{"id":"https://openalex.org/W3087140835","doi":"https://doi.org/10.20944/preprints201905.0326.v1","title":"Monoclonal Antibody as an Emerging Therapies for Ischemic Stroke","display_name":"Monoclonal Antibody as an Emerging Therapies for Ischemic Stroke","publication_year":2019,"publication_date":"2019-05-28","ids":{"openalex":"https://openalex.org/W3087140835","doi":"https://doi.org/10.20944/preprints201905.0326.v1","mag":"3087140835","pmid":"https://pubmed.ncbi.nlm.nih.gov/32934765","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7486556"},"language":"en","primary_location":{"id":"doi:10.20944/preprints201905.0326.v1","doi":"https://doi.org/10.20944/preprints201905.0326.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201905.0326.v1","pdf_url":"https://www.preprints.org/manuscript/201905.0326/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.preprints.org/manuscript/201905.0326/v1/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038191302","display_name":"Demi Woods","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Demi Woods","raw_affiliation_strings":["Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115589911","display_name":"Qian Jiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qian Jiang","raw_affiliation_strings":["Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015897926","display_name":"Xiang\u2010Ping Chu","orcid":"https://orcid.org/0000-0002-6781-0468","observed_orcids":["https://orcid.org/0000-0002-6781-0468"]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]},{"id":"https://openalex.org/I899859998","display_name":"Qiqihar Medical University","ror":"https://ror.org/01kzgyz42","country_code":"CN","type":"education","lineage":["https://openalex.org/I899859998"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Xiang-Ping Chu","raw_affiliation_strings":["Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA","Neuroscience Laboratory for Translational Medicine , School of Mental Health , Qiqihar Medical University , Qiqihar , Heilongjiang 161006 , China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, 64108, USA","institution_ids":["https://openalex.org/I75421653"]},{"raw_affiliation_string":"Neuroscience Laboratory for Translational Medicine , School of Mental Health , Qiqihar Medical University , Qiqihar , Heilongjiang 161006 , China;","institution_ids":["https://openalex.org/I899859998"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015897926"],"corresponding_institution_ids":["https://openalex.org/I75421653","https://openalex.org/I899859998"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"4","first_page":"95","last_page":"106"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.011300000362098217,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.006899999920278788,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8569999933242798},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9350000023841858},{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.6639999747276306},{"id":"https://openalex.org/keywords/tissue-plasminogen-activator","display_name":"tissue plasminogen activator","score":0.8209999799728394},{"id":"https://openalex.org/keywords/therapeutic-window","display_name":"therapeutic window","score":0.5879999995231628},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7720000147819519},{"id":"https://openalex.org/keywords/growth-factors","display_name":"growth factors","score":0.640999972820282},{"id":"https://openalex.org/keywords/acid-sensing-ion-channels","display_name":"acid-sensing ion channels","score":0.996999979019165},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9879999756813049},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.8040000200271606},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.7210000157356262},{"id":"https://openalex.org/keywords/stroke-treatment","display_name":"stroke treatment","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7416749000549316},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6193143129348755},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.6077022552490234},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.5402066707611084},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5272842049598694},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.44603610038757324},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4221588969230652},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3766101598739624},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3512808680534363},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3427814245223999},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30592066049575806},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27143555879592896},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.09587240219116211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09239867329597473},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.20944/preprints201905.0326.v1","doi":"https://doi.org/10.20944/preprints201905.0326.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201905.0326.v1","pdf_url":"https://www.preprints.org/manuscript/201905.0326/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},{"id":"pmid:32934765","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32934765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of physiology, pathophysiology and pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7486556","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7486556/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Physiol Pathophysiol Pharmacol","raw_type":"Text"},{"id":"mag:3087140835","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32934765","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.20944/preprints201905.0326.v1","doi":"https://doi.org/10.20944/preprints201905.0326.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints201905.0326.v1","pdf_url":"https://www.preprints.org/manuscript/201905.0326/v1/download","source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1051853935","display_name":"Brain ASIC2a-containing channels contribute to acute ischemic brain injury","funder_award_id":"19AIREA34470007","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309568","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06"},{"id":"https://openalex.org/F4320311312","display_name":"University of Missouri-Kansas City","ror":"https://ror.org/01w0d5g70"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3087140835.pdf","grobid_xml":"https://content.openalex.org/works/W3087140835.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W1133670233","https://openalex.org/W1675918302","https://openalex.org/W1967099353","https://openalex.org/W1967904415","https://openalex.org/W1971178238","https://openalex.org/W1974642350","https://openalex.org/W1980006560","https://openalex.org/W1984056547","https://openalex.org/W1985700135","https://openalex.org/W1986392692","https://openalex.org/W1993775981","https://openalex.org/W1996763992","https://openalex.org/W1997074250","https://openalex.org/W2000730164","https://openalex.org/W2001646873","https://openalex.org/W2005614483","https://openalex.org/W2009085444","https://openalex.org/W2011240126","https://openalex.org/W2016391008","https://openalex.org/W2024380057","https://openalex.org/W2031464600","https://openalex.org/W2033350085","https://openalex.org/W2034012085","https://openalex.org/W2036632895","https://openalex.org/W2037852973","https://openalex.org/W2042685592","https://openalex.org/W2043133738","https://openalex.org/W2049436088","https://openalex.org/W2051058230","https://openalex.org/W2065995663","https://openalex.org/W2069096776","https://openalex.org/W2072452087","https://openalex.org/W2074841206","https://openalex.org/W2076624461","https://openalex.org/W2078428052","https://openalex.org/W2079563099","https://openalex.org/W2080203024","https://openalex.org/W2085805107","https://openalex.org/W2086688096","https://openalex.org/W2090439922","https://openalex.org/W2093623913","https://openalex.org/W2095997760","https://openalex.org/W2096293984","https://openalex.org/W2104522961","https://openalex.org/W2109420322","https://openalex.org/W2123658895","https://openalex.org/W2123851168","https://openalex.org/W2126941038","https://openalex.org/W2130098213","https://openalex.org/W2140855329","https://openalex.org/W2163726533","https://openalex.org/W2166399330","https://openalex.org/W2172158557","https://openalex.org/W2228774679","https://openalex.org/W2267313779","https://openalex.org/W2271056960","https://openalex.org/W2274688283","https://openalex.org/W2289819802","https://openalex.org/W2292308933","https://openalex.org/W2299205717","https://openalex.org/W2317241980","https://openalex.org/W2366956643","https://openalex.org/W2466845996","https://openalex.org/W2508097989","https://openalex.org/W2509492259","https://openalex.org/W2512549335","https://openalex.org/W2550245877","https://openalex.org/W2566624312","https://openalex.org/W2587953391","https://openalex.org/W2589336895","https://openalex.org/W2591271008","https://openalex.org/W2597579173","https://openalex.org/W2607435600","https://openalex.org/W2609932849","https://openalex.org/W2618020069","https://openalex.org/W2749576197","https://openalex.org/W2783051872","https://openalex.org/W2800065914","https://openalex.org/W2803105756","https://openalex.org/W2803958951","https://openalex.org/W2884945321","https://openalex.org/W2895928174","https://openalex.org/W2897096830","https://openalex.org/W2904167785","https://openalex.org/W2909199457","https://openalex.org/W2912387895","https://openalex.org/W2922970403","https://openalex.org/W2943646566","https://openalex.org/W2945308813","https://openalex.org/W2946474480","https://openalex.org/W2949544179","https://openalex.org/W2949836841","https://openalex.org/W2951085116","https://openalex.org/W2952945137","https://openalex.org/W2954592897","https://openalex.org/W2954755570","https://openalex.org/W2955492602","https://openalex.org/W2955686537","https://openalex.org/W2957360511","https://openalex.org/W2957636399","https://openalex.org/W2959218190","https://openalex.org/W2959738862","https://openalex.org/W2963629436","https://openalex.org/W2964969092","https://openalex.org/W4210987237","https://openalex.org/W4406059073"],"related_works":["https://openalex.org/W2947239672","https://openalex.org/W4313472590","https://openalex.org/W2274688283","https://openalex.org/W2128027646","https://openalex.org/W1535293584","https://openalex.org/W1992889156","https://openalex.org/W2263446028","https://openalex.org/W1993735047","https://openalex.org/W2062305670","https://openalex.org/W2466241842"],"abstract_inverted_index":{"leading":[0,6],"cause":[1,7],"of":[2,8,41,59,76,79,92,113,146,151,205],"death":[3],"and":[4,17,54,182,193],"the":[5,12,33,38,42,50,77,93,110,118,149,179,202],"neurological":[9],"disability":[10],"in":[11,148],"United":[13],"States.":[14],"The":[15,44],"oxygen":[16],"glucose":[18],"deprivation":[19],"associated":[20],"with":[21],"AIS":[22,60,115,172],"not":[23],"only":[24,45,70],"leads":[25],"to":[26,103,108,200],"neuronal":[27],"cell":[28],"death,":[29],"but":[30],"also":[31],"increases":[32],"inflammatory":[34],"response,":[35],"therefore":[36],"decreasing":[37],"functional":[39],"outcome":[40],"brain.":[43],"pharmacological":[46],"intervention":[47],"approved":[48],"by":[49,135,174],"US":[51],"Federal":[52],"Food":[53],"Drug":[55],"Administration":[56],"for":[57,121,156,214],"treatment":[58,68,150],"is":[61],"tissue":[62],"plasminogen":[63],"activator":[64],"(t-PA),":[65],"however,":[66],"such":[67,185],"can":[69],"be":[71],"given":[72],"within":[73],"4.5":[74],"hours":[75],"onset":[78],"stroke-like":[80],"symptoms.":[81],"This":[82],"narrow":[83],"time-range":[84],"limits":[85],"its":[86],"therapeutic":[87,94,154],"application.":[88],"Administrating":[89],"t-PA":[90],"outside":[91],"window":[95],"may":[96],"induce":[97],"detrimental":[98],"rather":[99],"than":[100],"beneficial":[101],"effects":[102],"stroke":[104],"patients.":[105],"In":[106,162],"order":[107],"reduce":[109],"infarct":[111],"volume":[112],"an":[114,141,215],"while":[116],"increasing":[117],"time":[119],"period":[120],"treatment,":[122],"new":[123],"treatments":[124],"are":[125,158],"essential.":[126],"Emerging":[127],"monoclonal":[128],"antibody":[129],"(mAb)":[130],"therapies":[131],"reveal":[132],"great":[133],"potential":[134],"targeting":[136],"signaling":[137,180,203],"pathways":[138,204],"activated":[139],"after":[140],"AIS.":[142,216],"With":[143],"successful":[144],"application":[145],"mAb":[147,157,176,199],"cancer,":[152],"other":[153],"uses":[155],"currently":[159],"being":[160,212],"evaluated.":[161],"this":[163],"review,":[164],"we":[165],"will":[166,209],"focus":[167],"on":[168,171],"recent":[169],"advances":[170],"therapy":[173],"using":[175],"that":[177],"targets":[178],"cascades":[181],"endogenous":[183],"molecules":[184],"as":[186],"inflammation,":[187],"growth":[188],"factors,":[189],"acid-sensing":[190],"ion":[191],"channels,":[192],"N-methyl-D-aspartate":[194],"receptors.":[195],"Therefore,":[196],"developing":[197],"specific":[198],"target":[201],"ischemic":[206],"brain":[207],"injury":[208],"benefit":[210],"patients":[211],"treated":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2020-09-25T00:00:00"}
