{"id":"https://openalex.org/W3092880796","doi":"https://doi.org/10.1093/toxsci/kfaa161","title":"Early Life Exposure to Environmental Contaminants (BDE-47, TBBPA, and BPS) Produced Persistent Alterations in Fecal Microbiome in Adult Male Mice","display_name":"Early Life Exposure to Environmental Contaminants (BDE-47, TBBPA, and BPS) Produced Persistent Alterations in Fecal Microbiome in Adult Male Mice","publication_year":2020,"publication_date":"2020-10-08","ids":{"openalex":"https://openalex.org/W3092880796","doi":"https://doi.org/10.1093/toxsci/kfaa161","mag":"3092880796","pmid":"https://pubmed.ncbi.nlm.nih.gov/33078840","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8456301"},"language":"en","primary_location":{"id":"doi:10.1093/toxsci/kfaa161","doi":"https://doi.org/10.1093/toxsci/kfaa161","is_oa":false,"landing_page_url":"https://doi.org/10.1093/toxsci/kfaa161","pdf_url":null,"source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC8456301","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014440566","display_name":"Matthew V Gomez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew V Gomez","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101623540","display_name":"Moumita Dutta","orcid":"https://orcid.org/0000-0002-4893-4377","observed_orcids":["https://orcid.org/0000-0002-4893-4377"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moumita Dutta","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002597398","display_name":"Alexander Suvorov","orcid":"https://orcid.org/0000-0002-2757-5897","observed_orcids":["https://orcid.org/0000-0002-2757-5897"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander Suvorov","raw_affiliation_strings":["Environmental Health Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Environmental Health Sciences, University of Massachusetts Amherst, Amherst, Massachusetts, USA","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044809263","display_name":"Xiaojian Shi","orcid":"https://orcid.org/0000-0001-7456-2901","observed_orcids":["https://orcid.org/0000-0001-7456-2901"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaojian Shi","raw_affiliation_strings":["College of Health Solutions, Arizona State University, Tempe, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health Solutions, Arizona State University, Tempe, Arizona, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013952168","display_name":"Haiwei Gu","orcid":"https://orcid.org/0000-0002-7598-5022","observed_orcids":["https://orcid.org/0000-0002-7598-5022"]},"institutions":[{"id":"https://openalex.org/I55732556","display_name":"Arizona State University","ror":"https://ror.org/03efmqc40","country_code":"US","type":"education","lineage":["https://openalex.org/I55732556"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haiwei Gu","raw_affiliation_strings":["College of Health Solutions, Arizona State University, Tempe, Arizona, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Health Solutions, Arizona State University, Tempe, Arizona, USA","institution_ids":["https://openalex.org/I55732556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054253771","display_name":"Sridhar Mani","orcid":"https://orcid.org/0000-0003-4132-6157","observed_orcids":["https://orcid.org/0000-0003-4132-6157"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sridhar Mani","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, New York, USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083842467","display_name":"Julia Yue Cui","orcid":"https://orcid.org/0000-0002-8564-1784","observed_orcids":["https://orcid.org/0000-0002-8564-1784"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Julia Yue Cui","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington, USA","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5083842467"],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":{"value":4671,"currency":"USD","value_usd":4671},"apc_paid":null,"fwci":1.8645,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.8646063,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"179","issue":"1","first_page":"14","last_page":"30"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.013000000268220901,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bde-47","display_name":"BDE-47","score":0.7919999957084656},{"id":"https://openalex.org/keywords/tetrabromobisphenol-a","display_name":"tetrabromobisphenol A","score":0.9610000252723694},{"id":"https://openalex.org/keywords/bisphenol-s","display_name":"bisphenol S","score":0.9990000128746033},{"id":"https://openalex.org/keywords/maternal-exposure","display_name":"maternal exposure","score":0.7179999947547913},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7409999966621399},{"id":"https://openalex.org/keywords/fecal-microbiota","display_name":"fecal microbiota","score":0.7590000033378601},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.9769999980926514},{"id":"https://openalex.org/keywords/short-chain-fatty-acids","display_name":"short-chain fatty acids","score":0.968999981880188},{"id":"https://openalex.org/keywords/cyp7a1","display_name":"CYP7A1","score":0.7519999742507935},{"id":"https://openalex.org/keywords/microbial-biomarkers","display_name":"microbial biomarkers","score":0.6380000114440918},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.7879999876022339},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9079999923706055},{"id":"https://openalex.org/keywords/nqo1","display_name":"NQO1","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.796535849571228},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.7763532996177673},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.5468114018440247},{"id":"https://openalex.org/C112570922","wikidata":"https://www.wikidata.org/wiki/Q60528603","display_name":"Contamination","level":2,"score":0.5036715865135193},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4567999541759491},{"id":"https://openalex.org/C53927964","wikidata":"https://www.wikidata.org/wiki/Q3054611","display_name":"Environmental enrichment","level":2,"score":0.4498429298400879},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3891565203666687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3395266532897949},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.33156830072402954},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.3211216628551483},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.15916025638580322},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15781250596046448},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1444750428199768}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000098831","descriptor_name":"Bisphenol S Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010636","descriptor_name":"Phenols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013450","descriptor_name":"Sulfones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055768","descriptor_name":"Halogenated Diphenyl Ethers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/toxsci/kfaa161","doi":"https://doi.org/10.1093/toxsci/kfaa161","is_oa":false,"landing_page_url":"https://doi.org/10.1093/toxsci/kfaa161","pdf_url":null,"source":{"id":"https://openalex.org/S186282544","display_name":"Toxicological Sciences","issn_l":"1096-0929","issn":["1096-0929","1096-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:7347636","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8456301","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8456301","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8456301","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicol Sci","raw_type":"Text"},{"id":"pmid:33078840","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33078840","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicological sciences : an official journal of the Society of Toxicology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:7347636","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8456301","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2010323060","display_name":"Epigenetic Regulation of Drug Metabolism by Developmental Exposure to PBDEs","funder_award_id":"R01ES025708","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G4737149559","display_name":"Developmental Regulation of Drug Metabolism by Targeting the Gut Microbiome","funder_award_id":"R01GM111381","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000892520","display_name":"Supporting Undergraduate Research Experiences in Environmental Health (SURE-EH)","funder_award_id":"R25ES025503","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000896837","display_name":"University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment","funder_award_id":"P30ES007033","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000912825","display_name":"Developmental flame retardant exposure, gut microbiome, and obesity","funder_award_id":"R01ES030197","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1564013339","https://openalex.org/W1874311779","https://openalex.org/W1883566698","https://openalex.org/W1979308600","https://openalex.org/W1987636018","https://openalex.org/W1988925586","https://openalex.org/W1996678153","https://openalex.org/W1998273216","https://openalex.org/W1999786200","https://openalex.org/W2000777408","https://openalex.org/W2008654117","https://openalex.org/W2013811937","https://openalex.org/W2014444288","https://openalex.org/W2018274907","https://openalex.org/W2022454496","https://openalex.org/W2045357264","https://openalex.org/W2064897225","https://openalex.org/W2071124826","https://openalex.org/W2072970694","https://openalex.org/W2084444116","https://openalex.org/W2088310401","https://openalex.org/W2098235760","https://openalex.org/W2110300022","https://openalex.org/W2121965166","https://openalex.org/W2123424849","https://openalex.org/W2136769963","https://openalex.org/W2149606834","https://openalex.org/W2157629895","https://openalex.org/W2159140238","https://openalex.org/W2160703824","https://openalex.org/W2169233127","https://openalex.org/W2174278940","https://openalex.org/W2189392341","https://openalex.org/W2235809561","https://openalex.org/W2288101580","https://openalex.org/W2395812788","https://openalex.org/W2420632344","https://openalex.org/W2441372154","https://openalex.org/W2531514293","https://openalex.org/W2574920022","https://openalex.org/W2596094280","https://openalex.org/W2738962050","https://openalex.org/W2765688884","https://openalex.org/W2784137104","https://openalex.org/W2790677582","https://openalex.org/W2790851477","https://openalex.org/W2803028737","https://openalex.org/W2803293179","https://openalex.org/W2804460705","https://openalex.org/W2888444325","https://openalex.org/W2889133269","https://openalex.org/W2889675607","https://openalex.org/W2899763104","https://openalex.org/W2904270624","https://openalex.org/W2906191117","https://openalex.org/W2912816189","https://openalex.org/W2940611916","https://openalex.org/W2946265697","https://openalex.org/W2948641568","https://openalex.org/W2951903539","https://openalex.org/W2953093188","https://openalex.org/W2953486256","https://openalex.org/W2997053648","https://openalex.org/W3000433679","https://openalex.org/W3007555042","https://openalex.org/W3018546676","https://openalex.org/W6712244149"],"related_works":["https://openalex.org/W3043166105","https://openalex.org/W3185652346","https://openalex.org/W7213979365","https://openalex.org/W3176416008","https://openalex.org/W2803293179","https://openalex.org/W3198899368","https://openalex.org/W4379115200","https://openalex.org/W7155439930","https://openalex.org/W4313641675","https://openalex.org/W7154468311"],"abstract_inverted_index":{"The":[0,165,182],"gut":[1,45],"microbiome":[2,46,128],"is":[3],"a":[4,250,269],"pivotal":[5],"player":[6],"in":[7,47,94,114,188,253,271,301],"toxicological":[8],"responses.":[9],"We":[10],"investigated":[11],"the":[12,30,44,79,118,123,126,159,186,207,216,254,261,289],"effects":[13],"of":[14,43,81,96,125,155,257,275],"maternal":[15,282],"exposure":[16,283],"to":[17,56,78,185,212,278,284],"3":[18],"human":[19],"health-relevant":[20],"toxicants":[21,286],"(BDE-47,":[22],"tetrabromobisphenol":[23],"[TBBPA],":[24],"and":[25,32,38,89,109,132,145,162,177,203,229,238,260,268,297],"bisphenol":[26],"S":[27],"[BPS])":[28],"on":[29,122],"composition":[31],"metabolite":[33],"levels":[34,111],"(bile":[35],"acids":[36,41],"[BAs]":[37],"short-chain":[39],"fatty":[40],"[SCFAs])":[42],"adult":[48,98],"pups.":[49],"CD-1":[50],"mouse":[51],"dams":[52],"were":[53,92,112,137,148,157,163,170,191,223],"orally":[54],"exposed":[55],"vehicle":[57],"(corn":[58],"oil,":[59],"10":[60],"ml/kg),":[61],"BDE-47":[62,133,199],"(0.2":[63,66,70],"mg/kg),":[64,67],"TBBPA":[65,228,234],"or":[68],"BPS":[69,116,180,230,241],"mg/kg)":[71],"once":[72],"daily":[73],"from":[74,158],"gestational":[75],"day":[76,84],"8":[77],"end":[80],"lactation":[82],"(postnatal":[83],"21).":[85],"16S":[86],"rRNA":[87],"sequencing":[88],"targeted":[90],"metabolomics":[91],"performed":[93],"feces":[95],"20-week-old":[97],"male":[99],"pups":[100],"(n":[101],"=":[102],"14":[103],"-":[104],"23/group).":[105],"Host":[106],"gene":[107,266],"expression":[108],"BA":[110],"quantified":[113],"liver.":[115],"had":[117],"most":[119,166],"prominent":[120],"effect":[121],"beta-diversity":[124],"fecal":[127,202],"compared":[129],"with":[130,196,215],"TBPPA":[131],"(QIIME).":[134],"Seventy-three":[135],"taxa":[136,147],"persistently":[138,200,225,287],"altered":[139],"by":[140,151,227],"at":[141],"least":[142],"1":[143],"chemical,":[144],"12":[146],"commonly":[149],"regulated":[150],"all":[152],"chemicals":[153],"(most":[154],"which":[156,276,292],"Clostridia":[160],"class":[161],"decreased).":[164],"distinct":[167],"microbial":[168,189],"biomarkers":[169],"S24-7":[171],"for":[172,175,179],"BDE-47,":[173],"Rikenellaceae":[174],"TBBPA,":[176],"Lactobacillus":[178],"(LefSe).":[181],"community-wide":[183],"contributions":[184],"shift":[187],"pathways":[190],"predicted":[192],"using":[193],"FishTaco.":[194],"Consistent":[195],"FishTaco":[197],"predictions,":[198],"increased":[201,235],"hepatic":[204,217,255],"BAs":[205,222],"within":[206],"12\u03b1":[208],"hydroxylation":[209],"pathway,":[210],"corresponding":[211],"an":[213,295],"up-regulation":[214],"BA-synthetic":[218],"enzyme":[219],"Cyp7a1.":[220],"Fecal":[221],"also":[224],"up-regulated":[226],"(liquid":[231],"chromatography-mass":[232,246],"spectrometry).":[233,247],"propionic":[236],"acid":[237,244],"succinate,":[239],"whereas":[240],"decreased":[242],"acetic":[243],"(gas":[245],"There":[248],"was":[249],"general":[251],"trend":[252],"down-regulation":[256],"proinflammatory":[258],"cytokines":[259],"oxidative":[262],"stress":[263],"sensor":[264],"target":[265],"(Nqo1),":[267],"decrease":[270],"G6Pdx":[272],"(the":[273],"deficiency":[274],"leads":[277],"dyslipidemia).":[279],"In":[280],"conclusion,":[281],"these":[285],"modified":[288],"gut-liver":[290],"axis,":[291],"may":[293],"produce":[294],"immune-suppressive":[296],"dyslipidemia-prone":[298],"signature":[299],"later":[300],"life.":[302]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-22T00:00:00"}
