{"id":"https://openalex.org/W3092394865","doi":"https://doi.org/10.1007/s11864-020-00790-4","title":"The Potential of Immune Checkpoint Blockade in Cervical Cancer: Can Combinatorial Regimens Maximize Response? A Review of the Literature","display_name":"The Potential of Immune Checkpoint Blockade in Cervical Cancer: Can Combinatorial Regimens Maximize Response? A Review of the Literature","publication_year":2020,"publication_date":"2020-10-06","ids":{"openalex":"https://openalex.org/W3092394865","doi":"https://doi.org/10.1007/s11864-020-00790-4","mag":"3092394865","pmid":"https://pubmed.ncbi.nlm.nih.gov/33025260"},"language":"en","primary_location":{"id":"doi:10.1007/s11864-020-00790-4","doi":"https://doi.org/10.1007/s11864-020-00790-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11864-020-00790-4","pdf_url":null,"source":{"id":"https://openalex.org/S208090617","display_name":"Current Treatment Options in Oncology","issn_l":"1527-2729","issn":["1527-2729","1534-6277"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Treatment Options in Oncology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s11864-020-00790-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019614723","display_name":"Lennox Chitsike","orcid":"https://orcid.org/0000-0002-2901-353X","observed_orcids":["https://orcid.org/0000-0002-2901-353X"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lennox Chitsike","raw_affiliation_strings":["Department of Basic Sciences, Loma Linda University School of Medicine, 11021 Campus Street, 101 Alumni Hall, Loma Linda, CA, 92354, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Loma Linda University School of Medicine, 11021 Campus Street, 101 Alumni Hall, Loma Linda, CA, 92354, USA","institution_ids":["https://openalex.org/I26347476"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042664406","display_name":"Penelope J. Duerksen-Hughes","orcid":"https://orcid.org/0000-0002-0998-2157","observed_orcids":["https://orcid.org/0000-0002-0998-2157"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Penelope Duerksen-Hughes","raw_affiliation_strings":["Department of Basic Sciences, Loma Linda University School of Medicine, 11021 Campus Street, 101 Alumni Hall, Loma Linda, CA, 92354, USA. pdhughes@llu.edu","Department of Basic Sciences, Loma Linda University School of Medicine, 11021 Campus Street, 101 Alumni Hall, Loma Linda, CA, 92354, USA"],"raw_orcid":"https://orcid.org/0000-0002-0998-2157","affiliations":[{"raw_affiliation_string":"Department of Basic Sciences, Loma Linda University School of Medicine, 11021 Campus Street, 101 Alumni Hall, Loma Linda, CA, 92354, USA. pdhughes@llu.edu","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Basic Sciences, Loma Linda University School of Medicine, 11021 Campus Street, 101 Alumni Hall, Loma Linda, CA, 92354, USA","institution_ids":["https://openalex.org/I26347476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042664406"],"corresponding_institution_ids":["https://openalex.org/I26347476"],"apc_list":{"value":3860,"currency":"USD","value_usd":3860},"apc_paid":{"value":3860,"currency":"USD","value_usd":3860},"fwci":0.4297,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.48467002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":"12","first_page":"95","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cervical-cancer","display_name":"cervical cancer","score":0.9679999947547913},{"id":"https://openalex.org/keywords/immune-checkpoint-blockade","display_name":"immune checkpoint blockade","score":0.9509999752044678},{"id":"https://openalex.org/keywords/pd-1-pd-l1-inhibitors","display_name":"PD-1/PD-L1 inhibitors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pembrolizumab","display_name":"pembrolizumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6769999861717224},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.6399999856948853},{"id":"https://openalex.org/keywords/hpv-associated-cancers","display_name":"HPV-associated cancers","score":0.7129999995231628},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitor-resistance","display_name":"immune checkpoint inhibitor resistance","score":0.43700000643730164},{"id":"https://openalex.org/keywords/t-cell-suppression","display_name":"T cell suppression","score":0.6119999885559082},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9204758405685425},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.7658975124359131},{"id":"https://openalex.org/C2778220009","wikidata":"https://www.wikidata.org/wiki/Q160105","display_name":"Cervical cancer","level":3,"score":0.6383633613586426},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5383051633834839},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.5181195139884949},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.48585864901542664},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39984506368637085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3521750271320343},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11080923676490784},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000082082","descriptor_name":"Immune Checkpoint Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D002583","descriptor_name":"Uterine Cervical Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007109","descriptor_name":"Immunity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s11864-020-00790-4","doi":"https://doi.org/10.1007/s11864-020-00790-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11864-020-00790-4","pdf_url":null,"source":{"id":"https://openalex.org/S208090617","display_name":"Current Treatment Options in Oncology","issn_l":"1527-2729","issn":["1527-2729","1534-6277"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Treatment Options in Oncology","raw_type":"journal-article"},{"id":"pmid:33025260","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33025260","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current treatment options in oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s11864-020-00790-4","doi":"https://doi.org/10.1007/s11864-020-00790-4","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s11864-020-00790-4","pdf_url":null,"source":{"id":"https://openalex.org/S208090617","display_name":"Current Treatment Options in Oncology","issn_l":"1527-2729","issn":["1527-2729","1534-6277"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Treatment Options in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":126,"referenced_works":["https://openalex.org/W1531365979","https://openalex.org/W1587588102","https://openalex.org/W1593183731","https://openalex.org/W1601816155","https://openalex.org/W1663290761","https://openalex.org/W1809117905","https://openalex.org/W1889335134","https://openalex.org/W1969164310","https://openalex.org/W1982342760","https://openalex.org/W1982647056","https://openalex.org/W1983375287","https://openalex.org/W1989532996","https://openalex.org/W1992912767","https://openalex.org/W1994993231","https://openalex.org/W2009720434","https://openalex.org/W2016663954","https://openalex.org/W2036199480","https://openalex.org/W2042049210","https://openalex.org/W2046154013","https://openalex.org/W2049491375","https://openalex.org/W2060071366","https://openalex.org/W2064157766","https://openalex.org/W2066332001","https://openalex.org/W2075172158","https://openalex.org/W2079315541","https://openalex.org/W2096328590","https://openalex.org/W2096801163","https://openalex.org/W2097014506","https://openalex.org/W2097555726","https://openalex.org/W2106268456","https://openalex.org/W2120426523","https://openalex.org/W2121317935","https://openalex.org/W2122795727","https://openalex.org/W2129451926","https://openalex.org/W2130472599","https://openalex.org/W2130619064","https://openalex.org/W2133420310","https://openalex.org/W2133569215","https://openalex.org/W2141272547","https://openalex.org/W2141859344","https://openalex.org/W2146906100","https://openalex.org/W2151098145","https://openalex.org/W2152061559","https://openalex.org/W2153719039","https://openalex.org/W2155618350","https://openalex.org/W2164256280","https://openalex.org/W2169281418","https://openalex.org/W2169631209","https://openalex.org/W2172901603","https://openalex.org/W2173718005","https://openalex.org/W2206261849","https://openalex.org/W2210453860","https://openalex.org/W2254576822","https://openalex.org/W2257916459","https://openalex.org/W2280266688","https://openalex.org/W2292383635","https://openalex.org/W2318880831","https://openalex.org/W2330158443","https://openalex.org/W2338563218","https://openalex.org/W2342029300","https://openalex.org/W2394570772","https://openalex.org/W2394893668","https://openalex.org/W2401823071","https://openalex.org/W2408171712","https://openalex.org/W2460269057","https://openalex.org/W2472221349","https://openalex.org/W2553051584","https://openalex.org/W2559382297","https://openalex.org/W2560005855","https://openalex.org/W2565956677","https://openalex.org/W2567712538","https://openalex.org/W2575837388","https://openalex.org/W2578528809","https://openalex.org/W2590417095","https://openalex.org/W2597613988","https://openalex.org/W2598005763","https://openalex.org/W2606495925","https://openalex.org/W2607497548","https://openalex.org/W2612166547","https://openalex.org/W2617066209","https://openalex.org/W2621587943","https://openalex.org/W2625441281","https://openalex.org/W2626459434","https://openalex.org/W2732565107","https://openalex.org/W2736112119","https://openalex.org/W2738264210","https://openalex.org/W2741211555","https://openalex.org/W2743954556","https://openalex.org/W2744811451","https://openalex.org/W2750457495","https://openalex.org/W2753432434","https://openalex.org/W2754086962","https://openalex.org/W2763040936","https://openalex.org/W2765482995","https://openalex.org/W2766754072","https://openalex.org/W2767013407","https://openalex.org/W2772859838","https://openalex.org/W2779221466","https://openalex.org/W2782007611","https://openalex.org/W2782264718","https://openalex.org/W2783537573","https://openalex.org/W2785903627","https://openalex.org/W2787502121","https://openalex.org/W2789563811","https://openalex.org/W2791483720","https://openalex.org/W2791567488","https://openalex.org/W2792074753","https://openalex.org/W2796582438","https://openalex.org/W2797168197","https://openalex.org/W2797301174","https://openalex.org/W2800257598","https://openalex.org/W2804441916","https://openalex.org/W2806383117","https://openalex.org/W2809055041","https://openalex.org/W2833167137","https://openalex.org/W2883440009","https://openalex.org/W2883846231","https://openalex.org/W2886393653","https://openalex.org/W2890010536","https://openalex.org/W2892876553","https://openalex.org/W2901042358","https://openalex.org/W2912191040","https://openalex.org/W2918171974","https://openalex.org/W2950564916","https://openalex.org/W2954493758","https://openalex.org/W2990862008"],"related_works":["https://openalex.org/W4385252648","https://openalex.org/W4295094256","https://openalex.org/W3157556881","https://openalex.org/W2911143956","https://openalex.org/W4288467532","https://openalex.org/W2919729384","https://openalex.org/W3184286026","https://openalex.org/W4285612840","https://openalex.org/W4313462955","https://openalex.org/W3046253990"],"abstract_inverted_index":{"OPINION":[0],"STATEMENT:":[1],"Cervical":[2],"cancer":[3,55],"(CC)":[4],"is":[5],"most":[6],"often":[7],"caused":[8],"by":[9,31,67,108,159,184],"the":[10,19,32,58,62,69,109,114],"human":[11],"papillomavirus":[12],"(HPV).":[13],"In":[14],"principle,":[15],"these":[16,36,120],"ties":[17],"to":[18,42,60,77,91,133,137,179],"virus":[20],"should":[21],"make":[22],"HPV":[23],"tumors":[24,38],"a":[25,170],"relatively":[26],"easy":[27],"target":[28],"for":[29,162,175],"clearance":[30],"immune":[33,44,63,72,146],"system.":[34],"However,":[35],"HPV-associated":[37],"have":[39,122],"evolved":[40],"strategies":[41],"escape":[43,64],"attack.":[45],"Checkpoint":[46],"inhibition":[47,158],"immunotherapy,":[48],"which":[49],"has":[50,57,96],"had":[51],"remarkable":[52],"success":[53],"in":[54,65,87],"treatment,":[56],"potential":[59],"overcome":[61],"CC":[66,88],"harnessing":[68],"patient's":[70],"own":[71],"system":[73],"and":[74,79,102,126,128,164,190],"priming":[75],"it":[76],"recognize":[78],"kill":[80],"tumors.":[81],"Recent":[82],"work":[83],"involving":[84],"PD-1/PD-L1":[85],"inhibitors":[86,161],"lends":[89],"credence":[90],"this":[92,129],"belief,":[93],"as":[94,182],"pembrolizumab":[95],"shown":[97],"evidence":[98,185],"of":[99,142,155],"clinical":[100,167,192],"efficacy":[101],"consequently":[103],"been":[104,124],"granted":[105],"accelerated":[106],"approval":[107],"FDA.":[110],"That":[111],"being":[112],"said,":[113],"oncologic":[115],"outcomes":[116],"following":[117],"monotherapy":[118],"with":[119],"biologics":[121],"mostly":[123],"modest":[125],"variable,":[127],"can":[130],"be":[131],"attributed":[132],"alternative":[134],"resistance":[135],"mechanisms":[136],"tumor":[138],"response.":[139],"The":[140],"use":[141],"therapies":[143,181],"that":[144],"stimulate":[145],"responses":[147],"via":[148],"checkpoint-independent":[149],"activation":[150],"will":[151],"therefore":[152],"augment":[153],"release":[154],"T":[156],"cell":[157],"checkpoint":[160,180],"stronger":[163],"more":[165],"sustained":[166],"responses.":[168],"Such":[169],"combinatorial":[171],"approach":[172],"holds":[173],"promise":[174],"weak-":[176],"or":[177],"non-responders":[178],"supported":[183],"from":[186],"various,":[187],"recent":[188],"pre-clinical,":[189],"preliminary":[191],"studies.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-15T00:00:00"}
