{"id":"https://openalex.org/W3089353085","doi":null,"title":"The Management of Cytokine Storm in COVID-19.","display_name":"The Management of Cytokine Storm in COVID-19.","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3089353085","mag":"3089353085","pmid":"https://pubmed.ncbi.nlm.nih.gov/33020343"},"language":"en","primary_location":{"id":"pmh:oai:ojs.www.actamedindones.org:article/1580","doi":null,"is_oa":true,"landing_page_url":"https://actamedindones.org/index.php/ijim/article/view/1580","pdf_url":"https://actamedindones.org/index.php/ijim/article/download/1580/pdf","source":{"id":"https://openalex.org/S2756477992","display_name":"Acta medica Indonesiana","issn_l":"0125-9326","issn":["0125-9326","2338-2732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315135","host_organization_name":"Interna Publishing","host_organization_lineage":["https://openalex.org/P4310315135"],"host_organization_lineage_names":["Interna Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0125-9326","raw_type":"info:eu-repo/semantics/article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://actamedindones.org/index.php/ijim/article/download/1580/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028208673","display_name":"Cleopas Martin Rumende","orcid":"https://orcid.org/0000-0002-7305-7337","observed_orcids":["https://orcid.org/0000-0002-7305-7337"]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]},{"id":"https://openalex.org/I4210155152","display_name":"Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo","ror":"https://ror.org/05am7x020","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210155152"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Cleopas Martin Rumende","raw_affiliation_strings":["Division of Respirology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital. Jakarta, Indonesia. Rumende_martin@gmail.com","Division of Respirology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia \u2013 Cipto Mangunkusumo Hospital. Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Respirology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital. Jakarta, Indonesia. Rumende_martin@gmail.com","institution_ids":["https://openalex.org/I29617571","https://openalex.org/I4210155152"]},{"raw_affiliation_string":"Division of Respirology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia \u2013 Cipto Mangunkusumo Hospital. Jakarta, Indonesia","institution_ids":["https://openalex.org/I29617571","https://openalex.org/I4210155152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103813247","display_name":"Erwin C Susanto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]},{"id":"https://openalex.org/I4210155152","display_name":"Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo","ror":"https://ror.org/05am7x020","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210155152"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Erwin C Susanto","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine Universitas Indonesia \u2013 Cipto Mangunkusumo Hospital, Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine Universitas Indonesia \u2013 Cipto Mangunkusumo Hospital, Jakarta, Indonesia","institution_ids":["https://openalex.org/I29617571","https://openalex.org/I4210155152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007213238","display_name":"Truely Panca Sitorus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I29617571","display_name":"University of Indonesia","ror":"https://ror.org/0116zj450","country_code":"ID","type":"education","lineage":["https://openalex.org/I29617571"]},{"id":"https://openalex.org/I4210155152","display_name":"Rumah Sakit Umum Pusat Nasional Dr. Cipto Mangunkusumo","ror":"https://ror.org/05am7x020","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210155152"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Truely P Sitorus","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine Universitas Indonesia \u2013 Cipto Mangunkusumo Hospital, Jakarta, Indonesia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine Universitas Indonesia \u2013 Cipto Mangunkusumo Hospital, Jakarta, Indonesia","institution_ids":["https://openalex.org/I29617571","https://openalex.org/I4210155152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":7500000,"currency":"IDR","value_usd":500},"apc_paid":{"value":7500000,"currency":"IDR","value_usd":500},"fwci":0.2574,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.70787704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"52","issue":"3","first_page":"306","last_page":"313"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytokine-storm","display_name":"cytokine storm","score":0.9739999771118164},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9980000257492065},{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hyperinflammation","display_name":"hyperinflammation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5740000009536743},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.7310000061988831},{"id":"https://openalex.org/keywords/covid-19-pneumonia","display_name":"COVID-19 pneumonia","score":0.7870000004768372},{"id":"https://openalex.org/keywords/treatment-strategy","display_name":"treatment options","score":0.5260000228881836},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2779559532","wikidata":"https://www.wikidata.org/wiki/Q1076369","display_name":"Cytokine storm","level":5,"score":0.9780153036117554},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8344728946685791},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.710914134979248},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6935428977012634},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.677908718585968},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.6651690602302551},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6132655143737793},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5682691335678101},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5664811134338379},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.5446739196777344},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.4480562210083008},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.4377814829349518},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.23201876878738403},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11847180128097534}],"mesh":[{"descriptor_ui":"D000073640","descriptor_name":"Betacoronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011024","descriptor_name":"Pneumonia, Viral","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D018352","descriptor_name":"Coronavirus Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D019468","descriptor_name":"Disease Management","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"pmh:oai:ojs.www.actamedindones.org:article/1580","doi":null,"is_oa":true,"landing_page_url":"https://actamedindones.org/index.php/ijim/article/view/1580","pdf_url":"https://actamedindones.org/index.php/ijim/article/download/1580/pdf","source":{"id":"https://openalex.org/S2756477992","display_name":"Acta medica Indonesiana","issn_l":"0125-9326","issn":["0125-9326","2338-2732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315135","host_organization_name":"Interna Publishing","host_organization_lineage":["https://openalex.org/P4310315135"],"host_organization_lineage_names":["Interna Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0125-9326","raw_type":"info:eu-repo/semantics/article"},{"id":"pmid:33020343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33020343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta medica Indonesiana","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:85932b5ebc574224b985d851d9441185","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/85932b5ebc574224b985d851d9441185","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Indonesiana, Vol 52, Iss 3 (2020)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c1ef3a4af6974f27ba54399b8c3b656f","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c1ef3a4af6974f27ba54399b8c3b656f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Acta Medica Indonesiana, Vol 52, Iss 3 (2020)","raw_type":"article"},{"id":"mag:3089353085","doi":null,"is_oa":true,"landing_page_url":"https://www.actamedindones.org/index.php/ijim/article/download/1580/pdf","pdf_url":null,"source":{"id":"https://openalex.org/S2756477992","display_name":"Acta medica Indonesiana","issn_l":"0125-9326","issn":["0125-9326","2338-2732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315135","host_organization_name":"Interna Publishing","host_organization_lineage":["https://openalex.org/P4310315135"],"host_organization_lineage_names":["Interna Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Acta medica Indonesiana","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ojs.www.actamedindones.org:article/1580","doi":null,"is_oa":true,"landing_page_url":"https://actamedindones.org/index.php/ijim/article/view/1580","pdf_url":"https://actamedindones.org/index.php/ijim/article/download/1580/pdf","source":{"id":"https://openalex.org/S2756477992","display_name":"Acta medica Indonesiana","issn_l":"0125-9326","issn":["0125-9326","2338-2732"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315135","host_organization_name":"Interna Publishing","host_organization_lineage":["https://openalex.org/P4310315135"],"host_organization_lineage_names":["Interna Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"0125-9326","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3089353085.pdf","grobid_xml":"https://content.openalex.org/works/W3089353085.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3015228903","https://openalex.org/W3197383871","https://openalex.org/W3047763946","https://openalex.org/W3037905255","https://openalex.org/W3135921613","https://openalex.org/W3041451779","https://openalex.org/W3199268457","https://openalex.org/W3081790187","https://openalex.org/W3151970156","https://openalex.org/W3126343784"],"abstract_inverted_index":{"Cytokine":[0],"storm":[1,56,127],"in":[2,48,74,112,128],"COVID-19":[3,78,91,124],"infection":[4],"is":[5,16,25,70],"an":[6,53],"excessive":[7],"immune":[8,100],"response":[9],"to":[10,41,67,76,89,130],"external":[11],"stimuli":[12],"where":[13],"the":[14,23,31,42,118],"pathogenesis":[15,119],"complex.":[17],"The":[18],"disease":[19],"progresses":[20],"rapidly":[21],"and":[22,120],"mortality":[24],"high.":[26],"Certain":[27],"evidence":[28],"shows":[29],"that":[30,97],"severe":[32,113],"deterioration":[33],"of":[34,45,59,123],"some":[35],"patients":[36],"has":[37],"been":[38],"closely":[39],"related":[40],"strong":[43],"upregulation":[44],"cytokine":[46,55],"production":[47],"SARS-Co-V2":[49],"induced":[50],"pneumonia":[51],"with":[52,63],"associated":[54,79],"syndrome.":[57],"Identification":[58],"existing":[60],"approaved":[61],"therapy":[62],"proven":[64],"safety":[65],"profile":[66],"treat":[68,90],"hyperinflammation":[69],"critical":[71],"unmet":[72],"need":[73],"order":[75],"reduce":[77],"mortality.":[80],"To":[81],"date,":[82],"no":[83],"specific":[84],"therapeutic":[85],"drugs":[86],"are":[87],"available":[88],"infection.":[92],"Preliminary":[93],"studies":[94],"have":[95],"shown":[96],"immune-modulatory":[98],"or":[99],"suppressive":[101],"treatments":[102],"might":[103],"be":[104],"considered":[105],"as":[106],"treatment":[107,121],"choices":[108],"for":[109,135],"COVID-19,":[110],"particularly":[111],"disease.":[114],"This":[115],"article":[116],"review":[117],"strategies":[122],"virus-induced":[125],"inflammatory":[126],"attempt":[129],"provide":[131],"valuable":[132],"medication":[133],"guidance":[134],"clinical":[136],"treatment.":[137]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-08T00:00:00"}