{"id":"https://openalex.org/W3091786773","doi":null,"title":"Genetic study of kuru","display_name":"Genetic study of kuru","publication_year":2020,"publication_date":"2020-05-28","ids":{"openalex":"https://openalex.org/W3091786773","mag":"3091786773"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10096608","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10096608/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023400772","display_name":"Liam James Elgaard Quinn","orcid":"https://orcid.org/0000-0002-3597-2948","observed_orcids":["https://orcid.org/0000-0002-3597-2948"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Liam Quinn","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3597-2948","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5023400772"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.9419000148773193,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.033399999141693115,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kuru","display_name":"kuru","score":0.9940000176429749},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.8769999742507935},{"id":"https://openalex.org/keywords/population-structure","display_name":"population structure","score":0.7540000081062317},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.7239999771118164},{"id":"https://openalex.org/keywords/polygenic-architecture","display_name":"polygenic architecture","score":0.8700000047683716},{"id":"https://openalex.org/keywords/sporadic-creutzfeldt-jakob-disease","display_name":"sporadic Creutzfeldt-Jakob disease","score":0.968999981880188},{"id":"https://openalex.org/keywords/variant-creutzfeldt-jakob-disease","display_name":"variant Creutzfeldt-Jakob disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/linguistic-groups","display_name":"language groups","score":0.5090000033378601},{"id":"https://openalex.org/keywords/sorcery","display_name":"sorcery","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2779233500","wikidata":"https://www.wikidata.org/wiki/Q274615","display_name":"Kuru","level":5,"score":0.9084650278091431},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.6417397260665894},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5844942331314087},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.5421451330184937},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4911911189556122},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.47193071246147156},{"id":"https://openalex.org/C53553401","wikidata":"https://www.wikidata.org/wiki/Q47307","display_name":"Genealogy","level":1,"score":0.45013582706451416},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4475107491016388},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.42940765619277954},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.4110586941242218},{"id":"https://openalex.org/C2776735649","wikidata":"https://www.wikidata.org/wiki/Q170102","display_name":"Scrapie","level":4,"score":0.40192368626594543},{"id":"https://openalex.org/C2549261","wikidata":"https://www.wikidata.org/wiki/Q43455","display_name":"Ethnology","level":1,"score":0.40076884627342224},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.39342552423477173},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3622035086154938},{"id":"https://openalex.org/C95457728","wikidata":"https://www.wikidata.org/wiki/Q309","display_name":"History","level":0,"score":0.2591068148612976},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2178405225276947},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.1569107472896576},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11851105093955994},{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.08514535427093506},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10096608","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10096608/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:3091786773","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10096608/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W167977240","https://openalex.org/W438399891","https://openalex.org/W563345139","https://openalex.org/W589368898","https://openalex.org/W603437367","https://openalex.org/W1504905681","https://openalex.org/W1506040285","https://openalex.org/W1539118047","https://openalex.org/W1543046368","https://openalex.org/W1846679411","https://openalex.org/W1917421204","https://openalex.org/W1963862050","https://openalex.org/W1965218239","https://openalex.org/W1968960617","https://openalex.org/W1971004597","https://openalex.org/W1979677919","https://openalex.org/W1981234696","https://openalex.org/W1984089713","https://openalex.org/W1994263888","https://openalex.org/W1999623479","https://openalex.org/W2001741964","https://openalex.org/W2003734490","https://openalex.org/W2007793970","https://openalex.org/W2023247652","https://openalex.org/W2033243230","https://openalex.org/W2035004702","https://openalex.org/W2036645353","https://openalex.org/W2038086243","https://openalex.org/W2042006639","https://openalex.org/W2043400793","https://openalex.org/W2046137036","https://openalex.org/W2050381311","https://openalex.org/W2054904323","https://openalex.org/W2061539393","https://openalex.org/W2062076246","https://openalex.org/W2072295297","https://openalex.org/W2075021662","https://openalex.org/W2075975125","https://openalex.org/W2076034479","https://openalex.org/W2077450109","https://openalex.org/W2080873675","https://openalex.org/W2089589220","https://openalex.org/W2104549677","https://openalex.org/W2104688201","https://openalex.org/W2105826242","https://openalex.org/W2106531183","https://openalex.org/W2107780404","https://openalex.org/W2112083194","https://openalex.org/W2112140556","https://openalex.org/W2119444539","https://openalex.org/W2124362779","https://openalex.org/W2128945609","https://openalex.org/W2130447979","https://openalex.org/W2131098197","https://openalex.org/W2131317082","https://openalex.org/W2135397687","https://openalex.org/W2137295513","https://openalex.org/W2137782260","https://openalex.org/W2139131583","https://openalex.org/W2141155485","https://openalex.org/W2143113093","https://openalex.org/W2143795630","https://openalex.org/W2148097416","https://openalex.org/W2148307156","https://openalex.org/W2152799367","https://openalex.org/W2153118028","https://openalex.org/W2160343715","https://openalex.org/W2163722216","https://openalex.org/W2163829697","https://openalex.org/W2165370583","https://openalex.org/W2165826141","https://openalex.org/W2169294950","https://openalex.org/W2171305612","https://openalex.org/W2177180777","https://openalex.org/W2219771624","https://openalex.org/W2256016639","https://openalex.org/W2303255334","https://openalex.org/W2336081208","https://openalex.org/W2347169701","https://openalex.org/W2443413629","https://openalex.org/W2461271891","https://openalex.org/W2490504152","https://openalex.org/W2508627071","https://openalex.org/W2512040674","https://openalex.org/W2521412361","https://openalex.org/W2524596543","https://openalex.org/W2531014594","https://openalex.org/W2558477477","https://openalex.org/W2572862282","https://openalex.org/W2611707378","https://openalex.org/W2622530291","https://openalex.org/W2626606138","https://openalex.org/W2735744795","https://openalex.org/W2746549904","https://openalex.org/W2756127351","https://openalex.org/W2769118369","https://openalex.org/W2791986603","https://openalex.org/W2795653730","https://openalex.org/W2886752110","https://openalex.org/W2889245907","https://openalex.org/W2895288347","https://openalex.org/W2905542822","https://openalex.org/W2910642338","https://openalex.org/W2924359406","https://openalex.org/W2941158348","https://openalex.org/W2949385499","https://openalex.org/W2956070124","https://openalex.org/W3149557354","https://openalex.org/W4243477374","https://openalex.org/W4295031826"],"related_works":["https://openalex.org/W4392950737","https://openalex.org/W2163829697","https://openalex.org/W7099839923","https://openalex.org/W2107733273","https://openalex.org/W2414261562","https://openalex.org/W3012510924","https://openalex.org/W2115682083","https://openalex.org/W2594745539","https://openalex.org/W1930177285","https://openalex.org/W2135292352"],"abstract_inverted_index":{"Kuru":[0],"was":[1,52,115,135,157,189,222,246],"the":[2,19,25,29,34,38,47,56,80,88,105,119,123,136,144,160,168,171,175,179,203,253],"first":[3,35],"documented":[4],"epidemic":[5,59],"of":[6,18,37,68,77,91,109,128,139,170,211,219,255],"prion":[7,220],"disease":[8,232],"in":[9,14,33,46,55,79,104,122,143,149,154,159,193],"humans.":[10],"It":[11],"took":[12],"place":[13],"a":[15,66,94,126,182,225,235],"restricted":[16],"region":[17,108,124],"Papua":[20,110],"New":[21,111],"Guinea":[22,112],"Highlands":[23,107],"during":[24,167,202],"twentieth":[26],"century,":[27],"with":[28,75,234,239],"final":[30],"cases":[31],"occurring":[32],"decade":[36],"twenty-first":[39],"century.":[40],"Over":[41],"2,700":[42],"deaths":[43],"were":[44],"recorded":[45],"period":[48],"1957-2004":[49],"when":[50],"surveillance":[51],"carried":[53],"out":[54],"region.":[57,81],"The":[58],"impacted":[60],"greatly":[61],"upon":[62],"affected":[63,162],"communities":[64],"as":[65],"result":[67],"its":[69,73],"high":[70],"incidence,":[71],"and":[72,191,250],"association":[74],"practices":[76],"sorcery":[78],"This":[82],"project":[83],"sought":[84],"to":[85,117,195,259],"further":[86],"understand":[87],"genetic":[89,130,141,155,183,197,207],"impact":[90,177],"kuru":[92,204],"using":[93,125],"genotyped":[95],"data":[96],"from":[97,100],"943":[98],"individuals":[99],"21":[101],"ethno-linguistic":[102],"groups":[103],"Eastern":[106],"(EHPNG).":[113],"Analysis":[114],"conducted":[116],"classify":[118],"population":[120,129,140],"structure":[121,142],"suite":[127],"tools.":[131],"Linguistic":[132],"group":[133,166],"membership":[134],"strongest":[137],"descriptor":[138],"region,":[145],"informing":[146],"experimental":[147],"design":[148],"subsequent":[150],"analyses.":[151],"A":[152,185],"drop":[153],"diversity":[156],"observed":[158,247],"most":[161],"South":[163],"Fore":[164],"linguistic":[165],"course":[169],"epidemic,":[172],"confirming":[173],"that":[174],"drastic":[176],"on":[178],"ground":[180],"left":[181],"signature.":[184],"new":[186],"tool":[187],"(Chromomatcher)":[188],"developed":[190],"incorporated":[192],"attempts":[194],"find":[196],"variants":[198,208],"under":[199,213],"positive":[200],"selection":[201],"epidemic.":[205],"Several":[206],"show":[209],"evidence":[210],"being":[212],"recent":[214],"positive-selection.":[215],"Finally,":[216],"polygenic":[217,227],"architecture":[218,228,245],"diseases":[221],"investigated":[223],"revealing":[224],"significant":[226],"for":[229],"sporadic":[230],"Creutzfeldt\u2013Jakob":[231,241],"(sCJD)":[233],"substantial":[236],"portion":[237],"shared":[238,244],"variant":[240],"disease.":[242],"No":[243],"between":[248],"sCJD":[249],"kuru,":[251],"reflecting":[252],"challenges":[254],"applying":[256],"this":[257],"technology":[258],"under-studied":[260],"populations.":[261]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-10-15T00:00:00"}
