{"id":"https://openalex.org/W3086447566","doi":"https://doi.org/10.1242/jcs.253260","title":"Expression of Concern: Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer","display_name":"Expression of Concern: Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W3086447566","doi":"https://doi.org/10.1242/jcs.253260","mag":"3086447566","pmid":"https://pubmed.ncbi.nlm.nih.gov/32917731"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.253260","doi":"https://doi.org/10.1242/jcs.253260","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.253260","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082554315","display_name":"Arezoo Astanehe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arezoo Astanehe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012024330","display_name":"David J. Arenillas","orcid":"https://orcid.org/0000-0001-8639-3957","observed_orcids":["https://orcid.org/0000-0001-8639-3957"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Arenillas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026664289","display_name":"Wyeth W. Wasserman","orcid":"https://orcid.org/0000-0001-6098-6412","observed_orcids":["https://orcid.org/0000-0001-6098-6412"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wyeth W. Wasserman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083611772","display_name":"Peter C. K. Leung","orcid":"https://orcid.org/0000-0003-3152-3800","observed_orcids":["https://orcid.org/0000-0003-3152-3800"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter C. K. Leung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073718839","display_name":"Sandra Elaine Dunn","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra E. Dunn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000275517","display_name":"Barry R. Davies","orcid":"https://orcid.org/0000-0002-5414-9113","observed_orcids":["https://orcid.org/0000-0002-5414-9113"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barry R. Davies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5105415493","display_name":"Nelly Auersperg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nelly Auersperg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1004,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.431557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"133","issue":"17","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.24040000140666962,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.19689999520778656,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pik3ca","display_name":"PIK3CA","score":0.8970000147819519},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/ovarian-surface-epithelium","display_name":"ovarian surface epithelium","score":0.9789999723434448},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/research-misconduct-investigation","display_name":"scientific misconduct investigations","score":0.49799999594688416},{"id":"https://openalex.org/keywords/data-integrity","display_name":"data integrity","score":0.46000000834465027},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.652999997138977},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.6349999904632568},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.6100000143051147},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.4519999921321869},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.42899999022483826}],"concepts":[{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.8925641775131226},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7307541370391846},{"id":"https://openalex.org/C133307689","wikidata":"https://www.wikidata.org/wiki/Q48749","display_name":"Southern blot","level":3,"score":0.5442649722099304},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.5298787355422974},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3533802628517151},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32692480087280273},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2223566174507141},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19450774788856506}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1242/jcs.253260","doi":"https://doi.org/10.1242/jcs.253260","is_oa":false,"landing_page_url":"https://doi.org/10.1242/jcs.253260","pdf_url":null,"source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:32917731","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32917731","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:joces:133/17/jcs253260","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/133/17/jcs253260","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100897880","https://openalex.org/W2102684430","https://openalex.org/W4413993528","https://openalex.org/W2071755701","https://openalex.org/W2309979930","https://openalex.org/W2276329207","https://openalex.org/W4403474516","https://openalex.org/W2024248292","https://openalex.org/W3014991538","https://openalex.org/W3160047104"],"abstract_inverted_index":{"This":[0],"Expression":[1,537],"of":[2,96,153,172,185,224,261,283,318,328,348,359,396,411,419,423,459,462,502,511,514,538,544],"Concern":[3,539],"relates":[4],"to":[5,105,131,144,159,167,177,201,209,216,239,256,341,356,377,449,500,526,540,550],"J.":[6],"Cell":[7,97,412],"Sci.":[8],"(2008)":[9],"121,":[10],"664-674":[11],"(doi:10.1242/jcs.013029)A":[12],"reader":[13],"informed":[14],"the":[15,24,34,102,107,112,127,133,139,142,145,168,173,179,186,189,194,204,220,237,242,254,259,262,265,269,274,281,284,299,325,329,338,349,357,365,394,397,403,435,447,457,460,463,471,481,484,503,512,515],"journal":[16,140,180,221,235,370,426,444,507,532],"that":[17,203,229,249,273,291,298,372,386,428,470,483,496],"there":[18,519],"were":[19,30,40,114,303],"several":[20],"potential":[21,380],"issues":[22,436,546],"with":[23,528],"blots":[25,46,56,66,87,113,130,190,300,472],"in":[26,47,52,57,62,67,74,79,83,88,93,123,136,191,264,301,473,505],"this":[27,246,439,536],"paper,":[28,440,516],"which":[29,271],"also":[31,508],"highlighted":[32,41],"on":[33,258,280,343,393,406,456],"PubPeer":[35],"website.":[36],"Possible":[37],"band":[38],"duplications":[39],"in:":[42],"p21":[43],"and":[44,49,59,71,90,148,163,227,346,364,382,414,517,547],"actin":[45,55,65],"OSE457":[48],"MCF7":[50],"panels":[51,61,73,92],"Fig.":[53,63,75,84,94],"1A;":[54],"A2780":[58],"OVCAR5":[60],"1B;":[64],"IOSE":[68,80],"166":[69],"h":[70],"WI38":[72],"2A;":[76],"T-AKT":[77,86],"blot":[78],"166a":[81],"panel":[82],"3A;":[85],"OSEC2":[89],"IOSE166a":[91],"3B.Journal":[95],"Science":[98,413],"contacted":[99,219,509],"Dr":[100],"Auersperg,":[101],"corresponding":[103],"author,":[104],"request":[106],"original":[108,128],"blots,":[109,213],"but":[110,214,441],"unfortunately":[111],"no":[115,230,294],"longer":[116],"available.":[117],"As":[118],"is":[119,199,293,336,533],"our":[120,548],"standard":[121],"practice":[122],"such":[124],"cases,":[125],"without":[126],"full":[129],"support":[132],"results":[134,498],"shown":[135],"these":[137,545],"figures,":[138],"referred":[141,446],"matter":[143,448],"Vice-President,":[146],"Research":[147],"Innovation":[149],"at":[150,245],"The":[151,234,288,417,425],"University":[152],"British":[154],"Columbia":[155],"(UBC),":[156],"asking":[157],"them":[158,529],"provide":[160],"further":[161,524],"information":[162],"a":[164,182,316,431],"recommendation":[165,309],"as":[166],"next":[169],"steps.As":[170],"part":[171],"case":[174],"summary":[175],"provided":[176,268],"UBC,":[178],"included":[181],"visual":[183],"demonstration":[184],"similarities":[187,211],"between":[188,212],"question":[192,302,474],"using":[193,324],"open-source":[195],"software":[196,205,286],"\u2018Forensically\u2019.":[197],"It":[198],"important":[200],"note":[202],"was":[206,374,520],"not":[207,337,375],"used":[208,376],"detect":[210,378],"rather":[215],"highlight":[217],"them.UBC":[218],"upon":[222],"conclusion":[223],"its":[225,278,384,415],"investigation":[226,279,389,433],"stated":[228],"misconduct":[231],"had":[232,276],"occurred.":[233],"requested":[236,427],"report":[238,255,289,317,497],"understand":[240],"how":[241],"committee":[243,275],"arrived":[244],"conclusion,":[247],"stating":[248],"we":[250,352],"would":[251,390],"have":[252],"expected":[253],"comment":[257,342,392],"soundness":[260,345,458],"conclusions":[263,461,485],"paper.":[266],"UBC":[267,333,429,442],"report,":[270],"showed":[272],"focused":[277],"use":[282],"Forensically":[285,330,373],"tool.":[287],"concluded":[290],"\u201c\u2026there":[292],"basis":[295],"for":[296],"concluding":[297],"duplicated":[304],"or":[305],"improperly":[306],"altered.\u201d":[307],"Their":[308],"was:":[310],"\u201cCare":[311],"should":[312],"be":[313],"taken":[314],"whenever":[315],"duplication":[319],"has":[320],"resulted":[321],"from":[322,402],"analysis":[323],"current":[326],"version":[327],"software.\u201d":[331],"Furthermore,":[332],"stated:":[334],"\u201cIt":[335],"University's":[339],"place":[340],"[the":[344],"trustworthiness":[347],"data]":[350],"\u2013":[351],"leave":[353],"those":[354,501],"determinations":[355],"expertise":[358],"peer":[360],"reviewers,":[361],"editorial":[362],"boards":[363],"academic":[366],"community":[367],"more":[368],"generally.\u201dThe":[369],"clarified":[371],"any":[379],"duplications,":[381],"reiterated":[383],"expectations":[385],"an":[387,450,454],"institutional":[388],"indeed":[391],"validity":[395],"data,":[398],"highlighting":[399],"relevant":[400],"sections":[401],"COPE":[404],"(Committee":[405],"Publication":[407],"Ethics)":[408],"website;":[409],"Journal":[410],"publisher,":[416],"Company":[418],"Biologists,":[420],"are":[421,475,486],"members":[422],"COPE.":[424],"conduct":[430],"more-detailed":[432],"into":[434],"raised":[437],"about":[438],"declined.The":[443],"therefore":[445,534],"external":[451],"expert,":[452],"requesting":[453],"opinion":[455,482],"paper":[464,504],"by":[465],"Astanahe":[466],"et":[467],"al.,":[468],"considering":[469],"unreliable.":[476],"Our":[477],"expert":[478],"advisor":[479],"expressed":[480],"possibly":[487],"still":[488],"sound,":[489],"noting":[490],"two":[491],"additional":[492],"papers":[493],"published":[494],"subsequently":[495],"similar":[499],"question.The":[506],"all":[510],"co-authors":[513],"although":[518],"some":[521],"initial":[522],"correspondence,":[523],"attempts":[525],"communicate":[527],"went":[530],"unanswered.The":[531],"publishing":[535],"make":[541],"readers":[542],"aware":[543],"efforts":[549],"resolve":[551],"them.":[552]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2020-09-21T00:00:00"}
