{"id":"https://openalex.org/W3092023980","doi":"https://doi.org/10.1101/2020.10.09.332726","title":"Ultrasound-mediated mechanical forces selectively kill tumor cells","display_name":"Ultrasound-mediated mechanical forces selectively kill tumor cells","publication_year":2020,"publication_date":"2020-10-09","ids":{"openalex":"https://openalex.org/W3092023980","doi":"https://doi.org/10.1101/2020.10.09.332726","mag":"3092023980"},"language":"en","primary_location":{"id":"doi:10.1101/2020.10.09.332726","doi":"https://doi.org/10.1101/2020.10.09.332726","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.09.332726","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/09/2020.10.09.332726.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/09/2020.10.09.332726.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061892826","display_name":"Ajay Tijore","orcid":"https://orcid.org/0000-0002-0803-2168","observed_orcids":["https://orcid.org/0000-0002-0803-2168"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ajay Tijore","raw_affiliation_strings":["Mechanobiology Institute, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080288956","display_name":"Felix Margadant","orcid":"https://orcid.org/0000-0002-6729-6155","observed_orcids":["https://orcid.org/0000-0002-6729-6155"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Felix Margadant","raw_affiliation_strings":["Mechanobiology Institute, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mingxi Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Mingxi Yao","raw_affiliation_strings":["Mechanobiology Institute, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048970618","display_name":"Anushya Hariharan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Anushya Hariharan","raw_affiliation_strings":["Mechanobiology Institute, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030343810","display_name":"Claire Alexandra Zhen Chew","orcid":"https://orcid.org/0000-0002-4435-6127","observed_orcids":["https://orcid.org/0000-0002-4435-6127"]},"institutions":[{"id":"https://openalex.org/I4210137846","display_name":"National University Hospital","ror":"https://ror.org/02z79er63","country_code":"SY","type":"healthcare","lineage":["https://openalex.org/I4210137846"]},{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210146690","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG","SY"],"is_corresponding":false,"raw_author_name":"Claire Alexandra Zhen Chew","raw_affiliation_strings":["Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, National University Hospital, Singapore","Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, National University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, National University Hospital, Singapore","institution_ids":["https://openalex.org/I4210146690","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, National University Hospital","institution_ids":["https://openalex.org/I4210137846","https://openalex.org/I4210146690"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056895130","display_name":"Simon N. Powell","orcid":"https://orcid.org/0000-0002-8183-4765","observed_orcids":["https://orcid.org/0000-0002-8183-4765"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Simon Powell","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, Texas, USA","Biochemistry and Molecular Biology Department, University of Texas Medical Branch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, Texas, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, University of Texas Medical Branch","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035873423","display_name":"Glenn Kunnath Bonney","orcid":"https://orcid.org/0000-0002-9034-3255","observed_orcids":["https://orcid.org/0000-0002-9034-3255"]},"institutions":[{"id":"https://openalex.org/I4210137846","display_name":"National University Hospital","ror":"https://ror.org/02z79er63","country_code":"SY","type":"healthcare","lineage":["https://openalex.org/I4210137846"]},{"id":"https://openalex.org/I4210146690","display_name":"National University Hospital","ror":"https://ror.org/04fp9fm22","country_code":"SG","type":"healthcare","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210146690","https://openalex.org/I4210150261"]},{"id":"https://openalex.org/I4210150261","display_name":"National University Health System","ror":"https://ror.org/05tjjsh18","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596","https://openalex.org/I4210150261"]}],"countries":["SG","SY"],"is_corresponding":false,"raw_author_name":"Glenn Kunnath Bonney","raw_affiliation_strings":["Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, National University Hospital, Singapore","Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, National University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, National University Hospital, Singapore","institution_ids":["https://openalex.org/I4210146690","https://openalex.org/I4210150261"]},{"raw_affiliation_string":"Division of Hepatobiliary & Pancreatic Surgery, Department of Surgery, National University Hospital","institution_ids":["https://openalex.org/I4210137846","https://openalex.org/I4210146690"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040193425","display_name":"Michael P. Sheetz","orcid":"https://orcid.org/0000-0001-8747-3430","observed_orcids":["https://orcid.org/0000-0001-8747-3430"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I4405277086","display_name":"Mechanobiology Institute","ror":"https://ror.org/01dh8a666","country_code":"SG","type":"facility","lineage":["https://openalex.org/I4405277086"]},{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["SG","US"],"is_corresponding":true,"raw_author_name":"Michael Sheetz","raw_affiliation_strings":["Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, Texas, USA","Mechanobiology Institute, National University of Singapore, Singapore","Biochemistry and Molecular Biology Department, University of Texas Medical Branch","Mechanobiology Institute, National University of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, University of Texas Medical Branch, Galveston, Texas, USA","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]},{"raw_affiliation_string":"Biochemistry and Molecular Biology Department, University of Texas Medical Branch","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore","institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5040193425"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I4405277086","https://openalex.org/I55302922"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10958","display_name":"Ultrasound and Hyperthermia Applications","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11455","display_name":"Microbial Inactivation Methods","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/low-frequency-ultrasound","display_name":"low-frequency ultrasound","score":0.8650000095367432},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6470000147819519},{"id":"https://openalex.org/keywords/calpain","display_name":"calpain","score":0.7419999837875366},{"id":"https://openalex.org/keywords/mitochondrial-pathway","display_name":"mitochondrial pathway","score":0.7760000228881836},{"id":"https://openalex.org/keywords/piezo1-channels","display_name":"Piezo1 channels","score":0.7979999780654907},{"id":"https://openalex.org/keywords/non-invasive-cancer-treatment","display_name":"non-invasive cancer treatment","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C4001165","wikidata":"https://www.wikidata.org/wiki/Q6804689","display_name":"Mechanosensitive channels","level":4,"score":0.7612019777297974},{"id":"https://openalex.org/C143753070","wikidata":"https://www.wikidata.org/wiki/Q162564","display_name":"Ultrasound","level":2,"score":0.6022014021873474},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5552508234977722},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5452790856361389},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.48787403106689453},{"id":"https://openalex.org/C97230052","wikidata":"https://www.wikidata.org/wiki/Q3854334","display_name":"Chorioallantoic membrane","level":3,"score":0.4531053900718689},{"id":"https://openalex.org/C56928146","wikidata":"https://www.wikidata.org/wiki/Q2934402","display_name":"Calpain","level":3,"score":0.4377746880054474},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.4330163300037384},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37559419870376587},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3384430408477783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33268293738365173},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22969362139701843},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.1275707185268402},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.09737411141395569},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08123350143432617},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06854444742202759},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2020.10.09.332726","doi":"https://doi.org/10.1101/2020.10.09.332726","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.09.332726","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/09/2020.10.09.332726.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2020.10.09.332726","doi":"https://doi.org/10.1101/2020.10.09.332726","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.10.09.332726","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/10/09/2020.10.09.332726.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320698","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320322724","display_name":"Ministry of Education, India","ror":"https://ror.org/048xjjh50"},{"id":"https://openalex.org/F4320324605","display_name":"Mechanobiology Institute, Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3092023980.pdf","grobid_xml":"https://content.openalex.org/works/W3092023980.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W374143785","https://openalex.org/W1849681763","https://openalex.org/W1995475798","https://openalex.org/W1999720993","https://openalex.org/W2002930615","https://openalex.org/W2032526594","https://openalex.org/W2049233086","https://openalex.org/W2053145461","https://openalex.org/W2055805300","https://openalex.org/W2057627932","https://openalex.org/W2140204696","https://openalex.org/W2147288982","https://openalex.org/W2152578203","https://openalex.org/W2158504070","https://openalex.org/W2165375096","https://openalex.org/W2166635466","https://openalex.org/W2205358880","https://openalex.org/W2398129284","https://openalex.org/W2429225077","https://openalex.org/W2441337908","https://openalex.org/W2464801492","https://openalex.org/W2563801902","https://openalex.org/W2570023565","https://openalex.org/W2588123864","https://openalex.org/W2804153880","https://openalex.org/W2886636516","https://openalex.org/W2889646458","https://openalex.org/W2896032894","https://openalex.org/W2898202111","https://openalex.org/W2967883383","https://openalex.org/W2982144197","https://openalex.org/W2999269165","https://openalex.org/W3160383251","https://openalex.org/W4308648843"],"related_works":["https://openalex.org/W4405951134","https://openalex.org/W4409625982","https://openalex.org/W3164870017","https://openalex.org/W4205532263","https://openalex.org/W7165399903","https://openalex.org/W1965223777","https://openalex.org/W1972898732","https://openalex.org/W960841551","https://openalex.org/W2169074119","https://openalex.org/W1970544720"],"abstract_inverted_index":{"Abstract":[0],"Ultrasound":[1],"has":[2],"been":[3],"used":[4],"to":[5,34,110,146],"target":[6,24],"tumors":[7],"either":[8],"through":[9,70],"local":[10,13],"heating":[11],"or":[12],"nanobubbles":[14],"but":[15],"these":[16],"methods":[17],"damage":[18,109],"surrounding":[19],"normal":[20,45],"cells":[21,31,58,131],"in":[22,99,136],"the":[23,71,100,111],"area.":[25],"Recent":[26],"studies":[27],"show":[28],"that":[29,43,51,65],"tumor":[30,57,82,97,117,130,148],"are":[32,119],"susceptible":[33],"mechanical":[35],"stresses":[36],"and":[37],"undergo":[38],"calcium-dependent":[39],"apoptosis":[40,55,128],"under":[41],"conditions":[42],"promote":[44],"cell":[46,83],"growth.":[47],"Here":[48],"we":[49],"report":[50],"low-frequency":[52],"ultrasound":[53,94,122,126],"causes":[54,96,127],"of":[56,80,89,129],"by":[59,121],"activating":[60],"a":[61,77,142],"calpain-dependent":[62],"mitochondrial":[63],"pathway":[64],"depends":[66],"upon":[67],"calcium":[68],"entry":[69],"mechanosensitive":[72],"Piezo1":[73],"channels.":[74],"This":[75],"is":[76],"general":[78],"property":[79],"all":[81],"lines":[84],"tested":[85],"so":[86],"far":[87],"irrespective":[88],"tissue":[90],"origin.":[91],"In":[92],"animals,":[93],"irradiation":[95],"killing":[98],"chick":[101,112],"chorioallantoic":[102],"membrane":[103],"(CAM)":[104],"model":[105],"with":[106],"relatively":[107],"little":[108],"embryos.":[113],"Further,":[114],"patient-derived":[115],"pancreatic":[116],"organoids":[118],"killed":[120],"treatment.":[123],"Because":[124],"low-level":[125],"from":[132],"many":[133],"different":[134,137],"tissues":[135],"microenvironments,":[138],"it":[139],"may":[140],"offer":[141],"safe":[143],"non-invasive":[144],"approach":[145],"augment":[147],"treatments.":[149]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-10-15T00:00:00"}
