw_affiliation_strings":["Department of Emergency Medicine, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Medicine, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069057003","display_name":"Cayce A. Onks","orcid":"https://orcid.org/0000-0002-1107-5521","observed_orcids":["https://orcid.org/0000-0002-1107-5521"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cayce Onks","raw_affiliation_strings":["Department of Family Medicine, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066402878","display_name":"Raymond Y. Kim","orcid":"https://orcid.org/0000-0003-4229-904X","observed_orcids":["https://orcid.org/0000-0003-4229-904X"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond Y. Kim","raw_affiliation_strings":["Department of Orthopedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":"https://orcid.org/0000-0003-4229-904X","affiliations":[{"raw_affiliation_string":"Department of Orthopedics and Rehabilitation, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034225656","display_name":"Kevin J. Zhen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin J. Zhen","raw_affiliation_strings":["Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Penn State College of Medicine, Hershey, PA 17033, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013731239","display_name":"Gregory R. Fedorchak","orcid":"https://orcid.org/0000-0002-0772-6053","observed_orcids":["https://orcid.org/0000-0002-0772-6053"]},"institutions":[{"id":"https://openalex.org/I4405280792","display_name":"Quadrant Biosciences (United States)","ror":"https://ror.org/03epcj290","country_code":"US","type":"company","lineage":["https://openalex.org/I4405280792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Fedorchak","raw_affiliation_strings":["Quadrant Biosciences, Institute for Human Performance, Syracuse, NY 13210, USA"],"raw_orcid":"https://orcid.org/0000-0002-0772-6053","affiliations":[{"raw_affiliation_string":"Quadrant Biosciences, Institute for Human Performance, Syracuse, NY 13210, USA","institution_ids":["https://openalex.org/I4405280792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055629545","display_name":"Samantha DeVita","orcid":"https://orcid.org/0000-0002-4843-7709","observed_orcids":["https://orcid.org/0000-0002-4843-7709"]},"institutions":[{"id":"https://openalex.org/I4405280792","display_name":"Quadrant Biosciences (United States)","ror":"https://ror.org/03epcj290","country_code":"US","type":"company","lineage":["https://openalex.org/I4405280792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samantha DeVita","raw_affiliation_strings":["Quadrant Biosciences, Institute for Human Performance, Syracuse, NY 13210, USA"],"raw_orcid":"https://orcid.org/0000-0002-4843-7709","affiliations":[{"raw_affiliation_string":"Quadrant Biosciences, Institute for Human Performance, Syracuse, NY 13210, USA","institution_ids":["https://openalex.org/I4405280792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076113981","display_name":"Aakanksha Rangnekar","orcid":"https://orcid.org/0009-0009-9098-6320","observed_orcids":["https://orcid.org/0009-0009-9098-6320"]},"institutions":[{"id":"https://openalex.org/I4405280792","display_name":"Quadrant Biosciences (United States)","ror":"https://ror.org/03epcj290","country_code":"US","type":"company","lineage":["https://openalex.org/I4405280792"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aakanksha Rangnekar","raw_affiliation_strings":["Quadrant Biosciences, Institute for Human Performance, Syracuse, NY 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Quadrant Biosciences, Institute for Human Performance, Syracuse, NY 13210, USA","institution_ids":["https://openalex.org/I4405280792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072475599","display_name":"Matthew B. Heller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104314","display_name":"New York Institute of Technology","ror":"https://ror.org/01bghzb51","country_code":"US","type":"education","lineage":["https://openalex.org/I4210104314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Heller","raw_affiliation_strings":["Department of Family Medicine, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA","institution_ids":["https://openalex.org/I4210104314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068478026","display_name":"Hallie Zwibel","orcid":"https://orcid.org/0000-0003-1349-2027","observed_orcids":["https://orcid.org/0000-0003-1349-2027"]},"institutions":[{"id":"https://openalex.org/I4210104314","display_name":"New York Institute of Technology","ror":"https://ror.org/01bghzb51","country_code":"US","type":"education","lineage":["https://openalex.org/I4210104314"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hallie Zwibel","raw_affiliation_strings":["Department of Family Medicine, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Family Medicine, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, NY 11568, USA","institution_ids":["https://openalex.org/I4210104314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060121754","display_name":"Chuck Monteith","orcid":"https://orcid.org/0000-0001-8457-9184","observed_orcids":["https://orcid.org/0000-0001-8457-9184"]},"institutions":[{"id":"https://openalex.org/I39660569","display_name":"Colgate University","ror":"https://ror.org/05d23ve83","country_code":"US","type":"education","lineage":["https://openalex.org/I39660569"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuck Monteith","raw_affiliation_strings":["Department of Athletic Training, Colgate University, Hamilton, NY 13346, USA"],"raw_orcid":"https://orcid.org/0000-0001-8457-9184","affiliations":[{"raw_affiliation_string":"Department of Athletic Training, Colgate University, Hamilton, NY 13346, USA","institution_ids":["https://openalex.org/I39660569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110589976","display_name":"Zofia E. Gagnon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926137907","display_name":"Marist University","ror":"https://ror.org/04wx3x242","country_code":"US","type":"education","lineage":["https://openalex.org/I926137907"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zofia Gagnon","raw_affiliation_strings":["School of Science, Marist College, Poughkeepsie, NY 12601, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, Marist College, Poughkeepsie, NY 12601, USA","institution_ids":["https://openalex.org/I926137907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038149078","display_name":"Callan D. McLoughlin","orcid":"https://orcid.org/0000-0002-9555-3534","observed_orcids":["https://orcid.org/0000-0002-9555-3534"]},"institutions":[{"id":"https://openalex.org/I926137907","display_name":"Marist University","ror":"https://ror.org/04wx3x242","country_code":"US","type":"education","lineage":["https://openalex.org/I926137907"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Callan D. McLoughlin","raw_affiliation_strings":["School of Science, Marist College, Poughkeepsie, NY 12601, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, Marist College, Poughkeepsie, NY 12601, USA","institution_ids":["https://openalex.org/I926137907"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jason Randall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I926137907","display_name":"Marist University","ror":"https://ror.org/04wx3x242","country_code":"US","type":"education","lineage":["https://openalex.org/I926137907"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Randall","raw_affiliation_strings":["School of Science, Marist College, Poughkeepsie, NY 12601, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Science, Marist College, Poughkeepsie, NY 12601, USA","institution_ids":["https://openalex.org/I926137907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051009729","display_name":"Miguel M. Madeira","orcid":"https://orcid.org/0000-0001-9771-0727","observed_orcids":["https://orcid.org/0000-0001-9771-0727"]},"institutions":[{"id":"https://openalex.org/I926137907","display_name":"Marist University","ror":"https://ror.org/04wx3x242","country_code":"US","type":"education","lineage":["https://openalex.org/I926137907"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miguel Madeira","raw_affiliation_strings":["School of Science, Marist College, Poughkeepsie, NY 12601, USA"],"raw_orcid":"https://orcid.org/0000-0001-9771-0727","affiliations":[{"raw_affiliation_string":"School of Science, Marist College, Poughkeepsie, NY 12601, USA","institution_ids":["https://openalex.org/I926137907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090930024","display_name":"Thomas R. Campbell","orcid":"https://orcid.org/0000-0003-0879-2308","observed_orcids":["https://orcid.org/0000-0003-0879-2308"]},"institutions":[{"id":"https://openalex.org/I81365321","display_name":"Old Dominion University","ror":"https://ror.org/04zjtrb98","country_code":"US","type":"education","lineage":["https://openalex.org/I81365321"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas R. Campbell","raw_affiliation_strings":["School of Rehabilitation Sciences, Old Dominion University, Norfolk, VA 23529, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Rehabilitation Sciences, Old Dominion University, Norfolk, VA 23529, USA","institution_ids":["https://openalex.org/I81365321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041060396","display_name":"Elise Fengler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I70983195","display_name":"Syracuse University","ror":"https://ror.org/025r5qe02","country_code":"US","type":"education","lineage":["https://openalex.org/I70983195"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise Fengler","raw_affiliation_strings":["Department of Exercise Science, Syracuse University, Syracuse, NY 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Exercise Science, Syracuse University, Syracuse, NY 13210, USA","institution_ids":["https://openalex.org/I70983195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074705969","display_name":"Michael N. Dretsch","orcid":"https://orcid.org/0000-0001-8773-6376","observed_orcids":["https://orcid.org/0000-0001-8773-6376"]},"institutions":[{"id":"https://openalex.org/I4210088792","display_name":"United States Army","ror":"https://ror.org/00afsp483","country_code":"US","type":"government","lineage":["https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I4210088792"]},{"id":"https://openalex.org/I92664306","display_name":"Walter Reed Army Institute of Research","ror":"https://ror.org/0145znz58","country_code":"US","type":"government","lineage":["https://openalex.org/I106965489","https://openalex.org/I1304082316","https://openalex.org/I1330347796","https://openalex.org/I2802581893","https://openalex.org/I92664306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael N. Dretsch","raw_affiliation_strings":["US Army Medical Research Directorate-West, Walter Reed Army Institute of Research, Joint Base Lewis-McChord, WA 98433, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"US Army Medical Research Directorate-West, Walter Reed Army Institute of Research, Joint Base Lewis-McChord, WA 98433, USA","institution_ids":["https://openalex.org/I4210088792","https://openalex.org/I92664306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075573192","display_name":"Christopher Neville","orcid":"https://orcid.org/0000-0002-8601-976X","observed_orcids":["https://orcid.org/0000-0002-8601-976X"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Neville","raw_affiliation_strings":["Department of PT Education, Orthopedics, and Neuroscience, SUNY Upstate Medical University, Syracuse, NY 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of PT Education, Orthopedics, and Neuroscience, SUNY Upstate Medical University, Syracuse, NY 13210, USA","institution_ids":["https://openalex.org/I20388574"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084528838","display_name":"Frank A. Middleton","orcid":"https://orcid.org/0000-0002-3107-7188","observed_orcids":["https://orcid.org/0000-0002-3107-7188"]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frank A. Middleton","raw_affiliation_strings":["Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA","institution_ids":["https://openalex.org/I20388574"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5058606960"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2112},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2112},"fwci":2.5083,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.89957542,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"21","issue":"20","first_page":"7758","last_page":"7758"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recurrent-concussion","display_name":"recurrent concussion","score":0.8489999771118164},{"id":"https://openalex.org/keywords/salivary-micrornas","display_name":"salivary microRNAs","score":0.871999979019165},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.843999981880188},{"id":"https://openalex.org/keywords/mir-28-3p","display_name":"miR-28-3p","score":0.9369999766349792},{"id":"https://openalex.org/keywords/mir-339-3p","display_name":"miR-339-3p","score":0.9509999752044678},{"id":"https://openalex.org/keywords/post-concussion-symptoms","display_name":"post-concussion symptoms","score":0.906000018119812},{"id":"https://openalex.org/keywords/balance","display_name":"balance","score":0.5820000171661377},{"id":"https://openalex.org/keywords/neuropsychological-performance","display_name":"neuropsychological performance","score":0.8610000014305115},{"id":"https://openalex.org/keywords/concussion-pathophysiology","display_name":"concussion pathophysiology","score":0.8069999814033508}],"concepts":[{"id":"https://openalex.org/C2778426673","wikidata":"https://www.wikidata.org/wiki/Q326921","display_name":"Concussion","level":4,"score":0.974148690700531},{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.8055107593536377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6183607578277588},{"id":"https://openalex.org/C2781054738","wikidata":"https://www.wikidata.org/wiki/Q4813730","display_name":"Athletes","level":2,"score":0.532837986946106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4022918939590454},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.39656466245651245},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.38126546144485474},{"id":"https://openalex.org/C190385971","wikidata":"https://www.wikidata.org/wiki/Q373494","display_name":"Injury prevention","level":3,"score":0.36989614367485046},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.18179851770401},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1696353256702423},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.08054456114768982}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001924","descriptor_name":"Brain Concussion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005538","descriptor_name":"Football","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012463","descriptor_name":"Saliva","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056352","descriptor_name":"Athletes","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.3390/ijms21207758","doi":"https://doi.org/10.3390/ijms21207758","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21207758","pdf_url":"https://www.mdpi.com/1422-0067/21/20/7758/pdf?version=1603260440","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7589940","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7589940","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:33092191","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33092191","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.odu.edu:pt_pubs-1068","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.odu.edu/pt_pubs/68","pdf_url":null,"source":{"id":"https://openalex.org/S4377196314","display_name":"ODU Digital Commons (Old Dominion University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I81365321","host_organization_name":"Old Dominion University","host_organization_lineage":["https://openalex.org/I81365321"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Rehabilitation Sciences Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:231a0b76957f4f4bbfccf203c80b1a7d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/231a0b76957f4f4bbfccf203c80b1a7d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 21, Iss 7758, p 7758 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms21207758","doi":"https://doi.org/10.3390/ijms21207758","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms21207758","pdf_url":"https://www.mdpi.com/1422-0067/21/20/7758/pdf?version=1603260440","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093536381.pdf","grobid_xml":"https://content.openalex.org/works/W3093536381.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1423885769","https://openalex.org/W1609044025","https://openalex.org/W1944945174","https://openalex.org/W1964724904","https://openalex.org/W1964856354","https://openalex.org/W1977858895","https://openalex.org/W1983025973","https://openalex.org/W1996915289","https://openalex.org/W2005040118","https://openalex.org/W2011047709","https://openalex.org/W2011870453","https://openalex.org/W2018891183","https://openalex.org/W2036897871","https://openalex.org/W2038213195","https://openalex.org/W2068444550","https://openalex.org/W2074202258","https://openalex.org/W2088800239","https://openalex.org/W2090592546","https://openalex.org/W2096010550","https://openalex.org/W2099945370","https://openalex.org/W2100368061","https://openalex.org/W2105910930","https://openalex.org/W2123674272","https://openalex.org/W2124985265","https://openalex.org/W2146477797","https://openalex.org/W2152513460","https://openalex.org/W2159060882","https://openalex.org/W2234413196","https://openalex.org/W2288482887","https://openalex.org/W2326768077","https://openalex.org/W2331509664","https://openalex.org/W2541361002","https://openalex.org/W2610287704","https://openalex.org/W2739511015","https://openalex.org/W2755824084","https://openalex.org/W2765788989","https://openalex.org/W2766833230","https://openalex.org/W2770770994","https://openalex.org/W2885731210","https://openalex.org/W2890742967","https://openalex.org/W2897490206","https://openalex.org/W2907190321","https://openalex.org/W2922493891","https://openalex.org/W2974361058","https://openalex.org/W3003353489","https://openalex.org/W3030641976","https://openalex.org/W3036564912","https://openalex.org/W6682695112","https://openalex.org/W6779801654"],"related_works":["https://openalex.org/W3045569393","https://openalex.org/W3197431281","https://openalex.org/W4229375763","https://openalex.org/W7169591772","https://openalex.org/W6945879758","https://openalex.org/W4323036068","https://openalex.org/W2885731210","https://openalex.org/W2770770994","https://openalex.org/W2790496759","https://openalex.org/W4281920141"],"abstract_inverted_index":{"Recurrent":[0],"concussions":[1,112,185],"increase":[2],"risk":[3],"for":[4],"persistent":[5,25],"post-concussion":[6],"symptoms,":[7],"and":[8,77,128,166,173,191],"may":[9,193],"lead":[10],"to":[11,24],"chronic":[12],"neurocognitive":[13,121],"deficits.":[14],"Little":[15],"is":[16],"known":[17],"about":[18,49],"the":[19,50,124,181,198],"molecular":[20,51],"pathways":[21],"that":[22,30],"contribute":[23],"concussion":[26,44,100,106,137,144,149,204],"symptoms.":[27],"We":[28],"hypothesized":[29],"salivary":[31,155],"measurement":[32],"of":[33,39,74,82,91,98,170,183],"microribonucleic":[34],"acids":[35],"(miRNAs),":[36],"a":[37,62,72,88,96,104,195],"class":[38],"epitranscriptional":[40],"molecules":[41],"implicated":[42],"in":[43,61,87,120,197,202],"pathophysiology,":[45],"would":[46],"provide":[47],"insights":[48],"cascade":[52],"resulting":[53],"from":[54],"recurrent":[55,75,111],"concussions.":[56],"This":[57],"hypothesis":[58],"was":[59,117],"tested":[60],"case-control":[63],"study":[64,90],"involving":[65],"13":[66],"former":[67,125,163],"professional":[68,126,164],"football":[69],"athletes":[70,127,165],"with":[71,95,135,147,180],"history":[73,97],"concussion,":[76],"18":[78],"age/sex-matched":[79],"peers.":[80,168],"Molecules":[81],"interest":[83],"were":[84],"further":[85],"validated":[86],"cross-sectional":[89],"310":[92],"younger":[93,133,140,188],"individuals":[94,134,141],"no":[99,118],"(n":[101,107,113],"=":[102,108,114],"230),":[103],"single":[105],"56),":[109],"or":[110,131],"24).":[115],"There":[116],"difference":[119],"performance":[122],"between":[123,162],"their":[129,167],"peers,":[130],"among":[132],"varying":[136],"exposures.":[138],"However,":[139],"without":[142],"prior":[143,148,184],"outperformed":[145],"peers":[146],"on":[150],"three":[151],"balance":[152],"assessments.":[153],"Twenty":[154],"miRNAs":[156],"differed":[157],"(adj.":[158],"p":[159],"<":[160,178],"0.05)":[161,179],"Two":[169],"these":[171],"(miR-28-3p":[172],"miR-339-3p)":[174],"demonstrated":[175],"relationships":[176],"(p":[177],"number":[182],"reported":[186],"by":[187],"individuals.":[189],"miR-28-3p":[190],"miR-339-5p":[192],"play":[194],"role":[196],"pathophysiologic":[199],"mechanism":[200],"involved":[201],"cumulative":[203],"effects.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-29T00:00:00"}