{"id":"https://openalex.org/W3093201397","doi":"https://doi.org/10.7554/elife.56573","title":"Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver","display_name":"Weight loss, insulin resistance, and study design confound results in a meta-analysis of animal models of fatty liver","publication_year":2020,"publication_date":"2020-10-16","ids":{"openalex":"https://openalex.org/W3093201397","doi":"https://doi.org/10.7554/elife.56573","mag":"3093201397","pmid":"https://pubmed.ncbi.nlm.nih.gov/33063664","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7647398"},"language":"en","primary_location":{"id":"doi:10.7554/elife.56573","doi":"https://doi.org/10.7554/elife.56573","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.56573","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.56573","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024406598","display_name":"Harriet Hunter","orcid":"https://orcid.org/0000-0002-5204-2371","observed_orcids":["https://orcid.org/0000-0002-5204-2371"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Harriet Hunter","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080752283","display_name":"Dana de Gracia Hahn","orcid":"https://orcid.org/0000-0003-1916-0007","observed_orcids":["https://orcid.org/0000-0003-1916-0007"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Dana de Gracia Hahn","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062506190","display_name":"Am\u00e9dine Duret","orcid":"https://orcid.org/0000-0002-5810-2195","observed_orcids":["https://orcid.org/0000-0002-5810-2195"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Amedine Duret","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013381424","display_name":"Yu Ri Im","orcid":"https://orcid.org/0000-0001-7313-696X","observed_orcids":["https://orcid.org/0000-0001-7313-696X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Yu Ri Im","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050352393","display_name":"Qinrong Cheah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Qinrong Cheah","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039516363","display_name":"Jiawen Dong","orcid":"https://orcid.org/0000-0002-7204-9431","observed_orcids":["https://orcid.org/0000-0002-7204-9431"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jiawen Dong","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021744286","display_name":"Madison Fairey","orcid":"https://orcid.org/0000-0002-4696-1937","observed_orcids":["https://orcid.org/0000-0002-4696-1937"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Madison Fairey","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036164677","display_name":"Clarissa Hjalmarsson","orcid":"https://orcid.org/0000-0003-2961-5984","observed_orcids":["https://orcid.org/0000-0003-2961-5984"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Clarissa Hjalmarsson","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101645235","display_name":"Alice Li","orcid":"https://orcid.org/0000-0002-8777-2542","observed_orcids":["https://orcid.org/0000-0002-8777-2542"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alice Li","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041375975","display_name":"Hong Kai Lim","orcid":"https://orcid.org/0000-0002-7266-7790","observed_orcids":["https://orcid.org/0000-0002-7266-7790"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hong Kai Lim","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019397735","display_name":"Lorc\u00e1n McKeown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lorc\u00e1n McKeown","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031327536","display_name":"Claudia\u2010Gabriela Mitrofan","orcid":"https://orcid.org/0000-0003-1050-8767","observed_orcids":["https://orcid.org/0000-0003-1050-8767"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Claudia-Gabriela Mitrofan","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019299531","display_name":"Raunak Rao","orcid":"https://orcid.org/0000-0002-6954-575X","observed_orcids":["https://orcid.org/0000-0002-6954-575X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raunak Rao","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043756310","display_name":"Mrudula Utukuri","orcid":"https://orcid.org/0000-0003-1510-469X","observed_orcids":["https://orcid.org/0000-0003-1510-469X"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mrudula Utukuri","raw_affiliation_strings":["School of Clinical Medicine, University of Cambridge, Cambridge, UK","School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023545015","display_name":"Ian A.C. Rowe","orcid":"https://orcid.org/0000-0003-1288-0749","observed_orcids":["https://orcid.org/0000-0003-1288-0749"]},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ian A. Rowe","raw_affiliation_strings":["Leeds Institute for Medical Research & Leeds Institute for Data Analytics, University of Leeds, Leeds, UK","Leeds Institute for Medical Research & Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leeds Institute for Medical Research & Leeds Institute for Data Analytics, University of Leeds, Leeds, UK","institution_ids":["https://openalex.org/I130828816"]},{"raw_affiliation_string":"Leeds Institute for Medical Research & Leeds Institute for Data Analytics, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015567054","display_name":"Jake Peter Mann","orcid":"https://orcid.org/0000-0002-4711-9215","observed_orcids":["https://orcid.org/0000-0002-4711-9215"]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]},{"id":"https://openalex.org/I4210116691","display_name":"Wellcome/MRC Institute of Metabolic Science","ror":"https://ror.org/0264dxb48","country_code":"GB","type":"facility","lineage":["https://openalex.org/I241749","https://openalex.org/I2802466933","https://openalex.org/I4210087105","https://openalex.org/I4210116691","https://openalex.org/I87048295","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Jake P. Mann","raw_affiliation_strings":["Institute of Metabolic Science, University of Cambridge, Cambridge, UK","Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0002-4711-9215","affiliations":[{"raw_affiliation_string":"Institute of Metabolic Science, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210116691"]},{"raw_affiliation_string":"Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5015567054"],"corresponding_institution_ids":["https://openalex.org/I241749","https://openalex.org/I4210116691"],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":0.1628,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.18771527,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"9","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12281","display_name":"Animal testing and alternatives","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12964","display_name":"Diet, Metabolism, and Disease","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-alcoholic-fatty-liver-disease","display_name":"non-alcoholic fatty liver disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/animal-models-of-disease","display_name":"animal models of disease","score":0.8050000071525574},{"id":"https://openalex.org/keywords/rodent-studies","display_name":"rodent studies","score":0.8140000104904175},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.9509999752044678},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.9990000128746033},{"id":"https://openalex.org/keywords/publication-bias","display_name":"publication bias","score":0.6610000133514404},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.800000011920929},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.7440000176429749},{"id":"https://openalex.org/keywords/diet-composition","display_name":"diet composition","score":0.5979999899864197},{"id":"https://openalex.org/keywords/animal-age","display_name":"animal age","score":0.7149999737739563},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.8131966590881348},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8080240488052368},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.6420334577560425},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5666670799255371},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5494458675384521},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.48438960313796997},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4699808657169342},{"id":"https://openalex.org/C172268261","wikidata":"https://www.wikidata.org/wiki/Q4764988","display_name":"Animal studies","level":2,"score":0.4664878845214844},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.4470161199569702},{"id":"https://openalex.org/C2776954865","wikidata":"https://www.wikidata.org/wiki/Q1546498","display_name":"Nonalcoholic fatty liver disease","level":4,"score":0.4463537931442261},{"id":"https://openalex.org/C2777075537","wikidata":"https://www.wikidata.org/wiki/Q929737","display_name":"Liver disease","level":2,"score":0.43733346462249756},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.40444886684417725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4007042646408081},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.34702587127685547}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065626","descriptor_name":"Non-alcoholic Fatty Liver Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":9,"locations":[{"id":"doi:10.7554/elife.56573","doi":"https://doi.org/10.7554/elife.56573","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.56573","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},{"id":"doi:10.1101/2019.12.31.887919","doi":"https://doi.org/10.1101/2019.12.31.887919","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2019.12.31.887919","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/02/25/2019.12.31.887919.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:33063664","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33063664","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7647398","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7647398/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e3d2a6b4f51e4f3e833552afae4730a8","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e3d2a6b4f51e4f3e833552afae4730a8","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife, Vol 9 (2020)","raw_type":"article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/311681","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/311681","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/312584","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/312584","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.58771","doi":"https://doi.org/10.17863/cam.58771","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.58771","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.17863/cam.59685","doi":"https://doi.org/10.17863/cam.59685","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.59685","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.7554/elife.56573","doi":"https://doi.org/10.7554/elife.56573","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.56573","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"eLife","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[{"id":"https://openalex.org/G3805779214","display_name":"University of Cambridge PhD Programme for Clinicians","funder_award_id":"204017","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G582402242","display_name":"Human genetic evidence linking mitochondrial defects and adiposity.","funder_award_id":"216329","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320325442","display_name":"European Society for Paediatric Research","ror":"https://ror.org/004n3ms37"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093201397.pdf","grobid_xml":"https://content.openalex.org/works/W3093201397.grobid-xml"},"referenced_works_count":84,"referenced_works":["https://openalex.org/W90736706","https://openalex.org/W784232644","https://openalex.org/W1523155649","https://openalex.org/W1583321927","https://openalex.org/W1950977525","https://openalex.org/W1964572117","https://openalex.org/W1971092719","https://openalex.org/W2000053231","https://openalex.org/W2021000378","https://openalex.org/W2023380764","https://openalex.org/W2033585778","https://openalex.org/W2050034605","https://openalex.org/W2055564165","https://openalex.org/W2058148588","https://openalex.org/W2062812115","https://openalex.org/W2063437798","https://openalex.org/W2065655717","https://openalex.org/W2067740038","https://openalex.org/W2084072489","https://openalex.org/W2084889414","https://openalex.org/W2085452046","https://openalex.org/W2092695592","https://openalex.org/W2099067203","https://openalex.org/W2100068213","https://openalex.org/W2107031757","https://openalex.org/W2109963121","https://openalex.org/W2116952900","https://openalex.org/W2120244696","https://openalex.org/W2136462620","https://openalex.org/W2137516955","https://openalex.org/W2139168999","https://openalex.org/W2141759041","https://openalex.org/W2151096913","https://openalex.org/W2152652033","https://openalex.org/W2156665896","https://openalex.org/W2156801000","https://openalex.org/W2162382402","https://openalex.org/W2164074199","https://openalex.org/W2164759539","https://openalex.org/W2198678228","https://openalex.org/W2204701188","https://openalex.org/W2215535790","https://openalex.org/W2291538400","https://openalex.org/W2293061316","https://openalex.org/W2406493898","https://openalex.org/W2422375524","https://openalex.org/W2429102024","https://openalex.org/W2470709274","https://openalex.org/W2513840036","https://openalex.org/W2522782769","https://openalex.org/W2560438049","https://openalex.org/W2600119935","https://openalex.org/W2734724639","https://openalex.org/W2759997926","https://openalex.org/W2761773860","https://openalex.org/W2769826158","https://openalex.org/W2784764983","https://openalex.org/W2790635026","https://openalex.org/W2805710986","https://openalex.org/W2808672726","https://openalex.org/W2809030969","https://openalex.org/W2810423511","https://openalex.org/W2821544409","https://openalex.org/W2884823863","https://openalex.org/W2887350709","https://openalex.org/W2887902401","https://openalex.org/W2894776121","https://openalex.org/W2896985838","https://openalex.org/W2899389750","https://openalex.org/W2922156643","https://openalex.org/W2940657120","https://openalex.org/W2953396318","https://openalex.org/W2955603751","https://openalex.org/W2955615964","https://openalex.org/W2955835094","https://openalex.org/W3001786135","https://openalex.org/W3009945933","https://openalex.org/W3082261340","https://openalex.org/W3110298225","https://openalex.org/W4240484632","https://openalex.org/W4299627282","https://openalex.org/W4300869678","https://openalex.org/W4362504902","https://openalex.org/W6786972644"],"related_works":["https://openalex.org/W2998323822","https://openalex.org/W2160832007","https://openalex.org/W3109236894","https://openalex.org/W2409670205","https://openalex.org/W98885122","https://openalex.org/W2920366186","https://openalex.org/W2177414021","https://openalex.org/W1896344567","https://openalex.org/W2025680761","https://openalex.org/W2374679381"],"abstract_inverted_index":{"The":[0],"classical":[1],"drug":[2,90],"development":[3],"pipeline":[4],"necessitates":[5],"studies":[6,63],"using":[7],"animal":[8,51],"models":[9],"of":[10,50,59,79,111,119,138,145],"human":[11],"disease":[12,35,41],"to":[13,30,68,134],"gauge":[14],"future":[15],"efficacy":[16],"in":[17,28,66,87,97,102],"humans,":[18],"however":[19],"there":[20],"is":[21,37],"a":[22,38,47,55],"low":[23],"conversion":[24],"rate":[25],"from":[26],"success":[27],"animals":[29,112],"humans.":[31],"Non-alcoholic":[32],"fatty":[33],"liver":[34],"(NAFLD)":[36],"complex":[39],"chronic":[40],"without":[42],"any":[43],"established":[44],"therapies":[45],"and":[46,77,113,140],"major":[48],"field":[49,144],"research.":[52],"We":[53],"performed":[54],"meta-analysis":[56],"with":[57,85],"meta-regression":[58],"603":[60],"interventional":[61],"rodent":[62],"(10,364":[64],"animals)":[65],"NAFLD":[67],"assess":[69],"which":[70],"variables":[71],"influenced":[72,116],"treatment":[73,120],"response.":[74],"Weight":[75],"loss":[76,101],"alleviation":[78],"insulin":[80],"resistance":[81],"were":[82],"consistently":[83],"associated":[84],"improvement":[86],"NAFLD.":[88],"Multiple":[89],"classes":[91],"that":[92],"do":[93],"not":[94],"affect":[95],"weight":[96,100],"humans":[98],"caused":[99],"animals.":[103],"Other":[104],"study":[105],"design":[106],"variables,":[107],"such":[108],"as":[109],"age":[110],"dietary":[114],"composition,":[115],"the":[117,136,143],"magnitude":[118],"effect.":[121],"Publication":[122],"bias":[123],"may":[124],"have":[125],"increased":[126],"effect":[127],"estimates":[128],"by":[129],"37-79%.":[130],"These":[131],"findings":[132],"help":[133],"explain":[135],"challenge":[137],"reproducibility":[139],"translation":[141],"within":[142],"metabolism.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-10-22T00:00:00"}