{"id":"https://openalex.org/W3093042877","doi":"https://doi.org/10.1101/2020.10.18.344515","title":"Unraveling the transcriptional networks that drive oligodendrocyte fate specification in Sonic hedgehog-responsive neocortical progenitors","display_name":"Unraveling the transcriptional networks that drive oligodendrocyte fate specification in Sonic hedgehog-responsive neocortical progenitors","publication_year":2020,"publication_date":"2020-10-18","ids":{"openalex":"https://openalex.org/W3093042877","doi":"https://doi.org/10.1101/2020.10.18.344515","mag":"3093042877"},"language":"en","primary_location":{"id":"doi:10.1101/2020.10.18.344515","doi":"https://doi.org/10.1101/2020.10.18.344515","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.18.344515","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/18/2020.10.18.344515.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/18/2020.10.18.344515.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051478714","display_name":"Caitlin C. Winkler","orcid":"https://orcid.org/0000-0002-5947-5989","observed_orcids":["https://orcid.org/0000-0002-5947-5989"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Caitlin C. Winkler","raw_affiliation_strings":["Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine","Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine","RNA Biosciences Initiative, University of Colorado School of Medicine","Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA"],"raw_orcid":"https://orcid.org/0000-0002-5947-5989","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"RNA Biosciences Initiative, University of Colorado School of Medicine","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026859691","display_name":"Luuli N. Tran","orcid":"https://orcid.org/0000-0001-5546-9023","observed_orcids":["https://orcid.org/0000-0001-5546-9023"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luuli N. Tran","raw_affiliation_strings":["Graduate Program in Molecular Biology, University of Colorado Graduate School","Graduate Program in Molecular Biology, University of Colorado Graduate School -Anschutz Medical Campus, Aurora, CO 8005, USA"],"raw_orcid":"https://orcid.org/0000-0001-5546-9023","affiliations":[{"raw_affiliation_string":"Graduate Program in Molecular Biology, University of Colorado Graduate School","institution_ids":["https://openalex.org/I921990950"]},{"raw_affiliation_string":"Graduate Program in Molecular Biology, University of Colorado Graduate School -Anschutz Medical Campus, Aurora, CO 8005, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059996369","display_name":"Ellyn P. Milan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellyn P. Milan","raw_affiliation_strings":["Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine","Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060963085","display_name":"Fernando Garc\u00eda\u2010Moreno","orcid":"https://orcid.org/0000-0001-9048-4237","observed_orcids":["https://orcid.org/0000-0001-9048-4237"]},"institutions":[{"id":"https://openalex.org/I110594554","display_name":"Ikerbasque","ror":"https://ror.org/01cc3fy72","country_code":"ES","type":"other","lineage":["https://openalex.org/I110594554"]},{"id":"https://openalex.org/I169108374","display_name":"University of the Basque Country","ror":"https://ror.org/000xsnr85","country_code":"ES","type":"education","lineage":["https://openalex.org/I169108374"]},{"id":"https://openalex.org/I4210100306","display_name":"Achucarro Basque Center for Neuroscience","ror":"https://ror.org/00myw9y39","country_code":"ES","type":"education","lineage":["https://openalex.org/I2800374234","https://openalex.org/I4210100306"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fernando Garc\u00eda-Moreno","raw_affiliation_strings":["Achucarro Basque Center for Neuroscience, Edificio Sede del Parque Cient\u00edfico de la UPV/EHU","Ikerbasque - Basque Foundation for Science, Mar\u00eda D\u00edaz de Haro","Achucarro Basque Center for Neuroscience, Edificio Sede del Parque Cient\u00edfico de la UPV/EHU, Leioa, Spain","Ikerbasque - Basque Foundation for Science, Mar\u00eda D\u00edaz de Haro, Bilbao, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Achucarro Basque Center for Neuroscience, Edificio Sede del Parque Cient\u00edfico de la UPV/EHU","institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210100306"]},{"raw_affiliation_string":"Ikerbasque - Basque Foundation for Science, Mar\u00eda D\u00edaz de Haro","institution_ids":["https://openalex.org/I110594554"]},{"raw_affiliation_string":"Achucarro Basque Center for Neuroscience, Edificio Sede del Parque Cient\u00edfico de la UPV/EHU, Leioa, Spain","institution_ids":["https://openalex.org/I169108374","https://openalex.org/I4210100306"]},{"raw_affiliation_string":"Ikerbasque - Basque Foundation for Science, Mar\u00eda D\u00edaz de Haro, Bilbao, Spain","institution_ids":["https://openalex.org/I110594554"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001928112","display_name":"Santos J. Franco","orcid":"https://orcid.org/0000-0002-4478-5634","observed_orcids":["https://orcid.org/0000-0002-4478-5634"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Santos J. Franco","raw_affiliation_strings":["Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine","Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA"],"raw_orcid":"https://orcid.org/0000-0002-4478-5634","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA","institution_ids":["https://openalex.org/I51713134"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5001928112","https://openalex.org/A5051478714"],"corresponding_institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12009","display_name":"Hedgehog Signaling Pathway Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sonic-hedgehog-signaling","display_name":"Sonic hedgehog signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/oligodendrocyte-precursor-cells","display_name":"oligodendrocyte precursor cells","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ascl1","display_name":"ASCL1","score":0.9269999861717224},{"id":"https://openalex.org/keywords/transcriptional-regulatory-networks","display_name":"transcriptional regulatory networks","score":0.753000020980835},{"id":"https://openalex.org/keywords/lineage-tracing","display_name":"lineage tracing","score":0.6690000295639038},{"id":"https://openalex.org/keywords/pseudotime-trajectory-analysis","display_name":"pseudotime trajectory analysis","score":0.6399999856948853},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.8952196836471558},{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.7466707825660706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7400859594345093},{"id":"https://openalex.org/C2779055221","wikidata":"https://www.wikidata.org/wiki/Q18035130","display_name":"OLIG2","level":5,"score":0.6904895901679993},{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.679948091506958},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6718947291374207},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.550237774848938},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5458796620368958},{"id":"https://openalex.org/C2777222312","wikidata":"https://www.wikidata.org/wiki/Q726562","display_name":"Neocortex","level":2,"score":0.5129703879356384},{"id":"https://openalex.org/C2779715522","wikidata":"https://www.wikidata.org/wiki/Q507027","display_name":"Forebrain","level":3,"score":0.49478453397750854},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.41212689876556396},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39524224400520325},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.38096877932548523},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3109191060066223},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23568204045295715},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.19397491216659546},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19247058033943176},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1686815619468689},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1309899389743805}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2020.10.18.344515","doi":"https://doi.org/10.1101/2020.10.18.344515","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.18.344515","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/18/2020.10.18.344515.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2020.10.18.344515","doi":"https://doi.org/10.1101/2020.10.18.344515","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.18.344515","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/18/2020.10.18.344515.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3093042877.pdf","grobid_xml":"https://content.openalex.org/works/W3093042877.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1857568828","https://openalex.org/W1862183074","https://openalex.org/W1970795696","https://openalex.org/W1976626765","https://openalex.org/W1986209719","https://openalex.org/W1987176049","https://openalex.org/W1991026593","https://openalex.org/W1995960135","https://openalex.org/W1996117950","https://openalex.org/W2010441495","https://openalex.org/W2012139094","https://openalex.org/W2019433791","https://openalex.org/W2021258728","https://openalex.org/W2031224620","https://openalex.org/W2031482377","https://openalex.org/W2036848228","https://openalex.org/W2051588335","https://openalex.org/W2056404556","https://openalex.org/W2080417264","https://openalex.org/W2082631547","https://openalex.org/W2085393193","https://openalex.org/W2094065018","https://openalex.org/W2094842746","https://openalex.org/W2095921288","https://openalex.org/W2096806497","https://openalex.org/W2101147969","https://openalex.org/W2102212449","https://openalex.org/W2104135721","https://openalex.org/W2105720738","https://openalex.org/W2107665951","https://openalex.org/W2112066508","https://openalex.org/W2113377982","https://openalex.org/W2122199698","https://openalex.org/W2124142272","https://openalex.org/W2136051820","https://openalex.org/W2151515384","https://openalex.org/W2155082284","https://openalex.org/W2156328387","https://openalex.org/W2163642474","https://openalex.org/W2165981171","https://openalex.org/W2166643977","https://openalex.org/W2415341492","https://openalex.org/W2526467926","https://openalex.org/W2739798479","https://openalex.org/W2766437506","https://openalex.org/W2781205255","https://openalex.org/W2792558221","https://openalex.org/W2799466292","https://openalex.org/W2800392236","https://openalex.org/W2801000730","https://openalex.org/W2804420785","https://openalex.org/W2898901335","https://openalex.org/W2905710132","https://openalex.org/W2909288689","https://openalex.org/W2917499513","https://openalex.org/W2937177974","https://openalex.org/W2951799803","https://openalex.org/W2953332659","https://openalex.org/W3004345103","https://openalex.org/W3006081887","https://openalex.org/W3009370296","https://openalex.org/W3015072154","https://openalex.org/W3016174557","https://openalex.org/W3038104382","https://openalex.org/W3043189435","https://openalex.org/W3046514020","https://openalex.org/W3047141442","https://openalex.org/W3184208286","https://openalex.org/W3194376748","https://openalex.org/W7052477098"],"related_works":["https://openalex.org/W2054374722","https://openalex.org/W7134950684","https://openalex.org/W7214122229","https://openalex.org/W4396690135","https://openalex.org/W2801000730","https://openalex.org/W2017848407","https://openalex.org/W2167984281","https://openalex.org/W7162326423","https://openalex.org/W2886719934","https://openalex.org/W2149964069"],"abstract_inverted_index":{"In":[0],"the":[1,55,71,83,141,163,175],"developing":[2],"nervous":[3],"system,":[4],"progenitors":[5,26,61,102,151],"first":[6,58],"generate":[7],"neurons":[8],"before":[9],"making":[10],"astrocytes":[11],"and":[12,111,179],"oligodendrocytes.":[13,154],"We":[14,57,155],"previously":[15],"showed":[16],"that":[17,131],"increased":[18],"Sonic":[19],"hedgehog":[20],"(Shh)":[21],"signaling":[22],"in":[23,54,65,70,159],"dorsal":[24,73,150],"forebrain":[25],"is":[27],"important":[28],"for":[29,135],"their":[30],"production":[31],"of":[32],"oligodendrocytes":[33],"as":[34,98],"neurogenesis":[35,178],"winds":[36],"down.":[37],"Here,":[38],"we":[39,117,129],"analyzed":[40],"single-cell":[41],"RNA":[42],"sequencing":[43],"datasets":[44,107],"to":[45,82,103],"better":[46],"understand":[47],"how":[48],"Shh":[49,67,161],"controls":[50],"this":[51,92],"neuron-to-oligodendrocyte":[52],"switch":[53,176],"neocortex.":[56],"identified":[59],"Shh-responding":[60],"using":[62],"a":[63,79,95,119,136,157],"dataset":[64],"which":[66,160],"was":[68],"overexpressed":[69],"mouse":[72,110],"forebrain.":[74],"Pseudotime":[75],"trajectory":[76],"inferences":[77],"revealed":[78],"subpopulation":[80],"committed":[81],"oligodendrocyte":[84],"precursor":[85],"cell":[86],"(OPC)":[87],"lineage.":[88],"Genes":[89],"upregulated":[90],"along":[91],"lineage":[93],"defined":[94],"pre-OPC":[96,120],"state,":[97],"cells":[99],"transitioned":[100],"from":[101,108],"OPCs.":[104],"Using":[105],"several":[106],"wild-type":[109],"human":[112],"embryos":[113],"at":[114],"different":[115],"ages,":[116],"confirmed":[118],"state":[121],"preceding":[122],"OPC":[123],"emergence":[124],"during":[125],"normal":[126],"development.":[127],"Finally,":[128],"show":[130],"pre-OPCs":[132],"are":[133],"enriched":[134],"gene":[137],"regulatory":[138],"network":[139],"involving":[140],"transcription":[142],"factor":[143],"Ascl1.":[144],"Genetic":[145],"lineage-tracing":[146],"demonstrated":[147],"Ascl1":[148,171],"+":[149],"primarily":[152],"make":[153],"propose":[156],"model":[158],"shifts":[162],"balance":[164],"between":[165,177],"opposing":[166],"transcriptional":[167],"networks":[168],"toward":[169],"an":[170],"lineage,":[172],"thereby":[173],"facilitating":[174],"oligodendrogenesis.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-10-22T00:00:00"}