{"id":"https://openalex.org/W3089819043","doi":"https://doi.org/10.1128/mcb.00180-20","title":"The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion","display_name":"The Endoplasmic Reticulum Cargo Receptor SURF4 Facilitates Efficient Erythropoietin Secretion","publication_year":2020,"publication_date":"2020-09-29","ids":{"openalex":"https://openalex.org/W3089819043","doi":"https://doi.org/10.1128/mcb.00180-20","mag":"3089819043","pmid":"https://pubmed.ncbi.nlm.nih.gov/32989016","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7652404"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.00180-20","doi":"https://doi.org/10.1128/mcb.00180-20","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00180-20","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2019/12/06/866954.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070784484","display_name":"Zesen Lin","orcid":"https://orcid.org/0000-0002-1779-1967","observed_orcids":["https://orcid.org/0000-0002-1779-1967"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zesen Lin","raw_affiliation_strings":["Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109","Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richard King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard King","raw_affiliation_strings":["Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082375861","display_name":"Vi T. Tang","orcid":"https://orcid.org/0000-0001-6079-9756","observed_orcids":["https://orcid.org/0000-0001-6079-9756"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vi Tang","raw_affiliation_strings":["Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109","Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062596325","display_name":"Greggory Myers","orcid":"https://orcid.org/0000-0003-2810-8091","observed_orcids":["https://orcid.org/0000-0003-2810-8091"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Greggory Myers","raw_affiliation_strings":["Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109","Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004275676","display_name":"Ginette Balbin-Cuesta","orcid":"https://orcid.org/0000-0002-1062-6774","observed_orcids":["https://orcid.org/0000-0002-1062-6774"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ginette Balbin-Cuesta","raw_affiliation_strings":["Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109","Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109","Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Medical Scientist Training Program, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003717360","display_name":"Ann D. Friedman","orcid":"https://orcid.org/0000-0003-4915-4038","observed_orcids":["https://orcid.org/0000-0003-4915-4038"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Friedman","raw_affiliation_strings":["Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045998440","display_name":"Beth M. McGee","orcid":"https://orcid.org/0000-0001-5786-7164","observed_orcids":["https://orcid.org/0000-0001-5786-7164"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth McGee","raw_affiliation_strings":["Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018179300","display_name":"Karl C. Desch","orcid":"https://orcid.org/0000-0003-0392-4033","observed_orcids":["https://orcid.org/0000-0003-0392-4033"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karl Desch","raw_affiliation_strings":["Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109","Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109","Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA","Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Pediatrics, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012249054","display_name":"Ayse Bilge Ozel","orcid":"https://orcid.org/0000-0002-1112-4258","observed_orcids":["https://orcid.org/0000-0002-1112-4258"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ayse Bilge Ozel","raw_affiliation_strings":["Department of Human Genetics, Univeristy of Michigan, Ann Arbor, MI 48109","Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Human Genetics, Univeristy of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108264849","display_name":"David R. Siemieniak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Siemieniak","raw_affiliation_strings":["Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109","Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Life Sciences Institute, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078441495","display_name":"Pavan R. Reddy","orcid":"https://orcid.org/0000-0001-7264-8429","observed_orcids":["https://orcid.org/0000-0001-7264-8429"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavan Reddy","raw_affiliation_strings":["Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109","Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109","Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","University of Michigan Rogel Cancer Center, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"University of Michigan Rogel Cancer Center, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I4390039285"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020724887","display_name":"Brian T. Emmer","orcid":"https://orcid.org/0000-0001-7365-1021","observed_orcids":["https://orcid.org/0000-0001-7365-1021"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Emmer","raw_affiliation_strings":["Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054537855","display_name":"Rami N. Khoriaty","orcid":"https://orcid.org/0000-0003-2539-5953","observed_orcids":["https://orcid.org/0000-0003-2539-5953"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4390039285","display_name":"U-M Rogel Cancer Center","ror":"https://ror.org/05asdy483","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445","https://openalex.org/I4390039285"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Rami Khoriaty","raw_affiliation_strings":["Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109","Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109","Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109","Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA","Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA","Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","University of Michigan Rogel Cancer Center, Ann Arbor, Michigan, USA"],"raw_orcid":"https://orcid.org/0000-0003-2539-5953","affiliations":[{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal medicine, University of Michigan, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"University of Michigan Rogel Cancer Center, Ann Arbor, MI 48109","institution_ids":["https://openalex.org/I4390039285"]},{"raw_affiliation_string":"Cellular and Molecular Biology Program, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"University of Michigan Rogel Cancer Center, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I4390039285"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5054537855"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445","https://openalex.org/I4390039285"],"apc_list":null,"apc_paid":null,"fwci":2.8412,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.91962218,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"40","issue":"23","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.7645999789237976,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.10140000283718109,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.06989999860525131,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythropoietin","display_name":"erythropoietin","score":0.8790000081062317},{"id":"https://openalex.org/keywords/surf4","display_name":"SURF4","score":0.9919999837875366},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.8289999961853027},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.7820000052452087},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8159999847412109},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8690000176429749},{"id":"https://openalex.org/keywords/crispr-screening","display_name":"CRISPR screen","score":0.796999990940094},{"id":"https://openalex.org/keywords/hep3b-cells","display_name":"Hep3B cells","score":0.7839999794960022},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.898768424987793},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.833365797996521},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.6327895522117615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5895982384681702},{"id":"https://openalex.org/C162740809","wikidata":"https://www.wikidata.org/wiki/Q15334560","display_name":"STIM1","level":3,"score":0.43608325719833374},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4228048324584961},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20514297485351562},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20089581608772278}],"mesh":[{"descriptor_ui":"D000094704","descriptor_name":"RNA, Guide, CRISPR-Cas Systems","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D021381","descriptor_name":"Protein Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055786","descriptor_name":"Gene Knockout Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064113","descriptor_name":"CRISPR-Cas Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1128/mcb.00180-20","doi":"https://doi.org/10.1128/mcb.00180-20","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00180-20","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1101/866954","doi":"https://doi.org/10.1101/866954","is_oa":true,"landing_page_url":"https://doi.org/10.1101/866954","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/12/06/866954.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7652404","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7652404","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:32989016","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32989016","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1101/866954","doi":"https://doi.org/10.1101/866954","is_oa":true,"landing_page_url":"https://doi.org/10.1101/866954","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2019/12/06/866954.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2790894084","display_name":"Michigan Medical Scientist Training Program","funder_award_id":"T32GM007863","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G387883839","display_name":"Cholesterol regulation by the cargo receptor SURF4","funder_award_id":"K08HL148552","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G476337760","display_name":"University of Michigan Postbaccalaureate Research Education Program (UM PREP)","funder_award_id":"R25GM086262","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5264016259","display_name":"Cellular and Molecular Biology at Michigan","funder_award_id":"T32GM007315","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6714930019","display_name":"The Molecular Genetics of Venous Thromboembolic Disease","funder_award_id":"R01HL141399","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8927907454","display_name":"The Evolution of the Mammalian SEC23 Paralogs and the Molecular Pathogenesis of Congenital Dyserythropoietic Anemia type II","funder_award_id":"K08HL128794","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000862605","display_name":"University of Michigan Rogel Cancer Center Support Grant 2023-2028","funder_award_id":"P30CA046592","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000881291","display_name":"Oncology Research Training Grant","funder_award_id":"T32CA009357","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000896250","display_name":"The molecular pathophysiology of the congenital dyserythropoietic anemias","funder_award_id":"R01HL148333","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333102","display_name":"MCubed, University of Michigan","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3089819043.pdf","grobid_xml":"https://content.openalex.org/works/W3089819043.grobid-xml"},"referenced_works_count":105,"referenced_works":["https://openalex.org/W70161866","https://openalex.org/W103713913","https://openalex.org/W628038580","https://openalex.org/W805509078","https://openalex.org/W1493841569","https://openalex.org/W1503628938","https://openalex.org/W1515497590","https://openalex.org/W1540423321","https://openalex.org/W1573656797","https://openalex.org/W1579256537","https://openalex.org/W1594078235","https://openalex.org/W1850300651","https://openalex.org/W1855348513","https://openalex.org/W1966398753","https://openalex.org/W1970290216","https://openalex.org/W1977709885","https://openalex.org/W1980573861","https://openalex.org/W1981848451","https://openalex.org/W1983025818","https://openalex.org/W1983925960","https://openalex.org/W1985535116","https://openalex.org/W1991145891","https://openalex.org/W1991736711","https://openalex.org/W2005638084","https://openalex.org/W2011810742","https://openalex.org/W2012034410","https://openalex.org/W2014865621","https://openalex.org/W2014903824","https://openalex.org/W2017902030","https://openalex.org/W2022126917","https://openalex.org/W2024747540","https://openalex.org/W2029152767","https://openalex.org/W2031211461","https://openalex.org/W2033803279","https://openalex.org/W2037185463","https://openalex.org/W2038106939","https://openalex.org/W2039472102","https://openalex.org/W2041674095","https://openalex.org/W2044257922","https://openalex.org/W2052201224","https://openalex.org/W2064171438","https://openalex.org/W2064918807","https://openalex.org/W2064967620","https://openalex.org/W2065577646","https://openalex.org/W2068256856","https://openalex.org/W2074503465","https://openalex.org/W2079525793","https://openalex.org/W2082197167","https://openalex.org/W2082584138","https://openalex.org/W2085609942","https://openalex.org/W2087098834","https://openalex.org/W2090627731","https://openalex.org/W2097654747","https://openalex.org/W2100122648","https://openalex.org/W2101186663","https://openalex.org/W2105376178","https://openalex.org/W2106770740","https://openalex.org/W2112833469","https://openalex.org/W2115235864","https://openalex.org/W2118019127","https://openalex.org/W2119394080","https://openalex.org/W2125599080","https://openalex.org/W2129122050","https://openalex.org/W2131395804","https://openalex.org/W2135034560","https://openalex.org/W2136732413","https://openalex.org/W2137333423","https://openalex.org/W2137559379","https://openalex.org/W2140830841","https://openalex.org/W2142033642","https://openalex.org/W2142329004","https://openalex.org/W2144855464","https://openalex.org/W2157630652","https://openalex.org/W2161458516","https://openalex.org/W2179438025","https://openalex.org/W2180291937","https://openalex.org/W2191103386","https://openalex.org/W2265713480","https://openalex.org/W2268116636","https://openalex.org/W2337899633","https://openalex.org/W2426204902","https://openalex.org/W2443142075","https://openalex.org/W2559655684","https://openalex.org/W2580449060","https://openalex.org/W2584033231","https://openalex.org/W2593244426","https://openalex.org/W2594357415","https://openalex.org/W2601885162","https://openalex.org/W2725695211","https://openalex.org/W2749279500","https://openalex.org/W2788791702","https://openalex.org/W2793239896","https://openalex.org/W2797682301","https://openalex.org/W2801814883","https://openalex.org/W2807112850","https://openalex.org/W2884535700","https://openalex.org/W2886128958","https://openalex.org/W2904226822","https://openalex.org/W2917612467","https://openalex.org/W2935701969","https://openalex.org/W2938408085","https://openalex.org/W2948752663","https://openalex.org/W2953199283","https://openalex.org/W2963523373","https://openalex.org/W3002099227"],"related_works":["https://openalex.org/W4402326236","https://openalex.org/W2996472113","https://openalex.org/W2099849599","https://openalex.org/W4389221775","https://openalex.org/W2012143263","https://openalex.org/W2979900398","https://openalex.org/W2011103716","https://openalex.org/W2135190588","https://openalex.org/W4282918807","https://openalex.org/W7095418693"],"abstract_inverted_index":{"Abstract":[0],"Erythropoietin":[1],"(EPO),":[2],"a":[3,57,64,79,122,163,232],"glycoprotein":[4],"produced":[5],"by":[6,114,215],"specialized":[7],"peritubular":[8],"fibroblasts":[9],"in":[10,25,100,140,144,158,165,226],"the":[11,14,23,37,46,145,166,191],"kidney,":[12],"is":[13,20],"master":[15],"regulator":[16],"of":[17,40,49,69,90,106,109,116,131,137,142,168,175,194,210,229,239],"erythropoiesis.":[18],"EPO":[19,41,50,71,91,143,152,217],"secreted":[21],"into":[22],"plasma":[24],"response":[26],"to":[27],"tissue":[28],"hypoxia":[29],"and":[30,34,66,103,148,151],"stimulates":[31],"erythroid":[32],"differentiation":[33],"maturation.":[35],"Though":[36],"transcriptional":[38],"regulation":[39],"has":[42],"been":[43],"well":[44],"studied,":[45],"molecular":[47],"determinants":[48],"secretion":[51,167,193,228],"remain":[52],"unknown.":[53],"Here,":[54],"we":[55,77,133,220],"generated":[56],"HEK293T":[58],"reporter":[59],"cell":[60,75],"line":[61],"that":[62,83,135,149,181,189,200,212,222],"provides":[63],"quantifiable":[65],"selectable":[67],"readout":[68],"intracellular":[70,101],"levels.":[72,218],"Using":[73],"this":[74],"line,":[76],"performed":[78],"genome-scale":[80],"CRISPR":[81],"screen":[82],"identified":[84],"SURF4":[85,94,117,125,138,150,156,182,202,223],"as":[86,126,184],"an":[87,127,173,185,205],"important":[88],"mediator":[89],"secretion.":[92],"Targeting":[93],"with":[95,121],"multiple":[96],"independent":[97],"sgRNAs":[98],"resulted":[99,139],"accumulation":[102,141],"extracellular":[104],"depletion":[105],"EPO.":[107,195,241],"Both":[108],"these":[110],"phenotypes":[111],"were":[112],"rescued":[113],"expression":[115],"cDNA.":[118],"Additionally,":[119],"consistent":[120],"role":[123],"for":[124,208,235],"ER":[128,146,186],"cargo":[129,187],"receptor":[130,188],"EPO,":[132,170,230],"found":[134],"disruption":[136,157],"compartment,":[147],"physically":[153],"interact.":[154],"Furthermore,":[155],"Hep3B":[159],"cells":[160],"also":[161,198],"caused":[162],"defect":[164],"endogenous":[169],"ruling":[171],"out":[172],"artifact":[174],"heterologous":[176],"overexpression.":[177],"This":[178],"work":[179],"suggests":[180],"functions":[183],"mediates":[190],"efficient":[192,237],"Our":[196],"findings":[197],"suggest":[199],"modulating":[201],"may":[203],"be":[204],"effective":[206],"treatment":[207],"disorders":[209],"erythropoeisis":[211],"are":[213],"driven":[214],"aberrant":[216],"Finally,":[219],"show":[221],"overexpression":[224],"results":[225],"increased":[227],"suggesting":[231],"new":[233],"strategy":[234],"more":[236],"production":[238],"recombinant":[240]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-08T00:00:00"}