{"id":"https://openalex.org/W3090445757","doi":"https://doi.org/10.1186/s13195-020-00688-1","title":"Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer\u2019s disease mouse model with suppression of glymphatic clearance","display_name":"Microglia prevent beta-amyloid plaque formation in the early stage of an Alzheimer\u2019s disease mouse model with suppression of glymphatic clearance","publication_year":2020,"publication_date":"2020-10-02","ids":{"openalex":"https://openalex.org/W3090445757","doi":"https://doi.org/10.1186/s13195-020-00688-1","mag":"3090445757","pmid":"https://pubmed.ncbi.nlm.nih.gov/33008458","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7532614"},"language":"en","primary_location":{"id":"doi:10.1186/s13195-020-00688-1","doi":"https://doi.org/10.1186/s13195-020-00688-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13195-020-00688-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13195-020-00688-1.pdf","source":{"id":"https://openalex.org/S140755874","display_name":"Alzheimer s Research & Therapy","issn_l":"1758-9193","issn":["1758-9193"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's Research & Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://link.springer.com/content/pdf/10.1186/s13195-020-00688-1.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025148955","display_name":"Weixi Feng","orcid":"https://orcid.org/0000-0002-7201-5688","observed_orcids":["https://orcid.org/0000-0002-7201-5688"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weixi Feng","raw_affiliation_strings":["Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China","Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435005","display_name":"Yanli Zhang","orcid":"https://orcid.org/0000-0001-8173-2024","observed_orcids":["https://orcid.org/0000-0001-8173-2024"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanli Zhang","raw_affiliation_strings":["Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China","Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ze Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze Wang","raw_affiliation_strings":["Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China","Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101173124","display_name":"Hanrong Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hanrong Xu","raw_affiliation_strings":["Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China","Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102841343","display_name":"Ting Wu","orcid":"https://orcid.org/0009-0006-9110-1115","observed_orcids":["https://orcid.org/0009-0006-9110-1115"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ting Wu","raw_affiliation_strings":["Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055626874","display_name":"Charles Marshall","orcid":"https://orcid.org/0000-0001-7005-6868","observed_orcids":["https://orcid.org/0000-0001-7005-6868"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles Marshall","raw_affiliation_strings":["Department of Physical Therapy, University of Kentucky Center of Excellence in Rural Health, Hazard, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, University of Kentucky Center of Excellence in Rural Health, Hazard, KY, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100976449","display_name":"Junying Gao","orcid":"https://orcid.org/0000-0001-9087-8789","observed_orcids":["https://orcid.org/0000-0001-9087-8789"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Junying Gao","raw_affiliation_strings":["Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China. gaojunying@njmu.edu.cn","Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China. gaojunying@njmu.edu.cn","Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China. gaojunying@njmu.edu.cn","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China. gaojunying@njmu.edu.cn","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013586047","display_name":"Ming Xiao","orcid":"https://orcid.org/0000-0001-5528-9102","observed_orcids":["https://orcid.org/0000-0001-5528-9102"]},"institutions":[{"id":"https://openalex.org/I4210109791","display_name":"Nanjing Brain Hospital","ror":"https://ror.org/01wcx2305","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210109791"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Xiao","raw_affiliation_strings":["Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China. mingx@njmu.edu.cn","Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China. mingx@njmu.edu.cn","Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China"],"raw_orcid":"https://orcid.org/0000-0001-5528-9102","affiliations":[{"raw_affiliation_string":"Brain Institute, The Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China. mingx@njmu.edu.cn","institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China. mingx@njmu.edu.cn","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Jiangsu Province Key Laboratory of Neurodegeneration, Center for Global Health, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013586047","https://openalex.org/A5100976449"],"corresponding_institution_ids":["https://openalex.org/I4210109791","https://openalex.org/I83519826"],"apc_list":{"value":3170,"currency":"USD","value_usd":3170},"apc_paid":{"value":3170,"currency":"USD","value_usd":3170},"fwci":7.1891,"has_fulltext":true,"cited_by_count":150,"citation_normalized_percentile":{"value":0.98587843,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"125","last_page":"125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9624000191688538,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.03290000185370445,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8069999814033508},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.828000009059906},{"id":"https://openalex.org/keywords/glymphatic-system","display_name":"glymphatic system","score":0.7590000033378601},{"id":"https://openalex.org/keywords/microglia","display_name":"microglia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/aquaporin-4","display_name":"aquaporin-4","score":0.8980000019073486},{"id":"https://openalex.org/keywords/apolipoprotein-e","display_name":"apolipoprotein E","score":0.9259999990463257},{"id":"https://openalex.org/keywords/amyloid-plaque-formation","display_name":"amyloid plaque formation","score":0.7670000195503235},{"id":"https://openalex.org/keywords/app-ps1-mice","display_name":"APP/PS1 mice","score":0.8009999990463257},{"id":"https://openalex.org/keywords/clodronate-liposomes","display_name":"clodronate liposomes","score":0.777999997138977},{"id":"https://openalex.org/keywords/microglial-phagocytosis","display_name":"microglial phagocytosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/amyloid-clearance","display_name":"amyloid clearance","score":0.7860000133514404},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C101054994","wikidata":"https://www.wikidata.org/wiki/Q15474254","display_name":"Glymphatic system","level":3,"score":0.811556339263916},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.7878444790840149},{"id":"https://openalex.org/C15755913","wikidata":"https://www.wikidata.org/wiki/Q14902502","display_name":"Aquaporin 4","level":2,"score":0.7579934597015381},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6101531386375427},{"id":"https://openalex.org/C57089818","wikidata":"https://www.wikidata.org/wiki/Q424728","display_name":"Apolipoprotein E","level":3,"score":0.5123347043991089},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4858414828777313},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.4683152139186859},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.4328618049621582},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.36721113324165344},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.36714422702789307},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.36023712158203125},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35657334327697754},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3411864638328552},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3323535919189453},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3298623263835907},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3258550465106964},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12644609808921814},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.08823221921920776},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.08038711547851562},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016564","descriptor_name":"Amyloid beta-Protein Precursor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017628","descriptor_name":"Microglia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058225","descriptor_name":"Plaque, Amyloid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13195-020-00688-1","doi":"https://doi.org/10.1186/s13195-020-00688-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13195-020-00688-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13195-020-00688-1.pdf","source":{"id":"https://openalex.org/S140755874","display_name":"Alzheimer s Research & Therapy","issn_l":"1758-9193","issn":["1758-9193"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's Research & Therapy","raw_type":"journal-article"},{"id":"doi:10.21203/rs.2.19388/v1","doi":"https://doi.org/10.21203/rs.2.19388/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.19388/v1","pdf_url":"https://www.researchsquare.com/article/rs-10001/v1.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"doi:10.21203/rs.2.19388/v2","doi":"https://doi.org/10.21203/rs.2.19388/v2","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.2.19388/v2","pdf_url":"https://www.researchsquare.com/article/rs-10001/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7532614","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7532614","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimers Res Ther","raw_type":"Text"},{"id":"pmid:33008458","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33008458","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:uknowledge.uky.edu:rehabsci_facpub-1115","doi":null,"is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/rehabsci_facpub/115","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Physical Therapy Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ab65476074764ef6861298e293892760","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ab65476074764ef6861298e293892760","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Alzheimer\u2019s Research & Therapy, Vol 12, Iss 1, Pp 1-15 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13195-020-00688-1","doi":"https://doi.org/10.1186/s13195-020-00688-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13195-020-00688-1","pdf_url":"https://link.springer.com/content/pdf/10.1186/s13195-020-00688-1.pdf","source":{"id":"https://openalex.org/S140755874","display_name":"Alzheimer s Research & Therapy","issn_l":"1758-9193","issn":["1758-9193"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's Research & Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2403490970","display_name":null,"funder_award_id":"81772454","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4933857630","display_name":null,"funder_award_id":"81671070","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3090445757.pdf","grobid_xml":"https://content.openalex.org/works/W3090445757.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1535419310","https://openalex.org/W1580500775","https://openalex.org/W1588685142","https://openalex.org/W1616122655","https://openalex.org/W1767010801","https://openalex.org/W1923535990","https://openalex.org/W1945809300","https://openalex.org/W1975141413","https://openalex.org/W1980362319","https://openalex.org/W1981554609","https://openalex.org/W1993523012","https://openalex.org/W2015786514","https://openalex.org/W2022649067","https://openalex.org/W2028623620","https://openalex.org/W2032694200","https://openalex.org/W2037521832","https://openalex.org/W2048027386","https://openalex.org/W2051765035","https://openalex.org/W2057496129","https://openalex.org/W2083785381","https://openalex.org/W2092522921","https://openalex.org/W2094785614","https://openalex.org/W2095376056","https://openalex.org/W2098246435","https://openalex.org/W2100314515","https://openalex.org/W2101985994","https://openalex.org/W2103139149","https://openalex.org/W2106685134","https://openalex.org/W2110957609","https://openalex.org/W2111570868","https://openalex.org/W2117839560","https://openalex.org/W2127716652","https://openalex.org/W2136454944","https://openalex.org/W2150747374","https://openalex.org/W2167183660","https://openalex.org/W2170644095","https://openalex.org/W2265799967","https://openalex.org/W2329336071","https://openalex.org/W2333306266","https://openalex.org/W2345670786","https://openalex.org/W2397614738","https://openalex.org/W2559691789","https://openalex.org/W2560748808","https://openalex.org/W2576070094","https://openalex.org/W2588487507","https://openalex.org/W2588581682","https://openalex.org/W2593036876","https://openalex.org/W2746870493","https://openalex.org/W2756959977","https://openalex.org/W2766474578","https://openalex.org/W2767482362","https://openalex.org/W2883628966","https://openalex.org/W2890806217","https://openalex.org/W2892352916","https://openalex.org/W2913507637","https://openalex.org/W2914309526","https://openalex.org/W2917914009","https://openalex.org/W2921297416","https://openalex.org/W2921781039","https://openalex.org/W2944515500","https://openalex.org/W2944666647","https://openalex.org/W2965401191","https://openalex.org/W2966585649","https://openalex.org/W4248567869"],"related_works":["https://openalex.org/W7132837748","https://openalex.org/W2066165659","https://openalex.org/W2898244197","https://openalex.org/W2736420768","https://openalex.org/W6948928701","https://openalex.org/W2080970926","https://openalex.org/W2038594716","https://openalex.org/W1576335263","https://openalex.org/W3112447458","https://openalex.org/W1966338888"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Soluble":[2],"beta-amyloid":[3],"(A\u03b2)":[4],"can":[5],"be":[6,267],"cleared":[7],"from":[8],"the":[9,22,29,42,111,161,177,233,252,256,271],"brain":[10],"through":[11],"various":[12],"mechanisms":[13],"including":[14],"enzymatic":[15],"degradation,":[16],"glial":[17],"cell":[18],"phagocytosis,":[19],"transport":[20],"across":[21],"blood-brain":[23],"barrier":[24],"and":[25,36,56,67,86,119,133,138,156,213,238,241],"glymphatic":[26,64,130,234],"clearance.":[27,226],"However,":[28],"relative":[30],"contribution":[31],"of":[32,45,93,114,136,158,164,183,189,203,222,255,264,273],"each":[33],"clearance":[34,65,131,240],"system":[35,235],"their":[37],"compensatory":[38],"effects":[39],"in":[40,110,125,160,176,187,192,209,251],"delaying":[41,270],"pathological":[43],"process":[44],"Alzheimer\u2019s":[46],"disease":[47],"(AD)":[48],"are":[49],"currently":[50],"unknown.":[51],"Methods":[52],"Fluorescent":[53],"trace,":[54],"immunofluorescence":[55],"Western":[57],"blot":[58],"analyses":[59],"were":[60],"performed":[61],"to":[62,145,269],"compare":[63],"ability":[66],"A\u03b2":[68,105,137,146,159,190,207,225,237,244,248],"accumulation":[69,135],"among":[70],"3-month-old":[71],"APPSwe/PS1dE9":[72],"transgenic":[73],"(APP/PS1)":[74],"mice,":[75,77,168,196,217],"wild-type":[76],"aquaporin":[78],"4":[79],"knock":[80],"out":[81],"(AQP4":[82],"-/-":[83,88,116,166,194,215],")":[84],"mice":[85,118,127,212],"AQP4":[87,115,123,165,193,214],"/APP/PS1":[89,117,167,195,216],"mice.":[90,121,172,200],"The":[91,228],"consequence":[92],"selectively":[94],"eliminating":[95,174],"microglial":[96],"cells,":[97],"or":[98,262],"downregulating":[99],"apolipoprotein":[100],"E":[101],"(apoE)":[102],"expression,":[103],"on":[104,224],"burden":[106],"was":[107],"also":[108],"investigated":[109],"frontal":[112,178],"cortex":[113,163,179],"APP/PS1":[120,126,171,199,211],"Results":[122],"deletion":[124],"significantly":[128],"exaggerated":[129],"dysfunction":[132],"intraneuronal":[134,206],"apoE,":[139],"although":[140],"it":[141],"did":[142],"not":[143,152,198],"lead":[144],"plaque":[147],"deposition.":[148],"Notably,":[149],"microglia,":[150],"but":[151,197],"astrocytes,":[153],"increased":[154],"activation":[155],"phagocytosis":[157],"cerebral":[162],"compared":[169],"with":[170],"Selectively":[173],"microglia":[175,242],"via":[180],"local":[181],"injection":[182],"clodronate":[184],"liposomes":[185],"resulted":[186],"deposition":[188],"plaques":[191],"Moreover,":[201],"knockdown":[202],"apoE":[204,223,239],"reduced":[205],"levels":[208],"both":[210,263],"indicating":[218],"an":[219],"inhibitory":[220],"effect":[221],"Conclusion":[227],"above":[229],"results":[230],"suggest":[231],"that":[232],"mediated":[236,243],"degradation":[245],"synergistically":[246],"prevent":[247],"plague":[249],"formation":[250],"early":[253],"stages":[254],"AD":[257],"mouse":[258],"model.":[259],"Protecting":[260],"one":[261],"them":[265],"might":[266],"beneficial":[268],"onset":[272],"AD.":[274]},"counts_by_year":[{"year":2026,"cited_by_count":22},{"year":2025,"cited_by_count":27},{"year":2024,"cited_by_count":27},{"year":2023,"cited_by_count":34},{"year":2022,"cited_by_count":24},{"year":2021,"cited_by_count":15},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-10-08T00:00:00"}