{"id":"https://openalex.org/W3089924723","doi":"https://doi.org/10.1089/ten.tec.2020.0199","title":"Success Criteria and Preclinical Testing of Multifunctional Hydrogels for Tendon Regeneration","display_name":"Success Criteria and Preclinical Testing of Multifunctional Hydrogels for Tendon Regeneration","publication_year":2020,"publication_date":"2020-09-29","ids":{"openalex":"https://openalex.org/W3089924723","doi":"https://doi.org/10.1089/ten.tec.2020.0199","mag":"3089924723","pmid":"https://pubmed.ncbi.nlm.nih.gov/32988293","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7869878"},"language":"en","primary_location":{"id":"doi:10.1089/ten.tec.2020.0199","doi":"https://doi.org/10.1089/ten.tec.2020.0199","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tec.2020.0199","pdf_url":null,"source":{"id":"https://openalex.org/S190192123","display_name":"Tissue Engineering Part C Methods","issn_l":"1937-3384","issn":["1937-3384","1937-3392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part C: Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/07/17/2020.07.16.207274.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056202691","display_name":"Ryan C. Locke","orcid":"https://orcid.org/0000-0002-8466-3922","observed_orcids":["https://orcid.org/0000-0002-8466-3922"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan C. Locke","raw_affiliation_strings":["Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030552171","display_name":"Eden M. Ford","orcid":"https://orcid.org/0000-0003-1765-5989","observed_orcids":["https://orcid.org/0000-0003-1765-5989"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eden M. Ford","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056007514","display_name":"Karin Gr\u00e4vare Silbernagel","orcid":"https://orcid.org/0000-0001-7566-407X","observed_orcids":["https://orcid.org/0000-0001-7566-407X"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karin G. Silbernagel","raw_affiliation_strings":["Department of Physical Therapy, University of Delaware, Newark, Delaware, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physical Therapy, University of Delaware, Newark, Delaware, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030683908","display_name":"April M. Kloxin","orcid":"https://orcid.org/0000-0002-4594-2953","observed_orcids":["https://orcid.org/0000-0002-4594-2953"]},"institutions":[{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"April M. Kloxin","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA","Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, USA","April M. Kloxin, Departments of Chemical and Biomolecular Engineering and Materials Science and Engineering, University of Delaware, 207 Colburn Laboratory, Newark, DE 19716, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Materials Science and Engineering, University of Delaware, Newark, Delaware, USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"April M. Kloxin, Departments of Chemical and Biomolecular Engineering and Materials Science and Engineering, University of Delaware, 207 Colburn Laboratory, Newark, DE 19716, USA","institution_ids":["https://openalex.org/I86501945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017760564","display_name":"Megan Leigh Killian","orcid":"https://orcid.org/0000-0001-6868-5550","observed_orcids":["https://orcid.org/0000-0001-6868-5550"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I86501945","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82","country_code":"US","type":"education","lineage":["https://openalex.org/I86501945"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Megan L. Killian","raw_affiliation_strings":["Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA","Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Delaware, Newark, Delaware, USA","institution_ids":["https://openalex.org/I86501945"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017760564","https://openalex.org/A5030683908"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445","https://openalex.org/I86501945"],"apc_list":null,"apc_paid":null,"fwci":1.7471,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.82565213,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"26","issue":"10","first_page":"506","last_page":"518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11068","display_name":"Tendon Structure and Treatment","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.029100000858306885,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tendon-regeneration","display_name":"tendon regeneration","score":0.9800000190734863},{"id":"https://openalex.org/keywords/synthetic-hydrogels","display_name":"synthetic hydrogels","score":0.8579999804496765},{"id":"https://openalex.org/keywords/collagen-mimetic-peptides","display_name":"collagen mimetic peptides","score":0.828000009059906},{"id":"https://openalex.org/keywords/tendon-healing","display_name":"tendon healing","score":0.48100000619888306},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6779999732971191},{"id":"https://openalex.org/keywords/stem-cell-adhesion","display_name":"stem cell adhesion","score":0.718999981880188},{"id":"https://openalex.org/keywords/mechanical-properties-of-hydrogels","display_name":"hydrogel mechanical properties","score":0.8199999928474426},{"id":"https://openalex.org/keywords/tendon-defect","display_name":"tendon defect","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.8997185230255127},{"id":"https://openalex.org/C2780105995","wikidata":"https://www.wikidata.org/wiki/Q232358","display_name":"Tendon","level":2,"score":0.8822120428085327},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6306342482566833},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.5681142210960388},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5266028642654419},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.41469907760620117},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3940007984638214},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2685083746910095},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.21838340163230896},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1623603105545044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12803733348846436},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008422","descriptor_name":"Materials Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012038","descriptor_name":"Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D013708","descriptor_name":"Tendon Injuries","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D013710","descriptor_name":"Tendons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013710","descriptor_name":"Tendons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020100","descriptor_name":"Hydrogels","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020318","descriptor_name":"Rats, Long-Evans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058105","descriptor_name":"Polymerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1089/ten.tec.2020.0199","doi":"https://doi.org/10.1089/ten.tec.2020.0199","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tec.2020.0199","pdf_url":null,"source":{"id":"https://openalex.org/S190192123","display_name":"Tissue Engineering Part C Methods","issn_l":"1937-3384","issn":["1937-3384","1937-3392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part C: Methods","raw_type":"journal-article"},{"id":"doi:10.1101/2020.07.16.207274","doi":"https://doi.org/10.1101/2020.07.16.207274","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.07.16.207274","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/07/17/2020.07.16.207274.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:7374064","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC7869878","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:7869878","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7869878","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part C Methods","raw_type":"Text"},{"id":"pmid:32988293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32988293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part C, Methods","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/2020.07.16.207274","doi":"https://doi.org/10.1101/2020.07.16.207274","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.07.16.207274","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/07/17/2020.07.16.207274.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nd","license_id":"https://openalex.org/licenses/cc-by-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1137441127","display_name":null,"funder_award_id":"1144726","funder_id":"https://openalex.org/F4320337368","funder_display_name":"Division of Graduate Education"},{"id":"https://openalex.org/G3037964080","display_name":"Discovery of Chemical Probes and Therapeutic Leads, Phase II","funder_award_id":"P20GM104316","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5749153116","display_name":"Interdisciplinary Engineering Career Development Center in Movement and Rehabilitation Sciences","funder_award_id":"K12HD073945","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G7585001790","display_name":"IGERT:  Systems Biology of Cells in Engineered Environments (SBE2)","funder_award_id":"1144726","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8612150275","display_name":"Molecular Design of Advanced Biomaterials","funder_award_id":"P30GM110758","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000886344","display_name":"Delaware Clinical and Translational Research ACCEL Program","funder_award_id":"U54GM104941","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320307084","display_name":"University of Delaware Research Foundation","ror":"https://ror.org/01sbq1a82"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337364","display_name":"National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320337368","display_name":"Division of Graduate Education","ror":"https://ror.org/00whkrf32"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"},{"id":"https://openalex.org/F4320338113","display_name":"Accelerated Innovation Research Initiative Turning Top Science and Ideas into High-Impact Values","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3089924723.pdf","grobid_xml":"https://content.openalex.org/works/W3089924723.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W118422671","https://openalex.org/W1567880947","https://openalex.org/W1809541291","https://openalex.org/W1970152481","https://openalex.org/W1971433224","https://openalex.org/W1974683488","https://openalex.org/W1987412932","https://openalex.org/W1993714832","https://openalex.org/W1994008089","https://openalex.org/W1997068847","https://openalex.org/W1997401832","https://openalex.org/W1998289682","https://openalex.org/W1999201986","https://openalex.org/W2002312829","https://openalex.org/W2006415926","https://openalex.org/W2009225814","https://openalex.org/W2011935103","https://openalex.org/W2012334549","https://openalex.org/W2030865793","https://openalex.org/W2036827000","https://openalex.org/W2043225944","https://openalex.org/W2054635074","https://openalex.org/W2055171457","https://openalex.org/W2055588361","https://openalex.org/W2086324555","https://openalex.org/W2092154651","https://openalex.org/W2095471036","https://openalex.org/W2096193602","https://openalex.org/W2098383818","https://openalex.org/W2101245520","https://openalex.org/W2105895997","https://openalex.org/W2118627051","https://openalex.org/W2123349384","https://openalex.org/W2124694168","https://openalex.org/W2134952597","https://openalex.org/W2137281934","https://openalex.org/W2166827724","https://openalex.org/W2167279371","https://openalex.org/W2168979411","https://openalex.org/W2229444275","https://openalex.org/W2232321619","https://openalex.org/W2283156410","https://openalex.org/W2338136789","https://openalex.org/W2346124693","https://openalex.org/W2463839943","https://openalex.org/W2473926928","https://openalex.org/W2510034022","https://openalex.org/W2517340711","https://openalex.org/W2525780026","https://openalex.org/W2569136393","https://openalex.org/W2603619446","https://openalex.org/W2736974560","https://openalex.org/W2751760736","https://openalex.org/W2762867198","https://openalex.org/W2766510777","https://openalex.org/W2770108509","https://openalex.org/W2788122538","https://openalex.org/W2792419868","https://openalex.org/W2885840684","https://openalex.org/W2903336863","https://openalex.org/W2912720270","https://openalex.org/W2914934476","https://openalex.org/W2937717997","https://openalex.org/W2947390774","https://openalex.org/W2949807231","https://openalex.org/W2952847112","https://openalex.org/W2968408943","https://openalex.org/W2991416247","https://openalex.org/W2993976788","https://openalex.org/W2994634487","https://openalex.org/W2994979942","https://openalex.org/W2995082300","https://openalex.org/W3003400379","https://openalex.org/W3008592843","https://openalex.org/W3009056185","https://openalex.org/W3014577661","https://openalex.org/W3015824084","https://openalex.org/W3017146450","https://openalex.org/W3026295219","https://openalex.org/W4205142578"],"related_works":["https://openalex.org/W4319000899","https://openalex.org/W4398230463","https://openalex.org/W2519651042","https://openalex.org/W4403485914","https://openalex.org/W2325238973","https://openalex.org/W4392472088","https://openalex.org/W4404065480","https://openalex.org/W7160715537","https://openalex.org/W4297491972","https://openalex.org/W3030028329"],"abstract_inverted_index":{"ABSTRACT":[0],"Tendon":[1,295],"injuries":[2],"are":[3,207,221,348],"difficult":[4],"to":[5,61,204,236,266,271,277,305,325],"heal":[6],"in":[7,55,76,144,151,154,210,245,250,253,258,278,298,372,375],"part":[8],"because":[9],"intrinsic":[10,64],"tendon":[11,43,75,88,148,174,227,237,274,366],"healing,":[12],"which":[13],"is":[14,52,368],"dominated":[15],"by":[16,319],"scar":[17,301],"tissue":[18,353,392],"formation,":[19],"does":[20],"not":[21],"effectively":[22],"regenerate":[23,326],"the":[24,45,56,63,71,94,101,165,240,249,269,283,310,316,327,334,341,358,382],"native":[25,46],"structure":[26],"and":[27,69,97,110,121,133,153,176,191,216,224,232,244,252,281,287,337,374],"function":[28],"of":[29,40,48,58,74,100,123,129,164,171,181,242,285,309,340,361,388],"healthy":[30,49,328],"tendon.":[31,50,329],"Further,":[32],"many":[33],"current":[34],"treatment":[35],"strategies":[36,60,351],"also":[37],"fall":[38],"short":[39],"producing":[41],"regenerated":[42],"with":[44],"properties":[47,99,132,202,339],"There":[51],"increasing":[53],"interest":[54],"use":[57],"cell-instructive":[59,83,331],"limit":[62],"fibrotic":[65],"response":[66],"following":[67],"injury":[68],"improve":[70],"regenerative":[72],"capacity":[73],"vivo":[77,279],".":[78],"We":[79,183],"have":[80,200],"established":[81,177],"multi-functional,":[82],"hydrogels":[84,128,172,193,199,289,347,364,390],"for":[85,142,173,179,263,290,352,365,384,391],"treating":[86],"injured":[87,311],"that":[89,117,189,302,314],"afford":[90,323],"tunable":[91],"control":[92],"over":[93,229],"biomechanical,":[95,335],"biochemical,":[96,336],"structural":[98,338],"cell":[102,119,342],"microenvironments.":[103],"Specifically,":[104,197],"we":[105],"incorporated":[106],"integrin-binding":[107],"domains":[108],"(RGDS)":[109],"assembled":[111],"multi-functional":[112,190,286,345,362],"collagen":[113],"mimetic":[114],"peptides":[115],"(mfCMPs)":[116],"enable":[118],"adhesion":[120],"elongation":[122],"stem":[124],"cells":[125,320],"within":[126,226,344],"synthetic":[127,192,288,346,363,389],"designed":[130,262],"biomechanical":[131],"evaluated":[134,257],"these":[135,195,198],"materials":[136],"using":[137,186],"targeted":[138],"success":[139,156,255,377],"criteria":[140,157,256],"developed":[141],"testing":[143,180,280],"mechanically-demanding":[145],"environments":[146],"like":[147],"healing.":[149],"The":[150],"vitro":[152,251,373],"situ":[155,246,254,376],"were":[158,261],"determined":[159],"based":[160],"on":[161],"systematic":[162],"reviews":[163],"most":[166],"commonly":[167],"reported":[168],"outcome":[169],"measures":[170],"repair":[175,275,308,367],"standards":[178],"biomaterials.":[182],"then":[184],"showed,":[185],"validation":[187],"experiments,":[188],"meet":[194],"criteria.":[196,378],"mechanical":[201,234],"comparable":[203],"developing":[205],"tendon;":[206],"non-cytotoxic":[208],"both":[209],"2D":[211],"bolus":[212],"exposure":[213],"(hydrogel":[214],"components)":[215],"3D":[217],"encapsulation":[218],"(full":[219],"hydrogel);":[220],"formed,":[222],"retained,":[223],"visualized":[225],"defects":[228,238],"time":[230,241],"(two-weeks);":[231],"provide":[233],"support":[235],"at":[239],"injection":[243],"formation.":[247],"Ultimately,":[248],"this":[259,356],"study":[260,380],"preclinical":[264,359,386],"research":[265],"rigorously":[267],"test":[268],"potential":[270],"achieve":[272],"successful":[273],"prior":[276],"indicate":[282],"promise":[284,383],"continued":[291,385],"translation.":[292],"IMPACT":[293],"STATEMENT":[294],"healing":[296,322],"results":[297],"a":[299],"weak":[300],"forms":[303],"due":[304],"poor":[306],"cell-mediated":[307],"tissue.":[312],"Treatments":[313],"tailor":[315],"instructions":[317],"experienced":[318],"during":[321],"opportunities":[324],"Engineered":[330],"cues,":[332],"including":[333],"microenvironment,":[343],"promising":[349],"therapeutic":[350],"regeneration.":[354,393],"In":[355],"paper,":[357],"efficacy":[360],"tested":[369],"against":[370],"rigorous":[371],"This":[379],"indicates":[381],"translation":[387]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-08T00:00:00"}
