{"id":"https://openalex.org/W3091127361","doi":"https://doi.org/10.1186/s12935-020-01518-y","title":"Ibrutinib in B-cell lymphoma: single fighter might be enough?","display_name":"Ibrutinib in B-cell lymphoma: single fighter might be enough?","publication_year":2020,"publication_date":"2020-09-29","ids":{"openalex":"https://openalex.org/W3091127361","doi":"https://doi.org/10.1186/s12935-020-01518-y","mag":"3091127361","pmid":"https://pubmed.ncbi.nlm.nih.gov/33005100"},"language":"en","primary_location":{"id":"doi:10.1186/s12935-020-01518-y","doi":"https://doi.org/10.1186/s12935-020-01518-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12935-020-01518-y","pdf_url":"https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-020-01518-y","source":{"id":"https://openalex.org/S130214813","display_name":"Cancer Cell International","issn_l":"1475-2867","issn":["1475-2867"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-020-01518-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102953109","display_name":"Chao Xue","orcid":"https://orcid.org/0000-0002-7429-2187","observed_orcids":["https://orcid.org/0000-0002-7429-2187"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Xue","raw_affiliation_strings":["Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021 China","Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021 China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]},{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100327835","display_name":"Xin Wang","orcid":"https://orcid.org/0000-0001-8051-1481","observed_orcids":["https://orcid.org/0000-0001-8051-1481","https://orcid.org/0000-0001-5457-5799"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Wang","raw_affiliation_strings":["Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021 Jinan, Shandong China","Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021 China","School of Medicine, Shandong University, Jinan, 250012 Shandong China","Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021 Jinan, Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021 China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]},{"raw_affiliation_string":"School of Medicine, Shandong University, Jinan, 250012 Shandong China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101869213","display_name":"Lingyan Zhang","orcid":"https://orcid.org/0000-0002-2998-7406","observed_orcids":["https://orcid.org/0000-0002-2998-7406"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingyan Zhang","raw_affiliation_strings":["Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021 Jinan, Shandong China","Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021 Jinan, Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021, Jinan, Shandong, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089477261","display_name":"Qingyuan Qu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qingyuan Qu","raw_affiliation_strings":["Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021 China","Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021 China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]},{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China","institution_ids":["https://openalex.org/I154099455","https://openalex.org/I4210116517"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401614","display_name":"Qian Zhang","orcid":"https://orcid.org/0000-0002-1255-3724","observed_orcids":["https://orcid.org/0000-0002-1255-3724"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian Zhang","raw_affiliation_strings":["Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021 Jinan, Shandong China","Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021, Jinan, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021 Jinan, Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021, Jinan, Shandong, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101476541","display_name":"Yujie Jiang","orcid":"https://orcid.org/0000-0003-2199-238X","observed_orcids":["https://orcid.org/0000-0003-2199-238X"]},"institutions":[{"id":"https://openalex.org/I4210116517","display_name":"Shandong Provincial Hospital","ror":"https://ror.org/02ar2nf05","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116517"]},{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yujie Jiang","raw_affiliation_strings":["Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021 Jinan, Shandong China","Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021, Jinan, Shandong, China"],"raw_orcid":"https://orcid.org/0000-0003-2199-238X","affiliations":[{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021 Jinan, Shandong China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]},{"raw_affiliation_string":"Department of Hematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324, Jingwu Road, 250021, Jinan, Shandong, China","institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101476541"],"corresponding_institution_ids":["https://openalex.org/I4210116517","https://openalex.org/I4210163399"],"apc_list":{"value":2790,"currency":"USD","value_usd":2790},"apc_paid":{"value":2790,"currency":"USD","value_usd":2790},"fwci":1.5319,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.82657684,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"20","issue":"1","first_page":"467","last_page":"467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.5990999937057495,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.4004000127315521,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ibrutinib","display_name":"ibrutinib","score":1.0},{"id":"https://openalex.org/keywords/b-cell-lymphoma","display_name":"B-cell lymphoma","score":0.9760000109672546},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase","display_name":"Bruton's tyrosine kinase","score":0.8640000224113464},{"id":"https://openalex.org/keywords/bruton-tyrosine-kinase-inhibitors","display_name":"BTK inhibitors","score":0.8159999847412109},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.9449999928474426},{"id":"https://openalex.org/keywords/monotherapy","display_name":"monotherapy","score":0.8450000286102295},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/indolent-lymphoma","display_name":"indolent lymphoma","score":0.8529999852180481},{"id":"https://openalex.org/keywords/aggressive-lymphoma","display_name":"aggressive lymphoma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/remission","display_name":"remission","score":0.8259999752044678}],"concepts":[{"id":"https://openalex.org/C2779878957","wikidata":"https://www.wikidata.org/wiki/Q5984881","display_name":"Ibrutinib","level":4,"score":0.9917551279067993},{"id":"https://openalex.org/C90059517","wikidata":"https://www.wikidata.org/wiki/Q423572","display_name":"Bruton's tyrosine kinase","level":4,"score":0.9290879964828491},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.7354399561882019},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6332756280899048},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6206469535827637},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.6074807643890381},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.596855640411377},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.5346694588661194},{"id":"https://openalex.org/C2777257650","wikidata":"https://www.wikidata.org/wiki/Q4833719","display_name":"B-cell lymphoma","level":3,"score":0.4743931293487549},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.45348140597343445},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4263344407081604},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3274964690208435},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3042423129081726},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.27577728033065796},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.25863581895828247},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21938994526863098},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.11600148677825928}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s12935-020-01518-y","doi":"https://doi.org/10.1186/s12935-020-01518-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12935-020-01518-y","pdf_url":"https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-020-01518-y","source":{"id":"https://openalex.org/S130214813","display_name":"Cancer Cell International","issn_l":"1475-2867","issn":["1475-2867"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell International","raw_type":"journal-article"},{"id":"pmid:33005100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33005100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer cell international","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7523373","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7523373","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Cell Int","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:e07120e8692d487786c985c9f4d00fb7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/e07120e8692d487786c985c9f4d00fb7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Cell International, Vol 20, Iss 1, Pp 1-13 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12935-020-01518-y","doi":"https://doi.org/10.1186/s12935-020-01518-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12935-020-01518-y","pdf_url":"https://cancerci.biomedcentral.com/track/pdf/10.1186/s12935-020-01518-y","source":{"id":"https://openalex.org/S130214813","display_name":"Cancer Cell International","issn_l":"1475-2867","issn":["1475-2867"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Cell International","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7200000286102295,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8463639107","display_name":null,"funder_award_id":"2019GSF108207","funder_id":"https://openalex.org/F4320333596","funder_display_name":"Key Technology Research and Development Program of Shandong"}],"funders":[{"id":"https://openalex.org/F4320333596","display_name":"Key Technology Research and Development Program of Shandong","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3091127361.pdf","grobid_xml":"https://content.openalex.org/works/W3091127361.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1020989877","https://openalex.org/W1829587101","https://openalex.org/W2000875208","https://openalex.org/W2042887247","https://openalex.org/W2062457956","https://openalex.org/W2071549499","https://openalex.org/W2095099120","https://openalex.org/W2108206643","https://openalex.org/W2128139299","https://openalex.org/W2133192145","https://openalex.org/W2140395974","https://openalex.org/W2140606816","https://openalex.org/W2143766748","https://openalex.org/W2150487985","https://openalex.org/W2154066874","https://openalex.org/W2158450409","https://openalex.org/W2171771895","https://openalex.org/W2187899653","https://openalex.org/W2190884983","https://openalex.org/W2191219754","https://openalex.org/W2233614027","https://openalex.org/W2238159161","https://openalex.org/W2274360660","https://openalex.org/W2409078930","https://openalex.org/W2519500141","https://openalex.org/W2528264979","https://openalex.org/W2560708148","https://openalex.org/W2565099910","https://openalex.org/W2587684973","https://openalex.org/W2617968907","https://openalex.org/W2619999402","https://openalex.org/W2625473279","https://openalex.org/W2765414225","https://openalex.org/W2786522183","https://openalex.org/W2787370436","https://openalex.org/W2795301499","https://openalex.org/W2795473913","https://openalex.org/W2797584152","https://openalex.org/W2803298831","https://openalex.org/W2805689516","https://openalex.org/W2806379322","https://openalex.org/W2886452066","https://openalex.org/W2895398908","https://openalex.org/W2897636215","https://openalex.org/W2897902093","https://openalex.org/W2902300122","https://openalex.org/W2902706178","https://openalex.org/W2903075620","https://openalex.org/W2903669497","https://openalex.org/W2903942209","https://openalex.org/W2910063137","https://openalex.org/W2913393274","https://openalex.org/W2914575774","https://openalex.org/W2941834455","https://openalex.org/W2946882253","https://openalex.org/W2952653802","https://openalex.org/W2955067489","https://openalex.org/W2966190920","https://openalex.org/W2971191804","https://openalex.org/W2976534553","https://openalex.org/W2979432543","https://openalex.org/W4234743110"],"related_works":["https://openalex.org/W1830209188","https://openalex.org/W2990290302","https://openalex.org/W3083764575","https://openalex.org/W2955099322","https://openalex.org/W1837510895","https://openalex.org/W4385686212","https://openalex.org/W2039774331","https://openalex.org/W2141074545","https://openalex.org/W2617161142","https://openalex.org/W4375852245"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"recent":[2],"years,":[3],"the":[4,44,49,140,151,157],"B":[5],"cell":[6],"receptor":[7],"(BCR)":[8],"signaling":[9,46],"pathway":[10],"has":[11,55,71],"become":[12],"a":[13,19,40,78,130],"\"hot":[14],"point\"":[15],"because":[16],"it":[17],"plays":[18],"critical":[20],"role":[21],"in":[22,33,43,60,85,139],"B-cell":[23,37,65,87,114,146,167],"proliferation":[24],"and":[25,63,83,94,136,154],"function.":[26],"Bruton's":[27],"tyrosine":[28],"kinase":[29,42],"(BTK)":[30],"is":[31],"overexpressed":[32],"many":[34,86],"subtypes":[35,144],"of":[36,52,117,142,145,156,166],"lymphoma":[38,88],"as":[39],"downstream":[41],"BCR":[45],"pathway.":[47],"Ibrutinib,":[48],"first":[50],"generation":[51],"BTK":[53],"inhibitor,":[54],"shown":[56],"excellent":[57],"antitumor":[58],"activity":[59],"both":[61],"indolent":[62,113],"aggressive":[64,143],"lymphoma.":[66,147,168],"MAIN":[67],"BODY:":[68],"Ibrutinib":[69],"monotherapy":[70],"been":[72],"confirmed":[73],"to":[74,103,133],"be":[75,129],"effective":[76],"with":[77,112,121],"high":[79],"response":[80],"rate":[81],"(RR)":[82],"well-tolerated":[84],"subgroups.":[89],"To":[90],"achieve":[91,134],"much":[92],"deeper":[93,135],"faster":[95,137],"remission,":[96],"combination":[97],"strategies":[98,125,162],"contained":[99,126],"ibrutinib":[100,122,127,158],"were":[101],"conducted":[102],"evaluate":[104],"their":[105],"synergistic":[106],"anti-tumor":[107],"effect.":[108],"CONCLUSIONS:":[109],"For":[110],"patients":[111],"lymphoma,":[115],"most":[116],"them":[118],"respond":[119],"well":[120],"monotherapy.":[123],"Combination":[124],"might":[128],"better":[131],"choice":[132],"remission":[138],"treatment":[141,165],"Further":[148],"investigations":[149],"on":[150],"long-term":[152],"efficacy":[153],"safety":[155],"will":[159],"provide":[160],"novel":[161],"for":[163],"individualized":[164]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}
