{"id":"https://openalex.org/W3087313109","doi":"https://doi.org/10.1161/hypertensionaha.120.15772","title":"Heart-Microcirculation Connection","display_name":"Heart-Microcirculation Connection","publication_year":2020,"publication_date":"2020-09-21","ids":{"openalex":"https://openalex.org/W3087313109","doi":"https://doi.org/10.1161/hypertensionaha.120.15772","mag":"3087313109","pmid":"https://pubmed.ncbi.nlm.nih.gov/32951468"},"language":"en","primary_location":{"id":"doi:10.1161/hypertensionaha.120.15772","doi":"https://doi.org/10.1161/hypertensionaha.120.15772","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.120.15772","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021669502","display_name":"Katarina \u0160piranec Spes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Katarina \u0160piranec Spes","raw_affiliation_strings":["Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany","From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]},{"raw_affiliation_string":"From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100344166","display_name":"Wen Chen","orcid":"https://orcid.org/0000-0002-3589-0416","observed_orcids":["https://orcid.org/0000-0002-3589-0416"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["CN","DE"],"is_corresponding":true,"raw_author_name":"Wen Chen","raw_affiliation_strings":["Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany","From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany","The Affiliated Haimen Hospital, Nantong University, Jiangsu, China (W.C.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]},{"raw_affiliation_string":"From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]},{"raw_affiliation_string":"The Affiliated Haimen Hospital, Nantong University, Jiangsu, China (W.C.)","institution_ids":["https://openalex.org/I199305430"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085296399","display_name":"Lisa Krebes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lisa Krebes","raw_affiliation_strings":["From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030262806","display_name":"Katharina V\u00f6lker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Katharina V\u00f6lker","raw_affiliation_strings":["From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018856613","display_name":"Marco Abe\u00dfer","orcid":"https://orcid.org/0000-0003-3832-7618","observed_orcids":["https://orcid.org/0000-0003-3832-7618"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marco Abe\u00dfer","raw_affiliation_strings":["From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080111118","display_name":"Petra Eder-Negrin","orcid":"https://orcid.org/0000-0002-6072-8963","observed_orcids":["https://orcid.org/0000-0002-6072-8963"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Petra Eder Negrin","raw_affiliation_strings":["Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061190152","display_name":"Antonella Cellini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Antonella Cellini","raw_affiliation_strings":["Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002421224","display_name":"Alexander Georg Nickel","orcid":"https://orcid.org/0000-0002-2562-0439","observed_orcids":["https://orcid.org/0000-0002-2562-0439"]},"institutions":[{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alexander Nickel","raw_affiliation_strings":["Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Comprehensive Heart Failure Center (K.S.S., W.C., P.E.N., A.C., A.N., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072560625","display_name":"Viacheslav O. Nikolaev","orcid":"https://orcid.org/0000-0002-7529-5179","observed_orcids":["https://orcid.org/0000-0002-7529-5179"]},"institutions":[{"id":"https://openalex.org/I4210108711","display_name":"University Medical Center Hamburg-Eppendorf","ror":"https://ror.org/01zgy1s35","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I159176309","https://openalex.org/I4210108711"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Viacheslav O. Nikolaev","raw_affiliation_strings":["Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (V.O.N.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf, Germany (V.O.N.)","institution_ids":["https://openalex.org/I4210108711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102028201","display_name":"Franz Bruno Hofmann","orcid":"https://orcid.org/0000-0001-8571-1001","observed_orcids":["https://orcid.org/0000-0001-8571-1001"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Franz Hofmann","raw_affiliation_strings":["Institute of Pharmacology and Toxicology, TU Munich, Germany (F.H.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pharmacology and Toxicology, TU Munich, Germany (F.H.)","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064786839","display_name":"Kai Schuh","orcid":"https://orcid.org/0000-0003-4475-0412","observed_orcids":["https://orcid.org/0000-0003-4475-0412"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kai Schuh","raw_affiliation_strings":["From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028519463","display_name":"Frank Schweda","orcid":"https://orcid.org/0009-0002-1244-5843","observed_orcids":["https://orcid.org/0009-0002-1244-5843"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Frank Schweda","raw_affiliation_strings":["Institute of Physiology, University of Regensburg, Germany (F.S.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Physiology, University of Regensburg, Germany (F.S.)","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000953683","display_name":"Michaela K\u00fchn","orcid":"https://orcid.org/0000-0002-9812-5906","observed_orcids":["https://orcid.org/0000-0002-9812-5906"]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michaela Kuhn","raw_affiliation_strings":["From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-9812-5906","affiliations":[{"raw_affiliation_string":"From the Institute of Physiology, University of W\u00fcrzburg (K.S.S., W.C., L.K., K.V., M.A., K.S., M.K.), University Hospital W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5000953683","https://openalex.org/A5021669502","https://openalex.org/A5028519463","https://openalex.org/A5100344166"],"corresponding_institution_ids":["https://openalex.org/I199305430","https://openalex.org/I25974101","https://openalex.org/I4210126310","https://openalex.org/I60668342"],"apc_list":null,"apc_paid":null,"fwci":2.2486,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.88254871,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"76","issue":"5","first_page":"1637","last_page":"1648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.391400009393692,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.391400009393692,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.1835000067949295,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.1826000064611435,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atrial-natriuretic-peptide","display_name":"atrial natriuretic peptide","score":0.9959999918937683},{"id":"https://openalex.org/keywords/guanylyl-cyclase-a","display_name":"guanylyl cyclase-A","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cgmp-signaling","display_name":"cGMP signaling","score":0.8450000286102295},{"id":"https://openalex.org/keywords/microvascular-pericytes","display_name":"microvascular pericytes","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cgmp-dependent-protein-kinase-i","display_name":"cGMP-dependent protein kinase I","score":0.9739999771118164},{"id":"https://openalex.org/keywords/endothelin-1","display_name":"endothelin-1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/microvascular-tone","display_name":"microvascular tone","score":0.574999988079071},{"id":"https://openalex.org/keywords/blood-pressure-homeostasis","display_name":"blood pressure homeostasis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/intravascular-volume-expansion","display_name":"intravascular volume expansion","score":0.8240000009536743},{"id":"https://openalex.org/keywords/precapillary-arterioles","display_name":"precapillary arterioles","score":0.7120000123977661},{"id":"https://openalex.org/keywords/capillaries","display_name":"capillaries","score":0.9430000185966492}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7494627237319946},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7156501412391663},{"id":"https://openalex.org/C2778069365","wikidata":"https://www.wikidata.org/wiki/Q78185357","display_name":"Atrial natriuretic peptide","level":2,"score":0.6988182067871094},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.6934820413589478},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.5464211702346802},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5261054635047913},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.4387551248073578},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3925665020942688},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33528006076812744}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006152","descriptor_name":"Cyclic GMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009320","descriptor_name":"Atrial Natriuretic Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020286","descriptor_name":"Pericytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020286","descriptor_name":"Pericytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D062186","descriptor_name":"Arterial Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D062965","descriptor_name":"Cyclic GMP-Dependent Protein Kinase Type I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1161/hypertensionaha.120.15772","doi":"https://doi.org/10.1161/hypertensionaha.120.15772","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hypertensionaha.120.15772","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},{"id":"pmid:32951468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32951468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension (Dallas, Tex. : 1979)","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:49561","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/49561/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1617305","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1617305","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3055204393","display_name":null,"funder_award_id":"SFB-1350","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G3831163817","display_name":"SFB 1350: Tubulussystem und Interstitium der Niere: (Patho)Physiologie und Crosstalk","funder_award_id":"387509280","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5862684019","display_name":"Integriertes Forschungs- und Behandlungszentrum 'Pr\u00e4vention der Herzinsuffizienz und ihrer Komplikationen'","funder_award_id":"01EO1004","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G7807304230","display_name":"Integriertes Forschungs- und Behandlungszentrum 'Pr\u00e4vention der Herzinsuffizienz und ihrer Komplikationen'","funder_award_id":"01EO1504","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1893055997","https://openalex.org/W1964699341","https://openalex.org/W1984092953","https://openalex.org/W2013933388","https://openalex.org/W2019457908","https://openalex.org/W2021723069","https://openalex.org/W2044657479","https://openalex.org/W2049693465","https://openalex.org/W2070916256","https://openalex.org/W2087600652","https://openalex.org/W2109679295","https://openalex.org/W2110564525","https://openalex.org/W2118103351","https://openalex.org/W2136566187","https://openalex.org/W2141970649","https://openalex.org/W2154308897","https://openalex.org/W2158485980","https://openalex.org/W2159609666","https://openalex.org/W2203466990","https://openalex.org/W2220114192","https://openalex.org/W2319350696","https://openalex.org/W2400972443","https://openalex.org/W2416528252","https://openalex.org/W2460933928","https://openalex.org/W2769622791","https://openalex.org/W2770491814","https://openalex.org/W2795255885","https://openalex.org/W2796415004","https://openalex.org/W2802181904","https://openalex.org/W2946864783"],"related_works":["https://openalex.org/W1972477841","https://openalex.org/W2796415004","https://openalex.org/W2013933388","https://openalex.org/W3174526371","https://openalex.org/W4399373908","https://openalex.org/W7111883568","https://openalex.org/W2121217626","https://openalex.org/W2158485980","https://openalex.org/W3162196250","https://openalex.org/W7163133516"],"abstract_inverted_index":{"Cardiac":[0],"ANP":[1,38,50,64,91,122],"(atrial":[2],"natriuretic":[3],"peptide)":[4],"moderates":[5],"arterial":[6,189],"blood":[7,40,136,157,190],"pressure.":[8],"The":[9,30],"mechanisms":[10],"mediating":[11],"its":[12],"hypotensive":[13],"effects":[14,36,120],"are":[15,55],"complex":[16],"and":[17,28,73,95,126,178,185],"involve":[18],"inhibition":[19],"of":[20,32,37,48,77,81,98,113,121,151,159,176,188],"the":[21,33,49,75,78,93,183],"renin-angiotensin-aldosterone":[22],"system,":[23],"increased":[24,135],"natriuresis,":[25],"endothelial":[26],"permeability,":[27],"vasodilatation.":[29],"contribution":[31],"direct":[34],"vasodilating":[35,119],"to":[39,100,182],"pressure":[41,137,158,191],"homeostasis":[42],"is":[43,199],"controversial":[44],"because":[45],"variable":[46],"levels":[47],"receptor,":[51],"GC-A":[52,114,168],"(guanylyl":[53],"cyclase-A),":[54],"expressed":[56],"among":[57],"vascular":[58],"beds.":[59],"Here,":[60],"we":[61],"show":[62],"that":[63,173],"stimulates":[65],"GC-A/cyclic":[66],"GMP":[67],"signaling":[68],"in":[69,115,166],"cultured":[70],"microvascular":[71,105],"pericytes":[72,99,177],"thereby":[74],"phosphorylation":[76],"regulatory":[79],"subunit":[80],"myosin":[82],"phosphatase":[83],"1":[84],"by":[85,192],"cGMP-dependent":[86],"protein":[87],"kinase":[88],"I.":[89],"Moreover,":[90],"prevents":[92],"calcium":[94],"contractile":[96],"responses":[97],"endothelin-1":[101],"as":[102,104],"well":[103],"constrictions.":[106],"In":[107],"mice":[108,133,161],"with":[109],"conditional":[110],"inactivation":[111],"(knock-out)":[112],"microcirculatory":[116,179],"pericytes,":[117],"such":[118],"on":[123],"precapillary":[124],"arterioles":[125],"capillaries":[127],"were":[128],"fully":[129],"abolished.":[130],"Concordantly,":[131],"these":[132],"have":[134],"despite":[138],"preserved":[139],"renal":[140],"excretory":[141],"function.":[142],"Furthermore,":[143],"acute":[144,184],"intravascular":[145],"volume":[146],"expansion,":[147],"which":[148],"caused":[149],"release":[150],"cardiac":[152],"ANP,":[153],"did":[154],"not":[155],"affect":[156],"control":[160],"but":[162],"provoked":[163],"hypertensive":[164],"reactions":[165],"pericyte":[167],"knock-out":[169],"littermates.":[170],"We":[171],"conclude":[172],"GC-A/cGMP-dependent":[174],"modulation":[175],"tone":[180],"contributes":[181],"chronic":[186],"moderation":[187],"ANP.":[193],"Graphic":[194],"Abstract":[195],"A":[196],"graphic":[197],"abstract":[198],"available":[200],"for":[201],"this":[202],"article.":[203]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-09-25T00:00:00"}