{"id":"https://openalex.org/W3089146751","doi":"https://doi.org/10.1038/s41598-020-72946-z","title":"Differential epigenetic regulation between the alternative promoters, PRDM1\u03b1 and PRDM1\u03b2, of the tumour suppressor gene PRDM1 in human multiple myeloma cells","display_name":"Differential epigenetic regulation between the alternative promoters, PRDM1\u03b1 and PRDM1\u03b2, of the tumour suppressor gene PRDM1 in human multiple myeloma cells","publication_year":2020,"publication_date":"2020-09-28","ids":{"openalex":"https://openalex.org/W3089146751","doi":"https://doi.org/10.1038/s41598-020-72946-z","mag":"3089146751","pmid":"https://pubmed.ncbi.nlm.nih.gov/32985591","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7522722"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-020-72946-z","doi":"https://doi.org/10.1038/s41598-020-72946-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-72946-z","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41598-020-72946-z","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047244493","display_name":"Raquel Romero-Garc\u00eda","orcid":"https://orcid.org/0000-0001-9851-0487","observed_orcids":["https://orcid.org/0000-0001-9851-0487"]},"institutions":[{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]},{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Raquel Romero-Garc\u00eda","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210144722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086062539","display_name":"Laura G\u00f3mez-Jaramillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]},{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Laura G\u00f3mez-Jaramillo","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210144722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084950800","display_name":"Rosa Mar\u00eda Mateos","orcid":"https://orcid.org/0000-0002-9853-1103","observed_orcids":["https://orcid.org/0000-0002-9853-1103"]},"institutions":[{"id":"https://openalex.org/I39147953","display_name":"Universidad de C\u00e1diz","ror":"https://ror.org/04mxxkb11","country_code":"ES","type":"education","lineage":["https://openalex.org/I39147953"]},{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosa Mar\u00eda Mateos","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","\u00c1rea Bioqu\u00edmica y Biolog\u00eda Molecular, Dpto. Biomedicina Biotecnolog\u00eda y Salud P\u00fablica, Universidad de C\u00e1diz, 11510, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"\u00c1rea Bioqu\u00edmica y Biolog\u00eda Molecular, Dpto. Biomedicina Biotecnolog\u00eda y Salud P\u00fablica, Universidad de C\u00e1diz, 11510, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I39147953"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046865727","display_name":"Gema Jim\u00e9nez\u2010G\u00f3mez","orcid":"https://orcid.org/0000-0002-3400-745X","observed_orcids":["https://orcid.org/0000-0002-3400-745X"]},"institutions":[{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]},{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gema Jim\u00e9nez-G\u00f3mez","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210144722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084429080","display_name":"Nuria Pedre\u00f1o\u2010Horrillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nuria Pedre\u00f1o-Horrillo","raw_affiliation_strings":["Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210144722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047082189","display_name":"Esther Foncubierta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Esther Foncubierta","raw_affiliation_strings":["Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210144722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103960118","display_name":"Juan Francisco Rodr\u00edguez Guti\u00e9rrez","orcid":"https://orcid.org/0000-0002-3623-2917","observed_orcids":["https://orcid.org/0000-0002-3623-2917"]},"institutions":[{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]},{"id":"https://openalex.org/I4405252667","display_name":"Hospital Universitario de Jerez","ror":"https://ror.org/01fyp5w42","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210152975","https://openalex.org/I4405252667","https://openalex.org/I918821925"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Francisco Rodr\u00edguez-Guti\u00e9rrez","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","Unidad de Hematolog\u00eda, Hospital Universitario de Jerez, Ronda de Circunvalaci\u00f3n s/n, 11407, Jerez de La Frontera, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Unidad de Hematolog\u00eda, Hospital Universitario de Jerez, Ronda de Circunvalaci\u00f3n s/n, 11407, Jerez de La Frontera, Spain","institution_ids":["https://openalex.org/I4405252667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110406866","display_name":"Sebasti\u00e1n Garz\u00f3n","orcid":"https://orcid.org/0000-0002-8746-1891","observed_orcids":["https://orcid.org/0000-0002-8746-1891"]},"institutions":[{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]},{"id":"https://openalex.org/I4405252667","display_name":"Hospital Universitario de Jerez","ror":"https://ror.org/01fyp5w42","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210152975","https://openalex.org/I4405252667","https://openalex.org/I918821925"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Sebasti\u00e1n Garz\u00f3n","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","Unidad de Hematolog\u00eda, Hospital Universitario de Jerez, Ronda de Circunvalaci\u00f3n s/n, 11407, Jerez de La Frontera, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Unidad de Hematolog\u00eda, Hospital Universitario de Jerez, Ronda de Circunvalaci\u00f3n s/n, 11407, Jerez de La Frontera, Spain","institution_ids":["https://openalex.org/I4405252667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026085689","display_name":"Francisco Mora\u2010L\u00f3pez","orcid":"https://orcid.org/0000-0002-6423-0222","observed_orcids":["https://orcid.org/0000-0002-6423-0222"]},"institutions":[{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]},{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Francisco Mora-L\u00f3pez","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","Servicio de Inmunolog\u00eda, UGC de Hematolog\u00eda, Inmunolog\u00eda y Gen\u00e9tica, Hospital Universitario Puerta del Mar, 11009, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Servicio de Inmunolog\u00eda, UGC de Hematolog\u00eda, Inmunolog\u00eda y Gen\u00e9tica, Hospital Universitario Puerta del Mar, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210144722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005430553","display_name":"Carmen S Rodriguez","orcid":"https://orcid.org/0000-0002-3495-4430","observed_orcids":["https://orcid.org/0000-0002-3495-4430"]},"institutions":[{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]},{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Rodr\u00edguez","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","Servicio de Inmunolog\u00eda, UGC de Hematolog\u00eda, Inmunolog\u00eda y Gen\u00e9tica, Hospital Universitario Puerta del Mar, 11009, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Servicio de Inmunolog\u00eda, UGC de Hematolog\u00eda, Inmunolog\u00eda y Gen\u00e9tica, Hospital Universitario Puerta del Mar, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210144722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065717529","display_name":"Luis Miguel Valor","orcid":"https://orcid.org/0000-0002-1229-0565","observed_orcids":["https://orcid.org/0000-0002-1229-0565"]},"institutions":[{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]},{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis M. Valor","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I4210144722"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058496902","display_name":"Antonio Campos\u2010Caro","orcid":"https://orcid.org/0000-0001-8532-2153","observed_orcids":["https://orcid.org/0000-0001-8532-2153"]},"institutions":[{"id":"https://openalex.org/I39147953","display_name":"Universidad de C\u00e1diz","ror":"https://ror.org/04mxxkb11","country_code":"ES","type":"education","lineage":["https://openalex.org/I39147953"]},{"id":"https://openalex.org/I4210123493","display_name":"Biomedical Research and Innovation Institute of Cadiz","ror":"https://ror.org/02s5m5d51","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210123493"]},{"id":"https://openalex.org/I4210144722","display_name":"Hospital Universitario Puerta del Mar","ror":"https://ror.org/040xzg562","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I158283456","https://openalex.org/I4210144722"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Antonio Campos-Caro","raw_affiliation_strings":["Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain. antonio.campos@uca.es","Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain. antonio.campos@uca.es","\u00c1rea Gen\u00e9tica, Dpto. Biomedicina Biotecnolog\u00eda y Salud P\u00fablica, Universidad de C\u00e1diz, 11510, C\u00e1diz, Spain. antonio.campos@uca.es","\u00c1rea Gen\u00e9tica, Dpto. Biomedicina Biotecnolog\u00eda y Salud P\u00fablica, Universidad de C\u00e1diz, 11510, C\u00e1diz, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaci\u00f3n e Innovaci\u00f3n en Ciencias Biom\u00e9dicas de C\u00e1diz (INiBICA), Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain. antonio.campos@uca.es","institution_ids":["https://openalex.org/I39147953","https://openalex.org/I4210123493"]},{"raw_affiliation_string":"Unidad de Investigaci\u00f3n, Hospital Universitario Puerta del Mar, Avenida Ana de Viya 21, 11009, C\u00e1diz, Spain. antonio.campos@uca.es","institution_ids":["https://openalex.org/I4210144722"]},{"raw_affiliation_string":"\u00c1rea Gen\u00e9tica, Dpto. Biomedicina Biotecnolog\u00eda y Salud P\u00fablica, Universidad de C\u00e1diz, 11510, C\u00e1diz, Spain. antonio.campos@uca.es","institution_ids":["https://openalex.org/I39147953"]},{"raw_affiliation_string":"\u00c1rea Gen\u00e9tica, Dpto. Biomedicina Biotecnolog\u00eda y Salud P\u00fablica, Universidad de C\u00e1diz, 11510, C\u00e1diz, Spain","institution_ids":["https://openalex.org/I39147953"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058496902"],"corresponding_institution_ids":["https://openalex.org/I39147953","https://openalex.org/I4210123493","https://openalex.org/I4210144722"],"apc_list":{"value":1870,"currency":"USD","value_usd":1870},"apc_paid":{"value":1870,"currency":"USD","value_usd":1870},"fwci":0.3157,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.59288861,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"1","first_page":"15899","last_page":"15899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.573199987411499,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.573199987411499,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.3345000147819519,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.07400000095367432,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/blimp-1","display_name":"Blimp-1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.8479999899864197},{"id":"https://openalex.org/keywords/alternative-promoter-usage","display_name":"alternative promoters","score":0.6290000081062317},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.75},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.7250000238418579},{"id":"https://openalex.org/keywords/promoter-hypomethylation","display_name":"promoter hypomethylation","score":0.9470000267028809},{"id":"https://openalex.org/keywords/h3k4me1","display_name":"H3K4me1","score":0.9539999961853027},{"id":"https://openalex.org/keywords/h3k9me2","display_name":"H3K9me2","score":1.0},{"id":"https://openalex.org/keywords/epigenetic-regulation","display_name":"epigenetic regulation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/dna-methylation-inhibitors","display_name":"DNA methylation inhibitors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/cis-regulatory-elements","display_name":"cis-regulatory elements","score":0.7590000033378601},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7580000162124634},{"id":"https://openalex.org/keywords/plasma-cell-differentiation","display_name":"plasma cell differentiation","score":0.7149999737739563}],"concepts":[{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.7119097709655762},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.6518238186836243},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.6479653120040894},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6153212785720825},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5029260516166687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46935969591140747},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45478713512420654},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.37937480211257935},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37359750270843506},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2188996970653534},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16184905171394348}],"mesh":[{"descriptor_ui":"D000074462","descriptor_name":"Positive Regulatory Domain I-Binding Factor 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000074462","descriptor_name":"Positive Regulatory Domain I-Binding Factor 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41598-020-72946-z","doi":"https://doi.org/10.1038/s41598-020-72946-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-72946-z","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7522722","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7522722","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"},{"id":"pmid:32985591","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32985591","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:dnet:rodin_______::86ed1945c7437f6ddd5bfe5e12ec1442","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10498/23975","pdf_url":"http://hdl.handle.net/10498/23975","source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific RepoRtS | (2020) 10:15899","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.repositoriosalud.es:10668/16333","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7522722/pdf","pdf_url":"https://www.nature.com/articles/s41598-020-72946-z.pdf","source":{"id":"https://openalex.org/S4377196114","display_name":"RISalud Institutional Health Repository of Andaluc\u00eda","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"research article"},{"id":"pmh:oai:rodin.uca.es:10498/23975","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10498/23975","pdf_url":null,"source":{"id":"https://openalex.org/S4306400506","display_name":"RODIN (Universidad de C\u00e1diz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I39147953","host_organization_name":"Universidad de C\u00e1diz","host_organization_lineage":["https://openalex.org/I39147953"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scientific RepoRtS | (2020) 10:15899","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41598-020-72946-z","doi":"https://doi.org/10.1038/s41598-020-72946-z","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-020-72946-z","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1888088267","display_name":null,"funder_award_id":"2014-2020\u2019","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G2426432956","display_name":null,"funder_award_id":"20142020","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G2542571189","display_name":null,"funder_award_id":"CP15/00180","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2620658983","display_name":null,"funder_award_id":"PI11/","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5530534872","display_name":"Diferenciaci\u00f3n de las c\u00e9lulas plasm\u00e1ticas humanas en la salud y en la enfermedad: an\u00e1lisis de la expresi\u00f3n g\u00e9nica de c\u00e9lula \u00fanica en Lupus Eritrematoso Sist\u00e9mico y en Artritis Reumatoide","funder_award_id":"PI15/01147","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G8502706790","display_name":null,"funder_award_id":"PI11/01091","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320326754","display_name":"Junta de Andaluc\u00eda","ror":"https://ror.org/01jem9c82"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W69000459","https://openalex.org/W1485900506","https://openalex.org/W1566926046","https://openalex.org/W1605209343","https://openalex.org/W1950892569","https://openalex.org/W1964507957","https://openalex.org/W1969206687","https://openalex.org/W1974486643","https://openalex.org/W1976861142","https://openalex.org/W1977088407","https://openalex.org/W1980268334","https://openalex.org/W1980736090","https://openalex.org/W1982890873","https://openalex.org/W1990389934","https://openalex.org/W1991300427","https://openalex.org/W2006342636","https://openalex.org/W2012443495","https://openalex.org/W2016730049","https://openalex.org/W2018443217","https://openalex.org/W2030917930","https://openalex.org/W2033522935","https://openalex.org/W2043332368","https://openalex.org/W2045179620","https://openalex.org/W2045332472","https://openalex.org/W2051568429","https://openalex.org/W2053408851","https://openalex.org/W2054909295","https://openalex.org/W2057379398","https://openalex.org/W2058194048","https://openalex.org/W2076542478","https://openalex.org/W2090510808","https://openalex.org/W2095753802","https://openalex.org/W2105409819","https://openalex.org/W2107277218","https://openalex.org/W2114519694","https://openalex.org/W2118207747","https://openalex.org/W2119997582","https://openalex.org/W2122348846","https://openalex.org/W2126350805","https://openalex.org/W2131606648","https://openalex.org/W2139728074","https://openalex.org/W2142766411","https://openalex.org/W2143095919","https://openalex.org/W2144728882","https://openalex.org/W2145694215","https://openalex.org/W2146573874","https://openalex.org/W2153836963","https://openalex.org/W2163150086","https://openalex.org/W2166037178","https://openalex.org/W2166773843","https://openalex.org/W2169394657","https://openalex.org/W2170914979","https://openalex.org/W2203707504","https://openalex.org/W2476432860","https://openalex.org/W2520007230","https://openalex.org/W2528586727","https://openalex.org/W2566318589","https://openalex.org/W2605001832","https://openalex.org/W2607567607","https://openalex.org/W2750187773","https://openalex.org/W2776431612","https://openalex.org/W2804134268"],"related_works":["https://openalex.org/W2969203480","https://openalex.org/W2170914979","https://openalex.org/W2076542478","https://openalex.org/W1986560938","https://openalex.org/W4233779047","https://openalex.org/W3159598137","https://openalex.org/W2153961334","https://openalex.org/W4205219904","https://openalex.org/W2759493109","https://openalex.org/W2203707504"],"abstract_inverted_index":{"Multiple":[0],"myeloma":[1],"(MM)":[2],"is":[3,8,25,34,47],"a":[4,26],"B-cell":[5],"neoplasm":[6],"that":[7,55,136,153],"characterized":[9,87],"by":[10],"the":[11,18,52,59,63,68,71,88,107,120,145,148,155,162,166,169],"accumulation":[12],"of":[13,29,51,62,70,95,102,147,154,168,174],"malignant":[14],"plasma":[15,30],"cells":[16],"in":[17,40,74,123],"bone":[19],"marrow.":[20],"The":[21,44],"transcription":[22],"factor":[23],"PRDM1":[24,53],"master":[27],"regulator":[28],"cell":[31,125,130],"development":[32],"and":[33,76,92,104,109,113,116],"considered":[35],"to":[36,77,82,128,143,164],"be":[37],"an":[38,48],"oncosuppressor":[39],"several":[41],"lymphoid":[42],"neoplasms.":[43],"PRDM1\u03b2":[45,72,110,121,149],"isoform":[46,73],"alternative":[49],"promoter":[50,122,150],"gene":[54],"may":[56,160],"interfere":[57],"with":[58,134],"normal":[60],"role":[61],"PRDM1\u03b1":[64,108,156],"isoform.":[65],"To":[66],"explain":[67],"induction":[69],"MM":[75],"offer":[78,161],"potential":[79],"therapeutic":[80,176],"strategies":[81],"modulate":[83],"its":[84,96],"expression,":[85],"we":[86,140],"cis":[89],"regulatory":[90],"elements":[91],"epigenetic":[93],"status":[94],"promoter.":[97,157],"We":[98],"observed":[99],"unexpected":[100],"patterns":[101],"hypermethylation":[103],"hypomethylation":[105],"at":[106,119],"promoters,":[111],"respectively,":[112],"prominent":[114],"H3K4me1":[115],"H3K9me2":[117],"enrichment":[118],"non-expressing":[124],"lines":[126],"compared":[127],"PRDM1\u03b2-expressing":[129],"lines.":[131],"After":[132],"treatment":[133],"drugs":[135,159],"inhibit":[137],"DNA":[138],"methylation,":[139],"were":[141],"able":[142],"modify":[144],"activity":[146],"but":[151],"not":[152],"Epigenetic":[158],"ability":[163],"control":[165],"expression":[167],"PRDM1\u03b1/PRDM1\u03b2":[170],"promoters":[171],"as":[172],"components":[173],"novel":[175],"approaches.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-10-01T00:00:00"}