{"id":"https://openalex.org/W3092019062","doi":"https://doi.org/10.1016/j.jpba.2020.113676","title":"A highly sensitive quantification method for 12 plant toxins in human serum using liquid chromatography tandem mass spectrometry with a quick solid-phase extraction technique","display_name":"A highly sensitive quantification method for 12 plant toxins in human serum using liquid chromatography tandem mass spectrometry with a quick solid-phase extraction technique","publication_year":2020,"publication_date":"2020-10-09","ids":{"openalex":"https://openalex.org/W3092019062","doi":"https://doi.org/10.1016/j.jpba.2020.113676","mag":"3092019062","pmid":"https://pubmed.ncbi.nlm.nih.gov/33099112"},"language":"en","primary_location":{"id":"doi:10.1016/j.jpba.2020.113676","doi":"https://doi.org/10.1016/j.jpba.2020.113676","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpba.2020.113676","pdf_url":null,"source":{"id":"https://openalex.org/S174893293","display_name":"Journal of Pharmaceutical and Biomedical Analysis","issn_l":"0731-7085","issn":["0731-7085","1873-264X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Biomedical Analysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://nagoya.repo.nii.ac.jp/records/2000348","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Masaru Taniguchi","orcid":"https://orcid.org/0000-0002-4472-0400","observed_orcids":["https://orcid.org/0000-0002-4472-0400"]},"institutions":[{"id":"https://openalex.org/I4405256781","display_name":"Nagoya City Public Health Research Institute","ror":"https://ror.org/04hbvjm68","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256781"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Taniguchi","raw_affiliation_strings":["Nagoya City Public Health Research Institute, 2266-132 Shimoshidami, Moriyama-ku, Nagoya, 463-0003, Japan; Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan"],"raw_orcid":"https://orcid.org/0000-0002-4472-0400","affiliations":[{"raw_affiliation_string":"Nagoya City Public Health Research Institute, 2266-132 Shimoshidami, Moriyama-ku, Nagoya, 463-0003, Japan; Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I4405256781","https://openalex.org/I60134161"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090387518","display_name":"Tomiaki Minatani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405254178","display_name":"Gifu Prefectural Research Institute for Health and Environmental Sciences","ror":"https://ror.org/01gyv0x79","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405254178"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomiaki Minatani","raw_affiliation_strings":["Gifu Prefectural Research Institute for Health and Environmental Sciences, 1-1 Naka-Fudogaoka, Kagamigahara City, Gifu, 504-0838, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gifu Prefectural Research Institute for Health and Environmental Sciences, 1-1 Naka-Fudogaoka, Kagamigahara City, Gifu, 504-0838, Japan","institution_ids":["https://openalex.org/I4405254178"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hitoshi Miyazaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405256781","display_name":"Nagoya City Public Health Research Institute","ror":"https://ror.org/04hbvjm68","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405256781"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Miyazaki","raw_affiliation_strings":["Nagoya City Public Health Research Institute, 2266-132 Shimoshidami, Moriyama-ku, Nagoya, 463-0003, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nagoya City Public Health Research Institute, 2266-132 Shimoshidami, Moriyama-ku, Nagoya, 463-0003, Japan","institution_ids":["https://openalex.org/I4405256781"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110129884","display_name":"Hitoshi Tsuchihashi","orcid":"https://orcid.org/0000-0003-2693-8104","observed_orcids":["https://orcid.org/0000-0003-2693-8104"]},"institutions":[{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hitoshi Tsuchihashi","raw_affiliation_strings":["Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan","institution_ids":["https://openalex.org/I60134161"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067718958","display_name":"Kei Zaitsu","orcid":"https://orcid.org/0000-0001-7613-5735","observed_orcids":["https://orcid.org/0000-0001-7613-5735"]},"institutions":[{"id":"https://openalex.org/I4405287166","display_name":"Nagoya University Institute for Advanced Research","ror":"https://ror.org/049xpsw37","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405287166","https://openalex.org/I60134161"]},{"id":"https://openalex.org/I60134161","display_name":"Nagoya University","ror":"https://ror.org/04chrp450","country_code":"JP","type":"education","lineage":["https://openalex.org/I60134161"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Kei Zaitsu","raw_affiliation_strings":["Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan; In Vivo Real-Time Omics Laboratory, Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. Electronic address: kzaitsu@med.nagoya-u.ac.jp","In Vivo Real-time Omics Laboratory, Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Legal Medicine & Bioethics, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan; In Vivo Real-Time Omics Laboratory, Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8601, Japan. Electronic address: kzaitsu@med.nagoya-u.ac.jp","institution_ids":["https://openalex.org/I4405287166","https://openalex.org/I60134161"]},{"raw_affiliation_string":"In Vivo Real-time Omics Laboratory, Institute for Advanced Research, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan","institution_ids":["https://openalex.org/I4405287166","https://openalex.org/I60134161"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067718958"],"corresponding_institution_ids":["https://openalex.org/I4405287166","https://openalex.org/I60134161"],"apc_list":{"value":3060,"currency":"USD","value_usd":3060},"apc_paid":null,"fwci":1.3918,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77474159,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"192","issue":null,"first_page":"113676","last_page":"113676"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10800","display_name":"Forensic Toxicology and Drug Analysis","score":0.9164999723434448,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12756","display_name":"Plant Toxicity and Pharmacological Properties","score":0.026499999687075615,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10180","display_name":"Analytical chemistry methods development","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1602","display_name":"Analytical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plant-toxins","display_name":"plant toxins","score":0.996999979019165},{"id":"https://openalex.org/keywords/human-serum","display_name":"human serum","score":0.9269999861717224},{"id":"https://openalex.org/keywords/lycorine","display_name":"lycorine","score":0.7599999904632568},{"id":"https://openalex.org/keywords/galantamine","display_name":"galantamine","score":0.9549999833106995},{"id":"https://openalex.org/keywords/protoveratrine","display_name":"protoveratrine","score":0.8619999885559082},{"id":"https://openalex.org/keywords/veratridine","display_name":"veratridine","score":0.9179999828338623},{"id":"https://openalex.org/keywords/jervine","display_name":"jervine","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cyclopamine","display_name":"cyclopamine","score":0.9950000047683716},{"id":"https://openalex.org/keywords/alpha-solanine","display_name":"\u03b1-solanine","score":0.859000027179718},{"id":"https://openalex.org/keywords/alpha-chaconine","display_name":"\u03b1-chaconine","score":1.0},{"id":"https://openalex.org/keywords/solanidine","display_name":"solanidine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/solid-phase-extraction","display_name":"solid-phase extraction","score":0.7139999866485596},{"id":"https://openalex.org/keywords/simultaneous-determination","display_name":"simultaneous determination","score":0.6299999952316284},{"id":"https://openalex.org/keywords/method-validation","display_name":"method validation","score":0.4359999895095825}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9222902059555054},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.9004250764846802},{"id":"https://openalex.org/C10390740","wikidata":"https://www.wikidata.org/wiki/Q2282401","display_name":"Analyte","level":2,"score":0.6746724843978882},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.595300018787384},{"id":"https://openalex.org/C81426234","wikidata":"https://www.wikidata.org/wiki/Q1408763","display_name":"Solid phase extraction","level":3,"score":0.5536690950393677},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.5130609273910522},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.5078476071357727},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.5048595070838928}],"mesh":[{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002138","descriptor_name":"Calibration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052616","descriptor_name":"Solid Phase Extraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.jpba.2020.113676","doi":"https://doi.org/10.1016/j.jpba.2020.113676","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jpba.2020.113676","pdf_url":null,"source":{"id":"https://openalex.org/S174893293","display_name":"Journal of Pharmaceutical and Biomedical Analysis","issn_l":"0731-7085","issn":["0731-7085","1873-264X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical and Biomedical Analysis","raw_type":"journal-article"},{"id":"pmid:33099112","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33099112","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of pharmaceutical and biomedical analysis","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:01152:0005032199","doi":null,"is_oa":true,"landing_page_url":"https://nagoya.repo.nii.ac.jp/records/2000348","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:01152:0005032199","doi":null,"is_oa":true,"landing_page_url":"https://nagoya.repo.nii.ac.jp/records/2000348","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"doctoral thesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1960078460","display_name":"Elucidation of acute toxicity of drugs by real-time metabolome analysis and multivariate time-series analysis","funder_award_id":"18K10122","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3566067352","display_name":"Accurate measurement of natural toxins in body fluids using deuterated standards and search of specific markers for the rapid diagnosis","funder_award_id":"18H03064","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G4299747586","display_name":"Simple and Rapid metabolite analysis of crops by new mass spectrometry PESI/MS/MS","funder_award_id":"20K20372","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7134452536","display_name":"Neurogenesis and its pathogenesis in the neonatal brain: an integrated understanding using advanced analytical techniques","funder_award_id":"20H05700","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W787342000","https://openalex.org/W1539185773","https://openalex.org/W2008385258","https://openalex.org/W2014141124","https://openalex.org/W2020033101","https://openalex.org/W2022650645","https://openalex.org/W2026809855","https://openalex.org/W2038787567","https://openalex.org/W2060140430","https://openalex.org/W2076886729","https://openalex.org/W2090109354","https://openalex.org/W2102401826","https://openalex.org/W2109233592","https://openalex.org/W2113070433","https://openalex.org/W2130771384","https://openalex.org/W2167530111","https://openalex.org/W2170196375","https://openalex.org/W2298628607","https://openalex.org/W2300879313","https://openalex.org/W2617853301","https://openalex.org/W2754375997","https://openalex.org/W2755888911","https://openalex.org/W2769885370","https://openalex.org/W2793792389","https://openalex.org/W2901384518","https://openalex.org/W2947662896","https://openalex.org/W2966827389","https://openalex.org/W2972774050","https://openalex.org/W6684414556","https://openalex.org/W6829070255"],"related_works":["https://openalex.org/W4307820773","https://openalex.org/W2971328953","https://openalex.org/W2026809855","https://openalex.org/W4297880740","https://openalex.org/W4393076551","https://openalex.org/W4297757439","https://openalex.org/W2793792389","https://openalex.org/W2091195409","https://openalex.org/W4399660892","https://openalex.org/W2378337976"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-15T00:00:00"}