{"id":"https://openalex.org/W3087296239","doi":"https://doi.org/10.12788/cutis.0074","title":"Long-standing Dermatitis Treated With Dupilumab With Subsequent Progression to Cutaneous T-cell Lymphoma","display_name":"Long-standing Dermatitis Treated With Dupilumab With Subsequent Progression to Cutaneous T-cell Lymphoma","publication_year":2020,"publication_date":"2020-08-01","ids":{"openalex":"https://openalex.org/W3087296239","doi":"https://doi.org/10.12788/cutis.0074","mag":"3087296239","pmid":"https://pubmed.ncbi.nlm.nih.gov/32941565"},"language":"en","primary_location":{"id":"doi:10.12788/cutis.0074","doi":"https://doi.org/10.12788/cutis.0074","is_oa":true,"landing_page_url":"https://doi.org/10.12788/cutis.0074","pdf_url":"https://cdn.mdedge.com/files/s3fs-public/CT106002008_e.pdf","source":{"id":"https://openalex.org/S87393979","display_name":"Cutis","issn_l":"0011-4162","issn":["0011-4162","2326-6929"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322696809","host_organization_name":"Frontline Medical Communications","host_organization_lineage":["https://openalex.org/P4322696809"],"host_organization_lineage_names":["Frontline Medical Communications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://cdn.mdedge.com/files/s3fs-public/CT106002008_e.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020901707","display_name":"Lauren Claire Hollins","orcid":"https://orcid.org/0000-0002-7689-7462","observed_orcids":["https://orcid.org/0000-0002-7689-7462"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I123457487","display_name":"Hershey (United States)","ror":"https://ror.org/02c4ez492","country_code":"US","type":"company","lineage":["https://openalex.org/I123457487"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"L. Claire Hollins","raw_affiliation_strings":["Department of Dermatology, Penn State Milton S. Hershey Medical Center, USA","Department of Dermatology, Penn State Milton S. Hershey Medical Center, 500 University Dr, Ste 4300, HU14,","Department of Dermatology, Penn State Milton S. Hershey Medical Center. Dr. Fulchiero is from Keystone Dermatology & Center for Skin Surgery, Altoona, Pennsylvania","Department of Dermatology, University of North Carolina, Chapel Hill","UPC III, Hershey, PA 17033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Penn State Milton S. Hershey Medical Center, USA","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Dermatology, Penn State Milton S. Hershey Medical Center, 500 University Dr, Ste 4300, HU14,","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Dermatology, Penn State Milton S. Hershey Medical Center. Dr. Fulchiero is from Keystone Dermatology & Center for Skin Surgery, Altoona, Pennsylvania","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Dermatology, University of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UPC III, Hershey, PA 17033","institution_ids":["https://openalex.org/I123457487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110623441","display_name":"Paul J. Wirth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I123457487","display_name":"Hershey (United States)","ror":"https://ror.org/02c4ez492","country_code":"US","type":"company","lineage":["https://openalex.org/I123457487"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Wirth","raw_affiliation_strings":["Department of Dermatology, Penn State Milton S. Hershey Medical Center, USA","Department of Dermatology, Penn State Milton S. Hershey Medical Center, 500 University Dr, Ste 4300, HU14,","Department of Dermatology, Penn State Milton S. Hershey Medical Center. Dr. Fulchiero is from Keystone Dermatology & Center for Skin Surgery, Altoona, Pennsylvania","Department of Dermatology, University of North Carolina, Chapel Hill","UPC III, Hershey, PA 17033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Penn State Milton S. Hershey Medical Center, USA","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Dermatology, Penn State Milton S. Hershey Medical Center, 500 University Dr, Ste 4300, HU14,","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Dermatology, Penn State Milton S. Hershey Medical Center. Dr. Fulchiero is from Keystone Dermatology & Center for Skin Surgery, Altoona, Pennsylvania","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Dermatology, University of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UPC III, Hershey, PA 17033","institution_ids":["https://openalex.org/I123457487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086939463","display_name":"Gregory J. Fulchiero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory J Fulchiero Jr","raw_affiliation_strings":["Keystone Dermatology and Center for Skin Surgery, Altoona, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Keystone Dermatology and Center for Skin Surgery, Altoona, Pennsylvania, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026874121","display_name":"Galen Foulke","orcid":"https://orcid.org/0000-0002-4390-5200","observed_orcids":["https://orcid.org/0000-0002-4390-5200"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]},{"id":"https://openalex.org/I123457487","display_name":"Hershey (United States)","ror":"https://ror.org/02c4ez492","country_code":"US","type":"company","lineage":["https://openalex.org/I123457487"]},{"id":"https://openalex.org/I82783531","display_name":"Penn State Milton S. Hershey Medical Center","ror":"https://ror.org/01h22ap11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I82783531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Galen T Foulke","raw_affiliation_strings":["Department of Dermatology, University of North Carolina, Chapel Hill, USA","Department of Dermatology, Penn State Milton S. Hershey Medical Center, 500 University Dr, Ste 4300, HU14,","Department of Dermatology, Penn State Milton S. Hershey Medical Center. Dr. Fulchiero is from Keystone Dermatology & Center for Skin Surgery, Altoona, Pennsylvania","Department of Dermatology, University of North Carolina, Chapel Hill","UPC III, Hershey, PA 17033"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of North Carolina, Chapel Hill, USA","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"Department of Dermatology, Penn State Milton S. Hershey Medical Center, 500 University Dr, Ste 4300, HU14,","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Dermatology, Penn State Milton S. Hershey Medical Center. Dr. Fulchiero is from Keystone Dermatology & Center for Skin Surgery, Altoona, Pennsylvania","institution_ids":["https://openalex.org/I82783531"]},{"raw_affiliation_string":"Department of Dermatology, University of North Carolina, Chapel Hill","institution_ids":["https://openalex.org/I114027177"]},{"raw_affiliation_string":"UPC III, Hershey, PA 17033","institution_ids":["https://openalex.org/I123457487"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5020901707"],"corresponding_institution_ids":["https://openalex.org/I114027177","https://openalex.org/I123457487","https://openalex.org/I82783531"],"apc_list":null,"apc_paid":null,"fwci":5.3124,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.96707561,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"106","issue":"2","first_page":"E8","last_page":"E11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11811","display_name":"Cutaneous lymphoproliferative disorders research","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dupilumab","display_name":"dupilumab","score":0.9959999918937683},{"id":"https://openalex.org/keywords/cutaneous-t-cell-lymphoma","display_name":"cutaneous T-cell lymphoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/eczematous-dermatitis","display_name":"eczematous dermatitis","score":0.9169999957084656},{"id":"https://openalex.org/keywords/psoriasiform-dermatitis","display_name":"psoriasiform dermatitis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/il-13-receptor-alpha-2","display_name":"IL-13 receptor alpha 2","score":0.8259999752044678},{"id":"https://openalex.org/keywords/il-13","display_name":"IL-13","score":0.8949999809265137},{"id":"https://openalex.org/keywords/off-label-drug-use","display_name":"off-label drug use","score":0.7020000219345093},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7549999952316284},{"id":"https://openalex.org/keywords/disease-progression","display_name":"disease progression","score":0.8299999833106995},{"id":"https://openalex.org/keywords/il-4-receptor-blockade","display_name":"IL-4 receptor blockade","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2779824493","wikidata":"https://www.wikidata.org/wiki/Q5315925","display_name":"Dupilumab","level":3,"score":0.9735440015792847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8937515020370483},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5906938910484314},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.5051646828651428},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4649437963962555},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.4595870077610016},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4319971799850464},{"id":"https://openalex.org/C2776780870","wikidata":"https://www.wikidata.org/wiki/Q5196687","display_name":"Cutaneous T-cell lymphoma","level":4,"score":0.4157707691192627},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31210029125213623},{"id":"https://openalex.org/C2777756187","wikidata":"https://www.wikidata.org/wiki/Q1891209","display_name":"Mycosis fungoides","level":3,"score":0.29746735095977783},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2870268225669861}],"mesh":[{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004485","descriptor_name":"Eczema","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004485","descriptor_name":"Eczema","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011565","descriptor_name":"Psoriasis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016410","descriptor_name":"Lymphoma, T-Cell, Cutaneous","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016410","descriptor_name":"Lymphoma, T-Cell, Cutaneous","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016410","descriptor_name":"Lymphoma, T-Cell, Cutaneous","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018793","descriptor_name":"Interleukin-13","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D056687","descriptor_name":"Off-Label Use","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.12788/cutis.0074","doi":"https://doi.org/10.12788/cutis.0074","is_oa":true,"landing_page_url":"https://doi.org/10.12788/cutis.0074","pdf_url":"https://cdn.mdedge.com/files/s3fs-public/CT106002008_e.pdf","source":{"id":"https://openalex.org/S87393979","display_name":"Cutis","issn_l":"0011-4162","issn":["0011-4162","2326-6929"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322696809","host_organization_name":"Frontline Medical Communications","host_organization_lineage":["https://openalex.org/P4322696809"],"host_organization_lineage_names":["Frontline Medical Communications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutis","raw_type":"journal-article"},{"id":"pmid:32941565","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32941565","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutis","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.12788/cutis.0074","doi":"https://doi.org/10.12788/cutis.0074","is_oa":true,"landing_page_url":"https://doi.org/10.12788/cutis.0074","pdf_url":"https://cdn.mdedge.com/files/s3fs-public/CT106002008_e.pdf","source":{"id":"https://openalex.org/S87393979","display_name":"Cutis","issn_l":"0011-4162","issn":["0011-4162","2326-6929"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4322696809","host_organization_name":"Frontline Medical Communications","host_organization_lineage":["https://openalex.org/P4322696809"],"host_organization_lineage_names":["Frontline Medical Communications"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cutis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3087296239.pdf","grobid_xml":"https://content.openalex.org/works/W3087296239.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W145943815","https://openalex.org/W2023064301","https://openalex.org/W2056307363","https://openalex.org/W2185429351","https://openalex.org/W2801575199","https://openalex.org/W2809403868","https://openalex.org/W2811037313","https://openalex.org/W2904484343","https://openalex.org/W2919493709"],"related_works":["https://openalex.org/W4235290260","https://openalex.org/W3115096572","https://openalex.org/W4385575517","https://openalex.org/W4407064093","https://openalex.org/W4410729722","https://openalex.org/W4400105848","https://openalex.org/W4409151478","https://openalex.org/W3093711947","https://openalex.org/W4387728755","https://openalex.org/W3011879699"],"abstract_inverted_index":{"This":[0,95],"case":[1],"series":[2],"discusses":[3],"3":[4,22],"patients":[5,23],"with":[6,19,29,33,93],"long-standing":[7],"eczematous":[8],"or":[9],"psoriasiform":[10],"dermatitis,":[11],"demonstrated":[12],"by":[13],"multiple":[14],"biopsies.":[15],"Following":[16],"off-label":[17],"treatment":[18],"dupilumab,":[20],"all":[21],"had":[24],"clinical":[25],"expansion":[26,45],"of":[27,52,62,64,89],"disease,":[28],"histopathologic":[30],"features":[31],"consistent":[32],"cutaneous":[34],"T-cell":[35],"lymphoma":[36],"(CTCL)":[37],"on":[38,68,85],"subsequent":[39],"biopsy.":[40],"We":[41],"postulate":[42],"that":[43],"this":[44],"likely":[46],"was":[47],"secondary":[48],"to":[49,57],"an":[50],"exacerbation":[51],"extant":[53],"CTCL":[54,65],"following":[55,87],"exposure":[56],"dupilumab.":[58,94],"A":[59],"proposed":[60],"mechanism":[61],"promotion":[63],"is":[66],"based":[67],"the":[69,78,90],"functional":[70],"increase":[71],"in":[72],"IL-13":[73,80],"available":[74],"for":[75],"binding":[76],"at":[77],"upregulated":[79],"receptor":[81,92],"(IL-13R)":[82],"\u03b12":[83],"site":[84],"cells,":[86],"blockade":[88],"\u03b11":[91],"progression":[96],"merits":[97],"further":[98],"investigation.":[99]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-09-25T00:00:00"}
