{"id":"https://openalex.org/W3092449144","doi":"https://doi.org/10.1007/s00259-020-05053-w","title":"Brain metabolic changes across King\u2019s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study","display_name":"Brain metabolic changes across King\u2019s stages in amyotrophic lateral sclerosis: a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study","publication_year":2020,"publication_date":"2020-10-07","ids":{"openalex":"https://openalex.org/W3092449144","doi":"https://doi.org/10.1007/s00259-020-05053-w","mag":"3092449144","pmid":"https://pubmed.ncbi.nlm.nih.gov/33029654"},"language":"en","primary_location":{"id":"doi:10.1007/s00259-020-05053-w","doi":"https://doi.org/10.1007/s00259-020-05053-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00259-020-05053-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00259-020-05053-w.pdf","source":{"id":"https://openalex.org/S191349260","display_name":"European Journal of Nuclear Medicine and Molecular Imaging","issn_l":"1619-7070","issn":["1619-7070","1619-7089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Nuclear Medicine and Molecular Imaging","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s00259-020-05053-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013689467","display_name":"Antonio Canosa","orcid":"https://orcid.org/0000-0001-5876-4079","observed_orcids":["https://orcid.org/0000-0001-5876-4079"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonio Canosa","raw_affiliation_strings":["ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy. antonio.canosa@unito.it","Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy. antonio.canosa@unito.it","ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5876-4079","affiliations":[{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy. antonio.canosa@unito.it","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy. antonio.canosa@unito.it","institution_ids":["https://openalex.org/I4210086903"]},{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049549975","display_name":"Andrea Calvo","orcid":"https://orcid.org/0000-0002-5122-7243","observed_orcids":["https://orcid.org/0000-0002-5122-7243"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Andrea Calvo","raw_affiliation_strings":["ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy","Neuroscience Institute of Turin (NIT), Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]},{"raw_affiliation_string":"Neuroscience Institute of Turin (NIT), Turin, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082340666","display_name":"Cristina Moglia","orcid":"https://orcid.org/0000-0001-7377-7222","observed_orcids":["https://orcid.org/0000-0001-7377-7222"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristina Moglia","raw_affiliation_strings":["ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052801313","display_name":"Umberto Manera","orcid":"https://orcid.org/0000-0002-9995-8133","observed_orcids":["https://orcid.org/0000-0002-9995-8133"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Umberto Manera","raw_affiliation_strings":["ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066713645","display_name":"Rosario Vasta","orcid":"https://orcid.org/0000-0002-0393-4736","observed_orcids":["https://orcid.org/0000-0002-0393-4736"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Rosario Vasta","raw_affiliation_strings":["ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090312786","display_name":"Francesca Di Pede","orcid":"https://orcid.org/0000-0001-8959-0614","observed_orcids":["https://orcid.org/0000-0001-8959-0614"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Di Pede","raw_affiliation_strings":["ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062014296","display_name":"Sara Cabras","orcid":"https://orcid.org/0000-0002-4988-2855","observed_orcids":["https://orcid.org/0000-0002-4988-2855"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sara Cabras","raw_affiliation_strings":["ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075404324","display_name":"Davide Nardo","orcid":"https://orcid.org/0000-0002-8158-5738","observed_orcids":["https://orcid.org/0000-0002-8158-5738"]},"institutions":[{"id":"https://openalex.org/I192597271","display_name":"MRC Cognition and Brain Sciences Unit","ror":"https://ror.org/055bpw879","country_code":"GB","type":"facility","lineage":["https://openalex.org/I192597271","https://openalex.org/I241749","https://openalex.org/I4210087105","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Davide Nardo","raw_affiliation_strings":["MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK","institution_ids":["https://openalex.org/I192597271","https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053082535","display_name":"Vincenzo Arena","orcid":"https://orcid.org/0000-0002-4363-6311","observed_orcids":["https://orcid.org/0000-0002-4363-6311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vincenzo Arena","raw_affiliation_strings":["Positron Emission Tomography Centre AFFIDEA-IRMET S.p.A, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Positron Emission Tomography Centre AFFIDEA-IRMET S.p.A, Turin, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062052643","display_name":"Maurizio Grassano","orcid":"https://orcid.org/0000-0001-6714-6897","observed_orcids":["https://orcid.org/0000-0001-6714-6897"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Grassano","raw_affiliation_strings":["ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060627663","display_name":"Fabrizio D\u2019Ovidio","orcid":"https://orcid.org/0000-0001-6304-5415","observed_orcids":["https://orcid.org/0000-0001-6304-5415"]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fabrizio D\u2019Ovidio","raw_affiliation_strings":["ALS Centre, \u201cRita Levi Montalcini\u201d Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Centre, \u201cRita Levi Montalcini\u201d Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081304921","display_name":"Koen Van Laere","orcid":"https://orcid.org/0000-0001-5200-7245","observed_orcids":["https://orcid.org/0000-0001-5200-7245"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Koen Van Laere","raw_affiliation_strings":["Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging, KU Leuven - University of Leuven, Leuven, Belgium","Division of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium","Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging, KU Leuven \u2013 University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging, KU Leuven - University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"Division of Nuclear Medicine, University Hospitals Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]},{"raw_affiliation_string":"Department of Imaging and Pathology, Nuclear Medicine and Molecular Imaging, KU Leuven \u2013 University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013023361","display_name":"Philip Van Damme","orcid":"https://orcid.org/0000-0002-4010-2357","observed_orcids":["https://orcid.org/0000-0002-4010-2357","https://orcid.org/0000-0001-6384-0611"]},"institutions":[{"id":"https://openalex.org/I2800231306","display_name":"Universitair Ziekenhuis Leuven","ror":"https://ror.org/0424bsv16","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2800231306"]},{"id":"https://openalex.org/I4210153928","display_name":"VIB-KU Leuven Center for Brain & Disease Research","ror":"https://ror.org/045c7t348","country_code":"BE","type":"facility","lineage":["https://openalex.org/I2802017950","https://openalex.org/I4210153928","https://openalex.org/I99464096"]},{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Philip Van Damme","raw_affiliation_strings":["Department of Neurology, University Hospitals Leuven, Leuven, Belgium","Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium","VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium","Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven \u2013 University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University Hospitals Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I2800231306"]},{"raw_affiliation_string":"Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven - University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]},{"raw_affiliation_string":"VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium","institution_ids":["https://openalex.org/I4210153928"]},{"raw_affiliation_string":"Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), KU Leuven \u2013 University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091578936","display_name":"Marco Pagani","orcid":"https://orcid.org/0000-0003-4689-0750","observed_orcids":["https://orcid.org/0000-0003-4689-0750"]},"institutions":[{"id":"https://openalex.org/I1335113835","display_name":"Karolinska University Hospital","ror":"https://ror.org/00m8d6786","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1335113835"]},{"id":"https://openalex.org/I4210166865","display_name":"Institute of Cognitive Sciences and Technologies","ror":"https://ror.org/05w9g2j85","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210166865"]}],"countries":["IT","SE"],"is_corresponding":false,"raw_author_name":"Marco Pagani","raw_affiliation_strings":["Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden","Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden","institution_ids":["https://openalex.org/I1335113835"]},{"raw_affiliation_string":"Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy","institution_ids":["https://openalex.org/I4210166865"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090628289","display_name":"Adriano Chi\u00f2","orcid":"https://orcid.org/0000-0001-9579-5341","observed_orcids":["https://orcid.org/0000-0001-9579-5341"]},"institutions":[{"id":"https://openalex.org/I4210086903","display_name":"Azienda Ospedaliera Citta' della Salute e della Scienza di Torino","ror":"https://ror.org/001f7a930","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210086903"]},{"id":"https://openalex.org/I4210166865","display_name":"Institute of Cognitive Sciences and Technologies","ror":"https://ror.org/05w9g2j85","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210166865"]},{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Adriano Chi\u00f2","raw_affiliation_strings":["ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy","Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy","Neuroscience Institute of Turin (NIT), Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ALS Centre, \"Rita Levi Montalcini\" Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Italy","institution_ids":["https://openalex.org/I55143463"]},{"raw_affiliation_string":"Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino, Turin, Italy","institution_ids":["https://openalex.org/I4210086903"]},{"raw_affiliation_string":"Institute of Cognitive Sciences and Technologies, C.N.R., Rome, Italy","institution_ids":["https://openalex.org/I4210166865"]},{"raw_affiliation_string":"Neuroscience Institute of Turin (NIT), Turin, Italy","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5013689467"],"corresponding_institution_ids":["https://openalex.org/I4210086903","https://openalex.org/I55143463"],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":{"value":4480,"currency":"USD","value_usd":4480},"fwci":1.2064,"has_fulltext":true,"cited_by_count":24,"citation_normalized_percentile":{"value":0.82310648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"48","issue":"4","first_page":"1124","last_page":"1133"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10855","display_name":"Amyotrophic Lateral Sclerosis Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10949","display_name":"Genetic Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amyotrophic-lateral-sclerosis","display_name":"amyotrophic lateral sclerosis","score":1.0},{"id":"https://openalex.org/keywords/cerebral-metabolism","display_name":"brain metabolism","score":0.699999988079071},{"id":"https://openalex.org/keywords/18f-fdg-pet","display_name":"18F-FDG PET","score":0.8619999885559082},{"id":"https://openalex.org/keywords/frontal-lobe-hypometabolism","display_name":"frontal lobe hypometabolism","score":0.7609999775886536},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.7170000076293945},{"id":"https://openalex.org/keywords/alsfrs-r","display_name":"ALSFRS-R","score":0.8100000023841858},{"id":"https://openalex.org/keywords/motor-cortex","display_name":"motor cortex","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.8665533065795898},{"id":"https://openalex.org/C2780596555","wikidata":"https://www.wikidata.org/wiki/Q206901","display_name":"Amyotrophic lateral sclerosis","level":3,"score":0.8099260330200195},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.691539466381073},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.6200542449951172},{"id":"https://openalex.org/C2908761598","wikidata":"https://www.wikidata.org/wiki/Q3488638","display_name":"Positron Emission Tomography-Computed Tomography","level":3,"score":0.5153242945671082},{"id":"https://openalex.org/C112390072","wikidata":"https://www.wikidata.org/wiki/Q4955834","display_name":"Brain positron emission tomography","level":4,"score":0.4631459414958954},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.4338891804218292},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2300489842891693},{"id":"https://openalex.org/C29331040","wikidata":"https://www.wikidata.org/wiki/Q7239554","display_name":"Preclinical imaging","level":3,"score":0.20292174816131592},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.058894962072372437},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000690","descriptor_name":"Amyotrophic Lateral Sclerosis","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019788","descriptor_name":"Fluorodeoxyglucose F18","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":13,"locations":[{"id":"doi:10.1007/s00259-020-05053-w","doi":"https://doi.org/10.1007/s00259-020-05053-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00259-020-05053-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00259-020-05053-w.pdf","source":{"id":"https://openalex.org/S191349260","display_name":"European Journal of Nuclear Medicine and Molecular Imaging","issn_l":"1619-7070","issn":["1619-7070","1619-7089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Nuclear Medicine and Molecular Imaging","raw_type":"journal-article"},{"id":"pmid:33029654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33029654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of nuclear medicine and molecular imaging","raw_type":"Journal Article"},{"id":"pmh:oai:pure.amsterdamumc.nl:openaire/c6701708-4089-4c72-8623-ef22c6020350","doi":null,"is_oa":true,"landing_page_url":"https://pure.amsterdamumc.nl/en/publications/c6701708-4089-4c72-8623-ef22c6020350","pdf_url":null,"source":{"id":"https://openalex.org/S7407055222","display_name":"Pure Amsterdam UMC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canosa, A, Calvo, A, Moglia, C, Manera, U, Vasta, R, di Pede, F, Cabras, S, Nardo, D, Arena, V, Grassano, M, D\u2019Ovidio, F, van Laere, K, van Damme, P, Pagani, M & Chi\u00f2, A 2021, 'Brain metabolic changes across King\u2019s stages in amyotrophic lateral sclerosis : a 18F-2-fluoro-2-deoxy-d-glucose-positron emission tomography study', European journal of nuclear medicine and molecular imaging, vol. 48, no. 4, pp. 1124-1133. https://doi.org/10.1007/s00259-020-05053-w","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/662235","doi":null,"is_oa":true,"landing_page_url":"https://lirias.kuleuven.be/handle/123456789/662235","pdf_url":"https://lirias.kuleuven.be/retrieve/8073aae4-0e39-4739-9dc0-3d8810929bed","source":{"id":"https://openalex.org/S4306401954","display_name":"Lirias (KU Leuven)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I99464096","host_organization_name":"KU Leuven","host_organization_lineage":["https://openalex.org/I99464096"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal Of Nuclear Medicine And Molecular Imaging, vol. 48 (4), (1124-1133)","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8041703","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8041703","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Eur J Nucl Med Mol Imaging","raw_type":"Text"},{"id":"pmh:oai:iris.uniroma3.it:11590/418930","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11590/418930","pdf_url":null,"source":{"id":"https://openalex.org/S4377196120","display_name":"Iris (Roma Tre University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I119003972","host_organization_name":"Roma Tre University","host_organization_lineage":["https://openalex.org/I119003972"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/1759751","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/1759751","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/310984","doi":null,"is_oa":false,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/310984","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/319739","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/319739","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:www.repository.cam.ac.uk:1810/329081","doi":null,"is_oa":true,"landing_page_url":"https://www.repository.cam.ac.uk/handle/1810/329081","pdf_url":null,"source":{"id":"https://openalex.org/S4306401777","display_name":"Apollo (University of Cambridge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I241749","host_organization_name":"University of Cambridge","host_organization_lineage":["https://openalex.org/I241749"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"doi:10.17863/cam.58072","doi":"https://doi.org/10.17863/cam.58072","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.58072","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.17863/cam.66864","doi":"https://doi.org/10.17863/cam.66864","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.66864","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.17863/cam.76527","doi":"https://doi.org/10.17863/cam.76527","is_oa":true,"landing_page_url":"https://doi.org/10.17863/cam.76527","pdf_url":null,"source":{"id":"https://openalex.org/S7407050737","display_name":"Apollo","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1007/s00259-020-05053-w","doi":"https://doi.org/10.1007/s00259-020-05053-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00259-020-05053-w","pdf_url":"https://link.springer.com/content/pdf/10.1007/s00259-020-05053-w.pdf","source":{"id":"https://openalex.org/S191349260","display_name":"European Journal of Nuclear Medicine and Molecular Imaging","issn_l":"1619-7070","issn":["1619-7070","1619-7089"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Nuclear Medicine and Molecular Imaging","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1183686639","display_name":null,"funder_award_id":"RF-2016- 02362405","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G1184370674","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G1707306367","display_name":null,"funder_award_id":"259867","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G2312359103","display_name":"Deconstruct and rebuild phenotypes: a multimodal approach toward personalized medicine in ALS (DECIPHER-ALS)","funder_award_id":"2017SNW5MB","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G3178720459","display_name":null,"funder_award_id":"2017SNW5MB","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G393177772","display_name":null,"funder_award_id":"FP7 2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4097891252","display_name":null,"funder_award_id":"PRIN 2017SNW5MB","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G4597256219","display_name":null,"funder_award_id":"259867","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G4842425482","display_name":null,"funder_award_id":"Health Seventh Framework Programme (FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G569774987","display_name":null,"funder_award_id":"grant RF-2016-02362405","funder_id":"https://openalex.org/F4320321781","funder_display_name":"Ministero della Salute"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G581753051","display_name":null,"funder_award_id":"grant 2017SNW5MB","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G7209824943","display_name":null,"funder_award_id":"PRIN, grant 2017SNW5MB","funder_id":"https://openalex.org/F4320321873","funder_display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca"},{"id":"https://openalex.org/G8709469716","display_name":"European multidisciplinary ALS network identification to cure motor neuron degeneration","funder_award_id":"259867","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320308604","display_name":"Biogen","ror":"https://ror.org/02jqkb192"},{"id":"https://openalex.org/F4320311132","display_name":"Fondation Thierry Latran","ror":"https://ror.org/03jf78g10"},{"id":"https://openalex.org/F4320315432","display_name":"Cytokinetics","ror":"https://ror.org/03tx9ss94"},{"id":"https://openalex.org/F4320315433","display_name":"AveXis","ror":"https://ror.org/02gd4zp35"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320324041","display_name":"Universit\u00e0 degli Studi di Torino","ror":"https://ror.org/048tbm396"},{"id":"https://openalex.org/F4320328456","display_name":"Italfarmaco","ror":"https://ror.org/05xsppr58"},{"id":"https://openalex.org/F4320330821","display_name":"Azienda Ospedaliero-Universitaria Citt\u00e0 della Salute e della Scienza di Torino","ror":null},{"id":"https://openalex.org/F4320333065","display_name":"Seventh Framework Programme","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3092449144.pdf","grobid_xml":"https://content.openalex.org/works/W3092449144.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1503916499","https://openalex.org/W1971541410","https://openalex.org/W1981115828","https://openalex.org/W1994605917","https://openalex.org/W2004341548","https://openalex.org/W2014117421","https://openalex.org/W2095309401","https://openalex.org/W2113481412","https://openalex.org/W2117906150","https://openalex.org/W2118235736","https://openalex.org/W2135836882","https://openalex.org/W2140424820","https://openalex.org/W2161938104","https://openalex.org/W2187069291","https://openalex.org/W2226999535","https://openalex.org/W2562172900","https://openalex.org/W2590459453","https://openalex.org/W2741191987","https://openalex.org/W2765424614","https://openalex.org/W2766580430","https://openalex.org/W2776270597","https://openalex.org/W2801552310","https://openalex.org/W2809516213","https://openalex.org/W2886530147","https://openalex.org/W2924086781","https://openalex.org/W2962757802","https://openalex.org/W2967131242","https://openalex.org/W3007059348","https://openalex.org/W4210998205","https://openalex.org/W7074256479"],"related_works":["https://openalex.org/W2343585528","https://openalex.org/W2023362998","https://openalex.org/W3025710165","https://openalex.org/W4254019069","https://openalex.org/W2163232985","https://openalex.org/W1977854822","https://openalex.org/W2886755492","https://openalex.org/W2315958124","https://openalex.org/W2291170071","https://openalex.org/W2056327490"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"To":[2],"assess":[3],"the":[4,9,17,72,80,173,176,185,203,216,229,234,246],"brain":[5,22,52],"metabolic":[6,207,218],"correlates":[7],"of":[8,13,43,148,205,236],"different":[10],"regional":[11,241],"extent":[12],"ALS,":[14,233],"evaluated":[15],"with":[16,31,125,215],"King\u2019s":[18,32,56,88,90],"staging":[19],"system,":[20],"using":[21],"18F-2-fluoro-2-deoxy-d-glucose-PET":[23],"(18F-FDG-PET).":[24],"Methods":[25],"Three":[26],"hundred":[27],"ninety":[28],"ALS":[29],"cases":[30],"stages":[33,101,156,221],"1,":[34,44,87],"2,":[35,45,89],"and":[36,46,64,92,102,106,115,132,135,158,179,183,191,200,223,251],"3":[37,47,162],"(n":[38],"=":[39],"390),":[40],"i.e.,":[41],"involvement":[42],"body":[48],"regions":[49],"respectively,":[50],"underwent":[51],"18F-FDG-PET":[53],"at":[54,58,113],"diagnosis.":[55],"stage":[57,126,161,164,210,213],"PET":[59,114],"was":[60,65,122,151,170],"derived":[61],"from":[62,209,245],"ALSFRS-R":[63],"regressed":[66],"out":[67],"against":[68],"whole-brain":[69],"metabolism":[70,121],"in":[71,127,143,172,175,184,232],"whole":[73],"sample.":[74],"The":[75,138,195],"full":[76,139],"factorial":[77,140],"design":[78,141],"confirmed":[79],"hypothesis":[81,230],"that":[82,231],"differences":[83],"among":[84,100],"groups":[85],"(King\u2019s":[86],"3,":[91,214],"40":[93],"healthy":[94],"controls":[95],"(HC))":[96],"existed":[97],"overall.":[98],"Comparisons":[99],"between":[103,155,197,220],"each":[104,198],"group":[105,199],"HC":[107,201],"were":[108],"performed.":[109],"We":[110],"included":[111],"age":[112],"sex":[116],"as":[117],"covariates.":[118],"Results":[119],"Brain":[120],"inversely":[123],"correlated":[124],"medial":[128,180,187],"frontal":[129,181,193,206],"gyrus":[130],"bilaterally,":[131],"right":[133,186],"precentral":[134,178],"postcentral":[136],"gyri.":[137,194],"resulted":[142],"a":[144,166,239],"significant":[145,153,167],"main":[146],"effect":[147],"groups.":[149],"There":[150],"no":[152],"difference":[154],"1":[157,211],"2.":[159],"Comparing":[160],"to":[163,212,249],"1+2,":[165],"relative":[168],"hypometabolism":[169],"highlighted":[171],"former":[174],"left":[177],"gyri,":[182],"frontal,":[188],"postcentral,":[189],"precentral,":[190],"middle":[192],"comparisons":[196],"showed":[202],"extension":[204],"changes":[208],"larger":[217],"gap":[219],"2":[222],"3.":[224],"Conclusions":[225],"Our":[226],"findings":[227],"support":[228],"propagation":[235],"neurodegeneration":[237],"follows":[238],"corticofugal,":[240],"ordered":[242],"pattern,":[243],"extending":[244],"motor":[247],"cortex":[248],"posterior":[250],"anterior":[252],"regions.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2020-10-15T00:00:00"}