{"id":"https://openalex.org/W3092214675","doi":null,"title":"Astragaloside IV prevents myocardial hypertrophy induced by mechanical stress by activating autophagy and reducing inflammation.","display_name":"Astragaloside IV prevents myocardial hypertrophy induced by mechanical stress by activating autophagy and reducing inflammation.","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3092214675","mag":"3092214675","pmid":"https://pubmed.ncbi.nlm.nih.gov/33042423","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7540164"},"language":"en","primary_location":{"id":"pmid:33042423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33042423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7540164/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100378814","display_name":"Tong Zhang","orcid":"https://orcid.org/0000-0003-1123-7874","observed_orcids":["https://orcid.org/0000-0003-1123-7874","https://orcid.org/0009-0008-8485-0681"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Zhang","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081449674","display_name":"Hongxin Wang","orcid":"https://orcid.org/0000-0002-3256-3137","observed_orcids":["https://orcid.org/0000-0002-3256-3137"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongxin Wang","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028658881","display_name":"Meili L\u00fc","orcid":"https://orcid.org/0000-0001-5770-0911","observed_orcids":["https://orcid.org/0000-0001-5770-0911"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meili Lu","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114950188","display_name":"Kun Zhao","orcid":"https://orcid.org/0000-0003-0711-7335","observed_orcids":["https://orcid.org/0000-0003-0711-7335"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zhao","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University Jinzhou 121001, China","The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University Jinzhou 121001, China","institution_ids":["https://openalex.org/I85430964"]},{"raw_affiliation_string":"The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101460136","display_name":"Jiawei Yin","orcid":"https://orcid.org/0000-0002-8490-4992","observed_orcids":["https://orcid.org/0000-0002-8490-4992"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawei Yin","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355946","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0002-6033-0648","observed_orcids":["https://orcid.org/0000-0002-6033-0648"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Liu","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University Jinzhou 121001, China","The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University Jinzhou 121001, China","institution_ids":["https://openalex.org/I85430964"]},{"raw_affiliation_string":"The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001, China","institution_ids":["https://openalex.org/I85430964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101877871","display_name":"Yang Sun","orcid":"https://orcid.org/0000-0003-3751-2790","observed_orcids":["https://orcid.org/0000-0003-3751-2790"]},"institutions":[{"id":"https://openalex.org/I85430964","display_name":"Jinzhou Medical University","ror":"https://ror.org/02yd1yr68","country_code":"CN","type":"education","lineage":["https://openalex.org/I85430964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Sun","raw_affiliation_strings":["Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cardiovascular and Cerebrovascular Drug Research of Liaoning Province, Jinzhou Medical University, Jinzhou, 121001, China","institution_ids":["https://openalex.org/I85430964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I85430964"],"apc_list":null,"apc_paid":null,"fwci":2.2666,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.89496192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"12","issue":"9","first_page":"5332","last_page":"5342"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9398999810218811,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/astragaloside-iv","display_name":"astragaloside IV","score":1.0},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/mechanical-stress","display_name":"mechanical stress","score":0.9390000104904175},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9610000252723694},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9520000219345093},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiomyocyte-hypertrophy","display_name":"cardiomyocyte hypertrophy","score":0.7609999775886536},{"id":"https://openalex.org/keywords/aortic-banding","display_name":"aortic banding","score":0.9110000133514404},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.8619999885559082},{"id":"https://openalex.org/keywords/p62","display_name":"p62","score":0.6700000166893005},{"id":"https://openalex.org/keywords/lc3-ii","display_name":"LC3-II","score":0.7630000114440918},{"id":"https://openalex.org/keywords/cardiac-function","display_name":"cardiac function","score":0.7409999966621399}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6820792555809021},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.6429471373558044},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5765706300735474},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.5457971096038818},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5257340669631958},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.5097681879997253},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5012099742889404},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.49552953243255615},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.48914650082588196},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.36353302001953125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34823593497276306},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.1624763011932373},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1604636311531067},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08731228113174438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmid:33042423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33042423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7540164","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7540164/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:3092214675","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33042423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7540164","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7540164/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1989950165","https://openalex.org/W1993064649","https://openalex.org/W2000372234","https://openalex.org/W2042767581","https://openalex.org/W2048030072","https://openalex.org/W2050449334","https://openalex.org/W2050599772","https://openalex.org/W2077549620","https://openalex.org/W2137444266","https://openalex.org/W2160880055","https://openalex.org/W2168557745","https://openalex.org/W2335376262","https://openalex.org/W2339207243","https://openalex.org/W2406019088","https://openalex.org/W2474199515","https://openalex.org/W2725795600","https://openalex.org/W2735882751","https://openalex.org/W2744182556","https://openalex.org/W2747392223","https://openalex.org/W2770450661","https://openalex.org/W2777606180","https://openalex.org/W2791529560","https://openalex.org/W2792798083","https://openalex.org/W2804085690","https://openalex.org/W2836826811","https://openalex.org/W2883047923","https://openalex.org/W2889908918","https://openalex.org/W2896625032","https://openalex.org/W2904045437","https://openalex.org/W2906635253","https://openalex.org/W2921920633","https://openalex.org/W2945870418"],"related_works":["https://openalex.org/W4289399873","https://openalex.org/W1989950165","https://openalex.org/W2376223628","https://openalex.org/W2351479157","https://openalex.org/W2372265380","https://openalex.org/W2376109176","https://openalex.org/W2351570891","https://openalex.org/W7124150903","https://openalex.org/W2770450661","https://openalex.org/W3146667530"],"abstract_inverted_index":{"AIMS:":[0],"The":[1,101],"aim":[2],"of":[3,12,98,103,168,218],"the":[4,10,38,94,138,142,149,165,216],"present":[5],"study":[6],"was":[7,34,46,77,90,117,147,180],"to":[8,92],"investigate":[9],"effects":[11],"astragaloside":[13],"IV":[14],"(As-IV)":[15],"on":[16,24],"mechanical":[17,242],"stress-induced":[18],"myocardial":[19,99,113,184,238],"hypertrophy,":[20,199],"with":[21],"a":[22,42,207],"focus":[23],"autophagy":[25,246],"and":[26,41,56,67,86,96,109,115,124,129,155,163,173,177,186,194,197,220,222,231,247],"inflammation.":[27,249],"METHODS:":[28],"A":[29],"rat":[30],"cardiac":[31,57,143,192],"hypertrophy":[32,44,58,150,239],"model":[33,45],"established":[35,47],"by":[36,48,61,79,119,134,227,241,244],"narrowing":[37],"abdominal":[39],"aorta,":[40],"cell":[43,130],"mechanically":[49],"stretching":[50],"primary":[51],"cardiomyocytes.":[52,187],"Cardiac":[53],"function":[54,144,193],"index":[55,65,71,145],"were":[59,132,157,161,175],"measured":[60,78,133],"echocardiography,":[62],"heart":[63],"weight":[64,70],"(HWI)":[66],"left":[68],"ventriculus":[69],"(LVWI)":[72],"in":[73,82,111,127,182],"vivo.":[74],"Cell":[75],"size":[76],"phalloidin-tetramethyl":[80],"treatment":[81],"vitro,":[83],"while":[84,122,204],"hematoxylin":[85],"eosin":[87],"(HE)":[88],"staining":[89],"used":[91],"observe":[93],"arrangement":[95],"morphology":[97,196],"cells.":[100],"expression":[102,166,179,217,230],"ANP,":[104,169],"BNP,":[105,170],"LC3II,":[106],"p62,":[107],"NLRP3,":[108,171],"IL-1\u03b2":[110,172,221],"both":[112,183],"tissue":[114,185],"cardiomyocytes":[116,160],"assessed":[118],"Western":[120],"blot,":[121],"TNF-\u03b1":[123],"IL-18":[125],"levels":[126,167],"serum":[128],"supernatants":[131],"ELISA.":[135],"RESULTS:":[136],"In":[137,212],"aortic":[139],"banding":[140],"model,":[141],"LVEF":[146],"decreased;":[148],"indexes":[151],"LVPWd,":[152],"LVPWs,":[153],"IVSd":[154],"IVSs":[156],"significantly":[158,190],"increased;":[159,176],"enlarged":[162],"disordered;":[164],"p62":[174,233],"LC3II":[178,229],"decreased":[181,215,232],"As-IV":[188,214,236],"could":[189],"improve":[191],"cardiomyocyte":[195],"limit":[198],"thereby":[200],"protecting":[201],"damaged":[202],"hearts,":[203],"rapamycin":[205],"had":[206],"similar":[208],"effect":[209],"as":[210,225],"As-IV.":[211],"addition,":[213],"NLRP3":[219],"activated":[223],"autophagy,":[224],"evidenced":[226],"increased":[228],"levels.":[234],"CONCLUSION:":[235],"prevents":[237],"induced":[240],"stress":[243],"activating":[245],"reducing":[248]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-10-15T00:00:00"}