{"id":"https://openalex.org/W3088476576","doi":"https://doi.org/10.1016/j.celrep.2020.107793","title":"Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities","display_name":"Metabolic Reprogramming of Pancreatic Cancer Mediated by CDK4/6 Inhibition Elicits Unique Vulnerabilities","publication_year":2020,"publication_date":"2020-07-01","ids":{"openalex":"https://openalex.org/W3088476576","doi":"https://doi.org/10.1016/j.celrep.2020.107793","mag":"3088476576"},"language":"en","primary_location":{"id":"doi:10.1016/j.celrep.2020.107793","doi":"https://doi.org/10.1016/j.celrep.2020.107793","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2020.107793","pdf_url":"http://www.cell.com/article/S2211124720307749/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.cell.com/article/S2211124720307749/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109920465","display_name":"Jorge Franco","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge Franco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013049956","display_name":"Uthra Balaji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uthra Balaji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077754260","display_name":"Elizaveta Freinkman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizaveta Freinkman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034535391","display_name":"Agnieszka Katarzyna Witkiewicz","orcid":"https://orcid.org/0000-0003-4538-1145","observed_orcids":["https://orcid.org/0000-0003-4538-1145"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Agnieszka K. Witkiewicz","raw_affiliation_strings":["Pathology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029801038","display_name":"Erik S. Knudsen","orcid":"https://orcid.org/0000-0002-5130-5969","observed_orcids":["https://orcid.org/0000-0002-5130-5969"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Erik S. Knudsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5029801038","https://openalex.org/A5034535391"],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":{"value":5200,"currency":"USD","value_usd":5200},"fwci":0.6025,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.67348408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":96},"biblio":{"volume":"32","issue":"1","first_page":"107793","last_page":"107793"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.3871999979019165,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.3246999979019165,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.13199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.9919999837875366},{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.8690000176429749},{"id":"https://openalex.org/keywords/metabolic-reprogramming","display_name":"metabolic reprogramming","score":0.9399999976158142},{"id":"https://openalex.org/keywords/rb-tumor-suppressor","display_name":"Rb tumor suppressor","score":0.9169999957084656},{"id":"https://openalex.org/keywords/mtor-activation","display_name":"mTOR activation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.671999990940094},{"id":"https://openalex.org/keywords/therapeutic-vulnerabilities","display_name":"therapeutic vulnerabilities","score":0.609000027179718},{"id":"https://openalex.org/keywords/cell-cycle-inhibition","display_name":"cell cycle inhibition","score":0.7649999856948853}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6719641089439392},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.6037369966506958},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5519098043441772},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5132136344909668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46038177609443665},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.45953038334846497},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4538109302520752},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.360507071018219},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.33802908658981323},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2661590576171875},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.26170778274536133},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13745036721229553}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.celrep.2020.107793","doi":"https://doi.org/10.1016/j.celrep.2020.107793","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2020.107793","pdf_url":"http://www.cell.com/article/S2211124720307749/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.celrep.2020.107793","doi":"https://doi.org/10.1016/j.celrep.2020.107793","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.celrep.2020.107793","pdf_url":"http://www.cell.com/article/S2211124720307749/pdf","source":{"id":"https://openalex.org/S169236886","display_name":"Cell Reports","issn_l":"2211-1247","issn":["2211-1247","2639-1856"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5386917159","display_name":"Common Genetically Altered Pathways as Targets for Therapy in Pancreatic Cancer","funder_award_id":"R01CA211878","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W3088476576.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2928988549","https://openalex.org/W2914373477","https://openalex.org/W3127891467","https://openalex.org/W2118874870","https://openalex.org/W7162696032","https://openalex.org/W3136629222","https://openalex.org/W3199465727","https://openalex.org/W4230119701","https://openalex.org/W1984250518","https://openalex.org/W2921035885"],"abstract_inverted_index":{"(Cell":[0],"Reports":[1],"14,":[2],"979\u2013990;":[3],"February":[4],"9,":[5],"2016)":[6],"In":[7],"the":[8,21,32,77,91],"originally":[9],"published":[10],"version":[11,30],"of":[12,20,31,45,65,79,107],"this":[13,41,105],"article,":[14],"there":[15],"was":[16],"an":[17],"inadvertent":[18],"duplication":[19],"single":[22],"agent":[23],"controls":[24],"in":[25,81],"Figure":[26],"1E.":[27],"A":[28],"corrected":[29],"figure":[33],"panel":[34],"is":[35],"provided":[36],"here.":[37],"The":[38],"authors":[39],"regret":[40],"error.":[42],"Metabolic":[43],"Reprogramming":[44],"Pancreatic":[46],"Cancer":[47],"Mediated":[48],"by":[49],"CDK4/6":[50,80],"Inhibition":[51],"Elicits":[52],"Unique":[53],"VulnerabilitiesFranco":[54],"et":[55,73],"al.Cell":[56],"ReportsJanuary":[57],"21,":[58],"2016In":[59],"BriefCDK4/6":[60],"inhibitors":[61,64],"are":[62,69],"potent":[63],"cell":[66],"cycle":[67],"that":[68,76],"employed":[70],"clinically.":[71],"Franco":[72],"al.":[74],"report":[75],"inhibition":[78],"pancreatic":[82],"cancer":[83],"models":[84],"reprograms":[85],"metabolism":[86],"through":[87],"a":[88],"pathway":[89],"involving":[90],"RB":[92],"tumor":[93],"suppressor":[94],"and":[95,110],"MTOR":[96],"activation.":[97],"These":[98],"findings":[99],"demonstrate":[100],"specific":[101],"metabolic":[102],"adaptations":[103],"to":[104],"class":[106],"therapeutic":[108,115],"agents":[109],"delineate":[111],"vulnerabilities":[112],"for":[113],"future":[114],"intervention.":[116],"Full-Text":[117],"PDF":[118],"Open":[119],"Access":[120]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2020-10-01T00:00:00"}