{"id":"https://openalex.org/W3093388534","doi":"https://doi.org/10.1016/j.ijantimicag.2020.106199","title":"Treatment of infections caused by Gram-negative pathogens: current status on the pharmacokinetics/pharmacodynamics of parenteral and inhaled polymyxins in patients","display_name":"Treatment of infections caused by Gram-negative pathogens: current status on the pharmacokinetics/pharmacodynamics of parenteral and inhaled polymyxins in patients","publication_year":2020,"publication_date":"2020-10-16","ids":{"openalex":"https://openalex.org/W3093388534","doi":"https://doi.org/10.1016/j.ijantimicag.2020.106199","mag":"3093388534","pmid":"https://pubmed.ncbi.nlm.nih.gov/33075510","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7723449"},"language":"en","primary_location":{"id":"doi:10.1016/j.ijantimicag.2020.106199","doi":"https://doi.org/10.1016/j.ijantimicag.2020.106199","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijantimicag.2020.106199","pdf_url":null,"source":{"id":"https://openalex.org/S5248501","display_name":"International Journal of Antimicrobial Agents","issn_l":"0924-8579","issn":["0924-8579","1872-7913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Antimicrobial Agents","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7723449","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100391273","display_name":"Yu\u2010Wei Lin","orcid":"https://orcid.org/0000-0003-2045-6876","observed_orcids":["https://orcid.org/0000-0003-2045-6876"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yu-Wei Lin","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018308142","display_name":"Su Mon Aye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Su Mon Aye","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090898735","display_name":"Gauri G. Rao","orcid":"https://orcid.org/0000-0002-8704-7770","observed_orcids":["https://orcid.org/0000-0002-8704-7770"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gauri Rao","raw_affiliation_strings":["Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, The University of North Carolina, Chapel Hill, NC 27599, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, The University of North Carolina, Chapel Hill, NC 27599, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022732868","display_name":"Qi Tony Zhou","orcid":"https://orcid.org/0000-0002-1438-6990","observed_orcids":["https://orcid.org/0000-0002-1438-6990","https://orcid.org/0000-0002-7609-1725"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qi Tony Zhou","raw_affiliation_strings":["Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 1047907, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 1047907, USA","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026820693","display_name":"Hak\u2010Kim Chan","orcid":"https://orcid.org/0000-0002-7054-3137","observed_orcids":["https://orcid.org/0000-0002-7054-3137"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Hak-Kim Chan","raw_affiliation_strings":["Advanced Drug Delivery Group, School of Pharmacy, The University of Sydney, Faculty of Medicine and Health, Sydney, NSW 2006, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Drug Delivery Group, School of Pharmacy, The University of Sydney, Faculty of Medicine and Health, Sydney, NSW 2006, Australia","institution_ids":["https://openalex.org/I129604602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100402427","display_name":"Jian Li","orcid":"https://orcid.org/0000-0001-7953-8230","observed_orcids":["https://orcid.org/0000-0001-7953-8230"]},"institutions":[{"id":"https://openalex.org/I56590836","display_name":"Monash University","ror":"https://ror.org/02bfwt286","country_code":"AU","type":"education","lineage":["https://openalex.org/I56590836"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jian Li","raw_affiliation_strings":["Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia. Electronic address: jian.li@monash.edu","Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia"],"raw_orcid":"https://orcid.org/0000-0001-7953-8230","affiliations":[{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia. Electronic address: jian.li@monash.edu","institution_ids":["https://openalex.org/I56590836"]},{"raw_affiliation_string":"Monash Biomedicine Discovery Institute, Infection and Immunity Program and Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia","institution_ids":["https://openalex.org/I56590836"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100402427"],"corresponding_institution_ids":["https://openalex.org/I56590836"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":0.3258,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.32256617,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"56","issue":"6","first_page":"106199","last_page":"106199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.9262999892234802,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.061400000005960464,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polymyxins","display_name":"polymyxins","score":0.9980000257492065},{"id":"https://openalex.org/keywords/gram-negative-bacteria","display_name":"Gram-negative bacteria","score":0.6489999890327454},{"id":"https://openalex.org/keywords/multidrug-resistant-infections","display_name":"multidrug-resistant infections","score":0.7979999780654907},{"id":"https://openalex.org/keywords/pharmacokinetics-pharmacodynamics","display_name":"pharmacokinetics/pharmacodynamics","score":0.8970000147819519},{"id":"https://openalex.org/keywords/auc-mic","display_name":"AUC/MIC","score":0.6740000247955322},{"id":"https://openalex.org/keywords/toxicodynamics","display_name":"toxicodynamics","score":0.6899999976158142},{"id":"https://openalex.org/keywords/antimicrobial-resistance","display_name":"antimicrobial resistance","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C2780675486","wikidata":"https://www.wikidata.org/wiki/Q423765","display_name":"Polymyxin","level":3,"score":0.8765803575515747},{"id":"https://openalex.org/C111113717","wikidata":"https://www.wikidata.org/wiki/Q725307","display_name":"Pharmacodynamics","level":3,"score":0.7217710018157959},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6927996873855591},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6216104030609131},{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.5828055143356323},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5397641658782959},{"id":"https://openalex.org/C2780026444","wikidata":"https://www.wikidata.org/wiki/Q1088175","display_name":"Polymyxin B","level":3,"score":0.5212950706481934},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5167742967605591},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4740179181098938},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.15690380334854126},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10896360874176025}],"mesh":[{"descriptor_ui":"D000280","descriptor_name":"Administration, Inhalation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006090","descriptor_name":"Gram-Negative Bacteria","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011113","descriptor_name":"Polymyxins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011113","descriptor_name":"Polymyxins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011113","descriptor_name":"Polymyxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D016638","descriptor_name":"Critical Illness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016905","descriptor_name":"Gram-Negative Bacterial Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D016905","descriptor_name":"Gram-Negative Bacterial Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D024901","descriptor_name":"Drug Resistance, Multiple, Bacterial","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053717","descriptor_name":"Pneumonia, Ventilator-Associated","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ijantimicag.2020.106199","doi":"https://doi.org/10.1016/j.ijantimicag.2020.106199","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ijantimicag.2020.106199","pdf_url":null,"source":{"id":"https://openalex.org/S5248501","display_name":"International Journal of Antimicrobial Agents","issn_l":"0924-8579","issn":["0924-8579","1872-7913"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Antimicrobial Agents","raw_type":"journal-article"},{"id":"pmid:33075510","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33075510","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of antimicrobial agents","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7723449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7723449","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Antimicrob Agents","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7723449","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7723449","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Int J Antimicrob Agents","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1965130722","display_name":"Combating Deadly Gram-negative Lung Infections: An Inhalation and Systems Approach","funder_award_id":"R01AI132681","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6833959545","display_name":"Advancing innovative therapies against pandrug-resistant Gram-negative superbugs","funder_award_id":"R01AI146160","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7529013017","display_name":"Targeting the Urgent Need for New Antibiotics against Gram-negative \u2018Superbugs\u2019","funder_award_id":"R01AI132154","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W18840079","https://openalex.org/W1584251165","https://openalex.org/W1982462000","https://openalex.org/W1986647861","https://openalex.org/W1989974449","https://openalex.org/W1990526767","https://openalex.org/W2009293264","https://openalex.org/W2026238168","https://openalex.org/W2027986692","https://openalex.org/W2037270218","https://openalex.org/W2052899239","https://openalex.org/W2058219008","https://openalex.org/W2062595051","https://openalex.org/W2070752040","https://openalex.org/W2072437323","https://openalex.org/W2075863808","https://openalex.org/W2079457968","https://openalex.org/W2082161544","https://openalex.org/W2084542918","https://openalex.org/W2100773669","https://openalex.org/W2111882203","https://openalex.org/W2116660179","https://openalex.org/W2117795567","https://openalex.org/W2117992352","https://openalex.org/W2118734761","https://openalex.org/W2120266293","https://openalex.org/W2124882738","https://openalex.org/W2129842338","https://openalex.org/W2130614349","https://openalex.org/W2135373868","https://openalex.org/W2136291881","https://openalex.org/W2137700306","https://openalex.org/W2137755807","https://openalex.org/W2142212618","https://openalex.org/W2143796101","https://openalex.org/W2148455524","https://openalex.org/W2152344036","https://openalex.org/W2156522255","https://openalex.org/W2160312473","https://openalex.org/W2161447992","https://openalex.org/W2162268639","https://openalex.org/W2162661622","https://openalex.org/W2164032940","https://openalex.org/W2168502103","https://openalex.org/W2170001997","https://openalex.org/W2171214880","https://openalex.org/W2178886985","https://openalex.org/W2301193798","https://openalex.org/W2308304054","https://openalex.org/W2408883625","https://openalex.org/W2492752357","https://openalex.org/W2563139642","https://openalex.org/W2566638444","https://openalex.org/W2573177864","https://openalex.org/W2606797031","https://openalex.org/W2607217081","https://openalex.org/W2620438757","https://openalex.org/W2621076824","https://openalex.org/W2765209236","https://openalex.org/W2770244562","https://openalex.org/W2774452110","https://openalex.org/W2774590026","https://openalex.org/W2780938081","https://openalex.org/W2781961936","https://openalex.org/W2782523178","https://openalex.org/W2803136876","https://openalex.org/W2911566892","https://openalex.org/W2965288488","https://openalex.org/W2966535838","https://openalex.org/W4230925475","https://openalex.org/W4252795060"],"related_works":["https://openalex.org/W3206831896","https://openalex.org/W3014582796","https://openalex.org/W2107050135","https://openalex.org/W3143667616","https://openalex.org/W2386116535","https://openalex.org/W2917670078","https://openalex.org/W2590316564","https://openalex.org/W2066560470","https://openalex.org/W2000237020","https://openalex.org/W1999621758"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-10-22T00:00:00"}