{"id":"https://openalex.org/W3086777334","doi":null,"title":"Organoid models of glioblastoma: advances, applications and challenges.","display_name":"Organoid models of glioblastoma: advances, applications and challenges.","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3086777334","mag":"3086777334","pmid":"https://pubmed.ncbi.nlm.nih.gov/32905502","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7471358"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7471358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7471358","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7471358","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060257826","display_name":"Chaocai Zhang","orcid":"https://orcid.org/0000-0002-4098-2833","observed_orcids":["https://orcid.org/0000-0002-4098-2833"]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaocai Zhang","raw_affiliation_strings":["Department of Neurosurgery, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University Haikou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University Haikou, PR China","institution_ids":["https://openalex.org/I4210128478","https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112559320","display_name":"Ming-Zhu Jin","orcid":"https://orcid.org/0000-0001-8011-2405","observed_orcids":["https://orcid.org/0000-0001-8011-2405"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingzhu Jin","raw_affiliation_strings":["Shanghai Jiao Tong University School of Medicine, Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Jiao Tong University School of Medicine, Shanghai, PR China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101695734","display_name":"Jiannong Zhao","orcid":"https://orcid.org/0000-0001-7367-0652","observed_orcids":["https://orcid.org/0000-0001-7367-0652"]},"institutions":[{"id":"https://openalex.org/I4210128478","display_name":"Hainan General Hospital","ror":"https://ror.org/030sr2v21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128478"]},{"id":"https://openalex.org/I79731167","display_name":"Hainan Medical University","ror":"https://ror.org/004eeze55","country_code":"CN","type":"education","lineage":["https://openalex.org/I79731167"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiannong Zhao","raw_affiliation_strings":["Department of Neurosurgery, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University Haikou, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Hainan General Hospital/Hainan Affiliated Hospital of Hainan Medical University Haikou, PR China","institution_ids":["https://openalex.org/I4210128478","https://openalex.org/I79731167"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112897425","display_name":"Juxiang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juxiang Chen","raw_affiliation_strings":["Department of Neurosurgery, Shanghai Institute of Neurosurgery, Changzheng Hospital, Second Military Medical University Shanghai, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Shanghai Institute of Neurosurgery, Changzheng Hospital, Second Military Medical University Shanghai, PR China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064248970","display_name":"Weilin Jin","orcid":"https://orcid.org/0000-0001-8011-2405","observed_orcids":["https://orcid.org/0000-0001-8011-2405"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weilin Jin","raw_affiliation_strings":["Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, Department of Instrument Science and Engineering, Institute of Nano Biomedicine and Engineering, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University Shanghai, PR China","Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory for Thin Film and Microfabrication Technology of Ministry of Education, Department of Instrument Science and Engineering, Institute of Nano Biomedicine and Engineering, School of Electronic Information and Electronic Engineering, Shanghai Jiao Tong University Shanghai, PR China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2786,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.90563017,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"10","issue":"8","first_page":"2242","last_page":"2257"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9710000157356262},{"id":"https://openalex.org/keywords/organoid-models","display_name":"organoid models","score":0.8240000009536743},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9620000123977661},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.609000027179718},{"id":"https://openalex.org/keywords/personalized-treatment","display_name":"personalized treatment","score":0.5979999899864197},{"id":"https://openalex.org/keywords/vascularization","display_name":"vascularization","score":0.6050000190734863},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.5640000104904175},{"id":"https://openalex.org/keywords/genetic-engineering","display_name":"genetic engineering","score":0.6549999713897705},{"id":"https://openalex.org/keywords/biobanks","display_name":"biobanks","score":0.5910000205039978},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C31695470","wikidata":"https://www.wikidata.org/wiki/Q11293125","display_name":"Organoid","level":2,"score":0.8283436298370361},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7642863988876343},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.6976034641265869},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.5111344456672668},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47433653473854065},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4560047388076782},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.41798079013824463},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3897935450077057},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3656238913536072},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3488169014453888},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.33722251653671265},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32376253604888916},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.20780250430107117}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:7471358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7471358","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},{"id":"pmid:32905502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32905502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of cancer research","raw_type":"Journal Article"},{"id":"mag:3086777334","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32905502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7471358","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7471358","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Cancer Res","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":113,"referenced_works":["https://openalex.org/W1595064915","https://openalex.org/W1741548448","https://openalex.org/W1828443506","https://openalex.org/W1996955003","https://openalex.org/W2010916968","https://openalex.org/W2011728195","https://openalex.org/W2015811319","https://openalex.org/W2018286352","https://openalex.org/W2028251374","https://openalex.org/W2028433016","https://openalex.org/W2062004524","https://openalex.org/W2085652695","https://openalex.org/W2102435763","https://openalex.org/W2105879190","https://openalex.org/W2109816625","https://openalex.org/W2120785157","https://openalex.org/W2124736921","https://openalex.org/W2128130529","https://openalex.org/W2130072062","https://openalex.org/W2148977460","https://openalex.org/W2156483316","https://openalex.org/W2167923186","https://openalex.org/W2195294260","https://openalex.org/W2228561711","https://openalex.org/W2255555283","https://openalex.org/W2286284214","https://openalex.org/W2292375299","https://openalex.org/W2299137066","https://openalex.org/W2328171087","https://openalex.org/W2403475582","https://openalex.org/W2426345585","https://openalex.org/W2472832969","https://openalex.org/W2509121458","https://openalex.org/W2536032352","https://openalex.org/W2552754421","https://openalex.org/W2559282010","https://openalex.org/W2567424265","https://openalex.org/W2568963997","https://openalex.org/W2595863515","https://openalex.org/W2601380465","https://openalex.org/W2601414401","https://openalex.org/W2605626471","https://openalex.org/W2606301840","https://openalex.org/W2606864355","https://openalex.org/W2623685580","https://openalex.org/W2688905162","https://openalex.org/W2729617857","https://openalex.org/W2737053924","https://openalex.org/W2738678436","https://openalex.org/W2739601826","https://openalex.org/W2741520582","https://openalex.org/W2769614394","https://openalex.org/W2771057425","https://openalex.org/W2773338411","https://openalex.org/W2773981699","https://openalex.org/W2774253103","https://openalex.org/W2778283729","https://openalex.org/W2788894351","https://openalex.org/W2791835761","https://openalex.org/W2792476159","https://openalex.org/W2793869682","https://openalex.org/W2794257073","https://openalex.org/W2799444748","https://openalex.org/W2800799386","https://openalex.org/W2802314931","https://openalex.org/W2803681513","https://openalex.org/W2806820493","https://openalex.org/W2864786814","https://openalex.org/W2883445821","https://openalex.org/W2884636716","https://openalex.org/W2885067489","https://openalex.org/W2885650843","https://openalex.org/W2887361912","https://openalex.org/W2894717949","https://openalex.org/W2905157186","https://openalex.org/W2905447079","https://openalex.org/W2913284684","https://openalex.org/W2921139978","https://openalex.org/W2922854104","https://openalex.org/W2937767865","https://openalex.org/W2942656692","https://openalex.org/W2943362985","https://openalex.org/W2945338097","https://openalex.org/W2946138597","https://openalex.org/W2948402706","https://openalex.org/W2949020598","https://openalex.org/W2951426376","https://openalex.org/W2961217357","https://openalex.org/W2967026811","https://openalex.org/W2976292707","https://openalex.org/W2978986459","https://openalex.org/W2980438619","https://openalex.org/W2980541078","https://openalex.org/W2980654228","https://openalex.org/W2983134909","https://openalex.org/W2993566705","https://openalex.org/W2997366265","https://openalex.org/W2997979341","https://openalex.org/W3002319954","https://openalex.org/W3003714437","https://openalex.org/W3004193882","https://openalex.org/W3004345103","https://openalex.org/W3004587229","https://openalex.org/W3006464663","https://openalex.org/W3006830998","https://openalex.org/W3009070575","https://openalex.org/W3014253386","https://openalex.org/W3014756290","https://openalex.org/W3016319591","https://openalex.org/W3017129299","https://openalex.org/W4211132876","https://openalex.org/W4235973183","https://openalex.org/W4243727869"],"related_works":["https://openalex.org/W4383314579","https://openalex.org/W3101115760","https://openalex.org/W4320896403","https://openalex.org/W4379600510","https://openalex.org/W4404054135","https://openalex.org/W4286532401","https://openalex.org/W4406254876","https://openalex.org/W4416903797","https://openalex.org/W3111691151","https://openalex.org/W3129080706"],"abstract_inverted_index":{"The":[0,23],"high":[1],"mortality":[2],"and":[3,21,34,39,47,75,92,111,132,137,149,152,159],"poor":[4],"clinical":[5,49],"prognosis":[6],"of":[7,25,106,134,146],"glioblastoma":[8],"multiforme":[9],"(GBM)":[10],"are":[11,54],"concerns":[12],"for":[13],"many":[14],"GBM":[15,45,51,147],"patients":[16],"as":[17,19],"well":[18],"clinicians":[20],"researchers.":[22],"lack":[24],"a":[26,69],"preclinical":[27],"model":[28,63],"that":[29,58],"can":[30,59,126],"easily":[31],"be":[32,60,127],"established":[33],"accurately":[35],"recapitulate":[36],"tumour":[37,41,108],"biology":[38],"the":[40,64,104,120,144],"microenvironment":[42],"further":[43],"complicates":[44],"research":[46,112],"its":[48],"translation.":[50],"organoids":[52,136,148],"(GBOs)":[53],"promising":[55],"high-fidelity":[56],"models":[57,81,110,125],"applied":[61],"to":[62,119],"disease,":[65],"develop":[66],"drugs,":[67],"establish":[68],"living":[70],"biobank,":[71],"mimic":[72],"therapeutic":[73],"responses":[74],"explore":[76],"personalized":[77],"therapy.":[78],"However,":[79],"GBO":[80],"face":[82],"some":[83],"challenges,":[84],"including":[85],"deficient":[86],"immune":[87],"responses,":[88],"absent":[89],"vascular":[90],"system":[91],"controversial":[93],"reliability.":[94],"In":[95,117,139],"recent":[96],"years,":[97],"considerable":[98],"progress":[99],"has":[100],"been":[101],"achieved":[102],"in":[103],"improvement":[105],"brain":[107],"organoid":[109],"based":[113],"on":[114,156],"such":[115],"models.":[116],"addition":[118],"traditional":[121],"cultivation":[122],"method,":[123],"these":[124],"cultivated":[128],"via":[129],"genetic":[130],"engineering":[131],"co-culture":[133],"cerebral":[135],"GBM.":[138],"this":[140],"review,":[141],"we":[142],"summarize":[143],"applications":[145],"related":[150],"advances":[151],"provide":[153],"our":[154],"opinions":[155],"associated":[157],"limitations":[158],"challenges.":[160]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":35},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2020-09-21T00:00:00"}
