{"id":"https://openalex.org/W3086864451","doi":null,"title":"Meta-analysis of time to seizure relapse after a post-operative epilepsy surgery.","display_name":"Meta-analysis of time to seizure relapse after a post-operative epilepsy surgery.","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3086864451","mag":"3086864451"},"language":"en","primary_location":{"id":"pmh:oai:researchspace.ukzn.ac.za:10413/18653","doi":null,"is_oa":false,"landing_page_url":"https://researchspace.ukzn.ac.za/handle/10413/18653","pdf_url":null,"source":{"id":"https://openalex.org/S4306402416","display_name":"ResearchSpace (University of KwaZulu-Natal)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95023434","host_organization_name":"University of KwaZulu-Natal","host_organization_lineage":["https://openalex.org/I95023434"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"review","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060471148","display_name":"Smilo Patrick. Memela","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Smilo Patrick. Memela","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5060471148"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12267","display_name":"Diet and metabolism studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12622","display_name":"Neurosurgical Procedures and Complications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epilepsy-surgery","display_name":"epilepsy surgery","score":0.7450000047683716},{"id":"https://openalex.org/keywords/seizure-recurrence","display_name":"seizure recurrence","score":0.8349999785423279},{"id":"https://openalex.org/keywords/drug-resistant-epilepsy","display_name":"drug-resistant epilepsy","score":0.9399999976158142},{"id":"https://openalex.org/keywords/engel-classification","display_name":"Engel classification","score":0.6970000267028809},{"id":"https://openalex.org/keywords/seizure-freedom","display_name":"seizure freedom","score":0.7350000143051147},{"id":"https://openalex.org/keywords/resective-epilepsy-surgery","display_name":"resective epilepsy surgery","score":0.7549999952316284},{"id":"https://openalex.org/keywords/random-effects-model","display_name":"random effects models","score":0.6100000143051147},{"id":"https://openalex.org/keywords/fixed-effects-model","display_name":"fixed effects model","score":0.8389999866485596},{"id":"https://openalex.org/keywords/study-heterogeneity","display_name":"study heterogeneity","score":0.7419999837875366},{"id":"https://openalex.org/keywords/long-term-seizure-outcome","display_name":"long-term seizure outcome","score":0.7129999995231628},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"survival analysis","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.6745210886001587},{"id":"https://openalex.org/C2780803581","wikidata":"https://www.wikidata.org/wiki/Q1347108","display_name":"Epilepsy surgery","level":3,"score":0.5459959506988525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5351394414901733},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3563799560070038},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2037084400653839}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:researchspace.ukzn.ac.za:10413/18653","doi":null,"is_oa":false,"landing_page_url":"https://researchspace.ukzn.ac.za/handle/10413/18653","pdf_url":null,"source":{"id":"https://openalex.org/S4306402416","display_name":"ResearchSpace (University of KwaZulu-Natal)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I95023434","host_organization_name":"University of KwaZulu-Natal","host_organization_lineage":["https://openalex.org/I95023434"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:3086864451","doi":null,"is_oa":false,"landing_page_url":"https://researchspace.ukzn.ac.za/handle/10413/18653","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Systematic Review","id":"https://openalex.org/study-designs/systematic-review"},{"display_name":"Meta-Analysis","id":"https://openalex.org/study-designs/meta-analysis"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":4,"referenced_works":["https://openalex.org/W2035632263","https://openalex.org/W2044257801","https://openalex.org/W2045800993","https://openalex.org/W2606671826"],"related_works":["https://openalex.org/W7128960197","https://openalex.org/W2791773975","https://openalex.org/W4254404786","https://openalex.org/W3047346729","https://openalex.org/W2742090334","https://openalex.org/W2014133935","https://openalex.org/W4254890739","https://openalex.org/W2198088522","https://openalex.org/W2077525621","https://openalex.org/W3096354123"],"abstract_inverted_index":{"Epilepsy":[0],"is":[1,41,140,145,190,196],"a":[2,37,55,76,83,104,137,175,254,393,399],"common":[3,138],"disease":[4],"world-wide":[5],"whose":[6],"suggested":[7],"treatment":[8,248],"vary":[9],"from":[10],"\\nsurgical":[11],"to":[12,44,47,64,71,75,102,114,125,146,197,201,234,458,470,487],"non-surgical.":[13],"Although":[14],"surgical":[15,206],"treatments":[16],"may":[17,483],"be":[18,471,484],"commonly":[19],"recommended":[20],"\\nand":[21],"successful":[22,56],"in":[23,79,168,245,271,328,392,398,415,466,492],"pharmacoresistant":[24],"epilepsy":[25,53,80,154,158],"for":[26,334],"patients":[27,34,51,81],"with":[28,264],"refractory":[29,165],"\\nepilepsy,":[30],"there":[31],"are":[32,112,134],"some":[33,89],"who":[35],"experience":[36],"seizure":[38,77,150,191,203,211,290,386],"relapse.":[39],"It":[40],"of":[42,94,96,107,118,132,156,164,188,238,256,289,292,308,310,407],"interest":[43,189,195],"\\nmedical":[45],"practitioners":[46],"determine":[48,72,147],"how":[49],"long":[50],"survive":[52],"after":[54,152,205,273],"\\nsurgery.":[57,170],"Survival":[58],"analysis":[59,380,465,482],"methods":[60,121],"have":[61,88,122],"been":[62,123],"used":[63,233],"model":[65,231,396,411,469],"time-to-event":[66,490],"\\ndata.":[67],"Hence":[68],"we":[69,326],"attempt":[70],"the":[73,108,116,148,162,172,199,210,213,236,261,284,287,293,301,315,385,408,416,463,480,485,489],"time":[74,200,268,418,457],"relapse":[78,192,204,459],"\\nafter":[82],"surgery.":[84],"However,":[85],"single":[86,110,246],"study":[87,174],"limitations,":[90],"such":[91],"as":[92],"lack":[93],"\\naccommodation":[95],"spatial":[97],"factors,":[98],"different":[99],"research":[100],"approaches":[101],"mention":[103],"few.":[105],"\\nMost":[106],"time,":[109],"studies":[111,133,258,319],"under-powered":[113],"detect":[115],"factors":[117],"covariates.":[119],"\\nMeta-analysis":[120],"developed":[124],"overcome":[126],"this":[127],"problem,":[128],"where":[129],"\\na":[130],"number":[131],"amalgamated":[135],"and":[136,184,193,224,228,280,314,341,371,425,450],"conclusion":[139],"drawn.":[141],"This":[142],"thesis":[143],"\\naims":[144],"long-term":[149],"outcome":[151],"an":[153],"surgery":[155],"\\nrefractory":[157],"without":[159],"focusing":[160],"on":[161],"types":[163],"but":[166],"rather":[167],"resective":[169],"In":[171,283],"current":[173],"systematic":[176],"review":[177],"was":[178,220,243,306,321],"done":[179],"using":[180,462],"Google":[181],"Scholar,":[182],"\\nMedline,":[183],"PubMed.":[185],"The":[186,222,323,378,403,455],"event":[187],"our":[194],"\\npool":[198],"first":[202],"treatment.":[207],"To":[208],"measure":[209,235],"\\nfreedom":[212],"clinical":[214],"method":[215],"call":[216],"Engel":[217],"class":[218],"I":[219],"used.":[221],"univariate":[223,285,329],"metasurvival":[225],"\\nof":[226],"fixed":[227,294,394],"random":[229,302,330,400,409,467],"effect":[230,303,331,410],"were":[232,253,297,333,344,413,427],"proportion":[237],"\\nseizure":[239],"freedom.":[240],"Our":[241],"focus":[242],"only":[244],"arm":[247],"(surgical":[249],"treatment)":[250],".":[251],"\\nThere":[252],"total":[255],"18":[257],"that":[259,325,412,479],"satisfy":[260],"inclusion":[262],"criteria":[263],"observations":[265],"\\nat":[266],"6":[267],"points":[269],"measured":[270],"months":[272,343],"post-operative":[274],"(6,":[275],"12,":[276,337,421],"24,":[277,338,422],"36,":[278,339,423],"60":[279,340,424],"120":[281,342,426],"\\nmonths).":[282],"analysis,":[286],"probabilities":[288],"freedom":[291],"\\neffects":[295],"models":[296],"systematically":[298,382],"larger":[299,391],"than":[300,397],"results.":[304],"There":[305],"\\nevidence":[307],"significance":[309],"heterogeneity":[311],"between":[312],"studies,":[313],"true":[316],"variation":[317],"\\nbetween":[318],"test":[320],"large.":[322],"result":[324],"got":[327],"\\nmodel":[332],"time-points":[335],"6,":[336,420],"0.74":[345],"95%":[346,352,357,362,367,373,429,434,439,443,447],"confidence":[347],"\\ninterval":[348],"(CI)(0.66-":[349],"0.82),":[350],"0.69":[351],"CI":[353,358,363,368,374,430,435],"(0.61-":[354],"0.77),":[355],"0.64":[356],"(0.56-":[359],"0.71),":[360],"0.60":[361],"\\n(0.52-":[364],"0.68),":[365],"0.56":[366],"(0.48-":[369],"0.63)":[370],"0.47":[372],"(0.38-":[375],"0.56)":[376],"respectively.":[377,454],"\\nmeta-survival":[379],"also":[381],"showed":[383],"that,":[384],"free":[387],"probability":[388],"\\n":[389],"\\nwere":[390],"effects":[395,401,468],"model.":[402],"summary":[404],"\\nsurvival":[405],"estimates":[406],"pooled":[414],"following":[417],"\\npoints":[419],"0.7655":[428],"(0.6808-":[431],"0.8613),":[432],"0.7140":[433],"\\n(0.6246-":[436],"0.8163),":[437],"0.6462":[438],"(0.5614,":[440],"0.7438),":[441],"0.6105":[442],"(0.5225,":[444],"0.7133),":[445],"0.5700":[446],"\\n(0.4892,":[448],"0.6641)":[449],"0.4755":[451],"(0.4078,":[452],"0.5545)":[453],"median":[456],"\\nwas":[460],"found":[461],"meta-survival":[464,481],"104.46":[472],"\\nmonths":[473],"(8.87":[474],"years).":[475],"We":[476],"can":[477],"conclude":[478],"\\nmethod":[486],"pool":[488],"data":[491],"one-arm":[493],"treatment..":[494]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2020-09-21T00:00:00"}