{"id":"https://openalex.org/W308660587","doi":null,"title":"Hematopoietic growth factors and glucocorticoids synergize to mimic the effects of IL-1 on granulocyte differentiation and IL-1 receptor induction on bone marrow cells in vivo.","display_name":"Hematopoietic growth factors and glucocorticoids synergize to mimic the effects of IL-1 on granulocyte differentiation and IL-1 receptor induction on bone marrow cells in vivo.","publication_year":1993,"publication_date":"1993-02-01","ids":{"openalex":"https://openalex.org/W308660587","mag":"308660587","pmid":"https://pubmed.ncbi.nlm.nih.gov/7678814"},"language":"en","primary_location":{"id":"pmid:7678814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7678814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029285947","display_name":"Claire M. Dubois","orcid":"https://orcid.org/0000-0002-0751-2821","observed_orcids":["https://orcid.org/0000-0002-0751-2821"]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C M Dubois","raw_affiliation_strings":["Laboratory of Immunoregulation, NCI-Frederick Cancer Research & Development Center, MD 21702-1201"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Immunoregulation, NCI-Frederick Cancer Research & Development Center, MD 21702-1201","institution_ids":["https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112925154","display_name":"R Neta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Neta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103555411","display_name":"Jonathan R. Keller","orcid":"https://orcid.org/0000-0001-9767-0067","observed_orcids":["https://orcid.org/0000-0001-9767-0067"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J R Keller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086175851","display_name":"Sten Eirik W. Jacobsen","orcid":"https://orcid.org/0000-0002-1362-3659","observed_orcids":["https://orcid.org/0000-0002-1362-3659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S E Jacobsen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042240287","display_name":"Joost J. Oppenheim","orcid":"https://orcid.org/0000-0003-0271-7921","observed_orcids":["https://orcid.org/0000-0003-0271-7921"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J J Oppenheim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044812074","display_name":"F W Ruscetti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Ruscetti","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1557,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.50206796,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"21","issue":"2","first_page":"303","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.07880000025033951,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interleukin-1","display_name":"interleukin-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.8809999823570251},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":1.0},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.972000002861023},{"id":"https://openalex.org/keywords/granulocytic-differentiation","display_name":"granulocytic differentiation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bone-marrow","display_name":"bone marrow","score":0.5709999799728394},{"id":"https://openalex.org/keywords/granulocyte-colony-stimulating-factor","display_name":"granulocyte colony-stimulating factor","score":0.8700000047683716},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9649999737739563},{"id":"https://openalex.org/keywords/interleukin-3","display_name":"interleukin-3","score":0.8679999709129333},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9980000257492065},{"id":"https://openalex.org/keywords/myeloid-progenitor-cells","display_name":"myeloid progenitor cells","score":0.9010000228881836},{"id":"https://openalex.org/keywords/adrenalectomy","display_name":"adrenalectomy","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cytokine-synergy","display_name":"cytokine synergy","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6916273236274719},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.6659305095672607},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.6068623065948486},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5637600421905518},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.5411118865013123},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5384433269500732},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5248051881790161},{"id":"https://openalex.org/C14942488","wikidata":"https://www.wikidata.org/wiki/Q14908143","display_name":"Granulocyte colony-stimulating factor receptor","level":4,"score":0.4773845076560974},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4543946087360382},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42648792266845703},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3325662910938263},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23955726623535156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21800759434700012},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000305","descriptor_name":"Adrenal Cortex Hormones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006098","descriptor_name":"Granulocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007377","descriptor_name":"Interleukin-3","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016178","descriptor_name":"Granulocyte-Macrophage Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016298","descriptor_name":"Hematopoietic Cell Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016298","descriptor_name":"Hematopoietic Cell Growth Factors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7678814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7678814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"pmh:ADA268491","doi":null,"is_oa":false,"landing_page_url":"http://oai.dtic.mil/oai/oai?&verb=getRecord&metadataPrefix=html&identifier=ADA268491","pdf_url":null,"source":{"id":"https://openalex.org/S4406923043","display_name":"Defense Technical Information Center (DTIC)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"DTIC AND NTIS","raw_type":"Text"},{"id":"mag:308660587","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7678814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1445531638","display_name":"OPERATIONS AND TECHNICAL SUPPORT","funder_award_id":"n01co074102-094","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7054558947","https://openalex.org/W2413973815","https://openalex.org/W2073647756","https://openalex.org/W1605446351","https://openalex.org/W332014945","https://openalex.org/W237362409","https://openalex.org/W2437499640","https://openalex.org/W1497160354","https://openalex.org/W219303273","https://openalex.org/W2209447846"],"abstract_inverted_index":{"The":[0,94],"mechanisms":[1],"by":[2,79],"which":[3,132,211],"interleukin-1":[4],"(IL-1)":[5],"stimulates":[6,48],"hematopoiesis":[7],"are":[8],"not":[9],"clear.":[10],"We":[11],"have":[12],"previously":[13],"shown":[14],"that":[15,140,162,186],"in":[16,54,63,105,155,195,212],"vivo":[17,64,196],"administration":[18,95],"of":[19,57,73,96,151,189,207],"IL-1":[20,23,46,74,190,215],"indirectly":[21],"increases":[22],"receptor":[24,216],"(IL-1R)":[25],"expression":[26,107,169],"on":[27,83,136,170],"both":[28],"immature":[29],"and":[30,68,119,143,165,181,209],"mature":[31],"bone":[32,86,157],"marrow":[33,87],"(BM)":[34],"cells,":[35,138,173],"partly":[36,198],"due":[37,199],"to":[38,75,91,121,147,191,200,203],"IL-1-induced":[39],"hematopoietic":[40],"growth":[41],"factor":[42,113],"(HGF)":[43],"production.":[44],"Because":[45],"also":[47],"the":[49,55,129,156,187],"hypothalamic":[50],"pituitary-adrenal":[51],"axis":[52],"resulting":[53],"production":[56],"glucocorticoids":[58,69],"(GC),":[59],"we":[60],"assessed":[61],"whether":[62],"treatment":[65,145],"with":[66,110],"HGF":[67],"upregulates":[70],"IL-1R.":[71],"Administration":[72],"adrenalectomized":[76],"mice":[77],"reduces":[78],"53%":[80],"IL-specific":[81],"binding":[82],"light":[84],"density":[85],"(LDBM)":[88],"cells":[89],"compared":[90],"sham-operated":[92],"mice.":[93],"dexamethasone":[97],"(dex)":[98],"alone":[99],"induced":[100],"only":[101],"a":[102,205],"slight":[103],"increase":[104],"IL-1R":[106,123,168],"but":[108],"synergized":[109],"granulocyte":[111,193],"colony-stimulating":[112],"(G-CSF),":[114],"granulocyte-macrophage":[115],"CSF":[116],"(GM-CSF),":[117],"IL-3":[118],"IL-6":[120],"upregulate":[122],"expression.":[124,217],"Flow":[125],"cytometry":[126],"analysis":[127,160],"using":[128],"RB6-8C5":[130],"antibody,":[131],"is":[133,197],"differentially":[134],"expressed":[135],"myeloid":[137,153,172],"indicated":[139],"combined":[141],"G-CSF":[142,164],"dex":[144,166],"acts":[146],"promote":[148],"increased":[149,167],"numbers":[150],"differentiated":[152],"progenitors":[154],"marrow.":[158],"Autoradiographic":[159],"confirmed":[161],"while":[163],"all":[171],"it":[174],"was":[175],"particularly":[176],"pronounced":[177],"for":[178],"myelocytes,":[179],"promyelocytes":[180],"metamyelocytes.":[182],"These":[183],"results":[184],"suggest":[185],"ability":[188,202],"enhance":[192],"differentiation":[194],"its":[201],"induce":[204],"cascade":[206],"cytokines":[208],"steroids":[210],"turn":[213],"regulate":[214]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}