{"id":"https://openalex.org/W3093085773","doi":"https://doi.org/10.1002/jmv.26597","title":"Effects of SARS\u2010CoV\u20102 mutations on protein structures and intraviral protein\u2013protein interactions","display_name":"Effects of SARS\u2010CoV\u20102 mutations on protein structures and intraviral protein\u2013protein interactions","publication_year":2020,"publication_date":"2020-10-14","ids":{"openalex":"https://openalex.org/W3093085773","doi":"https://doi.org/10.1002/jmv.26597","mag":"3093085773","pmid":"https://pubmed.ncbi.nlm.nih.gov/33090512","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7675365"},"language":"en","primary_location":{"id":"doi:10.1002/jmv.26597","doi":"https://doi.org/10.1002/jmv.26597","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmv.26597","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.26597","source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.26597","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057659083","display_name":"Siqi Wu","orcid":"https://orcid.org/0000-0002-2442-5041","observed_orcids":["https://orcid.org/0000-0002-2442-5041"]},"institutions":[{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Wu","raw_affiliation_strings":["College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chang Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Tian","raw_affiliation_strings":["College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100384499","display_name":"Panpan Liu","orcid":"https://orcid.org/0000-0002-7447-7026","observed_orcids":["https://orcid.org/0000-0002-7447-7026"]},"institutions":[{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Panpan Liu","raw_affiliation_strings":["College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101338690","display_name":"Dongjie Guo","orcid":"https://orcid.org/0009-0008-8030-3111","observed_orcids":["https://orcid.org/0009-0008-8030-3111"]},"institutions":[{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongjie Guo","raw_affiliation_strings":["College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100693002","display_name":"Wei Hui Zheng","orcid":"https://orcid.org/0000-0002-2984-9003","observed_orcids":["https://orcid.org/0000-0002-2984-9003"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zheng","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":"https://orcid.org/0000-0002-2984-9003","affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072178740","display_name":"Xiaoqiang Huang","orcid":"https://orcid.org/0000-0002-1005-848X","observed_orcids":["https://orcid.org/0000-0002-1005-848X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoqiang Huang","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100354659","display_name":"Yang Zhang","orcid":"https://orcid.org/0000-0002-2739-1916","observed_orcids":["https://orcid.org/0000-0002-2739-1916","https://orcid.org/0000-0002-0789-4938","https://orcid.org/0000-0003-1405-0212"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Zhang","raw_affiliation_strings":["Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA","Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063684693","display_name":"Lijun Liu","orcid":"https://orcid.org/0000-0002-0027-4525","observed_orcids":["https://orcid.org/0000-0002-0027-4525"]},"institutions":[{"id":"https://openalex.org/I9224756","display_name":"Northeastern University","ror":"https://ror.org/03awzbc87","country_code":"CN","type":"education","lineage":["https://openalex.org/I9224756"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lijun Liu","raw_affiliation_strings":["College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China"],"raw_orcid":"https://orcid.org/0000-0002-0027-4525","affiliations":[{"raw_affiliation_string":"College of Life and Health Sciences, Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]},{"raw_affiliation_string":"Key Laboratory of Data Analytics and Optimization for Smart Industry (Ministry of Education), Northeastern University, Shenyang, Liaoning, China","institution_ids":["https://openalex.org/I9224756"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063684693"],"corresponding_institution_ids":["https://openalex.org/I9224756"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":3.0334,"has_fulltext":false,"cited_by_count":112,"citation_normalized_percentile":{"value":0.95317641,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"93","issue":"4","first_page":"2132","last_page":"2140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9950000047683716},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9020000100135803},{"id":"https://openalex.org/keywords/nonsynonymous-mutations","display_name":"non-synonymous mutations","score":0.9309999942779541},{"id":"https://openalex.org/keywords/protein-structure","display_name":"protein structure","score":0.6589999794960022},{"id":"https://openalex.org/keywords/binding-affinity","display_name":"binding affinity","score":0.5920000076293945},{"id":"https://openalex.org/keywords/hot-spots","display_name":"hot spots","score":0.609000027179718},{"id":"https://openalex.org/keywords/orf3a","display_name":"ORF3a","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nucleocapsid-protein","display_name":"nucleocapsid protein","score":0.9810000061988831},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.5109999775886536},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"viral evolution","score":0.460999995470047}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8000756502151489},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.6703931093215942},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5581973791122437},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5343856811523438},{"id":"https://openalex.org/C3020799909","wikidata":"https://www.wikidata.org/wiki/Q85438966","display_name":"Sars virus","level":5,"score":0.511756420135498},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4585670232772827},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43524667620658875},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3439881205558777},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23643600940704346},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19297993183135986},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.07170206308364868},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016366","descriptor_name":"Open Reading Frames","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/jmv.26597","doi":"https://doi.org/10.1002/jmv.26597","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmv.26597","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.26597","source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"doi:10.1101/2020.08.15.241349","doi":"https://doi.org/10.1101/2020.08.15.241349","is_oa":false,"landing_page_url":"https://doi.org/10.1101/2020.08.15.241349","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7675365","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7675365","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Med Virol","raw_type":"Text"},{"id":"pmid:33090512","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33090512","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/jmv.26597","doi":"https://doi.org/10.1002/jmv.26597","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jmv.26597","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.26597","source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6680100312","display_name":null,"funder_award_id":"N2020006","funder_id":"https://openalex.org/F4320315682","funder_display_name":"Northeastern University"}],"funders":[{"id":"https://openalex.org/F4320315682","display_name":"Northeastern University","ror":"https://ror.org/04t5xt781"}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093085773.pdf"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1491507080","https://openalex.org/W1968574388","https://openalex.org/W1989181256","https://openalex.org/W1989969147","https://openalex.org/W2037312364","https://openalex.org/W2056873822","https://openalex.org/W2058517217","https://openalex.org/W2070979531","https://openalex.org/W2083371701","https://openalex.org/W2094875270","https://openalex.org/W2099839322","https://openalex.org/W2099861795","https://openalex.org/W2102245393","https://openalex.org/W2107063920","https://openalex.org/W2107198142","https://openalex.org/W2108338199","https://openalex.org/W2126511940","https://openalex.org/W2129558039","https://openalex.org/W2130754579","https://openalex.org/W2140388343","https://openalex.org/W2146850348","https://openalex.org/W2154019529","https://openalex.org/W2154389387","https://openalex.org/W2162141791","https://openalex.org/W2167005142","https://openalex.org/W2289212387","https://openalex.org/W2306794997","https://openalex.org/W2512372054","https://openalex.org/W2519928122","https://openalex.org/W3003464757","https://openalex.org/W3004280078","https://openalex.org/W3004318991","https://openalex.org/W3012655066","https://openalex.org/W3013946074","https://openalex.org/W3015124303","https://openalex.org/W3015615405","https://openalex.org/W3020188044","https://openalex.org/W3024355434","https://openalex.org/W3025787542","https://openalex.org/W3032133680","https://openalex.org/W3034395518","https://openalex.org/W3034399120","https://openalex.org/W3035072925","https://openalex.org/W3039798227","https://openalex.org/W3039901154","https://openalex.org/W3041878751","https://openalex.org/W3088478741","https://openalex.org/W3094406762","https://openalex.org/W3188463142"],"related_works":["https://openalex.org/W4206450250","https://openalex.org/W4280609023","https://openalex.org/W4220720184","https://openalex.org/W4230952878","https://openalex.org/W4225919358","https://openalex.org/W3142381891","https://openalex.org/W3122061084","https://openalex.org/W3044612344","https://openalex.org/W3166508920","https://openalex.org/W3143532022"],"abstract_inverted_index":{"Since":[0],"2019,":[1],"severe":[2],"acute":[3],"respiratory":[4],"syndrome":[5],"coronavirus":[6,10],"2":[7],"(SARS-CoV-2)":[8],"causing":[9],"disease":[11],"2019":[12],"(COVID-19)":[13],"has":[14],"infected":[15],"10":[16],"millions":[17],"of":[18,35,89,108,147,198,230,243],"people":[19],"across":[20],"the":[21,32,56,66,77,98,144,153,165,185,196,231],"globe,":[22],"and":[23,51,93,96,123,131,173,187,202,227,241],"massive":[24],"mutations":[25,75,109,141,179,219],"in":[26,40,48,76,80,113,125,133,170,200,204,210],"virus":[27],"genome":[28,79],"have":[29,235],"occurred":[30],"during":[31],"rapid":[33],"spread":[34],"this":[36,69],"novel":[37],"coronavirus.":[38],"Variance":[39],"protein":[41,49,100,114,149,175,223],"sequence":[42],"might":[43,234],"lead":[44],"to":[45],"a":[46],"change":[47,221],"structure":[50],"interaction,":[52],"then":[53,94],"further":[54],"affect":[55],"viral":[57,222],"physiological":[58],"characteristics,":[59],"which":[60,81,120,164],"could":[61,220],"bring":[62],"tremendous":[63],"influence":[64],"on":[65,237],"pandemic.":[67],"In":[68,151],"study,":[70],"we":[71,137],"investigated":[72],"20":[73],"nonsynonymous":[74],"SARS-CoV-2":[78,218,238],"incidence":[82],"rates":[83],"were":[84,121,161,180,206],"all":[85,183],"\u2265":[86,117],"1%":[87],"as":[88,191],"September":[90],"1st,":[91],"2020,":[92],"modeled":[95],"analyzed":[97],"mutant":[99,159],"structures.":[101],"The":[102],"results":[103],"showed":[104],"that":[105,139,217],"four":[106],"types":[107],"caused":[110],"dramatic":[111],"changes":[112],"structures":[115],"(RMSD":[116],"5.0":[118],"\u00c5),":[119],"Q57H":[122,167,203],"G251V":[124],"open-reading":[126],"frames":[127],"3a":[128],"(ORF3a),":[129],"S194L,":[130],"R203K/G204R":[132,199],"nucleocapsid":[134],"(N).":[135],"Next,":[136],"found":[138],"these":[140,157,178],"also":[142],"affected":[143],"binding":[145,225],"affinity":[146],"intraviral":[148],"interactions.":[150,176],"addition,":[152],"hot":[154,228],"spots":[155,229],"within":[156],"docking":[158],"complexes":[160],"altered,":[162],"among":[163],"mutation":[166],"was":[168],"involved":[169],"both":[171,207],"Orf3a-S":[172],"Orf3a-Orf8":[174],"Besides,":[177],"widely":[181],"distributed":[182],"over":[184,208],"world,":[186],"their":[188],"occurrences":[189],"fluctuated":[190],"time":[192],"went":[193],"on.":[194],"Notably,":[195],"incidences":[197],"N":[201],"Orf3a":[205],"50%":[209],"some":[211],"countries.":[212],"Overall,":[213],"our":[214],"findings":[215],"suggest":[216],"structure,":[224],"affinity,":[226],"interface,":[232],"thereby":[233],"impacts":[236],"transmission,":[239],"diagnosis,":[240],"treatment":[242],"COVID-19.":[244]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":46},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-10-22T00:00:00"}
