{"id":"https://openalex.org/W3088616751","doi":"https://doi.org/10.1016/j.drudis.2020.09.017","title":"Pim kinase inhibitors in cancer: medicinal chemistry insights into their activity and selectivity","display_name":"Pim kinase inhibitors in cancer: medicinal chemistry insights into their activity and selectivity","publication_year":2020,"publication_date":"2020-09-21","ids":{"openalex":"https://openalex.org/W3088616751","doi":"https://doi.org/10.1016/j.drudis.2020.09.017","mag":"3088616751","pmid":"https://pubmed.ncbi.nlm.nih.gov/32971234"},"language":"en","primary_location":{"id":"doi:10.1016/j.drudis.2020.09.017","doi":"https://doi.org/10.1016/j.drudis.2020.09.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2020.09.017","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033340276","display_name":"Soraya Alnabulsi","orcid":"https://orcid.org/0000-0003-4805-8802","observed_orcids":["https://orcid.org/0000-0003-4805-8802"]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":true,"raw_author_name":"Soraya Alnabulsi","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan. Electronic address: smalnabulsi@just.edu.jo","Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan"],"raw_orcid":"https://orcid.org/0000-0003-4805-8802","affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan. Electronic address: smalnabulsi@just.edu.jo","institution_ids":["https://openalex.org/I156983542"]},{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan","institution_ids":["https://openalex.org/I156983542"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014474058","display_name":"Enas A. Al-Hurani","orcid":"https://orcid.org/0000-0002-1501-1971","observed_orcids":["https://orcid.org/0000-0002-1501-1971"]},"institutions":[{"id":"https://openalex.org/I156983542","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59","country_code":"JO","type":"education","lineage":["https://openalex.org/I156983542"]}],"countries":["JO"],"is_corresponding":false,"raw_author_name":"Enas A. Al-Hurani","raw_affiliation_strings":["Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, PO Box 3030, Irbid 22110, Jordan","institution_ids":["https://openalex.org/I156983542"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033340276"],"corresponding_institution_ids":["https://openalex.org/I156983542"],"apc_list":{"value":4250,"currency":"USD","value_usd":4250},"apc_paid":null,"fwci":0.2847,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.29296236,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"25","issue":"11","first_page":"2062","last_page":"2069"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.5224999785423279,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.20810000598430634,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pim-kinase-inhibitors","display_name":"PIM kinase inhibitors","score":0.968999981880188},{"id":"https://openalex.org/keywords/pim-1","display_name":"PIM-1","score":0.9290000200271606},{"id":"https://openalex.org/keywords/pim2","display_name":"PIM2","score":1.0},{"id":"https://openalex.org/keywords/pim3","display_name":"PIM3","score":1.0},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.5519999861717224},{"id":"https://openalex.org/keywords/drug-design","display_name":"drug design","score":0.5460000038146973},{"id":"https://openalex.org/keywords/kinase-inhibitor-selectivity","display_name":"kinase selectivity","score":0.7929999828338623},{"id":"https://openalex.org/keywords/hematological-cancer","display_name":"hematologic cancer","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/anticancer-drug-development","display_name":"anticancer drug development","score":0.640999972820282}],"concepts":[{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.7504400610923767},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5039133429527283},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4814531207084656},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4756859540939331},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43469682335853577},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3334934711456299},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3278019428253174},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32662415504455566},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09311583638191223}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1016/j.drudis.2020.09.017","doi":"https://doi.org/10.1016/j.drudis.2020.09.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.drudis.2020.09.017","pdf_url":null,"source":{"id":"https://openalex.org/S152068293","display_name":"Drug Discovery Today","issn_l":"1359-6446","issn":["1359-6446","1878-5832"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Discovery Today","raw_type":"journal-article"},{"id":"pmid:32971234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32971234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug discovery today","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9074000120162964,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322303","display_name":"Jordan University of Science and Technology","ror":"https://ror.org/03y8mtb59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1191502296","https://openalex.org/W1848609505","https://openalex.org/W1857478378","https://openalex.org/W1980609694","https://openalex.org/W1993523053","https://openalex.org/W1997238381","https://openalex.org/W2005940417","https://openalex.org/W2016384479","https://openalex.org/W2026256416","https://openalex.org/W2027274653","https://openalex.org/W2029968439","https://openalex.org/W2033341978","https://openalex.org/W2035634925","https://openalex.org/W2054942795","https://openalex.org/W2055540264","https://openalex.org/W2058448050","https://openalex.org/W2061562309","https://openalex.org/W2075586116","https://openalex.org/W2079410007","https://openalex.org/W2083351855","https://openalex.org/W2084882261","https://openalex.org/W2088552818","https://openalex.org/W2099825600","https://openalex.org/W2111803606","https://openalex.org/W2121323579","https://openalex.org/W2121573343","https://openalex.org/W2140697965","https://openalex.org/W2146827511","https://openalex.org/W2160066010","https://openalex.org/W2171218023","https://openalex.org/W2262454006","https://openalex.org/W2275959399","https://openalex.org/W2412295679","https://openalex.org/W2604334654","https://openalex.org/W2609016327","https://openalex.org/W2790323243","https://openalex.org/W2803557794","https://openalex.org/W2806210526","https://openalex.org/W2809023471","https://openalex.org/W2898600811","https://openalex.org/W2908994481","https://openalex.org/W2912589658","https://openalex.org/W2915173724","https://openalex.org/W2931990117","https://openalex.org/W2946759158","https://openalex.org/W2955497115","https://openalex.org/W3035503703","https://openalex.org/W4248625417","https://openalex.org/W6779978696"],"related_works":["https://openalex.org/W2042643638","https://openalex.org/W2786927509","https://openalex.org/W4220899499","https://openalex.org/W4402645134","https://openalex.org/W2326595915","https://openalex.org/W2115455525","https://openalex.org/W2129747161","https://openalex.org/W4389265089","https://openalex.org/W2156275265","https://openalex.org/W3031400838"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2020-10-01T00:00:00"}