{"id":"https://openalex.org/W3090801994","doi":null,"title":"Histamine is the Macrophage-derived Factor that Plays a Crucial Role in Promoting Axon Regeneration of Retinal Explants","display_name":"Histamine is the Macrophage-derived Factor that Plays a Crucial Role in Promoting Axon Regeneration of Retinal Explants","publication_year":2020,"publication_date":"2020-06-01","ids":{"openalex":"https://openalex.org/W3090801994","mag":"3090801994"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/101341","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/101341","pdf_url":"https://utoronto.scholaris.ca/bitstreams/8c195912-1cf5-406b-85e0-ceba3b55d78f/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/8c195912-1cf5-406b-85e0-ceba3b55d78f/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057181274","display_name":"Khyati Walia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Khyati Walia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5057181274"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":1.0},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9810000061988831},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.9750000238418579},{"id":"https://openalex.org/keywords/retinal-explants","display_name":"retinal explants","score":0.9190000295639038},{"id":"https://openalex.org/keywords/optic-nerve-injury","display_name":"optic nerve injury","score":0.8050000071525574},{"id":"https://openalex.org/keywords/histamine-h1-receptor","display_name":"histamine H1 receptor","score":0.7620000243186951},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9300000071525574},{"id":"https://openalex.org/keywords/exosome-release","display_name":"exosome secretion","score":0.8679999709129333},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.871999979019165},{"id":"https://openalex.org/keywords/central-nervous-system-injury","display_name":"central nervous system injury","score":0.6510000228881836},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8029999732971191}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.7538009285926819},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.609125018119812},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5375473499298096},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5204682350158691},{"id":"https://openalex.org/C157890192","wikidata":"https://www.wikidata.org/wiki/Q2561978","display_name":"Explant culture","level":3,"score":0.5066660046577454},{"id":"https://openalex.org/C2779530196","wikidata":"https://www.wikidata.org/wiki/Q178999","display_name":"Axon","level":2,"score":0.47520431876182556},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.38912367820739746},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3602142930030823},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34005188941955566},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.14052432775497437},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1385379433631897},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.12192589044570923}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/101341","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/101341","pdf_url":"https://utoronto.scholaris.ca/bitstreams/8c195912-1cf5-406b-85e0-ceba3b55d78f/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"mag:3090801994","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/handle/1807/101341","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/101341","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/101341","pdf_url":"https://utoronto.scholaris.ca/bitstreams/8c195912-1cf5-406b-85e0-ceba3b55d78f/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3090801994.pdf","grobid_xml":"https://content.openalex.org/works/W3090801994.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W82040228","https://openalex.org/W823049900","https://openalex.org/W936325803","https://openalex.org/W1141087116","https://openalex.org/W1497879842","https://openalex.org/W1569924411","https://openalex.org/W1701316286","https://openalex.org/W1924794724","https://openalex.org/W1976200396","https://openalex.org/W1986657126","https://openalex.org/W1990064978","https://openalex.org/W1991343786","https://openalex.org/W2009111405","https://openalex.org/W2015551349","https://openalex.org/W2018433476","https://openalex.org/W2035471044","https://openalex.org/W2039328257","https://openalex.org/W2039758887","https://openalex.org/W2041935553","https://openalex.org/W2060074949","https://openalex.org/W2070004275","https://openalex.org/W2089786859","https://openalex.org/W2092935442","https://openalex.org/W2094605937","https://openalex.org/W2101679513","https://openalex.org/W2124809007","https://openalex.org/W2127522048","https://openalex.org/W2130198578","https://openalex.org/W2209119157","https://openalex.org/W2304707465","https://openalex.org/W2335534790","https://openalex.org/W2402289750","https://openalex.org/W2482343112","https://openalex.org/W2496374556","https://openalex.org/W2509443154","https://openalex.org/W2510867843","https://openalex.org/W2525774399","https://openalex.org/W2552202354","https://openalex.org/W2598700789","https://openalex.org/W2733060293","https://openalex.org/W2736485888","https://openalex.org/W2765463353","https://openalex.org/W2767658071","https://openalex.org/W2777513196","https://openalex.org/W2780764893","https://openalex.org/W2783004471","https://openalex.org/W2783799309","https://openalex.org/W2793306489","https://openalex.org/W2794697922","https://openalex.org/W2800322704","https://openalex.org/W2802579564","https://openalex.org/W2802879466","https://openalex.org/W2807906301","https://openalex.org/W2885013112","https://openalex.org/W2887592114","https://openalex.org/W2889432911","https://openalex.org/W2889573274","https://openalex.org/W2890354388","https://openalex.org/W2891930060","https://openalex.org/W2897645746","https://openalex.org/W2898316565","https://openalex.org/W2911722708","https://openalex.org/W2926345669","https://openalex.org/W2931418311","https://openalex.org/W2942908901","https://openalex.org/W2948005666","https://openalex.org/W2961161544","https://openalex.org/W2970440612","https://openalex.org/W2970959902","https://openalex.org/W2978384597"],"related_works":["https://openalex.org/W4378071229","https://openalex.org/W2085213635","https://openalex.org/W2382190485","https://openalex.org/W4238959524","https://openalex.org/W2135551394","https://openalex.org/W1030761207","https://openalex.org/W1978352819","https://openalex.org/W2048602242","https://openalex.org/W6958285242","https://openalex.org/W7096675881"],"abstract_inverted_index":{"The":[0],"role":[1,131],"of":[2,47,60,132],"macrophages":[3,133],"in":[4,8,44,83,122],"promoting":[5,141],"axon":[6,55,143],"regeneration":[7],"the":[9,33,36,48,58,71,84,100,105,116,130,136,142,146],"injured":[10],"mammalian":[11],"CNS":[12,147],"is":[13,70,76,93,114],"still":[14,41],"strongly":[15],"debated.":[16],"While":[17],"there":[18,39],"have":[19],"been":[20],"past":[21],"studies":[22],"that":[23,53,68,75,91,112],"reported":[24],"regenerative":[25],"effects":[26,81,96],"induced":[27],"by":[28,97],"inflammation":[29],"following":[30],"injuries":[31],"to":[32,99],"lens":[34],"or":[35],"optic":[37],"nerve,":[38],"are":[40,140],"several":[42],"gaps":[43],"our":[45,109,127],"understanding":[46],"underlying":[49],"mechanisms":[50],"behind":[51],"achieving":[52],"successful":[54],"regeneration.":[56],"With":[57],"use":[59],"three":[61],"different":[62],"primary":[63],"cell":[64],"lines,":[65],"we":[66],"show":[67,135],"histamine":[69,92,113],"active":[72],"macrophage-derived":[73],"factor":[74],"responsible":[77],"for":[78],"neurite":[79],"growth-promoting":[80],"observed":[82],"retinal":[85],"explant":[86],"cultures.":[87],"We":[88],"also":[89],"report":[90],"mediating":[94],"these":[95,124],"binding":[98],"H1":[101],"receptors":[102],"found":[103],"on":[104],"astroglial":[106,120],"cells.":[107],"Furthermore,":[108],"findings":[110],"indicate":[111],"influencing":[115],"exosome":[117],"secretion":[118],"from":[119],"cells":[121],"eliciting":[123],"effects.":[125],"Therefore,":[126],"results":[128],"address":[129],"and":[134],"mechanism":[137],"whereby":[138],"they":[139],"regrowth":[144],"at":[145],"injury":[148],"site.":[149]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-10-08T00:00:00"}