{"id":"https://openalex.org/W3087701609","doi":"https://doi.org/10.1097/mbp.0000000000000476","title":"Potential hypotensive effects of Umezu polyphenols: a 14-week community-based, double-masked and placebo-controlled trial","display_name":"Potential hypotensive effects of Umezu polyphenols: a 14-week community-based, double-masked and placebo-controlled trial","publication_year":2020,"publication_date":"2020-09-15","ids":{"openalex":"https://openalex.org/W3087701609","doi":"https://doi.org/10.1097/mbp.0000000000000476","mag":"3087701609","pmid":"https://pubmed.ncbi.nlm.nih.gov/32947390"},"language":"en","primary_location":{"id":"doi:10.1097/mbp.0000000000000476","doi":"https://doi.org/10.1097/mbp.0000000000000476","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mbp.0000000000000476","pdf_url":null,"source":{"id":"https://openalex.org/S39823226","display_name":"Blood Pressure Monitoring","issn_l":"1359-5237","issn":["1359-5237","1473-5725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Pressure Monitoring","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015672103","display_name":"Shigeki Takemura","orcid":"https://orcid.org/0000-0002-2810-4077","observed_orcids":["https://orcid.org/0000-0002-2810-4077"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Shigeki Takemura","raw_affiliation_strings":["Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068510949","display_name":"Kouichi Yoshimasu","orcid":"https://orcid.org/0000-0002-5638-183X","observed_orcids":["https://orcid.org/0000-0002-5638-183X"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kouichi Yoshimasu","raw_affiliation_strings":["Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034167200","display_name":"Kanami Tsuno","orcid":"https://orcid.org/0000-0001-9399-6596","observed_orcids":["https://orcid.org/0000-0001-9399-6596"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]},{"id":"https://openalex.org/I74042192","display_name":"Kanagawa University of Human Services","ror":"https://ror.org/03dhz6n86","country_code":"JP","type":"education","lineage":["https://openalex.org/I74042192"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kanami Tsuno","raw_affiliation_strings":["Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama","School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama","institution_ids":["https://openalex.org/I190805021"]},{"raw_affiliation_string":"School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa","institution_ids":["https://openalex.org/I74042192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060275536","display_name":"Mototsugu Kuroda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mototsugu Kuroda","raw_affiliation_strings":["Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama","institution_ids":["https://openalex.org/I190805021"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058948242","display_name":"Kunihiro Kishida","orcid":"https://orcid.org/0000-0001-8496-7857","observed_orcids":["https://orcid.org/0000-0001-8496-7857"]},"institutions":[{"id":"https://openalex.org/I916559398","display_name":"Kindai University","ror":"https://ror.org/05kt9ap64","country_code":"JP","type":"education","lineage":["https://openalex.org/I916559398"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunihiro Kishida","raw_affiliation_strings":["Department of Science and Technology on Food Safety, Faculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Science and Technology on Food Safety, Faculty of Biology-Oriented Science and Technology, Kindai University, Kinokawa","institution_ids":["https://openalex.org/I916559398"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102104393","display_name":"Takahiko Mitani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75198481","display_name":"Wakayama University","ror":"https://ror.org/05wr49d48","country_code":"JP","type":"education","lineage":["https://openalex.org/I75198481"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takahiko Mitani","raw_affiliation_strings":["Research Center for Food and Agriculture, Center for Regional Revitalization, Wakayama University, Wakayama, Wakayama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Food and Agriculture, Center for Regional Revitalization, Wakayama University, Wakayama, Wakayama, Japan","institution_ids":["https://openalex.org/I75198481"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110698188","display_name":"Kazuhisa Miyashita","orcid":"https://orcid.org/0000-0003-3757-4334","observed_orcids":["https://orcid.org/0000-0003-3757-4334"]},"institutions":[{"id":"https://openalex.org/I190805021","display_name":"Wakayama Medical University","ror":"https://ror.org/005qv5373","country_code":"JP","type":"education","lineage":["https://openalex.org/I190805021"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhisa Miyashita","raw_affiliation_strings":["Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hygiene, School of Medicine, Wakayama Medical University, Wakayama","institution_ids":["https://openalex.org/I190805021"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015672103"],"corresponding_institution_ids":["https://openalex.org/I190805021"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.18456113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"25","issue":"6","first_page":"355","last_page":"358"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9531000256538391,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.03099999949336052,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prunus-salicina","display_name":"Prunus salicina","score":0.7730000019073486},{"id":"https://openalex.org/keywords/polyphenols","display_name":"polyphenols","score":0.7139999866485596},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hypertension-prevention","display_name":"hypertension prevention","score":0.6480000019073486},{"id":"https://openalex.org/keywords/antihypertensive-effect","display_name":"antihypertensive effect","score":0.722000002861023},{"id":"https://openalex.org/keywords/home-blood-pressure-monitoring","display_name":"home blood pressure monitoring","score":0.8349999785423279},{"id":"https://openalex.org/keywords/office-blood-pressure","display_name":"office blood pressure","score":0.9039999842643738},{"id":"https://openalex.org/keywords/community-dwelling-adults","display_name":"community-dwelling adults","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9052852392196655},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.8082990646362305},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.714902400970459},{"id":"https://openalex.org/C87813604","wikidata":"https://www.wikidata.org/wiki/Q1242899","display_name":"Crossover study","level":4,"score":0.5751394629478455},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5086420774459839},{"id":"https://openalex.org/C71839028","wikidata":"https://www.wikidata.org/wiki/Q7972627","display_name":"Washout","level":2,"score":0.45944535732269287},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.4462498426437378},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.4216330051422119},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.4129420816898346},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36247387528419495},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.33811086416244507},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.07825267314910889},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068242","descriptor_name":"Prunus domestica","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":true},{"descriptor_ui":"D019342","descriptor_name":"Acetic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D059808","descriptor_name":"Polyphenols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/mbp.0000000000000476","doi":"https://doi.org/10.1097/mbp.0000000000000476","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mbp.0000000000000476","pdf_url":null,"source":{"id":"https://openalex.org/S39823226","display_name":"Blood Pressure Monitoring","issn_l":"1359-5237","issn":["1359-5237","1473-5725"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood Pressure Monitoring","raw_type":"journal-article"},{"id":"pmid:32947390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32947390","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood pressure monitoring","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G8593173701","display_name":"Elucidation of metabolic fluctuations due to the interaction between fructose and fatty acids","funder_award_id":"18K11007","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W585547579","https://openalex.org/W1991834752","https://openalex.org/W2003027769","https://openalex.org/W2022180829","https://openalex.org/W2071485917","https://openalex.org/W2089074403","https://openalex.org/W2100337344","https://openalex.org/W2219674570","https://openalex.org/W2766551330","https://openalex.org/W2917732217"],"related_works":["https://openalex.org/W2022180829","https://openalex.org/W1967885989","https://openalex.org/W2775616506","https://openalex.org/W2282173005","https://openalex.org/W4307041117","https://openalex.org/W1598773480","https://openalex.org/W2123543103","https://openalex.org/W2113233378","https://openalex.org/W7096651354","https://openalex.org/W2505148335"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"blood":[3],"pressure":[4],"(BP)-lowering":[5],"effects":[6],"of":[7,35,62,146,152],"Umezu":[8,52,63,153],"polyphenols,":[9],"polyphenols":[10,53,64],"contained":[11],"in":[12,15,31,86,104,118,129,134],"Japanese":[13,26],"plums,":[14],"a":[16,72,87,147],"community-based":[17],"sample":[18],"by":[19,71],"double-masked":[20,88],"and":[21,78],"placebo-controlled":[22],"design.":[23],"METHODS:":[24],"Seventy-two":[25],"community-dwellers":[27],"who":[28,94],"were":[29,49,81],"interested":[30],"prevention":[32],"or":[33,41,54,65],"control":[34],"their":[36],"BP":[37,40,80,101,115,128],"(preferably":[38],"high-normal":[39],"grade":[42],"I":[43],"hypertension)":[44],"but":[45],"without":[46],"antihypertensive":[47],"medication":[48],"randomized":[50],"into":[51],"placebo":[55,66],"groups.":[56],"Each":[57],"subject":[58],"took":[59],"800":[60],"mg/day":[61],"for":[67,83],"12":[68],"weeks,":[69],"followed":[70],"2-week":[73],"washout":[74,124],"period.":[75],"Their":[76],"home":[77,126],"office":[79,114],"monitored":[82],"14":[84],"weeks":[85],"manner.":[89],"We":[90],"analyzed":[91],"56":[92],"subjects":[93],"met":[95],"the":[96,106,109,119,123,130,135],"inclusion":[97],"criteria.":[98],"RESULTS:":[99],"Home":[100],"increased":[102],"gradually":[103],"both":[105],"groups":[107],"during":[108],"intervention":[110,120,136],"period,":[111,125],"while":[112],"diastolic":[113],"insignificantly":[116],"decreased":[117],"group.":[121,137],"During":[122],"systolic":[127],"morning":[131],"elevated":[132],"only":[133],"CONCLUSIONS:":[138],"The":[139],"study":[140],"failed":[141],"to":[142],"collect":[143],"consistent":[144],"evidence":[145],"clear":[148],"persistent":[149],"hypotensive":[150],"effect":[151],"polyphenols.":[154]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-25T00:00:00"}