{"id":"https://openalex.org/W3087945263","doi":"https://doi.org/10.1002/pat.5090","title":"Synthesis and characterization of folic acid\u2010modified carboxymethyl chitosan\u2010ursolic acid targeted nano\u2010drug carrier for the delivery of ursolic acid and 10\u2010hydroxycamptothecin","display_name":"Synthesis and characterization of folic acid\u2010modified carboxymethyl chitosan\u2010ursolic acid targeted nano\u2010drug carrier for the delivery of ursolic acid and 10\u2010hydroxycamptothecin","publication_year":2020,"publication_date":"2020-09-17","ids":{"openalex":"https://openalex.org/W3087945263","doi":"https://doi.org/10.1002/pat.5090","mag":"3087945263"},"language":"en","primary_location":{"id":"doi:10.1002/pat.5090","doi":"https://doi.org/10.1002/pat.5090","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pat.5090","pdf_url":null,"source":{"id":"https://openalex.org/S40708307","display_name":"Polymers for Advanced Technologies","issn_l":"1042-7147","issn":["1042-7147","1099-1581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers for Advanced Technologies","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109545129","display_name":"Fanchen Jing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fanchen Jing","raw_affiliation_strings":["Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009435616","display_name":"Guiliang Li","orcid":"https://orcid.org/0000-0002-4570-2044","observed_orcids":["https://orcid.org/0000-0002-4570-2044"]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guiliang Li","raw_affiliation_strings":["Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038573440","display_name":"Yingsa Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yingsa Wang","raw_affiliation_strings":["Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000251823","display_name":"Shangbin Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shangbin Zhu","raw_affiliation_strings":["Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101595845","display_name":"Rundong Liu","orcid":"https://orcid.org/0000-0002-0558-029X","observed_orcids":["https://orcid.org/0000-0002-0558-029X"]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rundong Liu","raw_affiliation_strings":["Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101799038","display_name":"Jing He","orcid":"https://orcid.org/0000-0003-2486-6143","observed_orcids":["https://orcid.org/0000-0003-2486-6143"]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing He","raw_affiliation_strings":["Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China"],"raw_orcid":"https://orcid.org/0000-0003-2486-6143","affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China","institution_ids":["https://openalex.org/I31683504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023979600","display_name":"Jiandu Lei","orcid":"https://orcid.org/0000-0002-1432-0588","observed_orcids":["https://orcid.org/0000-0002-1432-0588","https://orcid.org/0000-0002-3297-2774","https://orcid.org/0000-0002-4303-9285"]},"institutions":[{"id":"https://openalex.org/I31683504","display_name":"Beijing Forestry University","ror":"https://ror.org/04xv2pc41","country_code":"CN","type":"education","lineage":["https://openalex.org/I1327237609","https://openalex.org/I31683504","https://openalex.org/I4210127390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiandu Lei","raw_affiliation_strings":["Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University  Beijing China","institution_ids":["https://openalex.org/I31683504"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101799038"],"corresponding_institution_ids":["https://openalex.org/I31683504"],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":0.7153,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.58676535,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"32","issue":"1","first_page":"343","last_page":"354"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.08449999988079071,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carboxymethyl-chitosan","display_name":"carboxymethyl chitosan","score":0.9350000023841858},{"id":"https://openalex.org/keywords/ursolic-acid","display_name":"ursolic acid","score":0.9860000014305115},{"id":"https://openalex.org/keywords/10-hydroxycamptothecin","display_name":"10-hydroxycamptothecin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.8690000176429749},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.6909999847412109},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.5180000066757202},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.6949999928474426},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.7990000247955322},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.7200000286102295},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.49799999594688416},{"id":"https://openalex.org/keywords/drug-loading-efficiency","display_name":"drug loading efficiency","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C2779513101","wikidata":"https://www.wikidata.org/wiki/Q416260","display_name":"Ursolic acid","level":2,"score":0.8954720497131348},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7298789024353027},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6901935338973999},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5845810770988464},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.5086315870285034},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49977874755859375},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.47447827458381653},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4379885196685791},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.4184374213218689},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3558776378631592},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.29283106327056885},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2631551921367645},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16677701473236084},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.1634598970413208},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1634155809879303},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.15047237277030945},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10875946283340454},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.07820352911949158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.044620364904403687},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.041252344846725464}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/pat.5090","doi":"https://doi.org/10.1002/pat.5090","is_oa":false,"landing_page_url":"https://doi.org/10.1002/pat.5090","pdf_url":null,"source":{"id":"https://openalex.org/S40708307","display_name":"Polymers for Advanced Technologies","issn_l":"1042-7147","issn":["1042-7147","1099-1581"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers for Advanced Technologies","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6141327019","display_name":"\u57fa\u4e8e\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\u6750\u6599\u7684\u8d85\u5927\u5b54\u5fae\u7403\u8868\u9762\u79bb\u5b50\u5370\u8ff9\u805a\u5408\u7269\u5236\u5907\u53ca\u6027\u80fd\u7814\u7a76","funder_award_id":"21576029","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1993046616","https://openalex.org/W2008644522","https://openalex.org/W2013765163","https://openalex.org/W2015600927","https://openalex.org/W2019207861","https://openalex.org/W2089931539","https://openalex.org/W2107705582","https://openalex.org/W2153484092","https://openalex.org/W2177205490","https://openalex.org/W2181115948","https://openalex.org/W2193596268","https://openalex.org/W2233813090","https://openalex.org/W2308380512","https://openalex.org/W2344233709","https://openalex.org/W2413359062","https://openalex.org/W2485088629","https://openalex.org/W2512875526","https://openalex.org/W2565205808","https://openalex.org/W2613089336","https://openalex.org/W2621669272","https://openalex.org/W2738220000","https://openalex.org/W2741469033","https://openalex.org/W2750815580","https://openalex.org/W2772903769","https://openalex.org/W2775509768","https://openalex.org/W2790073220","https://openalex.org/W2796781998","https://openalex.org/W2803010851","https://openalex.org/W2805562821","https://openalex.org/W2884304605","https://openalex.org/W2902216560","https://openalex.org/W2911297145","https://openalex.org/W2941927780","https://openalex.org/W2951461777","https://openalex.org/W3011824585","https://openalex.org/W3014271898"],"related_works":["https://openalex.org/W2030739147","https://openalex.org/W2378093497","https://openalex.org/W2385646201","https://openalex.org/W2805562821","https://openalex.org/W2077306877","https://openalex.org/W4280543331","https://openalex.org/W4318052129","https://openalex.org/W2569643693","https://openalex.org/W7117571183","https://openalex.org/W2007380072"],"abstract_inverted_index":{"Carboxymethyl":[0],"chitosan":[1],"(CMCS),":[2],"as":[3,128],"a":[4,15,23,57,113,129],"water\u2010soluble,":[5],"biocompatible,":[6],"and":[7,37,68,85,104,135],"biodegradable":[8],"polymer,":[9],"is":[10],"an":[11],"excellent":[12],"carrier":[13,29,41,130],"for":[14,131],"sustained":[16,83],"drug":[17,45,61,72,90],"delivery":[18,126],"system.":[19],"In":[20],"this":[21],"study,":[22],"amphiphilic":[24],"carboxymethyl":[25],"chitosan\u2010ursolic":[26],"acid":[27,33,66,133],"nano\u2010drug":[28,40],"modified":[30],"by":[31],"folic":[32],"(FPCU)":[34],"were":[35,47],"prepared,":[36],"then":[38],"the":[39,79,89,110],"wrapped":[42],"another":[43],"anticancer":[44],"10\u2010hydroxycamptothecin":[46,69,136],"self\u2010assembled":[48],"into":[49],"nanoparticles":[50,80,111],"(FPCU/HCPT":[51],"NPs).":[52],"The":[53,71,124],"FPCU/HCPT":[54],"NPs":[55],"had":[56],"suitable":[58],"size,":[59],"high":[60,114],"loading":[62],"efficiency":[63,116],"of":[64],"ursolic":[65,132],"(6.4%)":[67],"(14.1%).":[70],"release":[73,91],"study":[74,107],"in":[75,102,105,142],"vitro":[76,103],"indicated":[77],"that":[78,109],"have":[81],"obviously":[82],"effect":[84],"pH":[86,96,100],"sensitive":[87],"behaviors,":[88],"amount":[92],"was":[93],"higher":[94],"at":[95,99],"5.5":[97],"than":[98],"7.4.":[101],"vivo":[106],"showed":[108],"displayed":[112],"antitumor":[115],"to":[117],"tumor":[118],"cells":[119],"compared":[120],"with":[121],"free":[122],"drug.":[123],"nano":[125],"system":[127],"(UA)":[134],"(HCPT)":[137],"has":[138],"good":[139],"application":[140],"prospects":[141],"cancer":[143],"treatment.":[144]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2}],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2020-10-01T00:00:00"}
