{"id":"https://openalex.org/W3091782005","doi":"https://doi.org/10.1615/critrevoncog.2020036449","title":"Risk Factors for Esophageal Cancer, with an Emphasis on the Role of Specificity Protein Transcription Factors in Prognosis and Therapy","display_name":"Risk Factors for Esophageal Cancer, with an Emphasis on the Role of Specificity Protein Transcription Factors in Prognosis and Therapy","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3091782005","doi":"https://doi.org/10.1615/critrevoncog.2020036449","mag":"3091782005","pmid":"https://pubmed.ncbi.nlm.nih.gov/33639062"},"language":"en","primary_location":{"id":"doi:10.1615/critrevoncog.2020036449","doi":"https://doi.org/10.1615/critrevoncog.2020036449","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevoncog.2020036449","pdf_url":null,"source":{"id":"https://openalex.org/S183292605","display_name":"Critical Reviews\u2122 in Oncogenesis","issn_l":"0893-9675","issn":["0893-9675","2162-6448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u2122 in Oncogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050280101","display_name":"Sohail Siraj","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sohail Siraj","raw_affiliation_strings":["Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas 76107","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070219297","display_name":"Ananya Kurri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ananya Kurri","raw_affiliation_strings":["Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX 76107","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108631669","display_name":"Krishna J. Patel","orcid":"https://orcid.org/0009-0009-7963-0518","observed_orcids":["https://orcid.org/0009-0009-7963-0518"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krishna Patel","raw_affiliation_strings":["Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, Texas 76107","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064397875","display_name":"Nuri Hamby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nuri Hamby","raw_affiliation_strings":["Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas College of Osteopathic Medicine, University of North Texas Health Science Center, Fort Worth, TX 76107","institution_ids":["https://openalex.org/I165139151"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007695569","display_name":"Riyaz M. Basha","orcid":"https://orcid.org/0000-0002-4071-0993","observed_orcids":["https://orcid.org/0000-0002-4071-0993","https://orcid.org/0000-0002-6955-5448"]},"institutions":[{"id":"https://openalex.org/I165139151","display_name":"University of North Texas Health Science Center","ror":"https://ror.org/05msxaq47","country_code":"US","type":"education","lineage":["https://openalex.org/I165139151"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riyaz Basha","raw_affiliation_strings":["Department of Pediatrics and Women's Health, Texas College of Osteopathic Medicine, The University of North Texas Health Science Center, Fort Worth, Texas 76107"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics and Women's Health, Texas College of Osteopathic Medicine, The University of North Texas Health Science Center, Fort Worth, Texas 76107","institution_ids":["https://openalex.org/I165139151"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I165139151"],"apc_list":null,"apc_paid":null,"fwci":0.4564,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.64371404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"25","issue":"4","first_page":"355","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":1.0},{"id":"https://openalex.org/keywords/specificity-protein-transcription-factors","display_name":"specificity protein transcription factors","score":0.9580000042915344},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.9599999785423279},{"id":"https://openalex.org/keywords/sp3","display_name":"Sp3","score":0.996999979019165},{"id":"https://openalex.org/keywords/sp4","display_name":"Sp4","score":1.0},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.7319999933242798},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oncogenic-transcription-factor","display_name":"oncogenic transcription factor","score":0.7020000219345093},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/mithramycin","display_name":"mithramycin","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tolfenamic-acid","display_name":"tolfenamic acid","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.7206329107284546},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.578212559223175},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5374581813812256},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.513184130191803},{"id":"https://openalex.org/C57467964","wikidata":"https://www.wikidata.org/wiki/Q14888082","display_name":"Sp1 transcription factor","level":5,"score":0.505856454372406},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5053908824920654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4696848690509796},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.42565885186195374},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4110392928123474},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3691962957382202},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36358535289764404},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.35175958275794983},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3450908362865448},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.31730830669403076},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.29057949781417847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12917020916938782},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004938","descriptor_name":"Esophageal Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008926","descriptor_name":"Plicamycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051703","descriptor_name":"Sp Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D062367","descriptor_name":"ortho-Aminobenzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1615/critrevoncog.2020036449","doi":"https://doi.org/10.1615/critrevoncog.2020036449","is_oa":false,"landing_page_url":"https://doi.org/10.1615/critrevoncog.2020036449","pdf_url":null,"source":{"id":"https://openalex.org/S183292605","display_name":"Critical Reviews\u2122 in Oncogenesis","issn_l":"0893-9675","issn":["0893-9675","2162-6448"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews\u2122 in Oncogenesis","raw_type":"journal-article"},{"id":"pmid:33639062","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33639062","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in oncogenesis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2795236943","https://openalex.org/W234981837","https://openalex.org/W2944739875","https://openalex.org/W4323568226","https://openalex.org/W2792310468","https://openalex.org/W2121212064","https://openalex.org/W2167142486","https://openalex.org/W2365861092","https://openalex.org/W2314037142","https://openalex.org/W2166026694"],"abstract_inverted_index":{"Specificity":[0],"protein":[1,25],"(Sp)":[2],"transcription":[3,112],"factors":[4,113,120],"regulate":[5],"the":[6,41,59,68,108,142],"expression":[7,26],"of":[8,45,71,90,110],"genes":[9],"associated":[10],"with":[11,28,94],"several":[12],"cellular":[13],"processes":[14],"and":[15,43,48,56,64,114,150],"play":[16],"a":[17],"critical":[18],"role":[19,109],"in":[20,30,81,97,121,128],"early":[21],"development.":[22],"Typically,":[23],"Sp":[24,37,60,111],"decreases":[27],"age":[29],"healthy":[31,86],"adults.":[32],"Research":[33],"has":[34],"shown":[35,76],"that":[36,137],"proteins":[38],"can":[39],"impact":[40],"development":[42],"transformation":[44],"cancer":[46,82,123],"cells":[47,83],"other":[49],"oncogenic":[50],"processes,":[51],"including":[52,100],"survival,":[53],"proliferation,":[54],"spread,":[55],"metastasis.":[57],"Among":[58],"proteins,":[61],"Sp1,":[62],"Sp3,":[63],"Sp4":[65],"have":[66],"been":[67],"main":[69],"targets":[70],"study":[72],"as":[73,118],"they":[74],"are":[75,92,131],"to":[77,85],"be":[78],"highly":[79],"expressed":[80],"compared":[84],"cells.":[87],"Increased":[88],"levels":[89],"Sp1":[91],"correlated":[93],"poor":[95],"prognosis":[96],"some":[98],"malignancies,":[99],"gastrointestinal":[101],"cancers.":[102],"In":[103],"this":[104,129],"review,":[105],"we":[106],"discuss":[107],"examine":[115],"their":[116],"activities":[117],"pro-oncogenic":[119],"esophageal":[122],"(EC).":[124],"Other":[125],"aspects":[126],"presented":[127],"review":[130],"potential":[132],"therapeutic":[133],"options":[134],"for":[135],"EC":[136],"target":[138],"Sp1.":[139],"We":[140],"summarize":[141],"published":[143],"information":[144],"on":[145],"preclinical":[146],"results":[147],"using":[148],"mithramycin":[149],"tolfenamic":[151],"acid.":[152]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-15T00:00:00"}
