{"id":"https://openalex.org/W3088050992","doi":"https://doi.org/10.1002/nau.24527","title":"Overactive bladder medication: Persistence, drug switching, and reinitiation","display_name":"Overactive bladder medication: Persistence, drug switching, and reinitiation","publication_year":2020,"publication_date":"2020-09-28","ids":{"openalex":"https://openalex.org/W3088050992","doi":"https://doi.org/10.1002/nau.24527","mag":"3088050992","pmid":"https://pubmed.ncbi.nlm.nih.gov/32985716"},"language":"en","primary_location":{"id":"doi:10.1002/nau.24527","doi":"https://doi.org/10.1002/nau.24527","is_oa":false,"landing_page_url":"https://doi.org/10.1002/nau.24527","pdf_url":null,"source":{"id":"https://openalex.org/S22797964","display_name":"Neurourology and Urodynamics","issn_l":"0733-2467","issn":["0733-2467","1520-6777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurourology and Urodynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066002406","display_name":"Takeshi Soda","orcid":"https://orcid.org/0000-0002-9504-1539","observed_orcids":["https://orcid.org/0000-0002-9504-1539"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Takeshi Soda","raw_affiliation_strings":["Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"],"raw_orcid":"https://orcid.org/0000-0002-9504-1539","affiliations":[{"raw_affiliation_string":"Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059168662","display_name":"Yu Tashiro","orcid":"https://orcid.org/0000-0002-4417-8009","observed_orcids":["https://orcid.org/0000-0002-4417-8009"]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yu Tashiro","raw_affiliation_strings":["Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuhei Koike","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuhei Koike","raw_affiliation_strings":["Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011744240","display_name":"Ryosuke Ikeuchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Ikeuchi","raw_affiliation_strings":["Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210161392"]}]},{"author_position":"last","author":{"id":null,"display_name":"Takuya Okada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210161392","display_name":"Kitano Hospital","ror":"https://ror.org/05rsbck92","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161392"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takuya Okada","raw_affiliation_strings":["Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Tazuke Kofukai Medical Research Institute, Kitano Hospital, Osaka, Japan","institution_ids":["https://openalex.org/I4210161392"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5066002406"],"corresponding_institution_ids":["https://openalex.org/I4210161392"],"apc_list":{"value":4100,"currency":"USD","value_usd":4100},"apc_paid":null,"fwci":4.4379,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.95429384,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"39","issue":"8","first_page":"2527","last_page":"2534"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11620","display_name":"Medication Adherence and Compliance","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2714","display_name":"Family Practice"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/overactive-bladder","display_name":"overactive bladder","score":1.0},{"id":"https://openalex.org/keywords/medication-persistence","display_name":"treatment persistence","score":0.7910000085830688},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/drug-switching","display_name":"drug switching","score":0.9010000228881836},{"id":"https://openalex.org/keywords/antimuscarinic-agents","display_name":"antimuscarinic agents","score":0.8519999980926514},{"id":"https://openalex.org/keywords/beta3-adrenergic-agonists","display_name":"beta3-adrenergic agonists","score":0.8650000095367432},{"id":"https://openalex.org/keywords/mirabegron","display_name":"mirabegron","score":1.0},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.4690000116825104}],"concepts":[{"id":"https://openalex.org/C2778164427","wikidata":"https://www.wikidata.org/wiki/Q3702534","display_name":"Mirabegron","level":4,"score":0.9460415840148926},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.919959545135498},{"id":"https://openalex.org/C2778941218","wikidata":"https://www.wikidata.org/wiki/Q331231","display_name":"Overactive bladder","level":3,"score":0.8686872720718384},{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.8133460283279419},{"id":"https://openalex.org/C2781009140","wikidata":"https://www.wikidata.org/wiki/Q7170389","display_name":"Persistence (discontinuity)","level":2,"score":0.7479245662689209},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5951980352401733},{"id":"https://openalex.org/C2777844464","wikidata":"https://www.wikidata.org/wiki/Q1060922","display_name":"Oxybutynin","level":4,"score":0.5356791615486145},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.48622360825538635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41438591480255127},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.05798044800758362},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000083","descriptor_name":"Acetanilides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017060","descriptor_name":"Patient Satisfaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D053201","descriptor_name":"Urinary Bladder, Overactive","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055118","descriptor_name":"Medication Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057915","descriptor_name":"Drug Substitution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064804","descriptor_name":"Urological Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/nau.24527","doi":"https://doi.org/10.1002/nau.24527","is_oa":false,"landing_page_url":"https://doi.org/10.1002/nau.24527","pdf_url":null,"source":{"id":"https://openalex.org/S22797964","display_name":"Neurourology and Urodynamics","issn_l":"0733-2467","issn":["0733-2467","1520-6777"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurourology and Urodynamics","raw_type":"journal-article"},{"id":"pmid:32985716","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32985716","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurourology and urodynamics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1677663860","https://openalex.org/W1987464104","https://openalex.org/W2037706235","https://openalex.org/W2071052332","https://openalex.org/W2089648313","https://openalex.org/W2094737423","https://openalex.org/W2108691316","https://openalex.org/W2109238714","https://openalex.org/W2121960517","https://openalex.org/W2133603145","https://openalex.org/W2144564072","https://openalex.org/W2145888765","https://openalex.org/W2233761356","https://openalex.org/W2332614769","https://openalex.org/W2572362476","https://openalex.org/W2587662747","https://openalex.org/W2605284431","https://openalex.org/W2754529517","https://openalex.org/W2755274148","https://openalex.org/W2797096651","https://openalex.org/W2804178578","https://openalex.org/W2809303569","https://openalex.org/W2886986602","https://openalex.org/W2890479810","https://openalex.org/W2894990205","https://openalex.org/W2925701910","https://openalex.org/W4213351464","https://openalex.org/W4242985516"],"related_works":["https://openalex.org/W3162718727","https://openalex.org/W4392346545","https://openalex.org/W2981105730","https://openalex.org/W2754529517","https://openalex.org/W4382919235","https://openalex.org/W2939357368","https://openalex.org/W4414078910","https://openalex.org/W6980487183","https://openalex.org/W2904000124","https://openalex.org/W2984670170"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"assess":[2],"real-world":[3],"treatment":[4,17,110,214,247],"profiles,":[5],"including":[6],"the":[7,81,87,130,169,173,177,191,199,207],"time":[8,83],"to":[9,80,84,108,226,244],"and":[10,19,65,86,98,141,154,172,221],"reasons":[11],"for":[12,28,194,216],"discontinuation":[13,85],"or":[14,26,52,132],"drug":[15],"switching,":[16],"reinitiation,":[18],"postdiscontinuation":[20],"follow-up":[21,185],"in":[22,249],"patients":[23,162,204,217],"receiving":[24],"antimuscarinics":[25,125],"\u00df3-agonists":[27],"overactive":[29],"bladder":[30],"(OAB)":[31],"through":[32],"a":[33,183],"retrospective":[34],"chart":[35],"review.":[36],"METHODS:":[37],"We":[38],"retrospectively":[39],"reviewed":[40],"medical":[41],"charts":[42],"of":[43,143,160,176,186,201],"777":[44],"patients,":[45,95,97],"aged":[46],"\u226518":[47],"years,":[48],"who":[49,163,223],"underwent":[50],"antimuscarinic":[51],"\u00df3-agonist":[53],"therapy":[54,70,209],"at":[55,69,90,182],"our":[56],"hospital.":[57],"Data":[58],"on":[59,239],"patient's":[60],"age,":[61],"sex,":[62],"chief":[63],"complaint,":[64],"OAB":[66,113,178,195,250],"symptom":[67],"score":[68],"initiation":[71],"were":[72,105,145],"collected.":[73],"Treatment":[74,115],"persistence":[75,88,111,116,150,192],"was":[76,119,180],"assessed":[77],"with":[78,100,112,117,124,148,168,198,218],"respect":[79],"median":[82,184],"rate":[89,175],"12":[91],"months.":[92,188],"RESULTS:":[93],"Older":[94],"male":[96],"those":[99,222],"more":[101,106],"severe":[102],"urgency":[103,139],"symptoms":[104,220],"likely":[107],"show":[109],"medications.":[114],"mirabegron":[118,144],"significantly":[120],"longer":[121],"than":[122],"that":[123,138,235],"when":[126],"administered":[127],"as":[128],"either":[129],"first-":[131],"second-line":[133],"medication.":[134],"Multivariate":[135],"analyses":[136],"showed":[137],"severity":[140],"use":[142],"independently":[146],"associated":[147],"better":[149],"(p":[151],"=":[152,156],".026":[153],"p":[155],".018,":[157],"respectively).":[158],"Out":[159],"583":[161],"discontinued":[164,206],"medication,":[165],"344":[166],"continued":[167],"visit":[170],"schedule,":[171],"reinitiation":[174],"medication":[179,208,227],"19%":[181],"24":[187],"CONCLUSION:":[189],"Although":[190],"rates":[193],"medications":[196],"improved":[197],"introduction":[200],"mirabegron,":[202],"most":[203],"still":[205,229],"within":[210],"1":[211],"year.":[212],"The":[213],"strategies":[215],"mild":[219],"are":[224],"resistant":[225],"can":[228],"be":[230,242],"improved.":[231],"Tailored":[232],"individualized":[233],"treatments":[234],"avoid":[236],"excessive":[237],"reliance":[238],"pharmacotherapy":[240],"would":[241],"key":[243],"further":[245],"improve":[246],"outcomes":[248],"patients.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2020-10-01T00:00:00"}
