{"id":"https://openalex.org/W3091824919","doi":"https://doi.org/10.1002/jia2.25617","title":"Time\u2010varying age\u2010 and CD4\u2010stratified rates of mortality and WHO stage 3 and stage 4 events in children, adolescents and youth 0 to 24 years living with perinatally acquired HIV, before and after antiretroviral therapy initiation in the paediatric IeDEA Global Cohort Consortium","display_name":"Time\u2010varying age\u2010 and CD4\u2010stratified rates of mortality and WHO stage 3 and stage 4 events in children, adolescents and youth 0 to 24 years living with perinatally acquired HIV, before and after antiretroviral therapy initiation in the paediatric IeDEA Global Cohort Consortium","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W3091824919","doi":"https://doi.org/10.1002/jia2.25617","mag":"3091824919","pmid":"https://pubmed.ncbi.nlm.nih.gov/33034417","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7545918"},"language":"en","primary_location":{"id":"doi:10.1002/jia2.25617","doi":"https://doi.org/10.1002/jia2.25617","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jia2.25617","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jia2.25617","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jia2.25617","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039701597","display_name":"Sophie Desmonde","orcid":"https://orcid.org/0000-0001-9372-2819","observed_orcids":["https://orcid.org/0000-0001-9372-2819"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Sophie Desmonde","raw_affiliation_strings":["Inserm U1027 Universit\u00e9 Paul Sabatier Toulouse 3 Toulouse France","These authors have contributed equally to the work"],"raw_orcid":"https://orcid.org/0000-0001-9372-2819","affiliations":[{"raw_affiliation_string":"Inserm U1027 Universit\u00e9 Paul Sabatier Toulouse 3 Toulouse France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488"]},{"raw_affiliation_string":"These authors have contributed equally to the work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056622199","display_name":"Anne M. Neilan","orcid":"https://orcid.org/0000-0001-7915-4974","observed_orcids":["https://orcid.org/0000-0001-7915-4974"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne M Neilan","raw_affiliation_strings":["Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA, USA","These authors have contributed equally to the work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of General Academic Pediatrics, Department of Pediatrics, Massachusetts General Hospital for Children, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"These authors have contributed equally to the work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017588392","display_name":"Beverly Sue Musick","orcid":"https://orcid.org/0000-0003-0334-6798","observed_orcids":["https://orcid.org/0000-0003-0334-6798"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beverly Musick","raw_affiliation_strings":["School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087693280","display_name":"Gabriela Patten","orcid":"https://orcid.org/0000-0003-2511-1367","observed_orcids":["https://orcid.org/0000-0003-2511-1367"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gabriela Patten","raw_affiliation_strings":["School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009499406","display_name":"Kulkanya Chokephaibulkit","orcid":"https://orcid.org/0000-0002-0140-4600","observed_orcids":["https://orcid.org/0000-0002-0140-4600"]},"institutions":[{"id":"https://openalex.org/I1332387789","display_name":"Siriraj Hospital","ror":"https://ror.org/0331zs648","country_code":"TH","type":"healthcare","lineage":["https://openalex.org/I1332387789"]},{"id":"https://openalex.org/I25399158","display_name":"Mahidol University","ror":"https://ror.org/01znkr924","country_code":"TH","type":"education","lineage":["https://openalex.org/I25399158"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Kulkanya Chokephaibulkit","raw_affiliation_strings":["Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand","institution_ids":["https://openalex.org/I1332387789","https://openalex.org/I25399158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011474938","display_name":"Andrew Edmonds","orcid":"https://orcid.org/0000-0001-6768-0096","observed_orcids":["https://orcid.org/0000-0001-6768-0096"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Edmonds","raw_affiliation_strings":["Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088872453","display_name":"Stephany N. Duda","orcid":"https://orcid.org/0000-0001-6247-9350","observed_orcids":["https://orcid.org/0000-0001-6247-9350"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephany N Duda","raw_affiliation_strings":["Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024104370","display_name":"Karen Malateste","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210106115","display_name":"Bordeaux Population Health","ror":"https://ror.org/00xzzba89","country_code":"FR","type":"facility","lineage":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Karen Malateste","raw_affiliation_strings":["Bordeaux Population Health Center Universit\u00e9 de Bordeaux Bordeaux France","Inserm U1219 Universit\u00e9 de Bordeaux Bordeaux France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bordeaux Population Health Center Universit\u00e9 de Bordeaux Bordeaux France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I4210106115"]},{"raw_affiliation_string":"Inserm U1219 Universit\u00e9 de Bordeaux Bordeaux France","institution_ids":["https://openalex.org/I15057530","https://openalex.org/I154526488","https://openalex.org/I4210106115"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024622118","display_name":"Kara Wools\u2010Kaloustian","orcid":"https://orcid.org/0000-0002-3277-4452","observed_orcids":["https://orcid.org/0000-0002-3277-4452"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara Wools\u2010Kaloustian","raw_affiliation_strings":["School of Medicine, Indiana University, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Indiana University, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4388446366","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082620613","display_name":"Andrea L. Ciaranello","orcid":"https://orcid.org/0000-0002-4268-3263","observed_orcids":["https://orcid.org/0000-0002-4268-3263"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea L Ciaranello","raw_affiliation_strings":["Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027479790","display_name":"Mary\u2010Ann Davies","orcid":"https://orcid.org/0000-0001-8496-6475","observed_orcids":["https://orcid.org/0000-0001-8496-6475"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Mary\u2010Ann Davies","raw_affiliation_strings":["School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa"],"raw_orcid":"https://orcid.org/0000-0001-8496-6475","affiliations":[{"raw_affiliation_string":"School of Public Health and Family Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa","institution_ids":["https://openalex.org/I157614274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065596403","display_name":"Val\u00e9riane Leroy","orcid":"https://orcid.org/0000-0003-3542-8616","observed_orcids":["https://orcid.org/0000-0003-3542-8616"]},"institutions":[{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Val\u00e9riane Leroy","raw_affiliation_strings":["Inserm U1027 Universit\u00e9 Paul Sabatier Toulouse 3 Toulouse France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inserm U1027 Universit\u00e9 Paul Sabatier Toulouse 3 Toulouse France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":null,"display_name":"IeDEA","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"IeDEA","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5039701597"],"corresponding_institution_ids":["https://openalex.org/I134560555","https://openalex.org/I154526488"],"apc_list":{"value":2400,"currency":"USD","value_usd":2400},"apc_paid":{"value":2400,"currency":"USD","value_usd":2400},"fwci":0.2223,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.68869743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"23","issue":"10","first_page":"e25617","last_page":"e25617"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perinatal-hiv-infection","display_name":"perinatal HIV infection","score":0.9079999923706055},{"id":"https://openalex.org/keywords/pediatric-hiv","display_name":"pediatric HIV","score":0.9589999914169312},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.6389999985694885},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cd4-count","display_name":"CD4 count","score":0.8399999737739563},{"id":"https://openalex.org/keywords/age-stratified-incidence","display_name":"age-stratified incidence","score":0.7770000100135803},{"id":"https://openalex.org/keywords/incidence-rates","display_name":"incidence rates","score":0.527999997138977},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.5289999842643738},{"id":"https://openalex.org/keywords/hiv-disease-progression","display_name":"HIV disease progression","score":0.4729999899864197}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8859208822250366},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6498442888259888},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.5748546719551086},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.5342760682106018},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5259271264076233},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5239003896713257},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5143150091171265},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.4863510727882385},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.2861984968185425},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17767870426177979},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.149643212556839},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000353","descriptor_name":"Africa, Southern","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D001208","descriptor_name":"Asia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002489","descriptor_name":"Central America","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013020","descriptor_name":"South America","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014944","descriptor_name":"World Health Organization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000635","qualifier_name":"transmission","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017691","descriptor_name":"Caribbean Region","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D018791","descriptor_name":"CD4 Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1002/jia2.25617","doi":"https://doi.org/10.1002/jia2.25617","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jia2.25617","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jia2.25617","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7545918","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7545918","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Int AIDS Soc","raw_type":"Text"},{"id":"pmid:33034417","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33034417","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:ht24ww34m","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/773k-3t30","pdf_url":"https://doi.org/10.17615/773k-3t30","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the International AIDS Society, 23(10)","raw_type":"Article"},{"id":"pmh:oai:HAL:hal-03117887v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-03117887v1/document","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of the International AIDS Society, 2020, 23 (10), pp.e25617. &#x27E8;10.1002/jia2.25617&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:oskar-bordeaux.fr:20.500.12278/25943","doi":null,"is_oa":true,"landing_page_url":"https://oskar-bordeaux.fr/handle/20.500.12278/25943","pdf_url":null,"source":{"id":"https://openalex.org/S4306402569","display_name":"Oskar-Bordeaux (Universite de Bordeaux)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I15057530","host_organization_name":"Universit\u00e9 de Bordeaux","host_organization_lineage":["https://openalex.org/I15057530"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article de revue"},{"id":"doi:10.17615/773k-3t30","doi":"https://doi.org/10.17615/773k-3t30","is_oa":true,"landing_page_url":"https://doi.org/10.17615/773k-3t30","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1002/jia2.25617","doi":"https://doi.org/10.1002/jia2.25617","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jia2.25617","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jia2.25617","source":{"id":"https://openalex.org/S66330005","display_name":"Journal of the International AIDS Society","issn_l":"1758-2652","issn":["1758-2652"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320728","host_organization_name":"International AIDS Society","host_organization_lineage":["https://openalex.org/P4310320728"],"host_organization_lineage_names":["International AIDS Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the International AIDS Society","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1260030203","display_name":null,"funder_award_id":"U01AI069907","funder_id":"https://openalex.org/F4320320965","funder_display_name":"University of New South Wales"},{"id":"https://openalex.org/G6103184131","display_name":"Innovation across the spectrum of pediatric HIV care","funder_award_id":"R01HD079214","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6686697896","display_name":"Diagnosing and preventing HIV infection in adolescents and young adults in the US: clinical impact and cost-effectiveness","funder_award_id":"K08HD094638","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G8874923262","display_name":null,"funder_award_id":"U01AI069907","funder_id":"https://openalex.org/F4320306342","funder_display_name":"amfAR, The Foundation for AIDS Research"},{"id":"https://openalex.org/G9000873063","display_name":"IeDEA Asia-Pacific Research Collaboration","funder_award_id":"U01AI069907","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000888500","display_name":"Central Africa International Epidemiology databases to Evaluate AIDS","funder_award_id":"U01AI096299","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000896368","display_name":"Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research Networks","funder_award_id":"R24AI124872","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000897956","display_name":"East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional Consortium","funder_award_id":"U01AI069911","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000898549","display_name":"UCSF-Bay Area Center for AIDS Research","funder_award_id":"P30AI027763","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000903780","display_name":"Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet)","funder_award_id":"U01AI069923","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000904381","display_name":"Harvard University Center for AIDS Research","funder_award_id":"P30AI060354","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000906750","display_name":"International Epidemiology Databases to EvaluateAIDS (IeDEA) Renewal 4","funder_award_id":"U01AI069919","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000915114","display_name":"International epidemiology Databases to Evaluate AIDS (IeDEA) Southern Africa.","funder_award_id":"U01AI069924","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306342","display_name":"amfAR, The Foundation for AIDS Research","ror":"https://ror.org/02jesmk44"},{"id":"https://openalex.org/F4320315885","display_name":"Australian Government","ror":"https://ror.org/0314h5y94"},{"id":"https://openalex.org/F4320318932","display_name":"Universitas Udayana","ror":"https://ror.org/035qsg823"},{"id":"https://openalex.org/F4320320439","display_name":"Department of Health and Ageing, Australian Government","ror":"https://ror.org/02swcnz29"},{"id":"https://openalex.org/F4320320965","display_name":"University of New South Wales","ror":"https://ror.org/03r8z3t63"},{"id":"https://openalex.org/F4320323819","display_name":"Universitas Indonesia","ror":"https://ror.org/0116zj450"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337201","display_name":"Fakultas Kedokteran, Universitas Indonesia","ror":null},{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337356","display_name":"Fogarty International Center","ror":"https://ror.org/02xey9a22"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337372","display_name":"U.S. National Library of Medicine","ror":"https://ror.org/0060t0j89"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3091824919.pdf","grobid_xml":"https://content.openalex.org/works/W3091824919.grobid-xml"},"referenced_works_count":38,"referenced_works":["https://openalex.org/W122536532","https://openalex.org/W186299480","https://openalex.org/W1483676789","https://openalex.org/W1904518076","https://openalex.org/W1980233381","https://openalex.org/W1984502330","https://openalex.org/W1999528036","https://openalex.org/W2009045054","https://openalex.org/W2012380698","https://openalex.org/W2012392023","https://openalex.org/W2033860037","https://openalex.org/W2034191317","https://openalex.org/W2055664053","https://openalex.org/W2064391002","https://openalex.org/W2066835269","https://openalex.org/W2085628809","https://openalex.org/W2086586775","https://openalex.org/W2086670360","https://openalex.org/W2097345834","https://openalex.org/W2106056202","https://openalex.org/W2110278919","https://openalex.org/W2125603054","https://openalex.org/W2127184526","https://openalex.org/W2128082778","https://openalex.org/W2133652309","https://openalex.org/W2136376685","https://openalex.org/W2140369030","https://openalex.org/W2148521133","https://openalex.org/W2162030767","https://openalex.org/W2166759149","https://openalex.org/W2255800407","https://openalex.org/W2360099323","https://openalex.org/W2513297397","https://openalex.org/W2689870615","https://openalex.org/W2726792795","https://openalex.org/W2792621062","https://openalex.org/W2793658602","https://openalex.org/W2928649602"],"related_works":["https://openalex.org/W1971023097","https://openalex.org/W3110132728","https://openalex.org/W2598367514","https://openalex.org/W2787586772","https://openalex.org/W2803173188","https://openalex.org/W3200905734","https://openalex.org/W6983264210","https://openalex.org/W7074686743","https://openalex.org/W2765300653","https://openalex.org/W2560919814"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Evaluating":[1],"outcomes":[2,392],"of":[3,107,112,190,221,236,251,257,299,314,351],"paediatric":[4,51],"patients":[5,295],"with":[6,27,71,88,173,248,340,366],"HIV":[7,30,72,376],"provides":[8],"crucial":[9],"data":[10],"for":[11,78,209,218,233,311,370],"clinicians":[12],"and":[13,18,25,41,44,58,62,65,86,101,109,114,142,225,242,254,289,304,316,327,343,349,361,378,380,384],"policymakers.":[14],"We":[15,96,164],"analysed":[16],"mortality":[17,108,253,279,308],"clinical":[19,259,352],"events":[20,318,353],"rates":[21,99,250],"among":[22,393],"children,":[23],"adolescents,":[24],"youth":[26,365],"perinatally":[28],"acquired":[29],"(PHIV)":[31],"aged":[32],"0":[33],"to":[34,128,131,134,137,140,150,159,169,207,216,231,287,325,333,375,390],"24":[35],"years":[36,147,156,372,382],"stratified":[37],"by":[38,176],"time-varying":[39],"age":[40,75,125,244,301,345],"CD4,":[42],"before":[43,74],"after":[45],"antiretroviral":[46],"therapy":[47],"(ART),":[48],"in":[49,291,356],"the":[50,66,180,262,300],"IeDEA":[52,82],"multiregional":[53],"collaboration":[54],"(East,":[55],"West,":[56],"Central":[57],"Southern":[59],"Africa,":[60],"Asia-Pacific,":[61],"Central/South":[63],"America":[64],"Caribbean).":[67],"METHODS:":[68],"ART-na\u00efve":[69],"children":[70],"enrolled":[73],"10":[76,133],"(proxy":[77],"perinatal":[79],"infection)":[80],"at":[81,296],"sites":[83],"between":[84],"2004":[85],"2016,":[87],"\u22651":[89],"CD4":[90,143,171,241,293,342],"measurement":[91],"during":[92,119],"follow-up":[93,191],"were":[94,201,246,319,337,354],"included.":[95],"estimated":[97],"incidence":[98,350],"(IR)":[100],"95%":[102],"confidence":[103],"intervals":[104],"(95%":[105,204,213,228,284,322,330],"CI)":[106],"first":[110,219,234,255,312],"occurrence":[111,220,235,256,313],"WHO-4":[113,223,315],"WHO-3":[115,238,317],"events,":[116],"excluding":[117],"tuberculosis,":[118],"person-years":[120],"(PY)":[121],"spent":[122],"within":[123],"different":[124],"(<2,":[126],"2":[127],"4,":[129],"5":[130],"9,":[132],"14,":[135],"15":[136],"19,":[138],"20":[139],"24)":[141],"(percent":[144],"when":[145,154],"<5":[146],"[<15%,":[148],"15%":[149],"24%,":[151],"\u226525%];":[152],"count":[153],"\u22655":[155],"[<200,":[157],"200":[158],"499,":[160],"\u2265500":[161],"cells/\u00b5L])":[162],"strata.":[163,346],"used":[165],"linear":[166],"mixed":[167],"models":[168],"predict":[170],"evolution,":[172],"trends":[174],"modelled":[175],"region.":[177],"RESULTS:":[178],"In":[179,261],"pre-ART":[181,199],"period,":[182,264],"49":[183],"137":[184],"participants":[185],"contributed":[186,268],"51":[187],"966":[188],"PY":[189,203,212,227,271,283,321,329],"(median":[192],"enrolment":[193],"age:":[194,275],"3.9":[195],"years).":[196,277],"The":[197],"overall":[198],"IRs":[200,310],"2.8/100":[202],"CI:":[205,214,229,285,323,331],"2.7":[206],"2.9)":[208],"mortality,":[210],"3.3/100":[211],"3.0":[215],"3.5)":[217],"a":[222,237,258],"event,":[224],"7.0/100":[226],"6.7":[230],"7.4)":[232],"event.":[239,260],"Lower":[240],"younger":[243,344,358],"strata":[245],"associated":[247,339],"increased":[249,307],"both":[252,357],"post-ART":[263],"52":[265],"147":[266],"PHIVY":[267],"207":[269],"945":[270],"(ART":[272],"initiation":[273],"median":[274],"4.5":[276],"Overall":[278],"IR":[280],"was":[281],"1.4/100":[282],"1.4":[286],"1.5)":[288],"higher":[290],"low":[292],"strata;":[294],"each":[297],"end":[298],"spectrum":[302],"(<2":[303,359],">19)":[305],"had":[306],"post-ART.":[309],"1.3/100":[320],"1.2":[324],"1.4)":[326],"2.1/100":[328],"2.0":[332],"2.2)":[334],"respectively.":[335],"These":[336],"also":[338],"lower":[341],"CONCLUSIONS:":[347],"Mortality":[348],"highest":[355],"years)":[360,364],"older":[362],"(>19":[363],"PHIV.":[367],"Scaling-up":[368],"services":[369],"<2":[371],"(early":[373],"access":[374],"diagnosis":[377],"care)":[379],">19":[381],"(adolescent-":[383],"youth-focused":[385],"health":[386],"services)":[387],"is":[388],"critical":[389],"improve":[391],"PHIVY.":[394]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2020-10-15T00:00:00"}