{"id":"https://openalex.org/W3091418943","doi":"https://doi.org/10.1002/adtp.202000088","title":"Recent Advances in Clinical Translation of Intra\u2010Articular Osteoarthritis Drug Delivery Systems","display_name":"Recent Advances in Clinical Translation of Intra\u2010Articular Osteoarthritis Drug Delivery Systems","publication_year":2020,"publication_date":"2020-09-28","ids":{"openalex":"https://openalex.org/W3091418943","doi":"https://doi.org/10.1002/adtp.202000088","mag":"3091418943","pmid":"https://pubmed.ncbi.nlm.nih.gov/33709019","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7941755"},"language":"en","primary_location":{"id":"doi:10.1002/adtp.202000088","doi":"https://doi.org/10.1002/adtp.202000088","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adtp.202000088","pdf_url":null,"source":{"id":"https://openalex.org/S4210200121","display_name":"Advanced Therapeutics","issn_l":"2366-3987","issn":["2366-3987"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7941755","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025715048","display_name":"Carlisle R. DeJulius","orcid":"https://orcid.org/0009-0000-3547-8053","observed_orcids":["https://orcid.org/0009-0000-3547-8053"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlisle R. DeJulius","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232 USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039672679","display_name":"Shubham Gulati","orcid":"https://orcid.org/0000-0003-2157-6482","observed_orcids":["https://orcid.org/0000-0003-2157-6482"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shubham Gulati","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232 USA","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023635229","display_name":"Karen A. Hasty","orcid":"https://orcid.org/0000-0002-5049-6978","observed_orcids":["https://orcid.org/0000-0002-5049-6978"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210086422","display_name":"Memphis VA Medical Center","ror":"https://ror.org/000vjzq57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210086422","https://openalex.org/I4210112672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen A. Hasty","raw_affiliation_strings":["Department of Orthopedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, 1211 Union Ave. Suite 520, Memphis, TN, 38104 USA","Department of Veterans' Affairs, Memphis VA Medical Center, 1030 Jefferson Ave., Memphis, TN, 38104 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopedic Surgery and Biomedical Engineering, University of Tennessee Health Science Center, 1211 Union Ave. Suite 520, Memphis, TN, 38104 USA","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"Department of Veterans' Affairs, Memphis VA Medical Center, 1030 Jefferson Ave., Memphis, TN, 38104 USA","institution_ids":["https://openalex.org/I4210086422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069490679","display_name":"Leslie J. Crofford","orcid":"https://orcid.org/0000-0002-6347-5738","observed_orcids":["https://orcid.org/0000-0002-6347-5738"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leslie J. Crofford","raw_affiliation_strings":["Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN, 37232 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Division of Rheumatology and Immunology, Vanderbilt University Medical Center, 1161 21st Ave. S., Nashville, TN, 37232 USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075794128","display_name":"Craig L. Duvall","orcid":"https://orcid.org/0000-0003-3979-0620","observed_orcids":["https://orcid.org/0000-0003-3979-0620"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Craig L. Duvall","raw_affiliation_strings":["Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232 USA"],"raw_orcid":"https://orcid.org/0000-0003-3979-0620","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Vanderbilt University, 5824 Stevenson Center, Nashville, TN, 37232 USA","institution_ids":["https://openalex.org/I200719446"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5075794128"],"corresponding_institution_ids":["https://openalex.org/I200719446"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":3.6989,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.94543888,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"4","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoarthritis","display_name":"osteoarthritis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/intra-articular-drug-delivery","display_name":"intra-articular drug delivery","score":0.9950000047683716},{"id":"https://openalex.org/keywords/polymeric-drug-delivery","display_name":"polymeric drug delivery","score":0.9129999876022339},{"id":"https://openalex.org/keywords/hydrogels","display_name":"hydrogels","score":0.8320000171661377},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/polymeric-microparticles","display_name":"polymeric microparticles","score":0.9950000047683716},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.9639999866485596},{"id":"https://openalex.org/keywords/drug-conjugates","display_name":"drug conjugates","score":0.9649999737739563},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7099999785423279},{"id":"https://openalex.org/keywords/ph-responsive-delivery","display_name":"pH-responsive delivery","score":0.8859999775886536},{"id":"https://openalex.org/keywords/hydrolytic-degradation","display_name":"hydrolytic degradation","score":0.8190000057220459},{"id":"https://openalex.org/keywords/clinical-translation","display_name":"clinical translation","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.7429149150848389},{"id":"https://openalex.org/C2776164576","wikidata":"https://www.wikidata.org/wiki/Q62736","display_name":"Osteoarthritis","level":3,"score":0.7372810244560242},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6674692630767822},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5460696816444397},{"id":"https://openalex.org/C2776268809","wikidata":"https://www.wikidata.org/wiki/Q25581","display_name":"Synovial fluid","level":4,"score":0.4767402410507202},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42641887068748474},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.42361894249916077},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2548871636390686},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.1382867991924286},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.07852789759635925},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1002/adtp.202000088","doi":"https://doi.org/10.1002/adtp.202000088","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adtp.202000088","pdf_url":null,"source":{"id":"https://openalex.org/S4210200121","display_name":"Advanced Therapeutics","issn_l":"2366-3987","issn":["2366-3987"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Therapeutics","raw_type":"journal-article"},{"id":"pmid:33709019","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33709019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7941755","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7941755","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Ther (Weinh)","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7941755","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7941755","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Adv Ther (Weinh)","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2669998124","display_name":null,"funder_award_id":"CDMRP 0R130302","funder_id":"https://openalex.org/F4320306078","funder_display_name":"U.S. Department of Defense"},{"id":"https://openalex.org/G2704070337","display_name":null,"funder_award_id":"I01 BX004151","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5245336240","display_name":"Graduate Research Fellowship Program (GRFP)","funder_award_id":"1937963","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G811637282","display_name":null,"funder_award_id":"T32\u2010EB021937","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G9000863293","display_name":"Training Program for Innovative Engineering Research in Surgery and Intervention","funder_award_id":"T32EB021937","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":143,"referenced_works":["https://openalex.org/W76734072","https://openalex.org/W259194763","https://openalex.org/W601334014","https://openalex.org/W799912760","https://openalex.org/W1038569680","https://openalex.org/W1716794597","https://openalex.org/W1873023416","https://openalex.org/W1887061159","https://openalex.org/W1963533677","https://openalex.org/W1964733001","https://openalex.org/W1965977597","https://openalex.org/W1966124448","https://openalex.org/W1970289183","https://openalex.org/W1974006781","https://openalex.org/W1974079627","https://openalex.org/W1985586432","https://openalex.org/W1987226609","https://openalex.org/W1987931719","https://openalex.org/W1988638407","https://openalex.org/W1989277100","https://openalex.org/W1990635210","https://openalex.org/W1993523958","https://openalex.org/W1998719043","https://openalex.org/W1999879263","https://openalex.org/W2002221409","https://openalex.org/W2002387722","https://openalex.org/W2012787784","https://openalex.org/W2012829746","https://openalex.org/W2013693243","https://openalex.org/W2013758722","https://openalex.org/W2014140858","https://openalex.org/W2020845336","https://openalex.org/W2024461025","https://openalex.org/W2026035889","https://openalex.org/W2026502556","https://openalex.org/W2034411805","https://openalex.org/W2035107225","https://openalex.org/W2036703631","https://openalex.org/W2055319262","https://openalex.org/W2057647525","https://openalex.org/W2058435889","https://openalex.org/W2061510929","https://openalex.org/W2061782863","https://openalex.org/W2067288308","https://openalex.org/W2068138206","https://openalex.org/W2082862385","https://openalex.org/W2085111729","https://openalex.org/W2085359103","https://openalex.org/W2086214501","https://openalex.org/W2086847144","https://openalex.org/W2089557883","https://openalex.org/W2092282157","https://openalex.org/W2093652285","https://openalex.org/W2094100409","https://openalex.org/W2103767073","https://openalex.org/W2107557433","https://openalex.org/W2126243764","https://openalex.org/W2131102038","https://openalex.org/W2133410123","https://openalex.org/W2135785083","https://openalex.org/W2138004638","https://openalex.org/W2138520075","https://openalex.org/W2142801671","https://openalex.org/W2150669575","https://openalex.org/W2157276022","https://openalex.org/W2157651084","https://openalex.org/W2169365855","https://openalex.org/W2212499052","https://openalex.org/W2269139557","https://openalex.org/W2270765590","https://openalex.org/W2279202385","https://openalex.org/W2290746406","https://openalex.org/W2325919670","https://openalex.org/W2329043159","https://openalex.org/W2340344501","https://openalex.org/W2340790958","https://openalex.org/W2344408149","https://openalex.org/W2346740611","https://openalex.org/W2399442760","https://openalex.org/W2411985679","https://openalex.org/W2465849748","https://openalex.org/W2468144305","https://openalex.org/W2519862459","https://openalex.org/W2542203961","https://openalex.org/W2553909066","https://openalex.org/W2558353285","https://openalex.org/W2558792694","https://openalex.org/W2588922129","https://openalex.org/W2591025507","https://openalex.org/W2591860844","https://openalex.org/W2592615793","https://openalex.org/W2600050510","https://openalex.org/W2602864067","https://openalex.org/W2605857947","https://openalex.org/W2606554067","https://openalex.org/W2616167388","https://openalex.org/W2619901099","https://openalex.org/W2743234705","https://openalex.org/W2762671440","https://openalex.org/W2764192734","https://openalex.org/W2765240768","https://openalex.org/W2772913371","https://openalex.org/W2773785077","https://openalex.org/W2784014252","https://openalex.org/W2793229599","https://openalex.org/W2793970692","https://openalex.org/W2797995474","https://openalex.org/W2800248573","https://openalex.org/W2800408212","https://openalex.org/W2801332313","https://openalex.org/W2802379485","https://openalex.org/W2804309624","https://openalex.org/W2805724878","https://openalex.org/W2808020398","https://openalex.org/W2886128255","https://openalex.org/W2888353745","https://openalex.org/W2890535036","https://openalex.org/W2898287490","https://openalex.org/W2902300433","https://openalex.org/W2902807504","https://openalex.org/W2904036358","https://openalex.org/W2913202798","https://openalex.org/W2920883437","https://openalex.org/W2921070214","https://openalex.org/W2921580102","https://openalex.org/W2937058156","https://openalex.org/W2937154956","https://openalex.org/W2939902913","https://openalex.org/W2941517700","https://openalex.org/W2947378310","https://openalex.org/W2950449552","https://openalex.org/W2980989032","https://openalex.org/W2981258427","https://openalex.org/W2991372058","https://openalex.org/W2992823069","https://openalex.org/W2996581137","https://openalex.org/W3010361121","https://openalex.org/W3036475146","https://openalex.org/W3194762379","https://openalex.org/W4210254819","https://openalex.org/W4232024554","https://openalex.org/W4244523227","https://openalex.org/W4247623962"],"related_works":["https://openalex.org/W4225293127","https://openalex.org/W4200084832","https://openalex.org/W2131424870","https://openalex.org/W2804309624","https://openalex.org/W2051583934","https://openalex.org/W4205317370","https://openalex.org/W2103303906","https://openalex.org/W4416423335","https://openalex.org/W7165371424","https://openalex.org/W4412672896"],"abstract_inverted_index":{"Osteoarthritis":[0],"(OA)":[1],"is":[2,21,49,90,107],"a":[3,10,22,91,113],"degenerative":[4],"disease":[5],"of":[6,13,47,60,83,153],"the":[7,54,61,73,87,101,151],"joints":[8],"and":[9,64,67,143,160,177,182,187],"leading":[11],"cause":[12],"physical":[14],"disability":[15],"in":[16,86,112],"adults.":[17],"Intra-articular":[18],"(IA)":[19],"therapy":[20],"popular":[23],"treatment":[24],"strategy":[25,106],"for":[26,44,80,97,119,158,189],"localized,":[27],"single-joint":[28],"OA;":[29],"however,":[30],"small-molecule":[31],"drugs":[32],"such":[33,136],"as":[34,137],"corticosteroids":[35],"do":[36],"not":[37],"provide":[38],"prolonged":[39],"relief.":[40],"One":[41],"possible":[42],"reason":[43],"their":[45,70],"lack":[46],"efficacy":[48],"high":[50],"clearance":[51],"rates":[52],"from":[53],"joint":[55,88],"through":[56],"constant":[57],"lymphatic":[58],"drainage":[59],"synovial":[62,65,74],"tissues":[63],"fluid":[66],"also":[68],"by":[69,128],"exchange":[71],"via":[72],"vasculature.":[75],"Advanced":[76],"drug":[77,115,180],"delivery":[78,116],"strategies":[79,170],"extended":[81],"release":[82],"therapeutic":[84,110],"agents":[85,111],"space":[89],"promising":[92],"approach":[93],"to":[94,108,132],"improve":[95],"outcomes":[96],"OA":[98,159],"patients.":[99],"Broadly,":[100],"basic":[102],"principle":[103],"behind":[104],"this":[105,147],"encapsulate":[109],"polymeric":[114,174],"system":[117],"(DDS)":[118],"diffusion-":[120],"and/or":[121],"degradation-controlled":[122],"release,":[123],"whereby":[124],"degradation":[125],"can":[126],"occur":[127],"hydrolysis":[129],"or":[130],"tied":[131],"relevant":[133],"microenvironmental":[134],"cues":[135],"pH,":[138],"reactive":[139],"oxygen":[140],"species":[141],"(ROS),":[142],"protease":[144],"activity.":[145],"In":[146],"review,":[148],"we":[149],"highlight":[150,161],"development":[152],"clinically":[154],"tested":[155],"IA":[156],"therapies":[157],"recent":[162],"systems":[163,184],"which":[164],"have":[165],"been":[166],"investigated":[167],"preclinically.":[168],"DDS":[169],"including":[171],"hydrogels,":[172],"liposomes,":[173],"microparticles":[175],"(MPs)":[176],"nanoparticles":[178],"(NPs),":[179],"conjugates,":[181],"combination":[183],"are":[185],"introduced":[186],"evaluated":[188],"clinical":[190],"translational":[191],"potential.":[192]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2020-10-08T00:00:00"}
