{"id":"https://openalex.org/W3086798544","doi":"https://doi.org/10.15403/jgld-2667","title":"Autoimmune Hepatitis: a Review of Established and Evolving Treatments","display_name":"Autoimmune Hepatitis: a Review of Established and Evolving Treatments","publication_year":2020,"publication_date":"2020-09-09","ids":{"openalex":"https://openalex.org/W3086798544","doi":"https://doi.org/10.15403/jgld-2667","mag":"3086798544","pmid":"https://pubmed.ncbi.nlm.nih.gov/32919424"},"language":"en","primary_location":{"id":"doi:10.15403/jgld-2667","doi":"https://doi.org/10.15403/jgld-2667","is_oa":true,"landing_page_url":"https://doi.org/10.15403/jgld-2667","pdf_url":"https://www.jgld.ro/jgld/index.php/jgld/article/download/2667/1614","source":{"id":"https://openalex.org/S165008743","display_name":"Journal of Gastrointestinal and Liver Diseases","issn_l":"1221-4167","issn":["1221-4167","1841-8724","1842-1121"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310314547","host_organization_name":"Editura Medical\u0103 Universitar\u0103 Iuliu Hatieganu","host_organization_lineage":["https://openalex.org/P4310314547"],"host_organization_lineage_names":["Editura Medical\u0103 Universitar\u0103 Iuliu Hatieganu"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal and Liver Diseases","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.jgld.ro/jgld/index.php/jgld/article/download/2667/1614","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079299937","display_name":"Sebastian Bischoff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sebastian Bischoff","raw_affiliation_strings":["Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. . sebastian.bischoff@umm.de","Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. . sebastian.bischoff@umm.de","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073851198","display_name":"Kakharman Yesmembetov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210120689","display_name":"Universit\u00e4tsklinikum Aachen","ror":"https://ror.org/02gm5zw39","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210120689"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kakharman Yesmembetov","raw_affiliation_strings":["Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim; Department of Medicine III, University Medical Center Aachen, Aachen. kyesmembetov@gmail.com","Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim","Department of Medicine III, University Medical Center Aachen, Aachen"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim; Department of Medicine III, University Medical Center Aachen, Aachen. kyesmembetov@gmail.com","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Department of Medicine III, University Medical Center Aachen, Aachen","institution_ids":["https://openalex.org/I4210120689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044320481","display_name":"Christoph Antoni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Antoni","raw_affiliation_strings":["Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. christoph.antoni@umm.de","Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. christoph.antoni@umm.de","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055040059","display_name":"Janina Sollors","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Janina Sollors","raw_affiliation_strings":["Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. janina.sollors@umm.de","Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. janina.sollors@umm.de","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022582588","display_name":"Matthias Evert","orcid":"https://orcid.org/0009-0001-8412-9682","observed_orcids":["https://orcid.org/0009-0001-8412-9682"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Evert","raw_affiliation_strings":["Department of Pathology, University of Regensburg, Regensburg, Germany. matthias.evert@ukr.de","Department of Pathology, University of Regensburg, Regensburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Regensburg, Regensburg, Germany. matthias.evert@ukr.de","institution_ids":["https://openalex.org/I60668342"]},{"raw_affiliation_string":"Department of Pathology, University of Regensburg, Regensburg, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102816393","display_name":"Matthias P. Ebert","orcid":"https://orcid.org/0000-0003-3228-5138","observed_orcids":["https://orcid.org/0000-0003-3228-5138"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthias Ebert","raw_affiliation_strings":["Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. matthias.ebert@umm.de","Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. matthias.ebert@umm.de","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089643041","display_name":"Andreas Teufel","orcid":"https://orcid.org/0000-0001-7953-8927","observed_orcids":["https://orcid.org/0000-0001-7953-8927"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210156450","display_name":"University Medical Centre Mannheim","ror":"https://ror.org/05sxbyd35","country_code":"DE","type":"funder","lineage":["https://openalex.org/I4210156450"]},{"id":"https://openalex.org/I4387153978","display_name":"Medizinische Fakult\u00e4t Mannheim","ror":"https://ror.org/02m1z0a87","country_code":"DE","type":"education","lineage":["https://openalex.org/I4387153978"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Teufel","raw_affiliation_strings":["Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Andreas.Teufel@medma.uni-heidelberg.de","Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Andreas.Teufel@medma.uni-heidelberg.de","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]},{"raw_affiliation_string":"Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany","institution_ids":["https://openalex.org/I223822909","https://openalex.org/I4210156450","https://openalex.org/I4387153978"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1087,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.14853195,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"29","issue":"3","first_page":"429","last_page":"443"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11576","display_name":"IgG4-Related and Inflammatory Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoimmune-hepatitis","display_name":"autoimmune hepatitis","score":1.0},{"id":"https://openalex.org/keywords/immunosuppressive-therapy","display_name":"immunosuppressive therapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.9919999837875366},{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":1.0},{"id":"https://openalex.org/keywords/mycophenolate-mofetil","display_name":"mycophenolate mofetil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tacrolimus","display_name":"tacrolimus","score":1.0},{"id":"https://openalex.org/keywords/everolimus","display_name":"everolimus","score":1.0},{"id":"https://openalex.org/keywords/6-mercaptopurine","display_name":"6-mercaptopurine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/infliximab","display_name":"infliximab","score":1.0},{"id":"https://openalex.org/keywords/rituximab","display_name":"rituximab","score":1.0},{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9179999828338623},{"id":"https://openalex.org/keywords/disease-heterogeneity","display_name":"disease heterogeneity","score":0.6060000061988831},{"id":"https://openalex.org/keywords/diagnosis","display_name":"diagnosis","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9531413316726685},{"id":"https://openalex.org/C2777203481","wikidata":"https://www.wikidata.org/wiki/Q786844","display_name":"Autoimmune hepatitis","level":3,"score":0.8570190668106079},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.8162147402763367},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.7612018585205078},{"id":"https://openalex.org/C2909675724","wikidata":"https://www.wikidata.org/wiki/Q411648","display_name":"Tacrolimus","level":3,"score":0.6695414781570435},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.6416217088699341},{"id":"https://openalex.org/C2909935303","wikidata":"https://www.wikidata.org/wiki/Q420553","display_name":"Mycophenolate","level":3,"score":0.5035378336906433},{"id":"https://openalex.org/C2779699572","wikidata":"https://www.wikidata.org/wiki/Q421052","display_name":"Everolimus","level":2,"score":0.4785347878932953},{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.4777611792087555},{"id":"https://openalex.org/C2777138892","wikidata":"https://www.wikidata.org/wiki/Q415264","display_name":"Infliximab","level":3,"score":0.46665072441101074},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4224804639816284},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42108678817749023},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.39738699793815613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29876843094825745},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.1894739270210266},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.15470245480537415},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.1198490560054779}],"mesh":[{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012074","descriptor_name":"Remission Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D019693","descriptor_name":"Hepatitis, Autoimmune","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.15403/jgld-2667","doi":"https://doi.org/10.15403/jgld-2667","is_oa":true,"landing_page_url":"https://doi.org/10.15403/jgld-2667","pdf_url":"https://www.jgld.ro/jgld/index.php/jgld/article/download/2667/1614","source":{"id":"https://openalex.org/S165008743","display_name":"Journal of Gastrointestinal and Liver Diseases","issn_l":"1221-4167","issn":["1221-4167","1841-8724","1842-1121"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310314547","host_organization_name":"Editura Medical\u0103 Universitar\u0103 Iuliu Hatieganu","host_organization_lineage":["https://openalex.org/P4310314547"],"host_organization_lineage_names":["Editura Medical\u0103 Universitar\u0103 Iuliu Hatieganu"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal and Liver Diseases","raw_type":"journal-article"},{"id":"pmid:32919424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32919424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of gastrointestinal and liver diseases : JGLD","raw_type":"Journal Article"},{"id":"pmh:oai:epub.uni-regensburg.de:49699","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/49699/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.15403/jgld-2667","doi":"https://doi.org/10.15403/jgld-2667","is_oa":true,"landing_page_url":"https://doi.org/10.15403/jgld-2667","pdf_url":"https://www.jgld.ro/jgld/index.php/jgld/article/download/2667/1614","source":{"id":"https://openalex.org/S165008743","display_name":"Journal of Gastrointestinal and Liver Diseases","issn_l":"1221-4167","issn":["1221-4167","1841-8724","1842-1121"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310314547","host_organization_name":"Editura Medical\u0103 Universitar\u0103 Iuliu Hatieganu","host_organization_lineage":["https://openalex.org/P4310314547"],"host_organization_lineage_names":["Editura Medical\u0103 Universitar\u0103 Iuliu Hatieganu"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Gastrointestinal and Liver Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3086798544.pdf","grobid_xml":"https://content.openalex.org/works/W3086798544.grobid-xml"},"referenced_works_count":155,"referenced_works":["https://openalex.org/W116289366","https://openalex.org/W120599582","https://openalex.org/W136931462","https://openalex.org/W191284583","https://openalex.org/W193395234","https://openalex.org/W209030589","https://openalex.org/W1498948971","https://openalex.org/W1586317264","https://openalex.org/W1597600359","https://openalex.org/W1894277271","https://openalex.org/W1965393193","https://openalex.org/W1967086705","https://openalex.org/W1967353454","https://openalex.org/W1970535089","https://openalex.org/W1973339766","https://openalex.org/W1974817945","https://openalex.org/W1975469487","https://openalex.org/W1975698040","https://openalex.org/W1978949756","https://openalex.org/W1980062656","https://openalex.org/W1980922036","https://openalex.org/W1980989647","https://openalex.org/W1981928952","https://openalex.org/W1987135399","https://openalex.org/W1989120397","https://openalex.org/W1989365299","https://openalex.org/W1990151373","https://openalex.org/W1996955305","https://openalex.org/W2001163441","https://openalex.org/W2001705541","https://openalex.org/W2003991342","https://openalex.org/W2004188199","https://openalex.org/W2006127290","https://openalex.org/W2006834593","https://openalex.org/W2007606799","https://openalex.org/W2007813057","https://openalex.org/W2013133188","https://openalex.org/W2014154627","https://openalex.org/W2015153299","https://openalex.org/W2015528735","https://openalex.org/W2017729523","https://openalex.org/W2018626170","https://openalex.org/W2019029821","https://openalex.org/W2020950635","https://openalex.org/W2021947384","https://openalex.org/W2022202791","https://openalex.org/W2022562649","https://openalex.org/W2022816800","https://openalex.org/W2026062231","https://openalex.org/W2026650756","https://openalex.org/W2030572354","https://openalex.org/W2031678166","https://openalex.org/W2032007378","https://openalex.org/W2034868699","https://openalex.org/W2036791601","https://openalex.org/W2037442557","https://openalex.org/W2038543905","https://openalex.org/W2039036677","https://openalex.org/W2039049566","https://openalex.org/W2042321442","https://openalex.org/W2044351877","https://openalex.org/W2046122777","https://openalex.org/W2046124686","https://openalex.org/W2047028490","https://openalex.org/W2062185109","https://openalex.org/W2062888250","https://openalex.org/W2067292160","https://openalex.org/W2069757747","https://openalex.org/W2070475222","https://openalex.org/W2075259610","https://openalex.org/W2078373822","https://openalex.org/W2080304201","https://openalex.org/W2082174044","https://openalex.org/W2084694209","https://openalex.org/W2085324373","https://openalex.org/W2088332148","https://openalex.org/W2095182095","https://openalex.org/W2095262005","https://openalex.org/W2095647244","https://openalex.org/W2101690589","https://openalex.org/W2113126568","https://openalex.org/W2113857853","https://openalex.org/W2116981696","https://openalex.org/W2117250898","https://openalex.org/W2118422146","https://openalex.org/W2121007493","https://openalex.org/W2125081368","https://openalex.org/W2125709655","https://openalex.org/W2127767188","https://openalex.org/W2127814283","https://openalex.org/W2129116090","https://openalex.org/W2132675308","https://openalex.org/W2137507272","https://openalex.org/W2142434338","https://openalex.org/W2143774114","https://openalex.org/W2150198156","https://openalex.org/W2151235541","https://openalex.org/W2156605858","https://openalex.org/W2160569786","https://openalex.org/W2161878033","https://openalex.org/W2163866986","https://openalex.org/W2166653283","https://openalex.org/W2171662843","https://openalex.org/W2171863506","https://openalex.org/W2185562016","https://openalex.org/W2195795890","https://openalex.org/W2211775624","https://openalex.org/W2290078664","https://openalex.org/W2297263427","https://openalex.org/W2298369555","https://openalex.org/W2315245000","https://openalex.org/W2331543379","https://openalex.org/W2404303479","https://openalex.org/W2408764807","https://openalex.org/W2412238287","https://openalex.org/W2464853933","https://openalex.org/W2519012884","https://openalex.org/W2564761214","https://openalex.org/W2565864958","https://openalex.org/W2582697630","https://openalex.org/W2587387687","https://openalex.org/W2624661718","https://openalex.org/W2726880625","https://openalex.org/W2734761081","https://openalex.org/W2736237629","https://openalex.org/W2743762489","https://openalex.org/W2743998299","https://openalex.org/W2746514077","https://openalex.org/W2748908377","https://openalex.org/W2753001259","https://openalex.org/W2756905443","https://openalex.org/W2766076554","https://openalex.org/W2775913093","https://openalex.org/W2780225843","https://openalex.org/W2794211192","https://openalex.org/W2794476791","https://openalex.org/W2884444411","https://openalex.org/W2887437248","https://openalex.org/W2893520948","https://openalex.org/W2893531939","https://openalex.org/W2896188997","https://openalex.org/W2898625371","https://openalex.org/W2900674209","https://openalex.org/W2907382458","https://openalex.org/W2913318283","https://openalex.org/W2940220736","https://openalex.org/W2945792041","https://openalex.org/W2980406638","https://openalex.org/W2982382518","https://openalex.org/W2995815973","https://openalex.org/W2998166485","https://openalex.org/W2999789115","https://openalex.org/W4210992623","https://openalex.org/W4231144652","https://openalex.org/W4297752219"],"related_works":["https://openalex.org/W4322484472","https://openalex.org/W4310728561","https://openalex.org/W204019067","https://openalex.org/W3176621120","https://openalex.org/W2756259976","https://openalex.org/W3188394954","https://openalex.org/W4413101379","https://openalex.org/W1929337538","https://openalex.org/W2494579006","https://openalex.org/W2336771357"],"abstract_inverted_index":{"Autoimmune":[0],"hepatitis":[1],"(AIH)":[2],"is":[3],"a":[4,11,32],"necroinflammatory":[5],"liver":[6],"disease":[7,30],"commonly":[8],"presenting":[9],"with":[10],"fluctuating":[12],"course":[13],"of":[14,17,21,44,86,100,135,140],"activity,":[15],"presence":[16],"circulating":[18],"autoantibodies,":[19],"hyperglobulinemia":[20],"IgG,":[22],"and/or":[23],"response":[24],"to":[25,63,84,145],"immunosuppressive":[26],"drugs.":[27,88],"However,":[28,68],"the":[29,90,98,109,132],"displays":[31],"considerable":[33],"heterogeneity.":[34],"No":[35],"single":[36],"clinical":[37,51],"or":[38,79],"biochemical":[39],"test":[40],"may":[41,72],"establish":[42],"diagnosis":[43,47],"AIH.":[45],"Thus,":[46],"still":[48],"requires":[49],"extensive":[50],"evaluation":[52],"and":[53,56,105,124],"experience.":[54],"Prednisolone":[55],"azathioprine":[57],"are":[58,116],"considered":[59],"standard":[60,70,134],"treatment":[61,71,99],"leading":[62],"remission":[64],"in":[65,76],"most":[66],"patients.":[67,147],"this":[69,128],"not":[73,80],"be":[74,81],"effective":[75],"some":[77],"patients":[78],"feasible":[82],"due":[83],"one":[85],"these":[87],"Over":[89],"past":[91],"two":[92],"decades":[93],"additional":[94],"immunosuppressant":[95],"drugs":[96,115],"for":[97],"AIH":[101,146],"have":[102,106],"been":[103],"evaluated":[104],"significantly":[107],"extended":[108],"therapeutic":[110,143],"spectrum.":[111],"Among":[112],"those":[113],"novel":[114,142],"mycophenolate":[117],"mofetil,":[118],"tacrolimus,":[119],"everolimus,":[120],"6-mercaptopurine,":[121],"infliximab,":[122],"rituximab":[123],"several":[125],"others.":[126],"In":[127],"review":[129],"we":[130],"summarize":[131],"current":[133],"therapy":[136],"but":[137],"also":[138],"efforts":[139],"providing":[141],"strategies":[144]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-21T00:00:00"}