{"id":"https://openalex.org/W3092314864","doi":null,"title":"Quantification of Mutans Streptococci and Persister Cells in Orthodontic Patients: A Pilot Investigation","display_name":"Quantification of Mutans Streptococci and Persister Cells in Orthodontic Patients: A Pilot Investigation","publication_year":2018,"publication_date":"2018-11-01","ids":{"openalex":"https://openalex.org/W3092314864","mag":"3092314864"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/91438","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/91438","pdf_url":"https://utoronto.scholaris.ca/bitstreams/d3c5480b-cf8f-4477-902c-889b8b000d51/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/d3c5480b-cf8f-4477-902c-889b8b000d51/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071689066","display_name":"Chelsea Ko-Adams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Chelsea Ko-Adams","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071689066"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10368","display_name":"Dental Health and Care Utilization","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12439","display_name":"Dental Research and COVID-19","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutans-streptococci","display_name":"mutans streptococci","score":1.0},{"id":"https://openalex.org/keywords/persister-cells","display_name":"persister cells","score":0.9860000014305115},{"id":"https://openalex.org/keywords/orthodontic-patients","display_name":"orthodontic patients","score":0.8650000095367432},{"id":"https://openalex.org/keywords/fixed-orthodontic-appliances","display_name":"fixed orthodontic appliances","score":0.8799999952316284},{"id":"https://openalex.org/keywords/dental-plaque","display_name":"dental plaque","score":0.7459999918937683},{"id":"https://openalex.org/keywords/dental-caries","display_name":"dental caries","score":0.9139999747276306},{"id":"https://openalex.org/keywords/caries-risk","display_name":"caries risk","score":0.48399999737739563},{"id":"https://openalex.org/keywords/oral-microbiota","display_name":"oral microbiota","score":0.5339999794960022}],"concepts":[{"id":"https://openalex.org/C2778430296","wikidata":"https://www.wikidata.org/wiki/Q131452","display_name":"Streptococcus mutans","level":3,"score":0.7255815863609314},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.6858970522880554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6510433554649353},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.6325570344924927},{"id":"https://openalex.org/C2779914569","wikidata":"https://www.wikidata.org/wiki/Q143504","display_name":"Dental plaque","level":2,"score":0.5697855353355408},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.43317437171936035},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34111058712005615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14145365357398987},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.14126914739608765},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/91438","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/91438","pdf_url":"https://utoronto.scholaris.ca/bitstreams/d3c5480b-cf8f-4477-902c-889b8b000d51/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3092314864","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/91438/1/Ko-Adams_Chelsea_201811_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/91438","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/91438","pdf_url":"https://utoronto.scholaris.ca/bitstreams/d3c5480b-cf8f-4477-902c-889b8b000d51/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3092314864.pdf","grobid_xml":"https://content.openalex.org/works/W3092314864.grobid-xml"},"referenced_works_count":152,"referenced_works":["https://openalex.org/W135230180","https://openalex.org/W170995186","https://openalex.org/W203351345","https://openalex.org/W947521192","https://openalex.org/W1528273806","https://openalex.org/W1529947362","https://openalex.org/W1532659753","https://openalex.org/W1533689043","https://openalex.org/W1536518489","https://openalex.org/W1571437406","https://openalex.org/W1578444984","https://openalex.org/W1632257105","https://openalex.org/W1764386078","https://openalex.org/W1859685733","https://openalex.org/W1915744198","https://openalex.org/W1923945304","https://openalex.org/W1926726207","https://openalex.org/W1963603410","https://openalex.org/W1964356020","https://openalex.org/W1969244937","https://openalex.org/W1970518524","https://openalex.org/W1972583455","https://openalex.org/W1973192271","https://openalex.org/W1974053222","https://openalex.org/W1977423683","https://openalex.org/W1979551947","https://openalex.org/W1982375984","https://openalex.org/W1990828806","https://openalex.org/W1992414926","https://openalex.org/W1995937274","https://openalex.org/W1996664814","https://openalex.org/W1997796851","https://openalex.org/W2001164994","https://openalex.org/W2010218030","https://openalex.org/W2011275751","https://openalex.org/W2012203449","https://openalex.org/W2014337179","https://openalex.org/W2014396469","https://openalex.org/W2015850863","https://openalex.org/W2016391037","https://openalex.org/W2017806739","https://openalex.org/W2018400887","https://openalex.org/W2021166799","https://openalex.org/W2025319758","https://openalex.org/W2026130670","https://openalex.org/W2029814111","https://openalex.org/W2031986176","https://openalex.org/W2033074192","https://openalex.org/W2035192691","https://openalex.org/W2035820635","https://openalex.org/W2035860799","https://openalex.org/W2038921912","https://openalex.org/W2038990255","https://openalex.org/W2041367172","https://openalex.org/W2042395000","https://openalex.org/W2044917835","https://openalex.org/W2044991390","https://openalex.org/W2045878113","https://openalex.org/W2047759643","https://openalex.org/W2050045075","https://openalex.org/W2055327143","https://openalex.org/W2058313496","https://openalex.org/W2058677032","https://openalex.org/W2059657535","https://openalex.org/W2060500621","https://openalex.org/W2062765174","https://openalex.org/W2063653505","https://openalex.org/W2066300238","https://openalex.org/W2066616037","https://openalex.org/W2066742923","https://openalex.org/W2068246032","https://openalex.org/W2069250280","https://openalex.org/W2069704172","https://openalex.org/W2069785635","https://openalex.org/W2070300719","https://openalex.org/W2070791176","https://openalex.org/W2071854850","https://openalex.org/W2075329036","https://openalex.org/W2078502281","https://openalex.org/W2078557497","https://openalex.org/W2079064240","https://openalex.org/W2080848705","https://openalex.org/W2085306495","https://openalex.org/W2086218786","https://openalex.org/W2089339124","https://openalex.org/W2090280039","https://openalex.org/W2092345495","https://openalex.org/W2093126632","https://openalex.org/W2094177464","https://openalex.org/W2096008023","https://openalex.org/W2096260713","https://openalex.org/W2102636027","https://openalex.org/W2104246257","https://openalex.org/W2104255708","https://openalex.org/W2104771379","https://openalex.org/W2107228383","https://openalex.org/W2107741506","https://openalex.org/W2108562757","https://openalex.org/W2109833361","https://openalex.org/W2110926912","https://openalex.org/W2116883041","https://openalex.org/W2117189129","https://openalex.org/W2121261317","https://openalex.org/W2122836009","https://openalex.org/W2122963787","https://openalex.org/W2125284163","https://openalex.org/W2125343967","https://openalex.org/W2127240867","https://openalex.org/W2127927741","https://openalex.org/W2129544607","https://openalex.org/W2129566693","https://openalex.org/W2129642071","https://openalex.org/W2130873649","https://openalex.org/W2131932330","https://openalex.org/W2132584463","https://openalex.org/W2134348633","https://openalex.org/W2134627423","https://openalex.org/W2135133274","https://openalex.org/W2138608280","https://openalex.org/W2139962100","https://openalex.org/W2140654784","https://openalex.org/W2141824074","https://openalex.org/W2142111019","https://openalex.org/W2142417013","https://openalex.org/W2144440398","https://openalex.org/W2144610619","https://openalex.org/W2146236742","https://openalex.org/W2147104726","https://openalex.org/W2148323109","https://openalex.org/W2148521382","https://openalex.org/W2153148799","https://openalex.org/W2153424575","https://openalex.org/W2154106041","https://openalex.org/W2154963127","https://openalex.org/W2157107389","https://openalex.org/W2157961554","https://openalex.org/W2159620582","https://openalex.org/W2159828513","https://openalex.org/W2160566612","https://openalex.org/W2161755384","https://openalex.org/W2162149255","https://openalex.org/W2166967068","https://openalex.org/W2171115538","https://openalex.org/W2185246447","https://openalex.org/W2205203468","https://openalex.org/W2400674387","https://openalex.org/W2516439394","https://openalex.org/W2536687083","https://openalex.org/W2562944419","https://openalex.org/W2585686553","https://openalex.org/W2591498398","https://openalex.org/W2788704954"],"related_works":["https://openalex.org/W3008490459","https://openalex.org/W1976804036","https://openalex.org/W2381790147","https://openalex.org/W2076923516","https://openalex.org/W2516439394","https://openalex.org/W2021688267","https://openalex.org/W2993849194","https://openalex.org/W2200416383","https://openalex.org/W3047006112","https://openalex.org/W2903509357"],"abstract_inverted_index":{"Orthodontic":[0,127],"patients":[1,62,140],"have":[2],"higher":[3,147],"risk":[4],"for":[5,46,133],"dental":[6],"caries.":[7],"Within":[8],"plaque":[9],"biofilm,":[10],"mutans":[11],"streptococci":[12],"(MS)":[13],"are":[14,33],"present":[15],"together":[16],"with":[17,106,123,141],"persister":[18],"cells":[19],"(PC),":[20],"a":[21,131],"microbial":[22],"subset":[23],"that":[24],"confers":[25],"disease":[26],"chronicity":[27],"and":[28,51,66,76,89,144],"relapse":[29],"potential.":[30],"PC":[31,52,77],"levels":[32],"elevated":[34],"by":[35,80],"environmental":[36],"stresses,":[37],"e.g.,":[38],"orthodontic":[39,54,139],"treatment.":[40],"Our":[41],"purpose":[42],"was":[43],"to":[44,95,98,135,146],"quantify,":[45],"the":[47],"first":[48],"time,":[49],"MS":[50,75,134],"in":[53,60,114,121,137],"patients.":[55],"Plaque":[56],"samples":[57],"were":[58,78],"collected":[59],"17":[61],"at":[63,109],"0,":[64],"1":[65],"6":[67],"months":[68],"after":[69],"fixed":[70],"appliance":[71],"bonding.":[72],"Percentage":[73],"of":[74],"determined":[79],"microbiological":[81],"assays.":[82],"Overall,":[83],"treatment":[84,96,128],"did":[85],"not":[86],"affect":[87],"%MS":[88,103,108],"%PC":[90,93,115,119],"(P>0.05).":[91],"However,":[92],"response":[94],"appeared":[97],"be":[99],"dependent":[100],"on":[101],"baseline":[102,110,125],"values.":[104],"Patients":[105],"low":[107],"had":[111],"an":[112],"increase":[113],"during":[116],"treatment,":[117],"while":[118],"decreased":[120],"those":[122],"high":[124],"%MS.":[126],"may":[129],"provide":[130],"way":[132],"persist":[136],"individual":[138],"specific":[142],"subtypes":[143],"contribute":[145],"caries":[148],"incidence.":[149]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-10-15T00:00:00"}
