{"id":"https://openalex.org/W3092006072","doi":"https://doi.org/10.1002/jcph.1759","title":"Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation","display_name":"Hydroxyurea Pharmacokinetics in Pediatric Patients After Total Pancreatectomy With Islet Autotransplantation","publication_year":2020,"publication_date":"2020-10-07","ids":{"openalex":"https://openalex.org/W3092006072","doi":"https://doi.org/10.1002/jcph.1759","mag":"3092006072","pmid":"https://pubmed.ncbi.nlm.nih.gov/33029796"},"language":"en","primary_location":{"id":"doi:10.1002/jcph.1759","doi":"https://doi.org/10.1002/jcph.1759","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcph.1759","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009809709","display_name":"Alexander A. Boucher","orcid":"https://orcid.org/0000-0002-5392-1829","observed_orcids":["https://orcid.org/0000-0002-5392-1829"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alexander A. Boucher","raw_affiliation_strings":["Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Medical School, Minneapolis, Minnesota, USA"],"raw_orcid":"https://orcid.org/0000-0002-5392-1829","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Division of Pediatric Hematology and Oncology, University of Minnesota Medical School, Minneapolis, Minnesota, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090500677","display_name":"Min Dong","orcid":"https://orcid.org/0000-0002-8552-8298","observed_orcids":["https://orcid.org/0000-0002-8552-8298"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Dong","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0002-8552-8298","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040060343","display_name":"Alexander A. T. M. M. Vinks","orcid":"https://orcid.org/0000-0003-4224-2967","observed_orcids":["https://orcid.org/0000-0003-4224-2967"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Vinks","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0003-4224-2967","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081533913","display_name":"Anu Marahatta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anu Marahatta","raw_affiliation_strings":["Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082637572","display_name":"Thad A. Howard","orcid":"https://orcid.org/0000-0002-9257-6343","observed_orcids":["https://orcid.org/0000-0002-9257-6343"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thad A. Howard","raw_affiliation_strings":["Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040752648","display_name":"Russell E. Ware","orcid":"https://orcid.org/0000-0001-9582-0594","observed_orcids":["https://orcid.org/0000-0001-9582-0594"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell E. Ware","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0001-9582-0594","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054081350","display_name":"Jaimie D. Nathan","orcid":"https://orcid.org/0000-0002-5867-3326","observed_orcids":["https://orcid.org/0000-0002-5867-3326"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaimie D. Nathan","raw_affiliation_strings":["Departments of Surgery and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0002-5867-3326","affiliations":[{"raw_affiliation_string":"Departments of Surgery and Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063305803","display_name":"Maisam A. Abu\u2010El\u2010Haija","orcid":"https://orcid.org/0000-0002-8968-7851","observed_orcids":["https://orcid.org/0000-0002-8968-7851"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maisam Abu\u2010El\u2010Haija","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002520656","display_name":"Lori Luchtman\u2010Jones","orcid":"https://orcid.org/0000-0002-2737-9909","observed_orcids":["https://orcid.org/0000-0002-2737-9909"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lori Luchtman\u2010Jones","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009809709"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":null,"fwci":0.7181,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.70271818,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"61","issue":"4","first_page":"547","last_page":"554"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.6503999829292297,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0722000002861023,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.024000000208616257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.9860000014305115},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9890000224113464},{"id":"https://openalex.org/keywords/total-pancreatectomy-with-islet-autotransplantation","display_name":"total pancreatectomy with islet autotransplantation","score":0.9300000071525574},{"id":"https://openalex.org/keywords/pediatric-patients","display_name":"pediatric patients","score":0.8880000114440918},{"id":"https://openalex.org/keywords/roux-en-y-reconstruction","display_name":"Roux-en-Y reconstruction","score":0.7879999876022339},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.6349999904632568},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.9950000047683716},{"id":"https://openalex.org/keywords/thrombocytosis","display_name":"thrombocytosis","score":0.8090000152587891},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.878000020980835},{"id":"https://openalex.org/keywords/dose-normalization","display_name":"dose normalization","score":0.5180000066757202},{"id":"https://openalex.org/keywords/plasma-drug-concentration","display_name":"plasma drug concentration","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8200348615646362},{"id":"https://openalex.org/C2778122501","wikidata":"https://www.wikidata.org/wiki/Q379071","display_name":"Autotransplantation","level":3,"score":0.8036767244338989},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.6974471807479858},{"id":"https://openalex.org/C2779788118","wikidata":"https://www.wikidata.org/wiki/Q1542410","display_name":"Thrombocytosis","level":3,"score":0.6107065081596375},{"id":"https://openalex.org/C2779316324","wikidata":"https://www.wikidata.org/wiki/Q212272","display_name":"Hydroxycarbamide","level":3,"score":0.5135834217071533},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4948264956474304},{"id":"https://openalex.org/C2778620579","wikidata":"https://www.wikidata.org/wiki/Q185034","display_name":"Sickle cell anemia","level":3,"score":0.4813616871833801},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.43768736720085144},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.43554559350013733},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.43175193667411804},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3799945116043091},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3787018656730652},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.21934500336647034},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.2003563642501831},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18207061290740967}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010180","descriptor_name":"Pancreatectomy","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013922","descriptor_name":"Thrombocytosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013922","descriptor_name":"Thrombocytosis","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D014182","descriptor_name":"Transplantation, Autologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016381","descriptor_name":"Islets of Langerhans Transplantation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jcph.1759","doi":"https://doi.org/10.1002/jcph.1759","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jcph.1759","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:33029796","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33029796","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1540991620","https://openalex.org/W1752100137","https://openalex.org/W1894161045","https://openalex.org/W1917619866","https://openalex.org/W1965953367","https://openalex.org/W1966431174","https://openalex.org/W1973644848","https://openalex.org/W2004408173","https://openalex.org/W2015754438","https://openalex.org/W2017524098","https://openalex.org/W2018311291","https://openalex.org/W2020811156","https://openalex.org/W2023174165","https://openalex.org/W2031388170","https://openalex.org/W2034832239","https://openalex.org/W2060855634","https://openalex.org/W2094990777","https://openalex.org/W2100029868","https://openalex.org/W2110008598","https://openalex.org/W2113613653","https://openalex.org/W2135337547","https://openalex.org/W2171678230","https://openalex.org/W2172684893","https://openalex.org/W2249498033","https://openalex.org/W2320032845","https://openalex.org/W2369027685","https://openalex.org/W2415260608","https://openalex.org/W2736844263","https://openalex.org/W2742175805","https://openalex.org/W2742410006","https://openalex.org/W2752272969","https://openalex.org/W2772173038","https://openalex.org/W2805996267","https://openalex.org/W2899510796","https://openalex.org/W2908335803","https://openalex.org/W2943716814","https://openalex.org/W2944047055","https://openalex.org/W2944852231","https://openalex.org/W2981595737","https://openalex.org/W2985774233"],"related_works":["https://openalex.org/W2984283882","https://openalex.org/W2910037142","https://openalex.org/W4310161270","https://openalex.org/W2944047055","https://openalex.org/W2594867548","https://openalex.org/W4405043834","https://openalex.org/W4414642612","https://openalex.org/W2624736083","https://openalex.org/W2533785708","https://openalex.org/W2913883561"],"abstract_inverted_index":{"/L).":[0],"Thrombocytosis":[1],"can":[2],"be":[3,205],"prothrombotic,":[4],"so":[5],"cytoreductive":[6],"hydroxyurea":[7,30,55,62,104,192,222],"is":[8,223],"often":[9],"initiated":[10],"after":[11,31,87],"this":[12,32],"surgery;":[13],"however,":[14],"optimal":[15],"dosing":[16,159],"strategy":[17],"and":[18,84,96,110,124,138,194,211],"efficacy":[19],"are":[20,217],"unknown.":[21],"This":[22],"prospective":[23],"pilot":[24],"study":[25],"characterized":[26],"the":[27,50,88,149],"pharmacokinetics":[28,56],"of":[29,152,156,208],"procedure":[33],"in":[34,45,52,66,182,191,196],"children.":[35],"It":[36],"also":[37],"compared":[38,141],"them":[39],"with":[40,132,142,163,175,199],"previously":[41,180],"published":[42],"pediatric":[43,54],"parameters":[44],"sickle":[46,143,183,228],"cell":[47,144,184,229],"anemia":[48,145],"(SCA),":[49],"disease":[51],"which":[53],"have":[57],"primarily":[58,206],"been":[59],"studied.":[60],"Plasma":[61],"levels":[63],"were":[64,78],"quantified":[65],"14":[67],"participants":[68,107,135,166],"aged":[69],"4-19":[70],"years":[71],"using":[72],"high-performance":[73],"liquid":[74],"chromatography.":[75],"Blood":[76],"collections":[77],"scheduled":[79],"20":[80],"minutes,":[81],"1":[82,94],"hour,":[83],"4":[85],"hours":[86],"first":[89],"dose,":[90],"on":[91,103],"pharmacokinetic":[92,169,215],"day":[93],"(PK1),":[95],"again":[97],"2-3":[98],"months":[99],"later":[100],"if":[101],"still":[102],"(PK2).":[105],"Six":[106],"had":[108,121,127,136,167],"PK1":[109,122,172],"PK2":[111,128],"data":[112,147,216],"at":[113,171],"all":[114],"3":[115,125],"postdose":[116],"timed":[117],"collections,":[118],"5":[119],"only":[120,126],"samples,":[123],"samples.":[129],"Total":[130,161],"pancreatectomy":[131,162,198],"islet":[133,164,200],"autotransplantation":[134,165,201],"reduced":[137],"delayed":[139],"absorption":[140,193],"participant":[146],"from":[148],"Hydroxyurea":[150],"Study":[151],"Long-Term":[153],"Effects,":[154],"regardless":[155],"timing":[157],"or":[158],"methodology.":[160],"different":[168],"profiles":[170],"versus":[173],"PK2,":[174],"lower":[176],"dose-normalized":[177],"exposures":[178],"than":[179],"reported":[181],"anemia.":[185,230],"These":[186],"results":[187],"suggest":[188,212],"variability":[189],"exists":[190],"bioavailability":[195],"total":[197],"patients,":[202],"suspected":[203],"to":[204,225],"because":[207],"Roux-en-Y":[209],"reconstruction,":[210],"that":[213],"more":[214],"needed":[218],"for":[219],"scenarios":[220],"when":[221],"prescribed":[224],"children":[226],"without":[227]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-15T00:00:00"}
