{"id":"https://openalex.org/W3087671925","doi":"https://doi.org/10.1007/s10930-020-09915-y","title":"Isolation and Functional Identification of an Antiplatelet RGD-Containing Disintegrin from Cerastes cerastes Venom","display_name":"Isolation and Functional Identification of an Antiplatelet RGD-Containing Disintegrin from Cerastes cerastes Venom","publication_year":2020,"publication_date":"2020-09-22","ids":{"openalex":"https://openalex.org/W3087671925","doi":"https://doi.org/10.1007/s10930-020-09915-y","mag":"3087671925","pmid":"https://pubmed.ncbi.nlm.nih.gov/32960374"},"language":"en","primary_location":{"id":"doi:10.1007/s10930-020-09915-y","doi":"https://doi.org/10.1007/s10930-020-09915-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10930-020-09915-y","pdf_url":null,"source":{"id":"https://openalex.org/S201049572","display_name":"The Protein Journal","issn_l":"1572-3887","issn":["1572-3887","1875-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Protein Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029588149","display_name":"Meriem Ameziani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Meriem Ameziani","raw_affiliation_strings":["USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003600698","display_name":"Fatah Ch\u00e9rifi","orcid":"https://orcid.org/0000-0003-3440-9683","observed_orcids":["https://orcid.org/0000-0003-3440-9683"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Fatah Ch\u00e9rifi","raw_affiliation_strings":["USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082603820","display_name":"Hamida Kiheli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Hamida Kiheli","raw_affiliation_strings":["USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087611177","display_name":"Samah Saoud","orcid":"https://orcid.org/0000-0003-3086-6131","observed_orcids":["https://orcid.org/0000-0003-3086-6131"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Samah Saoud","raw_affiliation_strings":["USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019855955","display_name":"Ghania Hariti","orcid":"https://orcid.org/0000-0002-5461-3107","observed_orcids":["https://orcid.org/0000-0002-5461-3107"]},"institutions":[{"id":"https://openalex.org/I192268740","display_name":"University of Algiers Benyoucef Benkhedda","ror":"https://ror.org/011r6gp69","country_code":"DZ","type":"education","lineage":["https://openalex.org/I192268740"]},{"id":"https://openalex.org/I4210154551","display_name":"Centre Hospitalo-Universitaire Bab El Oued","ror":"https://ror.org/05qf3bt68","country_code":"DZ","type":"healthcare","lineage":["https://openalex.org/I4210154551"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Ghania Hariti","raw_affiliation_strings":["Faculty of Medicine, Blood Transfusion Center, Unverisity of Benyoucef Benkheda Algiers 1, CHU Bab El-Oued, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine, Blood Transfusion Center, Unverisity of Benyoucef Benkheda Algiers 1, CHU Bab El-Oued, Algiers, Algeria","institution_ids":["https://openalex.org/I192268740","https://openalex.org/I4210154551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091880376","display_name":"Safia Kellou\u2010Ta\u00efri","orcid":"https://orcid.org/0000-0002-2629-3521","observed_orcids":["https://orcid.org/0000-0002-2629-3521"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Safia Kellou-Ta\u00eeri","raw_affiliation_strings":["USTHB, Laboratory of Theoretical Physico-Chemistry and Computer Chemistry, Faculty of Chemistry, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"USTHB, Laboratory of Theoretical Physico-Chemistry and Computer Chemistry, Faculty of Chemistry, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081929184","display_name":"Fatima Laraba\u2010Djebari","orcid":"https://orcid.org/0000-0003-4641-261X","observed_orcids":["https://orcid.org/0000-0003-4641-261X"]},"institutions":[{"id":"https://openalex.org/I157169809","display_name":"University of Sciences and Technology Houari Boumediene","ror":"https://ror.org/02kb89c09","country_code":"DZ","type":"education","lineage":["https://openalex.org/I157169809"]}],"countries":["DZ"],"is_corresponding":true,"raw_author_name":"Fatima Laraba-Djebari","raw_affiliation_strings":["USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria. flaraba@hotmail.com","USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria"],"raw_orcid":"https://orcid.org/0000-0003-4641-261X","affiliations":[{"raw_affiliation_string":"USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria. flaraba@hotmail.com","institution_ids":["https://openalex.org/I157169809"]},{"raw_affiliation_string":"USTHB, Laboratory of Cellular and Molecular Biology, Faculty of Biological Sciences, BP 32 El-Alia, Bab Ezzouar, Algiers, Algeria","institution_ids":["https://openalex.org/I157169809"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081929184"],"corresponding_institution_ids":["https://openalex.org/I157169809"],"apc_list":{"value":2890,"currency":"EUR","value_usd":3690},"apc_paid":null,"fwci":1.2178,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.72538059,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"39","issue":"5","first_page":"574","last_page":"590"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/snake-venom-disintegrins","display_name":"snake venom disintegrins","score":0.796999990940094},{"id":"https://openalex.org/keywords/rgd-motif","display_name":"RGD motif","score":0.8949999809265137},{"id":"https://openalex.org/keywords/antiplatelet-activity","display_name":"antiplatelet activity","score":0.8510000109672546},{"id":"https://openalex.org/keywords/platelet-activation-inhibition","display_name":"platelet activation inhibition","score":0.6779999732971191},{"id":"https://openalex.org/keywords/glycoprotein-iib-iiia","display_name":"integrin \u03b1IIb\u03b23","score":0.8830000162124634},{"id":"https://openalex.org/keywords/p-selectin","display_name":"P-selectin","score":0.8360000252723694},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.7900000214576721},{"id":"https://openalex.org/keywords/protein-purification","display_name":"protein purification","score":0.597000002861023},{"id":"https://openalex.org/keywords/three-dimensional-structure","display_name":"three-dimensional structure","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.9248626232147217},{"id":"https://openalex.org/C2778259572","wikidata":"https://www.wikidata.org/wiki/Q407908","display_name":"Disintegrin","level":4,"score":0.9155553579330444},{"id":"https://openalex.org/C2779358239","wikidata":"https://www.wikidata.org/wiki/Q2124191","display_name":"RGD motif","level":4,"score":0.7183165550231934},{"id":"https://openalex.org/C2776725428","wikidata":"https://www.wikidata.org/wiki/Q424200","display_name":"Snake venom","level":3,"score":0.5920072793960571},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5545821189880371},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.530276894569397},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.49318116903305054},{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.4734610915184021},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4664897918701172},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.4542378783226013},{"id":"https://openalex.org/C2910624479","wikidata":"https://www.wikidata.org/wiki/Q163656","display_name":"Viper Venoms","level":4,"score":0.44594019651412964},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4290796220302582},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39695680141448975},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2651808261871338},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21461749076843262},{"id":"https://openalex.org/C55728118","wikidata":"https://www.wikidata.org/wiki/Q425402","display_name":"Metalloproteinase","level":3,"score":0.17815619707107544},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09889256954193115}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010975","descriptor_name":"Platelet Aggregation Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017819","descriptor_name":"Viperidae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019007","descriptor_name":"P-Selectin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019039","descriptor_name":"Platelet Glycoprotein GPIIb-IIIa Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10930-020-09915-y","doi":"https://doi.org/10.1007/s10930-020-09915-y","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10930-020-09915-y","pdf_url":null,"source":{"id":"https://openalex.org/S201049572","display_name":"The Protein Journal","issn_l":"1572-3887","issn":["1572-3887","1875-8355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Protein Journal","raw_type":"journal-article"},{"id":"pmid:32960374","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32960374","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The protein journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":68,"referenced_works":["https://openalex.org/W1701123637","https://openalex.org/W1888357425","https://openalex.org/W1963854263","https://openalex.org/W1967242219","https://openalex.org/W1969556495","https://openalex.org/W1971879774","https://openalex.org/W1976745046","https://openalex.org/W1987414594","https://openalex.org/W1994928637","https://openalex.org/W1998404570","https://openalex.org/W2001457449","https://openalex.org/W2002075122","https://openalex.org/W2002273518","https://openalex.org/W2006558708","https://openalex.org/W2014170224","https://openalex.org/W2016740830","https://openalex.org/W2019554080","https://openalex.org/W2024102985","https://openalex.org/W2029427323","https://openalex.org/W2030522696","https://openalex.org/W2033541484","https://openalex.org/W2037003265","https://openalex.org/W2039513104","https://openalex.org/W2039877375","https://openalex.org/W2042336071","https://openalex.org/W2043166299","https://openalex.org/W2043521254","https://openalex.org/W2049547470","https://openalex.org/W2054721875","https://openalex.org/W2058280421","https://openalex.org/W2064638030","https://openalex.org/W2065356123","https://openalex.org/W2073520272","https://openalex.org/W2080866550","https://openalex.org/W2082817389","https://openalex.org/W2083766642","https://openalex.org/W2084506323","https://openalex.org/W2087674525","https://openalex.org/W2090853097","https://openalex.org/W2096821978","https://openalex.org/W2101220662","https://openalex.org/W2104824020","https://openalex.org/W2122723623","https://openalex.org/W2126080067","https://openalex.org/W2140247386","https://openalex.org/W2148187441","https://openalex.org/W2159490612","https://openalex.org/W2164539751","https://openalex.org/W2172179129","https://openalex.org/W2210954824","https://openalex.org/W2244317753","https://openalex.org/W2334939265","https://openalex.org/W2418523472","https://openalex.org/W2461948604","https://openalex.org/W2560302567","https://openalex.org/W2605130747","https://openalex.org/W2606625770","https://openalex.org/W2734939816","https://openalex.org/W2752672623","https://openalex.org/W2780800364","https://openalex.org/W2806156174","https://openalex.org/W2891215819","https://openalex.org/W2894401039","https://openalex.org/W2902117321","https://openalex.org/W2905932069","https://openalex.org/W2952014517","https://openalex.org/W3135500716","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2052575616","https://openalex.org/W3049269390","https://openalex.org/W2057942062","https://openalex.org/W1969556495","https://openalex.org/W1968861934","https://openalex.org/W2019549683","https://openalex.org/W2122120273","https://openalex.org/W2095100313","https://openalex.org/W2466644272","https://openalex.org/W13049560"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-25T00:00:00"}