{"id":"https://openalex.org/W3087973071","doi":"https://doi.org/10.1371/journal.pone.0238819","title":"Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces","display_name":"Activation and degranulation of CAR-T cells using engineered antigen-presenting cell surfaces","publication_year":2020,"publication_date":"2020-09-25","ids":{"openalex":"https://openalex.org/W3087973071","doi":"https://doi.org/10.1371/journal.pone.0238819","mag":"3087973071","pmid":"https://pubmed.ncbi.nlm.nih.gov/32976541","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7518621"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0238819","doi":"https://doi.org/10.1371/journal.pone.0238819","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0238819","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0238819&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0238819&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076212770","display_name":"Qassim Dirar","orcid":"https://orcid.org/0000-0002-4258-4695","observed_orcids":["https://orcid.org/0000-0002-4258-4695"]},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qassim Dirar","raw_affiliation_strings":["FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America","Nanoengineering Department, Joint School of Nanoscience and Nanoengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America","institution_ids":["https://openalex.org/I35777872"]},{"raw_affiliation_string":"Nanoengineering Department, Joint School of Nanoscience and Nanoengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America","institution_ids":["https://openalex.org/I35777872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078772264","display_name":"Teal A. Russell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Teal Russell","raw_affiliation_strings":["FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America","institution_ids":["https://openalex.org/I35777872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075010539","display_name":"Lumei Liu","orcid":"https://orcid.org/0000-0001-9849-6881","observed_orcids":["https://orcid.org/0000-0001-9849-6881","https://orcid.org/0000-0002-9014-757X"]},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lumei Liu","raw_affiliation_strings":["FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America","institution_ids":["https://openalex.org/I35777872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040285533","display_name":"Sarah Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah Ahn","raw_affiliation_strings":["Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023649972","display_name":"Gianpietro Dotti","orcid":"https://orcid.org/0000-0002-2639-8526","observed_orcids":["https://orcid.org/0000-0002-2639-8526"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I4390039329","display_name":"UNC Lineberger Comprehensive Cancer Center","ror":"https://ror.org/043ehm030","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gianpietro Dotti","raw_affiliation_strings":["Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Lineberger Comprehensive Cancer Center, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America","institution_ids":["https://openalex.org/I114027177","https://openalex.org/I4390039329"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023215980","display_name":"Shyam Aravamudhan","orcid":"https://orcid.org/0000-0001-9968-7188","observed_orcids":["https://orcid.org/0000-0001-9968-7188"]},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shyam Aravamudhan","raw_affiliation_strings":["Nanoengineering Department, Joint School of Nanoscience and Nanoengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nanoengineering Department, Joint School of Nanoscience and Nanoengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America","institution_ids":["https://openalex.org/I35777872"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015632287","display_name":"Laura Conforti","orcid":"https://orcid.org/0000-0002-3761-7595","observed_orcids":["https://orcid.org/0000-0002-3761-7595"]},"institutions":[{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Laura Conforti","raw_affiliation_strings":["Division of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065656585","display_name":"Yeoheung Yun","orcid":"https://orcid.org/0000-0003-2288-6052","observed_orcids":["https://orcid.org/0000-0003-2288-6052"]},"institutions":[{"id":"https://openalex.org/I35777872","display_name":"North Carolina Agricultural and Technical State University","ror":"https://ror.org/02aze4h65","country_code":"US","type":"education","lineage":["https://openalex.org/I35777872"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yeoheung Yun","raw_affiliation_strings":["FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-2288-6052","affiliations":[{"raw_affiliation_string":"FIT BEST Laboratory, Department of Chemical, Biological, and Bioengineering, North Carolina Agricultural and Technical State University, Greensboro, North Carolina, United States of America","institution_ids":["https://openalex.org/I35777872"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5065656585"],"corresponding_institution_ids":["https://openalex.org/I35777872"],"apc_list":{"value":1695,"currency":"USD","value_usd":1695},"apc_paid":{"value":1695,"currency":"USD","value_usd":1695},"fwci":0.4417,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.61776304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"15","issue":"9","first_page":"e0238819","last_page":"e0238819"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chimeric-antigen-receptor-t-cells","display_name":"chimeric antigen receptor T cells","score":0.9369999766349792},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/t-cell-degranulation","display_name":"T cell degranulation","score":0.902999997138977},{"id":"https://openalex.org/keywords/anti-idiotypic-antibodies","display_name":"anti-idiotypic antibodies","score":0.8809999823570251},{"id":"https://openalex.org/keywords/microcontact-printing","display_name":"microcontact printing","score":0.9010000228881836},{"id":"https://openalex.org/keywords/cd19-car","display_name":"CD19 CAR","score":0.7400000095367432},{"id":"https://openalex.org/keywords/lamp1","display_name":"LAMP1","score":0.9890000224113464},{"id":"https://openalex.org/keywords/intracellular-calcium-flux","display_name":"intracellular calcium flux","score":0.9470000267028809},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/adoptive-cell-transfer","display_name":"adoptive cell transfer","score":0.7820000052452087},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.7206726670265198},{"id":"https://openalex.org/C49802076","wikidata":"https://www.wikidata.org/wiki/Q5251810","display_name":"Degranulation","level":3,"score":0.7173840403556824},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5758682489395142},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5737802982330322},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5667572617530823},{"id":"https://openalex.org/C67662055","wikidata":"https://www.wikidata.org/wiki/Q1047791","display_name":"Antigen-presenting cell","level":4,"score":0.5650025010108948},{"id":"https://openalex.org/C9756297","wikidata":"https://www.wikidata.org/wiki/Q126223","display_name":"Immunological synapse","level":5,"score":0.5328261256217957},{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.5031024813652039},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.44547346234321594},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.43548816442489624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4318172335624695},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3978191614151001},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.31747567653656006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2812068462371826},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21722206473350525},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21263602375984192},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.20780721306800842},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15766480565071106},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07097920775413513},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000938","descriptor_name":"Antigen-Presenting Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D018941","descriptor_name":"Antigens, CD19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019264","descriptor_name":"Adoptive Transfer","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0238819","doi":"https://doi.org/10.1371/journal.pone.0238819","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0238819","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0238819&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7518621","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7518621","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:32976541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32976541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:6q182v193","doi":null,"is_oa":false,"landing_page_url":"https://doi.org/10.17615/xr2c-1d03","pdf_url":null,"source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 15(44083)","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:6b80e12b69b74198a52290865f893f2b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6b80e12b69b74198a52290865f893f2b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 15, Iss 9, p e0238819 (2020)","raw_type":"article"},{"id":"doi:10.17615/xr2c-1d03","doi":"https://doi.org/10.17615/xr2c-1d03","is_oa":true,"landing_page_url":"https://doi.org/10.17615/xr2c-1d03","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0238819","doi":"https://doi.org/10.1371/journal.pone.0238819","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0238819","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0238819&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1332513478","display_name":"Studying Interface Behavior of Blood and Degradable Magnesium Stent","funder_award_id":"SC3GM113728","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3824688650","display_name":null,"funder_award_id":"1542174","funder_id":"https://openalex.org/F4320337392","funder_display_name":"Division of Electrical, Communications and Cyber Systems"},{"id":"https://openalex.org/G5852687768","display_name":"NNCI: Southeastern Nanotechnology Infrastructure Corridor (SENIC)","funder_award_id":"1542174","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5927359219","display_name":null,"funder_award_id":"ECCS 1542174","funder_id":"https://openalex.org/F4320337392","funder_display_name":"Division of Electrical, Communications and Cyber Systems"},{"id":"https://openalex.org/G6836202907","display_name":null,"funder_award_id":"74386","funder_id":"https://openalex.org/F4320338281","funder_display_name":"Army Research Office"},{"id":"https://openalex.org/G823303752","display_name":"EAGER:   Microfluidic-based device to transform the T cell manufacturing process for adoptive T cell therapy","funder_award_id":"1649243","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320317078","display_name":"Joint School of Nanoscience and Nanoengineering","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337392","display_name":"Division of Electrical, Communications and Cyber Systems","ror":"https://ror.org/01krpsy48"},{"id":"https://openalex.org/F4320338281","display_name":"Army Research Office","ror":"https://ror.org/05epdh915"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3087973071.pdf","grobid_xml":"https://content.openalex.org/works/W3087973071.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1562441478","https://openalex.org/W1753012612","https://openalex.org/W1841423094","https://openalex.org/W1900090349","https://openalex.org/W1924002940","https://openalex.org/W1978879640","https://openalex.org/W1982795546","https://openalex.org/W2005186358","https://openalex.org/W2015155629","https://openalex.org/W2021278812","https://openalex.org/W2022873157","https://openalex.org/W2034768511","https://openalex.org/W2039879202","https://openalex.org/W2040914515","https://openalex.org/W2061842603","https://openalex.org/W2064510700","https://openalex.org/W2076171916","https://openalex.org/W2080529573","https://openalex.org/W2096234619","https://openalex.org/W2124221877","https://openalex.org/W2125681247","https://openalex.org/W2138259609","https://openalex.org/W2145473645","https://openalex.org/W2147064595","https://openalex.org/W2152059298","https://openalex.org/W2330978427","https://openalex.org/W2626197392","https://openalex.org/W2779236169","https://openalex.org/W2785898023","https://openalex.org/W2787301955","https://openalex.org/W2787621143","https://openalex.org/W2793887515","https://openalex.org/W2919702688"],"related_works":["https://openalex.org/W2928724558","https://openalex.org/W4307234997","https://openalex.org/W4416479622","https://openalex.org/W2999088593","https://openalex.org/W7213494761","https://openalex.org/W2999246742","https://openalex.org/W2793887515","https://openalex.org/W7117983996","https://openalex.org/W2791398286","https://openalex.org/W3212191128"],"abstract_inverted_index":{"Adoptive":[0],"cell":[1,16,24,54,57,104,151,183],"transfer":[2],"of":[3,22,48,60,63,74,86,90,114,131,141,189],"Chimeric":[4],"Antigen":[5],"Receptor":[6],"(CAR)-T":[7],"cells":[8,30,51,76,80,94,100,133,145,161,174,199],"showed":[9],"promising":[10],"results":[11],"in":[12,193,196,200],"patients":[13],"with":[14,26,77,148],"B":[15],"malignancies.":[17],"However,":[18],"the":[19,27,44,72,102,112,115,120,132,149,190],"detailed":[20],"mechanism":[21],"CAR-T":[23,50,75,144,198],"interaction":[25,73],"target":[28,78],"tumor":[29,79],"is":[31],"still":[32],"not":[33],"well":[34],"understood.":[35],"This":[36],"work":[37],"provides":[38],"a":[39,186,201],"systematic":[40],"method":[41],"for":[42],"analyzing":[43],"activation":[45,87,164],"and":[46,88,98,108,119,129,143,159,175],"degranulation":[47,89,170],"second-generation":[49],"utilizing":[52],"antigen-presenting":[53,103,150,182],"surfaces.":[55],"Antigen-presenting":[56],"surfaces":[58,105,184],"composed":[59],"circular":[61],"micropatterns":[62],"CAR-specific":[64],"anti-idiotype":[65],"antibodies":[66],"have":[67,162,168],"been":[68],"developed":[69],"to":[70],"mimic":[71],"using":[81],"micro-contact":[82],"printing.":[83],"The":[84,127,137,178],"levels":[85,171],"fixed":[91],"non-transduced":[92],"T":[93],"(NT),":[95],"CD19.CAR-T":[96,160,173],"cells,":[97],"GD2.CAR-T":[99,176],"on":[101],"were":[106,134],"quantified":[107],"compared":[109],"by":[110],"measuring":[111],"intensity":[113],"CD3\u03b6":[116],"chain":[117],"phosphorylation":[118],"Lysosome-Associated":[121],"Membrane":[122],"Protein":[123],"1":[124],"(LAMP-1),":[125],"respectively.":[126],"size":[128],"morphology":[130],"also":[135],"measured.":[136],"intracellular":[138],"Ca2+":[139],"flux":[140],"NT":[142,158,167],"upon":[146],"engagement":[147],"surface":[152],"was":[153],"reported.":[154],"Results":[155],"suggest":[156],"that":[157,181],"comparable":[163],"levels,":[165],"while":[166],"higher":[169],"than":[172],"cells.":[177],"findings":[179],"show":[180],"allow":[185],"quantitative":[187],"analysis":[188],"molecules":[191],"involved":[192],"synapse":[194],"formation":[195],"different":[197],"systematic,":[202],"reproducible":[203],"manner.":[204]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-10-01T00:00:00"}
