{"id":"https://openalex.org/W3086444146","doi":"https://doi.org/10.1016/j.exphem.2020.09.188","title":"Detection of chemotherapy-resistant patient-derived acute lymphoblastic leukemia clones in murine xenografts using cellular barcodes","display_name":"Detection of chemotherapy-resistant patient-derived acute lymphoblastic leukemia clones in murine xenografts using cellular barcodes","publication_year":2020,"publication_date":"2020-09-15","ids":{"openalex":"https://openalex.org/W3086444146","doi":"https://doi.org/10.1016/j.exphem.2020.09.188","mag":"3086444146","pmid":"https://pubmed.ncbi.nlm.nih.gov/32946982"},"language":"en","primary_location":{"id":"doi:10.1016/j.exphem.2020.09.188","doi":"https://doi.org/10.1016/j.exphem.2020.09.188","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2020.09.188","pdf_url":"http://www.exphem.org/article/S0301472X20305531/pdf","source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.exphem.org/article/S0301472X20305531/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109186427","display_name":"Sabrina Jacobs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Sabrina Jacobs","raw_affiliation_strings":["Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001816377","display_name":"Albertina Ausema","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Albertina Ausema","raw_affiliation_strings":["Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017232137","display_name":"Erik Zwart","orcid":"https://orcid.org/0000-0002-4552-003X","observed_orcids":["https://orcid.org/0000-0002-4552-003X"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erik Zwart","raw_affiliation_strings":["Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-4552-003X","affiliations":[{"raw_affiliation_string":"Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085813896","display_name":"Ellen Weersing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ellen Weersing","raw_affiliation_strings":["Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025350377","display_name":"Gerald de Haan","orcid":"https://orcid.org/0000-0001-9706-0138","observed_orcids":["https://orcid.org/0000-0001-9706-0138"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gerald de Haan","raw_affiliation_strings":["Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088720149","display_name":"Leonid V Bystrykh","orcid":"https://orcid.org/0000-0001-6924-5602","observed_orcids":["https://orcid.org/0000-0001-6924-5602"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leonid V. Bystrykh","raw_affiliation_strings":["Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ageing Biology and Stem Cells, European Research Institute for the Biology of Ageing, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086779007","display_name":"Mirjam E. Belderbos","orcid":"https://orcid.org/0000-0002-6164-2918","observed_orcids":["https://orcid.org/0000-0002-6164-2918"]},"institutions":[{"id":"https://openalex.org/I4210111138","display_name":"Oncode Institute","ror":"https://ror.org/01n92vv28","country_code":"NL","type":"education","lineage":["https://openalex.org/I4210111138"]},{"id":"https://openalex.org/I4210127118","display_name":"Princess M\u00e1xima Center","ror":"https://ror.org/02aj7yc53","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210127118"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Mirjam E. Belderbos","raw_affiliation_strings":["Oncode Institute, Utrecht, The Netherlands; Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands. Electronic address: m.e.belderbos@prinsesmaximacentrum.nl","Oncode Institute, Utrecht, The Netherlands","Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncode Institute, Utrecht, The Netherlands; Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands. Electronic address: m.e.belderbos@prinsesmaximacentrum.nl","institution_ids":["https://openalex.org/I4210111138","https://openalex.org/I4210127118"]},{"raw_affiliation_string":"Oncode Institute, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210111138"]},{"raw_affiliation_string":"Princess M\u00e1xima Center for Pediatric Oncology, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I4210127118"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086779007"],"corresponding_institution_ids":["https://openalex.org/I4210111138","https://openalex.org/I4210127118"],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":{"value":2650,"currency":"USD","value_usd":2650},"fwci":2.6208,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.9067969,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"91","issue":null,"first_page":"46","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.9599999785423279,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.025200000032782555,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8709999918937683},{"id":"https://openalex.org/keywords/clonal-heterogeneity","display_name":"clonal heterogeneity","score":0.843999981880188},{"id":"https://openalex.org/keywords/cellular-barcoding","display_name":"cellular barcoding","score":0.9419999718666077},{"id":"https://openalex.org/keywords/patient-derived-xenografts","display_name":"patient-derived xenografts","score":0.9300000071525574},{"id":"https://openalex.org/keywords/clonal-dynamics","display_name":"clonal dynamics","score":0.7239999771118164},{"id":"https://openalex.org/keywords/methotrexate","display_name":"methotrexate","score":0.8399999737739563},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.9269999861717224},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/leukemia-relapse","display_name":"leukemia relapse","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C113968399","wikidata":"https://www.wikidata.org/wiki/Q7559241","display_name":"Somatic evolution in cancer","level":3,"score":0.6663538813591003},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6648778319358826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6643521189689636},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.6319577097892761},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5753107666969299},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5449584126472473},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.516242265701294},{"id":"https://openalex.org/C2781107101","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Acute lymphocytic leukemia","level":4,"score":0.47571972012519836},{"id":"https://openalex.org/C2781059491","wikidata":"https://www.wikidata.org/wiki/Q422232","display_name":"Methotrexate","level":2,"score":0.45594510436058044},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4537014663219452},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.4470875561237335},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32224559783935547},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.25338155031204224},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22576865553855896},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.19799938797950745},{"id":"https://openalex.org/C2909962599","wikidata":"https://www.wikidata.org/wiki/Q180664","display_name":"Lymphoblastic Leukemia","level":3,"score":0.19464394450187683},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14419978857040405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14253771305084229},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008727","descriptor_name":"Methotrexate","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014750","descriptor_name":"Vincristine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015448","descriptor_name":"Leukemia, B-Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015448","descriptor_name":"Leukemia, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053631","descriptor_name":"Interleukin Receptor Common gamma Subunit","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D058893","descriptor_name":"DNA Barcoding, Taxonomic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064593","descriptor_name":"Heterografts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.exphem.2020.09.188","doi":"https://doi.org/10.1016/j.exphem.2020.09.188","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2020.09.188","pdf_url":"http://www.exphem.org/article/S0301472X20305531/pdf","source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},{"id":"pmid:32946982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32946982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental hematology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/a38b9e72-b6d4-4b0a-9a2e-c9019eb2724d","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/a38b9e72-b6d4-4b0a-9a2e-c9019eb2724d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jacobs, S, Ausema, A, Zwart, E, Weersing, E, de Haan, G, Bystrykh, L V & Belderbos, M E 2020, 'Detection of chemotherapy-resistant patient-derived acute lymphoblastic leukemia clones in murine xenografts using cellular barcodes', Experimental Hematology, vol. 91, pp. 46-54. https://doi.org/10.1016/j.exphem.2020.09.188","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/a38b9e72-b6d4-4b0a-9a2e-c9019eb2724d","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/a38b9e72-b6d4-4b0a-9a2e-c9019eb2724d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Experimental Hematology, 91, 46 - 54. ELSEVIER SCIENCE INC","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1016/j.exphem.2020.09.188","doi":"https://doi.org/10.1016/j.exphem.2020.09.188","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.exphem.2020.09.188","pdf_url":"http://www.exphem.org/article/S0301472X20305531/pdf","source":{"id":"https://openalex.org/S72188638","display_name":"Experimental Hematology","issn_l":"0301-472X","issn":["0301-472X","1873-2399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Hematology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1460730983","display_name":null,"funder_award_id":"2014-7178","funder_id":"https://openalex.org/F4320322777","funder_display_name":"KWF Kankerbestrijding"},{"id":"https://openalex.org/G170239557","display_name":null,"funder_award_id":"RUG 2015-7964","funder_id":"https://openalex.org/F4320322777","funder_display_name":"KWF Kankerbestrijding"},{"id":"https://openalex.org/G4726263880","display_name":null,"funder_award_id":"RUG 2014-7178","funder_id":"https://openalex.org/F4320322777","funder_display_name":"KWF Kankerbestrijding"},{"id":"https://openalex.org/G7395004360","display_name":null,"funder_award_id":"TRTH201","funder_id":"https://openalex.org/F4320310646","funder_display_name":"European Hematology Association"}],"funders":[{"id":"https://openalex.org/F4320310646","display_name":"European Hematology Association","ror":"https://ror.org/05hk0hn26"},{"id":"https://openalex.org/F4320322777","display_name":"KWF Kankerbestrijding","ror":"https://ror.org/0368jnd28"},{"id":"https://openalex.org/F4320323105","display_name":"Universitair Medisch Centrum Groningen","ror":"https://ror.org/03cv38k47"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3086444146.pdf","grobid_xml":"https://content.openalex.org/works/W3086444146.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W1801876107","https://openalex.org/W1985384725","https://openalex.org/W2008271309","https://openalex.org/W2023560061","https://openalex.org/W2033666853","https://openalex.org/W2035151737","https://openalex.org/W2048968984","https://openalex.org/W2060383229","https://openalex.org/W2082876325","https://openalex.org/W2087320619","https://openalex.org/W2114104545","https://openalex.org/W2116758852","https://openalex.org/W2117481657","https://openalex.org/W2130116522","https://openalex.org/W2130122821","https://openalex.org/W2146512944","https://openalex.org/W2152061559","https://openalex.org/W2168127427","https://openalex.org/W2337451127","https://openalex.org/W2605703200","https://openalex.org/W2613468286","https://openalex.org/W2760863738","https://openalex.org/W2794478094","https://openalex.org/W2801820889","https://openalex.org/W2971839198","https://openalex.org/W2981608667","https://openalex.org/W2990707587","https://openalex.org/W2996234406","https://openalex.org/W3003583769","https://openalex.org/W3008763686"],"related_works":["https://openalex.org/W2605703200","https://openalex.org/W6926997612","https://openalex.org/W3210437179","https://openalex.org/W2996234406","https://openalex.org/W2983542472","https://openalex.org/W2575384568","https://openalex.org/W2980316725","https://openalex.org/W2021428141","https://openalex.org/W3179869469","https://openalex.org/W2594295055"],"abstract_inverted_index":{"Clonal":[0],"heterogeneity":[1],"fuels":[2],"leukemia":[3,13,65,84,209,231,254],"evolution,":[4],"therapeutic":[5],"resistance,":[6],"and":[7,22,37,42,87,94,97,143,151,256],"relapse.":[8,262],"Upfront":[9],"detection":[10],"of":[11,20,24,33,50,61,63,193,208,228,241,252],"therapy-resistant":[12,253],"clones":[14,66,122,183,210,255],"at":[15],"diagnosis":[16],"may":[17,248],"allow":[18,249],"adaptation":[19],"treatment":[21],"prevention":[23],"relapse,":[25],"but":[26],"this":[27],"is":[28,219],"hampered":[29],"by":[30],"a":[31,110,204,220],"paucity":[32],"methods":[34,49],"to":[35,54,91,162,223,235,260],"identify":[36,257],"trace":[38,55,224],"single":[39],"leukemia-propagating":[40],"cells":[41,86,232],"their":[43],"clonal":[44,89,107,139,171,176,226],"offspring.":[45],"Here,":[46],"we":[47,167,197],"tested":[48],"cellular":[51,217,242],"barcoding":[52,218,243],"analysis,":[53],"the":[56,225,238],"in":[57,109,141,188,203,233],"vivo":[58],"competitive":[59],"dynamics":[60,227],"hundreds":[62],"patient-derived":[64,79,117,190,230],"upon":[67],"chemotherapy-mediated":[68,200],"selective":[69],"pressure.":[70],"We":[71,102,180,214],"transplanted":[72],"Nod/Scid/Il2R\u03b3":[73],"\u2212/\u2212":[74],"(NSG)":[75],"mice":[76,126],"with":[77,124,244],"barcoded":[78],"or":[80,178],"SupB15":[81],"acute":[82],"lymphoblastic":[83],"(ALL)":[85],"assessed":[88],"responses":[90],"dexamethasone,":[92],"methotrexate,":[93],"vincristine,":[95],"longitudinally":[96],"across":[98,211],"nine":[99],"anatomic":[100,212],"locations.":[101],"illustrate":[103],"that":[104,184,199,216],"chemotherapy":[105],"reduces":[106],"diversity":[108],"drug-dependent":[111],"manner.":[112],"At":[113],"end-stage":[114],"disease,":[115],"methotrexate-treated":[116,189],"xenografts":[118,145],"had":[119],"significantly":[120],"fewer":[121],"compared":[123],"placebo-treated":[125],"(100":[127],"\u00b1":[128,132,149,153],"10":[129],"vs.":[130],"160":[131],"15":[133],"clones,":[134,155],"p":[135,156],"=":[136,157],"0.0005),":[137],"while":[138],"complexity":[140],"vincristine-":[142],"dexamethasone-treated":[144],"was":[146],"unaffected":[147],"(115":[148],"33":[150],"150":[152],"7":[154],"NS).":[158],"Using":[159],"tools":[160],"developed":[161],"assess":[163],"differential":[164],"gene":[165],"expression,":[166],"determined":[168],"whether":[169],"these":[170],"patterns":[172],"resulted":[173,202],"from":[174],"random":[175],"drift":[177],"selection.":[179],"identified":[181],"5":[182],"were":[185],"reproducibly":[186],"enriched":[187],"xenografts,":[191],"suggestive":[192],"pre-existent":[194],"resistance.":[195],"Finally,":[196],"found":[198,215],"selection":[201],"more":[205],"asymmetric":[206],"distribution":[207],"sites.":[213],"powerful":[221],"method":[222],"human":[229],"response":[234],"chemotherapy.":[236],"In":[237],"future,":[239],"integration":[240],"single-cell":[245],"sequencing":[246],"technology":[247],"in-depth":[250],"characterization":[251],"novel":[258],"targets":[259],"prevent":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2020-09-21T00:00:00"}