{"id":"https://openalex.org/W3089067166","doi":"https://doi.org/10.1101/2020.09.27.316174","title":"Discovery and Development of Human SARS-CoV-2 Neutralizing Antibodies using an Unbiased Phage Display Library Approach","display_name":"Discovery and Development of Human SARS-CoV-2 Neutralizing Antibodies using an Unbiased Phage Display Library Approach","publication_year":2020,"publication_date":"2020-09-28","ids":{"openalex":"https://openalex.org/W3089067166","doi":"https://doi.org/10.1101/2020.09.27.316174","mag":"3089067166"},"language":"en","primary_location":{"id":"doi:10.1101/2020.09.27.316174","doi":"https://doi.org/10.1101/2020.09.27.316174","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.09.27.316174","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/09/29/2020.09.27.316174.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/09/29/2020.09.27.316174.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076214110","display_name":"Xia Cao","orcid":"https://orcid.org/0000-0002-0453-9615","observed_orcids":["https://orcid.org/0000-0002-0453-9615"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xia Cao","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075271903","display_name":"Junki Maruyama","orcid":"https://orcid.org/0000-0003-0088-4793","observed_orcids":["https://orcid.org/0000-0003-0088-4793"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junki Maruyama","raw_affiliation_strings":["University of Texas Medical Branch, Department of Pathology, Galveston National Laboratory, Galveston, TX 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Department of Pathology, Galveston National Laboratory, Galveston, TX 77555","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102238909","display_name":"Heyue Zhou","orcid":"https://orcid.org/0000-0003-2456-1876","observed_orcids":["https://orcid.org/0000-0003-2456-1876"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Heyue Zhou","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026876956","display_name":"Lisa Kerwin","orcid":"https://orcid.org/0000-0002-0081-4931","observed_orcids":["https://orcid.org/0000-0002-0081-4931"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa Kerwin","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109451992","display_name":"Rachel A. Sattler","orcid":"https://orcid.org/0000-0001-6504-0191","observed_orcids":["https://orcid.org/0000-0001-6504-0191"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Sattler","raw_affiliation_strings":["University of Texas Medical Branch, Department of Pathology, Galveston National Laboratory, Galveston, TX 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Department of Pathology, Galveston National Laboratory, Galveston, TX 77555","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":null,"display_name":"John T. Manning","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John T. Manning","raw_affiliation_strings":["University of Texas Medical Branch, Department of Pathology, Galveston National Laboratory, Galveston, TX 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Department of Pathology, Galveston National Laboratory, Galveston, TX 77555","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058626363","display_name":"Sachi Johnson","orcid":"https://orcid.org/0000-0002-4318-9232","observed_orcids":["https://orcid.org/0000-0002-4318-9232"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sachi Johnson","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Susan Richards","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Richards","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yan Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yan Li","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065448742","display_name":"Weiqun Shen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiqun Shen","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011546651","display_name":"Benjamin Blair","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Blair","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014559643","display_name":"Na Du","orcid":"https://orcid.org/0009-0006-0805-1680","observed_orcids":["https://orcid.org/0009-0006-0805-1680"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Na Du","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055202877","display_name":"Kyndal Morais","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyndal Morais","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kate Lawrence","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate Lawrence","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045734819","display_name":"Lucy Lu","orcid":"https://orcid.org/0000-0002-6368-3721","observed_orcids":["https://orcid.org/0000-0002-6368-3721","https://orcid.org/0009-0005-7505-2555"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucy Lu","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028613478","display_name":"Chin-I Pai","orcid":"https://orcid.org/0000-0002-2517-6155","observed_orcids":["https://orcid.org/0000-0002-2517-6155"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chin-I Pai","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336695","display_name":"Donghui Li","orcid":"https://orcid.org/0000-0002-7542-0662","observed_orcids":["https://orcid.org/0000-0002-7542-0662"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donghui Li","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036344021","display_name":"Mark Brunswick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Brunswick","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101910781","display_name":"Yanliang Zhang","orcid":"https://orcid.org/0000-0002-0460-2995","observed_orcids":["https://orcid.org/0000-0002-0460-2995"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanliang Zhang","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015669503","display_name":"Henry Ji","orcid":"https://orcid.org/0009-0006-0234-7253","observed_orcids":["https://orcid.org/0009-0006-0234-7253"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Henry Ji","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028744430","display_name":"Slobodan Paessler","orcid":"https://orcid.org/0000-0002-2213-9551","observed_orcids":["https://orcid.org/0000-0002-2213-9551"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Slobodan Paessler","raw_affiliation_strings":["University of Texas Medical Branch, Department of Pathology, Galveston National Laboratory, Galveston, TX 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas Medical Branch, Department of Pathology, Galveston National Laboratory, Galveston, TX 77555","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019686908","display_name":"ROBERT DAY ALLEN","orcid":"https://orcid.org/0000-0001-9950-103X","observed_orcids":["https://orcid.org/0000-0001-9950-103X"]},"institutions":[{"id":"https://openalex.org/I4210102651","display_name":"Sorrento Therapeutics (United States)","ror":"https://ror.org/01bqy5z80","country_code":"US","type":"company","lineage":["https://openalex.org/I4210102651"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Allen","raw_affiliation_strings":["Sorrento Therapeutics, Inc., San Diego, CA 92121","Sorrento Therapeutics, Inc., San Diego, CA 922"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 92121","institution_ids":["https://openalex.org/I4210102651"]},{"raw_affiliation_string":"Sorrento Therapeutics, Inc., San Diego, CA 922","institution_ids":["https://openalex.org/I4210102651"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015669503","https://openalex.org/A5028744430"],"corresponding_institution_ids":["https://openalex.org/I4210102651","https://openalex.org/I55302922"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/neutralizing-antibodies","display_name":"neutralizing antibodies","score":0.9480000138282776},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.7799999713897705},{"id":"https://openalex.org/keywords/naive-antibody-library","display_name":"naive antibody library","score":0.7799999713897705},{"id":"https://openalex.org/keywords/syrian-golden-hamster-model","display_name":"Syrian golden hamster model","score":0.7879999876022339},{"id":"https://openalex.org/keywords/covid-19-treatment","display_name":"COVID-19 treatment","score":0.9440000057220459},{"id":"https://openalex.org/keywords/viral-load-reduction","display_name":"viral load reduction","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7525160312652588},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7220453023910522},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.6590747833251953},{"id":"https://openalex.org/C186268636","wikidata":"https://www.wikidata.org/wiki/Q896217","display_name":"Phage display","level":3,"score":0.6138486862182617},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.6000576615333557},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.5925740599632263},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.551655113697052},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5243159532546997},{"id":"https://openalex.org/C14086860","wikidata":"https://www.wikidata.org/wiki/Q337120","display_name":"Neutralization","level":3,"score":0.49400025606155396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4747379422187805},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.4360820949077606},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.41704726219177246},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.397153377532959},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34927889704704285},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3483548164367676},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3154156804084778},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.28556570410728455},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2557687759399414},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.19559139013290405},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.18571490049362183},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.16577225923538208},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12735092639923096},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2020.09.27.316174","doi":"https://doi.org/10.1101/2020.09.27.316174","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.09.27.316174","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/09/29/2020.09.27.316174.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2020.09.27.316174","doi":"https://doi.org/10.1101/2020.09.27.316174","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.09.27.316174","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/09/29/2020.09.27.316174.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3089067166.pdf","grobid_xml":"https://content.openalex.org/works/W3089067166.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1974901207","https://openalex.org/W2000040025","https://openalex.org/W2014171938","https://openalex.org/W2028352585","https://openalex.org/W2113391111","https://openalex.org/W2123781753","https://openalex.org/W2167384912","https://openalex.org/W2256756668","https://openalex.org/W2509039973","https://openalex.org/W2797213740","https://openalex.org/W3001897055","https://openalex.org/W3010698037","https://openalex.org/W3012831148","https://openalex.org/W3013348202","https://openalex.org/W3015647640","https://openalex.org/W3023349022","https://openalex.org/W3023698680","https://openalex.org/W3023992792","https://openalex.org/W3025744748","https://openalex.org/W3028205632","https://openalex.org/W3030146162","https://openalex.org/W3031830637","https://openalex.org/W3032255042","https://openalex.org/W3033828105","https://openalex.org/W3036386821","https://openalex.org/W3036733096","https://openalex.org/W3039066506","https://openalex.org/W3039901154","https://openalex.org/W3045281619","https://openalex.org/W3082102108","https://openalex.org/W3083773456","https://openalex.org/W3084109555","https://openalex.org/W3086741758","https://openalex.org/W3088521725","https://openalex.org/W6783274764"],"related_works":["https://openalex.org/W4295949456","https://openalex.org/W4319433688","https://openalex.org/W3028205632","https://openalex.org/W3095090886","https://openalex.org/W3131556104","https://openalex.org/W4200371305","https://openalex.org/W3108593684","https://openalex.org/W3105213311","https://openalex.org/W3192845544","https://openalex.org/W7171784253"],"abstract_inverted_index":{"ABSTRACT":[0],"SARS-CoV-2":[1,40],"neutralizing":[2,41],"antibodies":[3,90,130],"represent":[4],"an":[5,49],"important":[6],"component":[7],"of":[8,15,26,37,87,98,105,118,121,128,138],"the":[9,24,61,65,71,82,95,99,109],"ongoing":[10],"search":[11],"for":[12,77],"effective":[13],"treatment":[14],"and":[16,70,101,135],"protection":[17,93],"against":[18,48,94,133],"COVID-19.":[19,88],"We":[20],"report":[21],"here":[22],"on":[23],"use":[25,137],"a":[27,35,56,102,115],"na\u00efve":[28],"phage":[29],"display":[30],"antibody":[31],"library":[32],"to":[33,141],"identify":[34],"panel":[36],"fully":[38],"human":[39],"antibodies.":[42],"Following":[43],"functional":[44],"profiling":[45],"in":[46,78,81,108],"vitro":[47],"early":[50],"pandemic":[51,145],"isolate":[52,59],"as":[53,55,131],"well":[54],"recently":[57],"emerged":[58],"bearing":[60],"D614G":[62],"Spike":[63],"mutation,":[64],"clinical":[66],"candidate":[67],"antibody,":[68],"STI-1499,":[69],"affinity-engineered":[72],"variant,":[73],"STI-2020,":[74],"were":[75],"evaluated":[76],"vivo":[79],"efficacy":[80],"Syrian":[83],"golden":[84],"hamster":[85],"model":[86],"Both":[89],"demonstrated":[91],"potent":[92],"pathogenic":[96],"effects":[97],"disease":[100,146],"dose-dependent":[103],"reduction":[104],"virus":[106],"load":[107],"lungs,":[110],"reaching":[111],"undetectable":[112],"levels":[113],"following":[114],"single":[116],"dose":[117],"500":[119],"micrograms":[120],"STI-2020.":[122],"These":[123],"data":[124],"support":[125],"continued":[126],"development":[127],"these":[129],"therapeutics":[132],"COVID-19":[134],"future":[136],"this":[139],"approach":[140],"address":[142],"novel":[143],"emerging":[144],"threats.":[147]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-10-01T00:00:00"}
