{"id":"https://openalex.org/W3087288588","doi":"https://doi.org/10.1128/jvi.01163-20","title":"Reovirus \u03c31 Conformational Flexibility Modulates the Efficiency of Host Cell Attachment","display_name":"Reovirus \u03c31 Conformational Flexibility Modulates the Efficiency of Host Cell Attachment","publication_year":2020,"publication_date":"2020-09-15","ids":{"openalex":"https://openalex.org/W3087288588","doi":"https://doi.org/10.1128/jvi.01163-20","mag":"3087288588","pmid":"https://pubmed.ncbi.nlm.nih.gov/32938765","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7654274"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.01163-20","doi":"https://doi.org/10.1128/jvi.01163-20","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01163-20","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/12/2020.06.09.143594.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048622074","display_name":"Julia R. Diller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia R. Diller","raw_affiliation_strings":["Department of Pediatrics, Vanderbilt University Medical Center","Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051796354","display_name":"Sean R. Halloran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean R. Halloran","raw_affiliation_strings":["Department of Pediatrics, Vanderbilt University Medical Center","Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111830518","display_name":"Melanie Koehler","orcid":"https://orcid.org/0000-0003-3042-1749","observed_orcids":["https://orcid.org/0000-0003-3042-1749"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Melanie Koehler","raw_affiliation_strings":["Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain","Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain, Ottignies-Louvain-la-Neuve, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain, Ottignies-Louvain-la-Neuve, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047500119","display_name":"Rita dos Santos Natividade","orcid":"https://orcid.org/0000-0002-0123-4760","observed_orcids":["https://orcid.org/0000-0002-0123-4760"]},"institutions":[{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Rita dos Santos Natividade","raw_affiliation_strings":["Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain","Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain, Ottignies-Louvain-la-Neuve, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain, Ottignies-Louvain-la-Neuve, Belgium","institution_ids":["https://openalex.org/I95674353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071387345","display_name":"David Alsteens","orcid":"https://orcid.org/0000-0001-9229-113X","observed_orcids":["https://orcid.org/0000-0001-9229-113X"]},"institutions":[{"id":"https://openalex.org/I4210142098","display_name":"Walloon Excellence in Lifesciences and Biotechnology","ror":"https://ror.org/04qbvw321","country_code":"BE","type":"nonprofit","lineage":["https://openalex.org/I4210142098"]},{"id":"https://openalex.org/I95674353","display_name":"UCLouvain","ror":"https://ror.org/02495e989","country_code":"BE","type":"education","lineage":["https://openalex.org/I95674353"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"David Alsteens","raw_affiliation_strings":["Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain","Walloon Excellence in Life sciences and Biotechnology (WELBIO), 1300 Wavre, Belgium","Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain, Ottignies-Louvain-la-Neuve, Belgium","Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Wavre, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Walloon Excellence in Life sciences and Biotechnology (WELBIO), 1300 Wavre, Belgium","institution_ids":["https://openalex.org/I4210142098"]},{"raw_affiliation_string":"Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 Catholique de Louvain, Ottignies-Louvain-la-Neuve, Belgium","institution_ids":["https://openalex.org/I95674353"]},{"raw_affiliation_string":"Walloon Excellence in Life Sciences and Biotechnology (WELBIO), Wavre, Belgium","institution_ids":["https://openalex.org/I4210142098"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029265500","display_name":"Thilo Stehle","orcid":"https://orcid.org/0000-0002-4571-8548","observed_orcids":["https://orcid.org/0000-0002-4571-8548"]},"institutions":[{"id":"https://openalex.org/I8087733","display_name":"University of T\u00fcbingen","ror":"https://ror.org/03a1kwz48","country_code":"DE","type":"education","lineage":["https://openalex.org/I8087733"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thilo Stehle","raw_affiliation_strings":["Interfaculty Institute of Biochemistry, University of T\u00fcbingen","Interfaculty Institute of Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4571-8548","affiliations":[{"raw_affiliation_string":"Interfaculty Institute of Biochemistry, University of T\u00fcbingen","institution_ids":["https://openalex.org/I8087733"]},{"raw_affiliation_string":"Interfaculty Institute of Biochemistry, University of T\u00fcbingen, T\u00fcbingen, Germany","institution_ids":["https://openalex.org/I8087733"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023812277","display_name":"Terence S. Dermody","orcid":"https://orcid.org/0000-0003-1853-8741","observed_orcids":["https://orcid.org/0000-0003-1853-8741"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210130600","display_name":"Children's Hospital of Pittsburgh","ror":"https://ror.org/03763ep67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"id":"https://openalex.org/I4210134769","display_name":"University of Pittsburgh Medical Center","ror":"https://ror.org/04ehecz88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210098814","https://openalex.org/I4210134769"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Terence S. Dermody","raw_affiliation_strings":["Departments of Pediatrics and Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, and Center for Microbial Pathogenesis, UPMC Children\u2019s Hospital of Pittsburgh","Departments of Pediatrics and Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, and Center for Microbial Pathogenesis, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA"],"raw_orcid":"https://orcid.org/0000-0003-1853-8741","affiliations":[{"raw_affiliation_string":"Departments of Pediatrics and Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, and Center for Microbial Pathogenesis, UPMC Children\u2019s Hospital of Pittsburgh","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]},{"raw_affiliation_string":"Departments of Pediatrics and Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, and Center for Microbial Pathogenesis, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210130600","https://openalex.org/I4210134769"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069026252","display_name":"Kristen M. Ogden","orcid":"https://orcid.org/0000-0002-2670-4335","observed_orcids":["https://orcid.org/0000-0002-2670-4335"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristen M. Ogden","raw_affiliation_strings":["Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center","Department of Pediatrics, Vanderbilt University Medical Center","Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA","Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":"https://orcid.org/0000-0002-2670-4335","affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5023812277","https://openalex.org/A5069026252"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210130600","https://openalex.org/I4210134769","https://openalex.org/I901861585"],"apc_list":null,"apc_paid":null,"fwci":0.1588,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.6395437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"94","issue":"23","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.9390000104904175,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/reovirus","display_name":"reovirus","score":0.9929999709129333},{"id":"https://openalex.org/keywords/conformational-flexibility","display_name":"conformational flexibility","score":0.8999999761581421},{"id":"https://openalex.org/keywords/host-cell-attachment","display_name":"host cell attachment","score":0.781000018119812},{"id":"https://openalex.org/keywords/receptor-binding-domain","display_name":"receptor binding domain","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cysteine-cross-linking","display_name":"cysteine cross-linking","score":0.9549999833106995},{"id":"https://openalex.org/keywords/viral-uncoating","display_name":"viral uncoating","score":0.6980000138282776},{"id":"https://openalex.org/keywords/plaque-size","display_name":"plaque size","score":0.6779999732971191},{"id":"https://openalex.org/keywords/viral-replication-kinetics","display_name":"viral replication kinetics","score":0.8769999742507935}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7581861019134521},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5791770219802856},{"id":"https://openalex.org/C2777339483","wikidata":"https://www.wikidata.org/wiki/Q647203","display_name":"Conformational change","level":2,"score":0.5629591941833496},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5556723475456238},{"id":"https://openalex.org/C58475186","wikidata":"https://www.wikidata.org/wiki/Q4118894","display_name":"Viral entry","level":4,"score":0.5226585268974304},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.506353497505188},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.4866998493671417},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.47187677025794983},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4161185026168823},{"id":"https://openalex.org/C97380033","wikidata":"https://www.wikidata.org/wiki/Q994215","display_name":"Viral envelope","level":3,"score":0.4127481281757355},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.3002797067165375},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2918708324432373},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2641405165195465},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1521555781364441}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007739","descriptor_name":"L Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012087","descriptor_name":"Reoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012087","descriptor_name":"Reoviridae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D036022","descriptor_name":"Capsid Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053585","descriptor_name":"Virus Attachment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053586","descriptor_name":"Virus Internalization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/jvi.01163-20","doi":"https://doi.org/10.1128/jvi.01163-20","is_oa":false,"landing_page_url":"https://doi.org/10.1128/jvi.01163-20","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"doi:10.1101/2020.06.09.143594","doi":"https://doi.org/10.1101/2020.06.09.143594","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.09.143594","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/12/2020.06.09.143594.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7654274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7654274","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:32938765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32938765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"},{"id":"pmh:oai:dial.uclouvain.be:boreal:252506","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2078.1/252506","pdf_url":null,"source":{"id":"https://openalex.org/S4306401902","display_name":"Digital Access to Libraries (Universit\u00e9 catholique de Louvain (UCL), l'Universit\u00e9 de Namur (UNamur) and the Universit\u00e9 Saint-Louis (USL-B))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95674353","host_organization_name":"UCLouvain","host_organization_lineage":["https://openalex.org/I95674353"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of virology, Vol. 94, no.23, p. e01163-20 [1-18] (2020)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1101/2020.06.09.143594","doi":"https://doi.org/10.1101/2020.06.09.143594","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.09.143594","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/12/2020.06.09.143594.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3394017648","display_name":"Reovirus Attachment Mechanisms","funder_award_id":"R01AI118887","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G9000862353","display_name":"Molecular and Cellular Basis for Digestive Diseases","funder_award_id":"P30DK058404","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320332432","display_name":"School of Medicine, Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3087288588.pdf","grobid_xml":"https://content.openalex.org/works/W3087288588.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W15145901","https://openalex.org/W184342374","https://openalex.org/W1507590754","https://openalex.org/W1592046893","https://openalex.org/W1654444165","https://openalex.org/W1895388300","https://openalex.org/W1944073862","https://openalex.org/W1956535100","https://openalex.org/W1970863640","https://openalex.org/W1971638410","https://openalex.org/W1972616945","https://openalex.org/W1974262428","https://openalex.org/W1982097445","https://openalex.org/W1984355682","https://openalex.org/W1997019840","https://openalex.org/W1999853046","https://openalex.org/W2001075249","https://openalex.org/W2007841228","https://openalex.org/W2008217463","https://openalex.org/W2013290029","https://openalex.org/W2019877102","https://openalex.org/W2028804476","https://openalex.org/W2036258571","https://openalex.org/W2036475903","https://openalex.org/W2050717189","https://openalex.org/W2056484137","https://openalex.org/W2057397861","https://openalex.org/W2069087293","https://openalex.org/W2070556034","https://openalex.org/W2076868305","https://openalex.org/W2081047238","https://openalex.org/W2082471681","https://openalex.org/W2095433366","https://openalex.org/W2095549733","https://openalex.org/W2101200006","https://openalex.org/W2115094328","https://openalex.org/W2115994196","https://openalex.org/W2117582775","https://openalex.org/W2122170158","https://openalex.org/W2130419042","https://openalex.org/W2130685885","https://openalex.org/W2142630646","https://openalex.org/W2145386287","https://openalex.org/W2157477381","https://openalex.org/W2158062405","https://openalex.org/W2160360322","https://openalex.org/W2160759985","https://openalex.org/W2165151174","https://openalex.org/W2167003293","https://openalex.org/W2170737085","https://openalex.org/W2403933179","https://openalex.org/W2542260424","https://openalex.org/W2560832589","https://openalex.org/W2577696913","https://openalex.org/W2604301236","https://openalex.org/W2762701457","https://openalex.org/W2766222975","https://openalex.org/W2802153773","https://openalex.org/W2898634673","https://openalex.org/W2950758399","https://openalex.org/W2977244776","https://openalex.org/W3007744741","https://openalex.org/W4322697540"],"related_works":["https://openalex.org/W4410333189","https://openalex.org/W2130685885","https://openalex.org/W2802153773","https://openalex.org/W2523890065","https://openalex.org/W4398168345","https://openalex.org/W2003161836","https://openalex.org/W1997878763","https://openalex.org/W2033790311","https://openalex.org/W2214448694","https://openalex.org/W4376602988"],"abstract_inverted_index":{"ABSTRACT":[0],"Reovirus":[1],"attachment":[2,220,291],"protein":[3],"\u03c31":[4,17,45,66,84,98,190,242,261,286,301],"is":[5,205],"a":[6,61,68,125,253,263],"trimeric":[7],"molecule":[8],"containing":[9,158,237],"tail,":[10,109],"body,":[11,110],"and":[12,21,47,111,139,167,179,227,234,274],"head":[13,112,130,164],"domains.":[14,113],"During":[15],"infection,":[16],"engages":[18],"sialylated":[19],"glycans":[20],"junctional":[22],"adhesion":[23],"molecule-A":[24],"(JAM-A),":[25],"triggering":[26],"uptake":[27],"into":[28,54],"the":[29,55,81,108,119,129,147,163,176,194,212,219,250,257,271,285,305],"endocytic":[30],"compartment,":[31],"where":[32],"virions":[33,72],"are":[34,180,230],"proteolytically":[35],"converted":[36],"to":[37,73,91,146,175,182],"infectious":[38],"subvirion":[39],"particles":[40,157],"(ISVPs).":[41],"Further":[42],"disassembly":[43],"allows":[44],"release":[46],"escape":[48],"of":[49,83,152,196,215,252,260,307],"transcriptionally":[50],"active":[51],"reovirus":[52,197,290,308],"cores":[53],"cytosol.":[56],"Electron":[57],"microscopy":[58],"has":[59],"revealed":[60],"distinct":[62],"conformational":[63,85,191,216,302],"change":[64],"in":[65,107,128,218,244,256],"from":[67],"compact":[69],"form":[70,76],"on":[71,77],"an":[74,206],"extended":[75],"ISVPs.":[78,153],"To":[79],"determine":[80],"importance":[82],"mobility,":[86],"we":[87,281],"used":[88],"reverse":[89],"genetics":[90],"introduce":[92],"cysteine":[93,126,159,238,254],"mutations":[94,160,239],"that":[95,161,189,223,240,249,265,283,300],"can":[96],"crosslink":[97,162,241],"by":[99],"establishing":[100],"disulfide":[101],"bonds":[102],"between":[103],"structurally":[104],"adjacent":[105],"sites":[106],"We":[114,232,247],"detected":[115],"phenotypic":[116],"differences":[117],"among":[118],"engineered":[120,233],"viruses.":[121],"A":[122],"mutant":[123],"with":[124,133,172,267],"pair":[127,255],"domain":[131,165,259,288],"replicates":[132,266],"enhanced":[134],"kinetics,":[135],"forms":[136,275],"large":[137],"plaques,":[138],"displays":[140],"increased":[141],"avidity":[142],"for":[143],"JAM-A":[144],"relative":[145],"parental":[148,177,272],"virus,":[149],"mimicking":[150],"properties":[151],"However,":[154],"unlike":[155],"ISVPs,":[156],"uncoat":[166],"transcribe":[168],"viral":[169],"positive-sense":[170],"RNA":[171],"kinetics":[173,269],"similar":[174],"virus":[178,203,264,273],"sensitive":[181],"ammonium":[183],"chloride.":[184],"Together,":[185],"these":[186],"data":[187,298],"suggest":[188,299],"flexibility":[192],"modulates":[193,289],"efficiency":[195,306],"host":[198,309],"cell":[199,310],"attachment.":[200,311],"IMPORTANCE":[201],"Nonenveloped":[202],"entry":[204,226],"incompletely":[207],"understood":[208],"process.":[209],"For":[210],"reovirus,":[211],"functional":[213,279],"significance":[214],"rearrangements":[217,303],"protein,":[221],"\u03c31,":[222],"occur":[224],"during":[225],"particle":[228],"uncoating":[229,294],"unknown.":[231],"characterized":[235],"reoviruses":[236],"monomers":[243],"non-reducing":[245],"conditions.":[246],"found":[248,282],"introduction":[251],"receptor-binding":[258,287],"yielded":[262],"faster":[268],"than":[270],"larger":[276],"plaques.":[277],"Using":[278],"assays,":[280],"crosslinking":[284],"but":[292],"not":[293],"or":[295],"transcription.":[296],"These":[297],"mediate":[304]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-25T00:00:00"}