{"id":"https://openalex.org/W3086339686","doi":"https://doi.org/10.1097/shk.0000000000001632","title":"TBK1/IKK\u03b5 Negatively Regulate LPS-Induced Neutrophil Necroptosis and Lung Inflammation","display_name":"TBK1/IKK\u03b5 Negatively Regulate LPS-Induced Neutrophil Necroptosis and Lung Inflammation","publication_year":2020,"publication_date":"2020-09-09","ids":{"openalex":"https://openalex.org/W3086339686","doi":"https://doi.org/10.1097/shk.0000000000001632","mag":"3086339686","pmid":"https://pubmed.ncbi.nlm.nih.gov/32925605","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8183424"},"language":"en","primary_location":{"id":"doi:10.1097/shk.0000000000001632","doi":"https://doi.org/10.1097/shk.0000000000001632","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0000000000001632","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8183424","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003495432","display_name":"Jieyan Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Jieyan Wang","raw_affiliation_strings":["Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050702153","display_name":"Yingyi Luan","orcid":"https://orcid.org/0000-0002-6986-1701","observed_orcids":["https://orcid.org/0000-0002-6986-1701"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I4210160531","display_name":"Chinese People's Liberation Army","ror":"https://ror.org/05tf9r976","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210160531"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Yingyi Luan","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing China","institution_ids":["https://openalex.org/I2802939634","https://openalex.org/I4210160531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079756426","display_name":"Erica Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erica K. Fan","raw_affiliation_strings":["Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005234320","display_name":"Melanie J. Scott","orcid":"https://orcid.org/0000-0001-6864-5970","observed_orcids":["https://orcid.org/0000-0001-6864-5970"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Melanie J. Scott","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100721624","display_name":"Yuehua Li","orcid":"https://orcid.org/0000-0002-1504-946X","observed_orcids":["https://orcid.org/0000-0002-1504-946X","https://orcid.org/0000-0002-0018-6613"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210133905","display_name":"VA Pittsburgh Healthcare System","ror":"https://ror.org/02qm18h86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuehua Li","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","Research and Development, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Research and Development, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I4210133905"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062076820","display_name":"Timothy R. Billiar","orcid":"https://orcid.org/0000-0002-2949-0811","observed_orcids":["https://orcid.org/0000-0002-2949-0811"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy R. Billiar","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102970238","display_name":"Mark A. Wilson","orcid":"https://orcid.org/0000-0002-9130-9120","observed_orcids":["https://orcid.org/0000-0002-9130-9120"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark A. Wilson","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016655840","display_name":"Yong Jiang","orcid":"https://orcid.org/0000-0002-8087-5717","observed_orcids":["https://orcid.org/0000-0002-8087-5717","https://orcid.org/0009-0007-7837-1193"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I58200834","display_name":"Southern Medical University","ror":"https://ror.org/01vjw4z39","country_code":"CN","type":"education","lineage":["https://openalex.org/I58200834"]}],"countries":["CN","US"],"is_corresponding":true,"raw_author_name":"Yong Jiang","raw_affiliation_strings":["Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology, Guangdong Provincial Key Laboratory of Proteomics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China","institution_ids":["https://openalex.org/I58200834"]},{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103098465","display_name":"Jie Fan","orcid":"https://orcid.org/0000-0002-0090-2704","observed_orcids":["https://orcid.org/0000-0002-0090-2704"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210133905","display_name":"VA Pittsburgh Healthcare System","ror":"https://ror.org/02qm18h86","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210133905","https://openalex.org/I4210147340"]},{"id":"https://openalex.org/I4210155891","display_name":"McGowan Institute for Regenerative Medicine","ror":"https://ror.org/04js6xx21","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210098814","https://openalex.org/I4210134769","https://openalex.org/I4210155891"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jie Fan","raw_affiliation_strings":["Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania","Research and Development, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210155891"]},{"raw_affiliation_string":"Research and Development, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania","institution_ids":["https://openalex.org/I4210133905"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003495432","https://openalex.org/A5005234320","https://openalex.org/A5016655840","https://openalex.org/A5050702153","https://openalex.org/A5062076820","https://openalex.org/A5100721624","https://openalex.org/A5102970238","https://openalex.org/A5103098465"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2802939634","https://openalex.org/I4210133905","https://openalex.org/I4210155891","https://openalex.org/I4210160531","https://openalex.org/I58200834"],"apc_list":null,"apc_paid":null,"fwci":0.5607,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.58823716,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"55","issue":"3","first_page":"338","last_page":"348"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.05310000106692314,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/ikkepsilon","display_name":"IKK\u03b5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lps","display_name":"LPS","score":0.5960000157356262},{"id":"https://openalex.org/keywords/tlr4-signaling","display_name":"TLR4 signaling","score":0.9869999885559082},{"id":"https://openalex.org/keywords/ripk1","display_name":"RIPK1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/ripk3","display_name":"RIPK3","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mlkl","display_name":"MLKL","score":0.9950000047683716},{"id":"https://openalex.org/keywords/necrosome","display_name":"necrosome","score":0.9070000052452087},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.925000011920929}],"concepts":[{"id":"https://openalex.org/C94030615","wikidata":"https://www.wikidata.org/wiki/Q3346925","display_name":"Necroptosis","level":4,"score":0.9740919470787048},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6942753195762634},{"id":"https://openalex.org/C2776550021","wikidata":"https://www.wikidata.org/wiki/Q18033276","display_name":"RIPK1","level":5,"score":0.6028367877006531},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5937608480453491},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5545729398727417},{"id":"https://openalex.org/C156155473","wikidata":"https://www.wikidata.org/wiki/Q18258483","display_name":"TANK-binding kinase 1","level":5,"score":0.5233132839202881},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.49097946286201477},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.4905835688114166},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4522084891796112},{"id":"https://openalex.org/C43929388","wikidata":"https://www.wikidata.org/wiki/Q4050587","display_name":"TRIF","level":5,"score":0.4405054450035095},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43635112047195435},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3758843243122101},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3394858241081238},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3359344005584717},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.30743497610092163},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30309587717056274},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.21485641598701477},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.18606486916542053},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.13827955722808838},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.08616596460342407},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08438009023666382},{"id":"https://openalex.org/C137361374","wikidata":"https://www.wikidata.org/wiki/Q6714442","display_name":"MAP kinase kinase kinase","level":4,"score":0.07388794422149658}],"mesh":[{"descriptor_ui":"D000079302","descriptor_name":"Necroptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D011014","descriptor_name":"Pneumonia","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051550","descriptor_name":"I-kappa B Kinase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/shk.0000000000001632","doi":"https://doi.org/10.1097/shk.0000000000001632","is_oa":false,"landing_page_url":"https://doi.org/10.1097/shk.0000000000001632","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock","raw_type":"journal-article"},{"id":"pmid:32925605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32925605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8183424","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8183424","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Shock","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8183424","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8183424","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Shock","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3920510648","display_name":null,"funder_award_id":"I01 BX004838","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G4401434136","display_name":"Cell Priming, Receptor Cross-Talk, and Acute Lung Injury","funder_award_id":"R01HL079669","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6368452753","display_name":null,"funder_award_id":"I01 BX002729","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G7553139419","display_name":"Macrophage Pyroptosis Mechanism of Post-Trauma Acute Lung Injury","funder_award_id":"R01HL139547","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7636237419","display_name":null,"funder_award_id":"IK6 BX004211","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G9000856717","display_name":"Improvement of Organ Function after Severe Hypovolemia","funder_award_id":"R01HL076179","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000863479","display_name":"Inflammasome activation in trauma-hemorrhagic shock","funder_award_id":"R01GM102146","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W1523845694","https://openalex.org/W1902960727","https://openalex.org/W1963586806","https://openalex.org/W1966977448","https://openalex.org/W1979032223","https://openalex.org/W1983924398","https://openalex.org/W1991380853","https://openalex.org/W1998983498","https://openalex.org/W2003786318","https://openalex.org/W2016552531","https://openalex.org/W2018204131","https://openalex.org/W2023122823","https://openalex.org/W2026134797","https://openalex.org/W2046180063","https://openalex.org/W2052605153","https://openalex.org/W2060204808","https://openalex.org/W2063548806","https://openalex.org/W2069375519","https://openalex.org/W2077317536","https://openalex.org/W2081053802","https://openalex.org/W2083513831","https://openalex.org/W2087232320","https://openalex.org/W2091363184","https://openalex.org/W2097750604","https://openalex.org/W2113290014","https://openalex.org/W2118621467","https://openalex.org/W2139552156","https://openalex.org/W2141738274","https://openalex.org/W2141792857","https://openalex.org/W2147140524","https://openalex.org/W2150794310","https://openalex.org/W2153778363","https://openalex.org/W2156795714","https://openalex.org/W2158662692","https://openalex.org/W2280404143","https://openalex.org/W2291007191","https://openalex.org/W2299422902","https://openalex.org/W2331975416","https://openalex.org/W2510385322","https://openalex.org/W2586088194","https://openalex.org/W2600881183","https://openalex.org/W2744245692","https://openalex.org/W2888515069","https://openalex.org/W2900410132","https://openalex.org/W2938247032","https://openalex.org/W6631379225","https://openalex.org/W6641271181","https://openalex.org/W6645109838","https://openalex.org/W6646516924","https://openalex.org/W6648279213","https://openalex.org/W6650112691","https://openalex.org/W6654589369","https://openalex.org/W6665336618","https://openalex.org/W6672362614","https://openalex.org/W6676694936","https://openalex.org/W6680841574","https://openalex.org/W6680880287","https://openalex.org/W6683454709","https://openalex.org/W6694862919","https://openalex.org/W6702220540","https://openalex.org/W6725567701","https://openalex.org/W6733443446","https://openalex.org/W6736043376","https://openalex.org/W6754373602","https://openalex.org/W7126786685"],"related_works":["https://openalex.org/W2029673642","https://openalex.org/W4408223476","https://openalex.org/W2415306073","https://openalex.org/W2058759831","https://openalex.org/W2981397129","https://openalex.org/W2799624283","https://openalex.org/W1548039283","https://openalex.org/W2740070809","https://openalex.org/W2073819064","https://openalex.org/W2291007191"],"abstract_inverted_index":{"ABSTRACT:":[0],"Cell":[1,38],"necroptosis,":[2],"a":[3,175,184],"form":[4],"of":[5,12,19,36,53,59,76,79,90,94,101,123,138],"regulated":[6],"inflammatory":[7,20],"cell":[8,17,60],"death,":[9],"is":[10],"one":[11],"the":[13,34,57,63,124,136,170],"mechanisms":[14],"that":[15,106,169],"controls":[16],"release":[18,58],"mediators":[21],"from":[22],"innate":[23],"immune":[24],"cells,":[25],"such":[26],"as":[27,174],"polymorphonuclear":[28],"neutrophils":[29],"(PMNs),":[30],"and":[31,46,66,96,112,115,143,146,149,152,181,191],"critically":[32],"regulates":[33],"progress":[35],"inflammation.":[37,69,165,192],"necroptosis":[39,80,155,180],"features":[40],"receptor-interacting":[41],"protein":[42],"(RIPK)":[43],"1":[44],"activation":[45],"necroptosome":[47],"formation.":[48],"This":[49],"leads":[50],"to":[51,159],"loss":[52],"plasma":[54],"membrane":[55],"integrity,":[56],"contents":[61],"into":[62],"extracellular":[64],"space,":[65],"subsequent":[67,162],"increased":[68],"Here,":[70],"we":[71,104],"report":[72],"an":[73,85],"intra-PMN":[74],"mechanism":[75],"negative":[77,176],"regulation":[78],"mediated":[81],"through":[82],"TBK1/IKK\u03b5.":[83],"Using":[84],"in":[86,97,109,118,157],"vivo":[87],"mouse":[88,102],"model":[89],"intratracheal":[91],"injection":[92],"(i.t.)":[93],"LPS":[95,99],"vitro":[98],"stimulation":[100],"PMN,":[103],"found":[105],"LPS-TLR4":[107],"signaling":[108],"PMNs":[110],"activates":[111],"phosphorylates":[113],"TBK1":[114,128],"IKK\u03b5,":[116],"which":[117],"turn":[119],"suppress":[120],"LPS-induced":[121],"formation":[122],"RIPK1-RIPK3-MLKL":[125],"(necrosome)":[126],"complex.":[127],"dysfunction":[129],"by":[130],"knockdown":[131],"or":[132],"inhibitor":[133],"significantly":[134],"increases":[135,153],"phosphorylation":[137],"RIPK1":[139],"(\u223c67%),":[140],"RIPK3":[141],"(\u223c68%),":[142],"MLKL":[144],"(\u223c50%)":[145],"promotes":[147],"RIPK1-RIPK3":[148],"RIPK3-MLKL":[150],"interactions":[151],"PMN":[154,179,189],"(\u223c83%)":[156],"response":[158],"LPS,":[160],"with":[161],"augmented":[163],"lung":[164],"These":[166],"findings":[167],"suggest":[168],"LPS-TLR4-TBK1":[171],"axis":[172],"serves":[173],"regulator":[177],"for":[178,187],"might":[182],"be":[183],"therapeutic":[185],"target":[186],"modulating":[188],"death":[190]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-21T00:00:00"}