{"id":"https://openalex.org/W3092466801","doi":"https://doi.org/10.1158/1557-3125.pi3k-mtor18-a08","title":"Abstract A08: PI3Kbeta regulates beta-1 integrin signaling in invadopodia through formation of PI(3,4)P2","display_name":"Abstract A08: PI3Kbeta regulates beta-1 integrin signaling in invadopodia through formation of PI(3,4)P2","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W3092466801","doi":"https://doi.org/10.1158/1557-3125.pi3k-mtor18-a08","mag":"3092466801"},"language":"en","primary_location":{"id":"doi:10.1158/1557-3125.pi3k-mtor18-a08","doi":"https://doi.org/10.1158/1557-3125.pi3k-mtor18-a08","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.pi3k-mtor18-a08","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002907693","display_name":"Zahra Erami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zahra Erami","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047492660","display_name":"Anne R. Bresnick","orcid":"https://orcid.org/0000-0003-1674-4568","observed_orcids":["https://orcid.org/0000-0003-1674-4568"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne R. Bresnick","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032267904","display_name":"Jonathan Backer","orcid":"https://orcid.org/0000-0002-0360-5692","observed_orcids":["https://orcid.org/0000-0002-0360-5692"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan M. Backer","raw_affiliation_strings":["Albert Einstein College of Medicine, Bronx, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Albert Einstein College of Medicine, Bronx, NY","institution_ids":["https://openalex.org/I129975664"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I129975664"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"10_Supplement","first_page":"A08","last_page":"A08"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.5713000297546387,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.2831999957561493,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.04740000143647194,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3kbeta","display_name":"PI3K\u03b2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/invadopodia","display_name":"invadopodia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pi-3-4-p2","display_name":"PI(3,4)P2","score":0.9430000185966492},{"id":"https://openalex.org/keywords/ship2","display_name":"SHIP2","score":0.9200000166893005},{"id":"https://openalex.org/keywords/haptotaxis","display_name":"haptotaxis","score":0.753000020980835},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.9760000109672546},{"id":"https://openalex.org/keywords/breast-cancer-cells","display_name":"breast cancer cells","score":0.6499999761581421},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/gelatin-degradation","display_name":"gelatin degradation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/collagen-degradation","display_name":"collagen degradation","score":0.5550000071525574},{"id":"https://openalex.org/keywords/pertussis-toxin","display_name":"pertussis toxin","score":0.7599999904632568}],"concepts":[{"id":"https://openalex.org/C200786668","wikidata":"https://www.wikidata.org/wiki/Q3498029","display_name":"Invadopodia","level":4,"score":0.9707444906234741},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.7634943723678589},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6778102517127991},{"id":"https://openalex.org/C119524353","wikidata":"https://www.wikidata.org/wiki/Q5145908","display_name":"Collagen receptor","level":4,"score":0.5370575189590454},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4302525520324707},{"id":"https://openalex.org/C141073059","wikidata":"https://www.wikidata.org/wiki/Q7207063","display_name":"Podosome","level":4,"score":0.42462703585624695},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3857768177986145},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.360832542181015},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35997673869132996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35006415843963623},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32492032647132874},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13216093182563782},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.11902740597724915},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.11121019721031189},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1557-3125.pi3k-mtor18-a08","doi":"https://doi.org/10.1158/1557-3125.pi3k-mtor18-a08","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1557-3125.pi3k-mtor18-a08","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2885037336","https://openalex.org/W2962976318","https://openalex.org/W2086542633","https://openalex.org/W7096103508","https://openalex.org/W4206033181","https://openalex.org/W2003038247","https://openalex.org/W2136818310","https://openalex.org/W7017222509","https://openalex.org/W3131441563","https://openalex.org/W2088671515"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"PI3Kbeta":[2,36,62,90,105,120,144,177,218,263,273,308,352,377],"isoform":[3],"of":[4,20,34,61,69,76,79,119,169,201,221,242,259,262,267,307,316,328,338,351,357,386,391],"PI":[5],"3-kinase,":[6],"which":[7,59,197,244,291,361],"is":[8,16,72,82,353,362],"activated":[9],"downstream":[10,220],"from":[11],"both":[12,130],"RTKs":[13],"and":[14,88,104,132,150,160,226],"GPCRs,":[15],"an":[17,233,240],"important":[18],"regulator":[19],"invadopodia":[21,70,81,102,293,323,339,383],"formation.":[22],"We":[23,52,114,345],"have":[24,53,94],"previously":[25],"reported":[26],"that":[27,217,253,347],"in":[28,48,84,101,109,112,125,276,280,335,359,382],"MDA-MB-231":[29],"breast":[30,126],"cancer":[31,127],"cells,":[32],"replacement":[33],"endogenous":[35],"with":[37,190],"kinase":[38],"dead":[39],"(KD)":[40],"or":[41,142,309],"GPCR-uncoupled":[42],"(KK-DD)":[43],"mutants":[44],"leads":[45],"to":[46,247,264,270,322],"defects":[47],"invadopodia-mediated":[49],"gelatin":[50],"degradation.":[51],"now":[54],"studied":[55],"the":[56,67,191,257,265,317,336,392],"mechanism":[57],"by":[58,74,156,166,182,214,232,239,305,326],"loss":[60],"signaling":[63,111,124,255,279,334,342,381],"affects":[64],"invadopodia.":[65],"While":[66],"number":[68],"precursors":[71],"unaffected":[73],"mutation":[75,118],"PI3Kbeta,":[77],"formation":[78,294,356,385],"mature":[80],"reduced":[83,325],"cells":[85,139,189,285],"expressing":[86,140],"KK-DD":[87,143],"KD":[89,141],"mutants.":[91],"Previous":[92],"studies":[93],"demonstrated":[95],"a":[96,146],"role":[97],"for":[98,355,364],"beta-1":[99,193,222,277,296,332,379],"integrins":[100,181],"maturation,":[103],"has":[106],"been":[107],"implicated":[108],"integrin":[110,123,194,202,254,278,297,333,380],"platelets.":[113],"therefore":[115],"tested":[116],"whether":[117,176,272],"would":[121],"affect":[122],"cells.":[128],"In":[129,330],"haptotaxis":[131,225],"cell":[133,151,206,227],"spreading":[134,152,207,228],"assays":[135],"on":[136,180,208,286,301,396],"collagen":[137,289],"I,":[138],"showed":[145],"significant":[147],"impairment.":[148],"Haptotaxis":[149],"was":[153,178,212,274,303,324],"also":[154],"inhibited":[155],"TGX221":[157],"(PI3Kbeta":[158],"inhibitor)":[159],"pertussis":[161],"toxin":[162],"(PTX),":[163],"but":[164,210,236,311],"not":[165,230,312],"specific":[167],"inhibitors":[168],"other":[170],"Class":[171],"I":[172],"PI3Ks.":[173],"To":[174],"distinguish":[175],"acting":[179],"inside-out":[183,199],"versus":[184],"outside-in":[185],"mechanisms,":[186],"we":[187,282],"treated":[188],"activating":[192],"antibody":[195],"TS2/16,":[196],"bypasses":[198],"regulation":[200],"binding.":[203],"TS2/16":[204],"increased":[205],"gelatin,":[209],"this":[211],"blocked":[213,238,304],"TGX221,":[215],"suggesting":[216],"acts":[219],"integrins.":[223],"Importantly,":[224],"were":[229,237],"affected":[231],"Akt":[234],"inhibitor,":[235],"inhibitor":[241],"SHIP2,":[243,310],"hydrolyzes":[245],"PIP3":[246],"produce":[248],"PI[3,4]P2.":[249,268],"These":[250],"data":[251],"suggest":[252],"requires":[256,341],"coupling":[258],"Gbeta/gamma-mediated":[260],"activation":[261,350],"production":[266],"Finally,":[269],"determine":[271],"involved":[275],"invadopodia,":[281,360],"plated":[283],"starved":[284],"high-density":[287],"fibrillar":[288],"(HDFC),":[290],"drives":[292],"through":[295,343,384],"activation.":[298],"Collagen":[299],"degradation":[300],"HDFC":[302],"inhibition":[306,327],"PI3Kalpha.":[313],"Moreover,":[314],"recruitment":[315],"PI(3,4)P2":[318,358,387],"binding":[319],"protein":[320],"lamellipodin":[321],"PI3Kbeta.":[329,344],"summary,":[331],"context":[337],"maturation":[340],"propose":[346],"heterotrimeric":[348],"G-protein":[349],"necessary":[354],"required":[363],"invadopodial":[365],"maturation.":[366],"Citation":[367],"Format:":[368],"Zahra":[369],"Erami,":[370],"Anne":[371],"R.":[372],"Bresnick,":[373],"Jonathan":[374],"M.":[375],"Backer.":[376],"regulates":[378],"[abstract].":[388],"In:":[389],"Proceedings":[390],"AACR":[393],"Special":[394],"Conference":[395],"Targeting":[397],"PI3K/mTOR":[398],"Signaling;":[399],"2018":[400],"Nov":[401],"30-Dec":[402],"8;":[403],"Boston,":[404],"MA.":[405],"Philadelphia":[406],"(PA):":[407],"AACR;":[408],"Mol":[409],"Cancer":[410],"Res":[411],"2020;18(10_Suppl):Abstract":[412],"nr":[413],"A08.":[414]},"counts_by_year":[],"updated_date":"2026-07-14T23:27:15.235271","created_date":"2020-10-15T00:00:00"}
