{"id":"https://openalex.org/W3091085673","doi":"https://doi.org/10.1186/s41232-020-00146-3","title":"How COVID-19 induces cytokine storm with high mortality","display_name":"How COVID-19 induces cytokine storm with high mortality","publication_year":2020,"publication_date":"2020-10-01","ids":{"openalex":"https://openalex.org/W3091085673","doi":"https://doi.org/10.1186/s41232-020-00146-3","mag":"3091085673","pmid":"https://pubmed.ncbi.nlm.nih.gov/33014208","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7527296"},"language":"en","primary_location":{"id":"doi:10.1186/s41232-020-00146-3","doi":"https://doi.org/10.1186/s41232-020-00146-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41232-020-00146-3","pdf_url":"https://inflammregen.biomedcentral.com/counter/pdf/10.1186/s41232-020-00146-3","source":{"id":"https://openalex.org/S143716263","display_name":"Inflammation and Regeneration","issn_l":"1346-8022","issn":["1346-8022","1880-5795","1880-8190","1880-9693"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://inflammregen.biomedcentral.com/counter/pdf/10.1186/s41232-020-00146-3","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062258961","display_name":"Shintaro Hojyo","orcid":"https://orcid.org/0000-0001-6132-543X","observed_orcids":["https://orcid.org/0000-0001-6132-543X"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shintaro Hojyo","raw_affiliation_strings":["Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076549540","display_name":"Mona Uchida","orcid":"https://orcid.org/0000-0002-5781-9485","observed_orcids":["https://orcid.org/0000-0002-5781-9485"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mona Uchida","raw_affiliation_strings":["Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013872354","display_name":"Kumiko Tanaka","orcid":"https://orcid.org/0000-0003-4671-8395","observed_orcids":["https://orcid.org/0000-0003-4671-8395"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumiko Tanaka","raw_affiliation_strings":["Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013790579","display_name":"Rie Hasebe","orcid":"https://orcid.org/0000-0003-2009-0595","observed_orcids":["https://orcid.org/0000-0003-2009-0595"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rie Hasebe","raw_affiliation_strings":["Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101794234","display_name":"Yuki Tanaka","orcid":"https://orcid.org/0000-0001-9822-9804","observed_orcids":["https://orcid.org/0000-0001-9822-9804"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuki Tanaka","raw_affiliation_strings":["Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068093589","display_name":"Masaaki Murakami","orcid":"https://orcid.org/0000-0001-7159-7279","observed_orcids":["https://orcid.org/0000-0001-7159-7279","https://orcid.org/0000-0001-7544-9791"]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masaaki Murakami","raw_affiliation_strings":["Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan"],"raw_orcid":"https://orcid.org/0000-0001-7159-7279","affiliations":[{"raw_affiliation_string":"Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815, Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100809847","display_name":"Toshio Hirano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205349734","display_name":"Hokkaido University","ror":"https://ror.org/02e16g702","country_code":"JP","type":"education","lineage":["https://openalex.org/I205349734"]},{"id":"https://openalex.org/I4210114217","display_name":"National Institutes for Quantum Science and Technology","ror":"https://ror.org/020rbyg91","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4210114217"]},{"id":"https://openalex.org/I4405286760","display_name":"Institute for Genetic Medicine, Hokkaido University","ror":"https://ror.org/0319h6x77","country_code":"JP","type":"facility","lineage":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Toshio Hirano","raw_affiliation_strings":["Headquarters, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan","Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headquarters, National Institutes for Quantum and Radiological Science and Technology, Chiba, 263-8555, Japan","institution_ids":["https://openalex.org/I4210114217"]},{"raw_affiliation_string":"Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Hokkaido, 060-0815 Japan","institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4405286760"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068093589","https://openalex.org/A5100809847"],"corresponding_institution_ids":["https://openalex.org/I205349734","https://openalex.org/I4210114217","https://openalex.org/I4405286760"],"apc_list":{"value":1230,"currency":"USD","value_usd":1230},"apc_paid":{"value":1230,"currency":"USD","value_usd":1230},"fwci":6.5921,"has_fulltext":true,"cited_by_count":658,"citation_normalized_percentile":{"value":0.97423121,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"40","issue":"1","first_page":"37","last_page":"37"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":1.0},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.9909999966621399},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9860000014305115},{"id":"https://openalex.org/keywords/stat3-signaling","display_name":"STAT3 signaling","score":0.9670000076293945},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.9480000138282776},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.9319999814033508},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.9980000257492065},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6359999775886536},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.9058136940002441},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.7705917358398438},{"id":"https://openalex.org/C105306849","wikidata":"https://www.wikidata.org/wiki/Q81054","display_name":"Storm","level":2,"score":0.6324938535690308},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.5916317701339722},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5523656606674194},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45641475915908813},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.44402462244033813},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3450013995170593},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2759597599506378},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.17425790429115295},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17054888606071472},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.15983232855796814},{"id":"https://openalex.org/C153294291","wikidata":"https://www.wikidata.org/wiki/Q25261","display_name":"Meteorology","level":1,"score":0.14757797122001648},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.14432799816131592},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.13115429878234863}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1186/s41232-020-00146-3","doi":"https://doi.org/10.1186/s41232-020-00146-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41232-020-00146-3","pdf_url":"https://inflammregen.biomedcentral.com/counter/pdf/10.1186/s41232-020-00146-3","source":{"id":"https://openalex.org/S143716263","display_name":"Inflammation and Regeneration","issn_l":"1346-8022","issn":["1346-8022","1880-5795","1880-8190","1880-9693"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal-article"},{"id":"pmid:33014208","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33014208","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and regeneration","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3c8164f803ad4a53be2cb476c31b42a0","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3c8164f803ad4a53be2cb476c31b42a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Inflammation and Regeneration, Vol 40, Iss 1, Pp 1-7 (2020)","raw_type":"article"},{"id":"pmh:oai:irdb.nii.ac.jp:01116:0004812867","doi":null,"is_oa":true,"landing_page_url":"https://repo.qst.go.jp/records/82077","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal article"},{"id":"pmh:oai:repo.qst.go.jp:00082077","doi":null,"is_oa":true,"landing_page_url":"https://repo.qst.go.jp/?action=repository_uri&item_id=82077","pdf_url":null,"source":{"id":"https://openalex.org/S4377196694","display_name":"QST-Repository (National Institutes for Quantum and Radiological Science and Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210114217","host_organization_name":"National Institutes for Quantum Science and Technology","host_organization_lineage":["https://openalex.org/I4210114217"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://inflammregen.biomedcentral.com/articles/10.1186/s41232-020-00146-3","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s41232-020-00146-3","doi":"https://doi.org/10.1186/s41232-020-00146-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s41232-020-00146-3","pdf_url":"https://inflammregen.biomedcentral.com/counter/pdf/10.1186/s41232-020-00146-3","source":{"id":"https://openalex.org/S143716263","display_name":"Inflammation and Regeneration","issn_l":"1346-8022","issn":["1346-8022","1880-5795","1880-8190","1880-9693"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","oarl","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammation and Regeneration","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1071259831","display_name":"Analysis of Stress Gateway Reflex","funder_award_id":"20H00502","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3091085673.pdf","grobid_xml":"https://content.openalex.org/works/W3091085673.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W311927316","https://openalex.org/W1836377684","https://openalex.org/W1964982019","https://openalex.org/W1966238900","https://openalex.org/W1982931411","https://openalex.org/W1989588757","https://openalex.org/W1993413291","https://openalex.org/W2017213437","https://openalex.org/W2050202560","https://openalex.org/W2061786382","https://openalex.org/W2063260802","https://openalex.org/W2091671824","https://openalex.org/W2111827378","https://openalex.org/W2114853101","https://openalex.org/W2120801007","https://openalex.org/W2129542667","https://openalex.org/W2154268960","https://openalex.org/W2162360300","https://openalex.org/W2167384912","https://openalex.org/W2470646526","https://openalex.org/W2608823051","https://openalex.org/W2745585316","https://openalex.org/W2754562068","https://openalex.org/W2790198199","https://openalex.org/W2805472045","https://openalex.org/W2894240904","https://openalex.org/W2926411573","https://openalex.org/W2936183454","https://openalex.org/W2991073473","https://openalex.org/W3001118548","https://openalex.org/W3002108456","https://openalex.org/W3002539152","https://openalex.org/W3003951199","https://openalex.org/W3004280078","https://openalex.org/W3004318991","https://openalex.org/W3005079553","https://openalex.org/W3005655936","https://openalex.org/W3006887307","https://openalex.org/W3006961006","https://openalex.org/W3007643904","https://openalex.org/W3007678386","https://openalex.org/W3007940623","https://openalex.org/W3008452791","https://openalex.org/W3008827533","https://openalex.org/W3009335299","https://openalex.org/W3009859788","https://openalex.org/W3009885589","https://openalex.org/W3009906937","https://openalex.org/W3009912996","https://openalex.org/W3010233963","https://openalex.org/W3011024121","https://openalex.org/W3013486442","https://openalex.org/W3013871850","https://openalex.org/W3014003872","https://openalex.org/W3014027512","https://openalex.org/W3014333693","https://openalex.org/W3014573995","https://openalex.org/W3014663601","https://openalex.org/W3015438945","https://openalex.org/W3016084006","https://openalex.org/W3016263512","https://openalex.org/W3016288338","https://openalex.org/W3016572296","https://openalex.org/W3016900702","https://openalex.org/W3017331996","https://openalex.org/W3018517500","https://openalex.org/W3019598142","https://openalex.org/W3020710323","https://openalex.org/W3021915688","https://openalex.org/W3022970339","https://openalex.org/W3023982717","https://openalex.org/W3025160648","https://openalex.org/W3030136428","https://openalex.org/W3035854673","https://openalex.org/W3041206342","https://openalex.org/W3081407919","https://openalex.org/W3163226127"],"related_works":["https://openalex.org/W4281552311","https://openalex.org/W4382656542","https://openalex.org/W3132106350","https://openalex.org/W3214264133","https://openalex.org/W3196326822","https://openalex.org/W4390410335","https://openalex.org/W3041667892","https://openalex.org/W3040956296","https://openalex.org/W3092259479","https://openalex.org/W3035539078"],"abstract_inverted_index":{"The":[0],"newly":[1],"emerging":[2],"coronavirus":[3,13],"disease":[4],"2019":[5],"(COVID-19)":[6],"caused":[7],"by":[8,58,78],"severe":[9,35],"acute":[10,38],"respiratory":[11,39],"syndrome":[12,41],"2":[14],"(SARS-CoV-2)":[15],"was":[16],"first":[17],"reported":[18],"in":[19,94,118,142],"Wuhan,":[20],"China,":[21],"but":[22],"has":[23],"rapidly":[24],"spread":[25],"all":[26],"over":[27],"the":[28,59,69,79,115,133],"world.":[29],"Some":[30],"COVID-19":[31,143],"patients":[32],"encounter":[33],"a":[34,52,110,123],"symptom":[36],"of":[37,82,87,140],"distress":[40],"(ARDS)":[42],"with":[43],"high":[44,47],"mortality.":[45],"This":[46],"severity":[48],"is":[49,64,109,122],"dependent":[50],"on":[51],"cytokine":[53,116],"storm,":[54],"most":[55],"likely":[56],"induced":[57],"interleukin-6":[60],"(IL-6)":[61],"amplifier,":[62],"which":[63],"hyper-activation":[65],"machinery":[66],"that":[67,106],"regulates":[68],"nuclear":[70],"factor":[71],"kappa":[72],"B":[73],"(NF-\u03baB)":[74],"pathway":[75],"and":[76,85,91,101,136],"stimulated":[77],"simultaneous":[80],"activation":[81],"IL-6-signal":[83],"transducer":[84],"activator":[86],"transcription":[88],"3":[89],"(STAT3)":[90],"NF-\u03baB":[92],"signaling":[93,108],"non-immune":[95],"cells":[96,100],"including":[97],"alveolar":[98],"epithelial":[99],"endothelial":[102],"cells.":[103],"We":[104,130],"hypothesize":[105],"IL-6-STAT3":[107],"promising":[111],"therapeutic":[112,138],"target":[113],"for":[114],"storm":[117],"COVID-19,":[119],"because":[120],"IL-6":[121],"major":[124],"STAT3":[125],"stimulator,":[126],"particularly":[127],"during":[128],"inflammation.":[129],"herein":[131],"review":[132],"pathogenic":[134],"mechanism":[135],"potential":[137],"targets":[139],"ARDS":[141],"patients.":[144]},"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":40},{"year":2024,"cited_by_count":69},{"year":2023,"cited_by_count":120},{"year":2022,"cited_by_count":211},{"year":2021,"cited_by_count":195},{"year":2020,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-10-08T00:00:00"}