{"id":"https://openalex.org/W3091451909","doi":null,"title":"Role of Fas/Fas Ligand Pathway in a Sample of Iraqi Diabetic Foot Patients","display_name":"Role of Fas/Fas Ligand Pathway in a Sample of Iraqi Diabetic Foot Patients","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W3091451909","mag":"3091451909"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:25f77991df9446cf82ab5b88479ce7ec","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/25f77991df9446cf82ab5b88479ce7ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diyala Journal of Medicine, Vol 5, Iss 1 (2019)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.iasj.net/iasj?func=fulltext&aId=88792","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000565837","display_name":"Sabah Khorsheed Hussian","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabah Khorsheed Hussian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069384610","display_name":"Isam Noori Al-Karawi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isam Noori Al-Karawi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021580703","display_name":"Khalid Shaalan Sahab","orcid":"https://orcid.org/0000-0001-5379-8448","observed_orcids":["https://orcid.org/0000-0001-5379-8448","https://orcid.org/0000-0001-9881-3656"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khalid Shalaan Sahab","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11227","display_name":"Diabetic Foot Ulcer Assessment and Management","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12433","display_name":"Skin Diseases and Diabetes","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-foot","display_name":"diabetic foot","score":0.7979999780654907},{"id":"https://openalex.org/keywords/fas-fas-ligand-pathway","display_name":"Fas/Fas ligand pathway","score":0.9190000295639038},{"id":"https://openalex.org/keywords/soluble-fas","display_name":"soluble Fas","score":0.8989999890327454},{"id":"https://openalex.org/keywords/soluble-fas-ligand","display_name":"soluble Fas ligand","score":0.996999979019165},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9120000004768372},{"id":"https://openalex.org/keywords/diabetic-foot-ulcer","display_name":"diabetic foot ulcer","score":0.722000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8640000224113464},{"id":"https://openalex.org/keywords/fasting-blood-glucose","display_name":"fasting blood glucose","score":0.7799999713897705},{"id":"https://openalex.org/keywords/lipid-profile","display_name":"lipid profile","score":0.8809999823570251},{"id":"https://openalex.org/keywords/high-sensitivity-c-reactive-protein","display_name":"high-sensitivity C-reactive protein","score":0.8130000233650208},{"id":"https://openalex.org/keywords/wound-healing","display_name":"wound healing","score":0.5899999737739563},{"id":"https://openalex.org/keywords/iraqi-patients","display_name":"Iraqi patients","score":0.7459999918937683},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.43299999833106995},{"id":"https://openalex.org/keywords/amputation-risk","display_name":"amputation risk","score":0.6269999742507935},{"id":"https://openalex.org/keywords/smoking","display_name":"smoking","score":0.5},{"id":"https://openalex.org/keywords/alcohol-consumption","display_name":"alcohol consumption","score":0.5090000033378601},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.5},{"id":"https://openalex.org/keywords/family-history-of-diabetes","display_name":"family history of diabetes","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2777858829","wikidata":"https://www.wikidata.org/wiki/Q52856","display_name":"Diabetic foot","level":3,"score":0.580292820930481},{"id":"https://openalex.org/C115076146","wikidata":"https://www.wikidata.org/wiki/Q1651051","display_name":"Foot (prosody)","level":2,"score":0.5371373891830444},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.4891410171985626},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.44126245379447937},{"id":"https://openalex.org/C198531522","wikidata":"https://www.wikidata.org/wiki/Q485146","display_name":"Sample (material)","level":2,"score":0.4256262183189392},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.370403528213501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3580334186553955},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24037086963653564},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.23791241645812988},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18511813879013062},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.11136314272880554},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:doaj.org/article:25f77991df9446cf82ab5b88479ce7ec","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/25f77991df9446cf82ab5b88479ce7ec","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diyala Journal of Medicine, Vol 5, Iss 1 (2019)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:cf275399b4be4757b5a3faab8ebb3e13","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/cf275399b4be4757b5a3faab8ebb3e13","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Diyala Journal of Medicine, Vol 5, Iss 1 (2019)","raw_type":"article"},{"id":"mag:3091451909","doi":null,"is_oa":true,"landing_page_url":"https://www.iasj.net/iasj?func=fulltext&aId=88792","pdf_url":null,"source":{"id":"https://openalex.org/S4306508197","display_name":"Diyala Journal of Medicine","issn_l":"2219-9764","issn":["2219-9764","2617-8982"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4404675497","host_organization_name":"University of Diyala","host_organization_lineage":["https://openalex.org/P4404675497"],"host_organization_lineage_names":["University of Diyala"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Diyala Journal of Medicine","raw_type":null}],"best_oa_location":{"id":"mag:3091451909","doi":null,"is_oa":true,"landing_page_url":"https://www.iasj.net/iasj?func=fulltext&aId=88792","pdf_url":null,"source":{"id":"https://openalex.org/S4306508197","display_name":"Diyala Journal of Medicine","issn_l":"2219-9764","issn":["2219-9764","2617-8982"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4404675497","host_organization_name":"University of Diyala","host_organization_lineage":["https://openalex.org/P4404675497"],"host_organization_lineage_names":["University of Diyala"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Diyala Journal of Medicine","raw_type":null},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W107242029","https://openalex.org/W1513833217","https://openalex.org/W1552511798","https://openalex.org/W1946263363","https://openalex.org/W1969806743","https://openalex.org/W1977164764","https://openalex.org/W1977519702","https://openalex.org/W1982369929","https://openalex.org/W1982625802","https://openalex.org/W1988587584","https://openalex.org/W1993149192","https://openalex.org/W1993438388","https://openalex.org/W1995710159","https://openalex.org/W2013529909","https://openalex.org/W2023286233","https://openalex.org/W2029062218","https://openalex.org/W2029186987","https://openalex.org/W2040790649","https://openalex.org/W2044192315","https://openalex.org/W2045752338","https://openalex.org/W2059158127","https://openalex.org/W2073675322","https://openalex.org/W2075882809","https://openalex.org/W2081695451","https://openalex.org/W2085050051","https://openalex.org/W2092821557","https://openalex.org/W2109543794","https://openalex.org/W2115337518","https://openalex.org/W2115653936","https://openalex.org/W2116404316","https://openalex.org/W2117545273","https://openalex.org/W2130582638","https://openalex.org/W2132927588","https://openalex.org/W2154774609","https://openalex.org/W2160399930","https://openalex.org/W2161305604","https://openalex.org/W2321680823","https://openalex.org/W2520432709"],"related_works":["https://openalex.org/W398700291","https://openalex.org/W2967937625","https://openalex.org/W2560339610","https://openalex.org/W2412350776","https://openalex.org/W3093231818","https://openalex.org/W7216353275","https://openalex.org/W2169704952","https://openalex.org/W7167248691","https://openalex.org/W7056261012","https://openalex.org/W2085773540"],"abstract_inverted_index":{"Background:":[0],"Diabetic":[1],"foot":[2,69,99,106,154,179,189,208,236,271,276,309,316,346,352,385,408,432],"(DF)":[3],"is":[4,12],"one":[5],"of":[6,21,24,32,143,167,199,219,356,358,406,412,417,430],"diabetes":[7,65],"mellitus":[8],"(DM)":[9],"complication,":[10],"it":[11,257],"delayed":[13],"wound":[14],"healing":[15],"and":[16,74,102,125,132,162,181,201,210,224,234,273,368,380,392,394],"may":[17,422],"end":[18],"with":[19,62,79,92,96,108,152,187,240,289,307,312,331,361,390],"amputation":[20],"limbs.":[22],"Involvement":[23],"Fas/Fas":[25,58],"ligand":[26],"(FasL)":[27],"pathway":[28,402],"in":[29,52,60,83,140,230,238,249,253,266,284,305,325,344,383,403,427],"the":[30,80,185,254,300,340,388,400,404,413,415,428],"pathogenesis":[31],"diabetic":[33,68,98,105,153,178,188,207,231,270,275,286,308,315,327,345,351,384,407,431],"complications":[34],"has":[35,42],"been":[36,43],"proposed.":[37],"Apoptosis":[38],"via":[39],"Fas/FasL":[40],"interactions":[41],"proposed":[44],"to":[45,158,175,193,204],"be":[46,159,194],"a":[47],"major":[48],"T-cell-mediated":[49],"effector":[50],"mechanism":[51],"autoimmune":[53],"diabetes.":[54],"Objectives:":[55],"To":[56],"investigate":[57],"Ligand,":[59],"patients":[61,91,107,151,176,186,205,232,272,306,317,328,347,359],"type":[63,93,109],"2":[64,94,110],"who":[66],"have":[67,196],"ulcerations.":[70],"Methods:":[71],"sFas,":[72],"sFasL":[73,319],"high":[75],"sensetive-CRP":[76],"were":[77,134,156,191,226,281,302,322,342,360],"measured":[78],"ELISA":[81],"method":[82],"thirty(30)":[84],"normal":[85,242,290,332],"controls":[86,291],"(group":[87,100,112],"I),":[88],"twenty":[89,103],"five":[90,104],"DM":[95,111,357],"no":[97,263],"II)":[101],"III).":[113],"Besides,":[114],"serum":[115,279,320],"glucose":[116,170],"(Fasting),":[117],"lipid":[118,267],"profile":[119,268],"(total":[120],"cholesterol,":[121,221],"triacylglycerol,":[122,222],"HDL,":[123],"LDL":[124,223],"VLDL),":[126],"body":[127],"mass":[128],"index,":[129],"Waist":[130],"circumstance":[131],"age":[133,364],"determined.The":[135],"study":[136],"was":[137,247,258,376],"carried":[138],"out":[139],"National":[141],"center":[142],"diabetes,":[144],"Al-Mustansirya":[145],"University,":[146],"Baghdad,":[147],"Iraq.":[148],"Results:":[149],"The":[150,354],"lesions":[155,180,190,209,433],"found":[157,192],"poorly":[160],"controlled":[161],"had":[163],"significantly":[164,195,227,282,303],"higher":[165,197,228,304,343],"levels":[166,198,218,280,301,321,341],"fasting":[168],"blood":[169],"(FBG)":[171],"(p<0.05,":[172],"p<0.001)":[173],"compared":[174,203,288,311,330],"without":[177,206,235,274,314,350],"healthy":[182,211,241],"control":[183,212,255],"groups.Also":[184],"sFas":[200,278,379,391],"FasL":[202],"groups":[213,251,287],"(p<0.001,":[214],"p<0.05)":[215],"respectively.":[216],"Serum":[217],"total":[220],"vLDL":[225],"(p<0.05)":[229],"(with":[233],"ulceration)":[237],"comparison":[239],"control.":[243],"While":[244],"HDL-c":[245],"level":[246],"lower":[248],"both":[250,285,326],"than":[252,348],"group,":[256],"reach":[259],"statistical":[260],"significance.There":[261],"are":[262],"significant":[264,373],"different":[265],"between":[269,378],"patients.":[277,353,386],"increased":[283],"(12.2\u00b12.18":[292],",10.55\u00b12.57":[293],"ng/ml":[294,335],"Vs":[295,336],"5.91\u00b13.1":[296],"ng/ml,":[297],"p<0.001),":[298],"but":[299,339],"when":[310],"those":[313,349],"(p<0.05).":[318],"also":[323],"increase":[324],"as":[329],"controls(2.55+1.06,":[333],"1.75+0.62":[334],"1.59+0.32":[337],"ng/ml,p<0.05),":[338],"duration":[355],">10":[362],"yrs,":[363,367],">":[365],"58":[366],"BMI":[369],">25":[370],"Kg/m2.":[371],"A":[372],"positive":[374],"correlation":[375],"observed":[377],"(sFasLand":[381],"hs-CRP)":[382],"Also":[387],"same":[389],"(FBG,":[393],"lipids).":[395],"Conclusion:":[396],"We":[397],"conclude":[398],"that":[399],"apoptotic":[401],"development":[405,416],"increases":[409],"by":[410],"means":[411],"Fas/FasL,and":[414],"new":[418],"treatment":[419],"against":[420],"apoptosis":[421],"play":[423],"an":[424],"important":[425],"role":[426],"management":[429]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-10-08T00:00:00"}
