{"id":"https://openalex.org/W3086255239","doi":"https://doi.org/10.1016/j.cherd.2020.09.002","title":"Development of high-performance hybrid ANN-finite volume scheme (ANN-FVS) for simulation of pharmaceutical continuous granulation","display_name":"Development of high-performance hybrid ANN-finite volume scheme (ANN-FVS) for simulation of pharmaceutical continuous granulation","publication_year":2020,"publication_date":"2020-09-12","ids":{"openalex":"https://openalex.org/W3086255239","doi":"https://doi.org/10.1016/j.cherd.2020.09.002","mag":"3086255239"},"language":"en","primary_location":{"id":"doi:10.1016/j.cherd.2020.09.002","doi":"https://doi.org/10.1016/j.cherd.2020.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cherd.2020.09.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S026387622030455X/pdf","source":{"id":"https://openalex.org/S166351637","display_name":"Process Safety and Environmental Protection","issn_l":"0263-8762","issn":["0263-8762","0957-5820","1744-3563","1744-3598","1876-4800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","dongbi-c","jufo-1","norway-1","poland-100","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Research and Design","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S026387622030455X/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039940573","display_name":"Hamza Y. Ismail","orcid":"https://orcid.org/0000-0003-3575-5297","observed_orcids":["https://orcid.org/0000-0003-3575-5297"]},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Hamza Y. Ismail","raw_affiliation_strings":["Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","Pharmaceutical Manufacturing Technology Centre, Bernal Institute, University of Limerick, Limerick, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]},{"raw_affiliation_string":"Pharmaceutical Manufacturing Technology Centre, Bernal Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001129409","display_name":"Mehakpreet Singh","orcid":"https://orcid.org/0000-0002-6392-6068","observed_orcids":["https://orcid.org/0000-0002-6392-6068"]},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Mehakpreet Singh","raw_affiliation_strings":["Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","Pharmaceutical Manufacturing Technology Centre, Bernal Institute, University of Limerick, Limerick, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]},{"raw_affiliation_string":"Pharmaceutical Manufacturing Technology Centre, Bernal Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112512208","display_name":"Saeed Shirazian","orcid":"https://orcid.org/0000-0002-9247-5446","observed_orcids":["https://orcid.org/0000-0002-9247-5446","https://orcid.org/0000-0002-6619-6654"]},"institutions":[{"id":"https://openalex.org/I170238339","display_name":"Duy Tan University","ror":"https://ror.org/05ezss144","country_code":"VN","type":"education","lineage":["https://openalex.org/I170238339"]},{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE","VN"],"is_corresponding":true,"raw_author_name":"Saeed Shirazian","raw_affiliation_strings":["Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam","The Faculty of Environmental and Chemical Engineering, Duy Tan University, Da Nang 550000, Viet Nam"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]},{"raw_affiliation_string":"Institute of Research and Development, Duy Tan University, Da Nang 550000, Viet Nam","institution_ids":["https://openalex.org/I170238339"]},{"raw_affiliation_string":"The Faculty of Environmental and Chemical Engineering, Duy Tan University, Da Nang 550000, Viet Nam","institution_ids":["https://openalex.org/I170238339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029135596","display_name":"Ahmad B. Albadarin","orcid":"https://orcid.org/0000-0002-5686-564X","observed_orcids":["https://orcid.org/0000-0002-5686-564X","https://orcid.org/0009-0002-9487-4296"]},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ahmad B. Albadarin","raw_affiliation_strings":["Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","Pharmaceutical Manufacturing Technology Centre, Bernal Institute, University of Limerick, Limerick, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]},{"raw_affiliation_string":"Pharmaceutical Manufacturing Technology Centre, Bernal Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077833180","display_name":"Gavin Walker","orcid":"https://orcid.org/0000-0003-4102-0019","observed_orcids":["https://orcid.org/0000-0003-4102-0019"]},"institutions":[{"id":"https://openalex.org/I230495080","display_name":"University of Limerick","ror":"https://ror.org/00a0n9e72","country_code":"IE","type":"education","lineage":["https://openalex.org/I230495080"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Gavin M. Walker","raw_affiliation_strings":["Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","Pharmaceutical Manufacturing Technology Centre, Bernal Institute, University of Limerick, Limerick, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Sciences, Bernal Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]},{"raw_affiliation_string":"Pharmaceutical Manufacturing Technology Centre, Bernal Institute, University of Limerick, Limerick, Ireland","institution_ids":["https://openalex.org/I230495080"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112512208"],"corresponding_institution_ids":["https://openalex.org/I170238339","https://openalex.org/I230495080"],"apc_list":{"value":3300,"currency":"USD","value_usd":3300},"apc_paid":{"value":3300,"currency":"USD","value_usd":3300},"fwci":4.5427,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.96902149,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"163","issue":null,"first_page":"320","last_page":"326"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10615","display_name":"Granular flow and fluidized beds","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10615","display_name":"Granular flow and fluidized beds","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2206","display_name":"Computational Mechanics"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12282","display_name":"Mineral Processing and Grinding","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11881","display_name":"Crystallization and Solubility Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population-balance-model","display_name":"population balance model","score":0.8949999809265137},{"id":"https://openalex.org/keywords/neural-network","display_name":"artificial neural networks","score":0.9150000214576721},{"id":"https://openalex.org/keywords/finite-volume-method","display_name":"finite volume method","score":0.7710000276565552},{"id":"https://openalex.org/keywords/particle-size-distribution","display_name":"particle size distribution","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mean-residence-time","display_name":"mean residence time","score":0.8659999966621399},{"id":"https://openalex.org/keywords/microcrystalline-cellulose","display_name":"microcrystalline cellulose","score":0.9480000138282776},{"id":"https://openalex.org/keywords/pharmaceutical-granulation","display_name":"pharmaceutical granulation","score":0.6700000166893005}],"concepts":[{"id":"https://openalex.org/C88463166","wikidata":"https://www.wikidata.org/wiki/Q1543243","display_name":"Granulation","level":2,"score":0.9038275480270386},{"id":"https://openalex.org/C2779351475","wikidata":"https://www.wikidata.org/wiki/Q417374","display_name":"Microcrystalline cellulose","level":3,"score":0.8017248511314392},{"id":"https://openalex.org/C2779015675","wikidata":"https://www.wikidata.org/wiki/Q92796261","display_name":"Breakage","level":2,"score":0.7363132238388062},{"id":"https://openalex.org/C49760210","wikidata":"https://www.wikidata.org/wiki/Q5596727","display_name":"Granule (geology)","level":2,"score":0.6956698894500732},{"id":"https://openalex.org/C97103648","wikidata":"https://www.wikidata.org/wiki/Q2738101","display_name":"Plastics extrusion","level":2,"score":0.6082632541656494},{"id":"https://openalex.org/C144058455","wikidata":"https://www.wikidata.org/wiki/Q3030793","display_name":"Residence time distribution","level":3,"score":0.534368097782135},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.44668281078338623},{"id":"https://openalex.org/C2084832","wikidata":"https://www.wikidata.org/wiki/Q2666694","display_name":"Fluidized bed","level":2,"score":0.41198596358299255},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3322734236717224},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.2716370224952698},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.22621306777000427},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1561785638332367},{"id":"https://openalex.org/C2779251873","wikidata":"https://www.wikidata.org/wiki/Q80294","display_name":"Cellulose","level":2,"score":0.11135968565940857},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.07513993978500366},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C548081761","wikidata":"https://www.wikidata.org/wiki/Q180388","display_name":"Waste management","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1016/j.cherd.2020.09.002","doi":"https://doi.org/10.1016/j.cherd.2020.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cherd.2020.09.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S026387622030455X/pdf","source":{"id":"https://openalex.org/S166351637","display_name":"Process Safety and Environmental Protection","issn_l":"0263-8762","issn":["0263-8762","0957-5820","1744-3563","1744-3598","1876-4800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","dongbi-c","jufo-1","norway-1","poland-100","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Research and Design","raw_type":"journal-article"},{"id":"pmh:oai:researchrepository.ul.ie:10344/10403","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10344/10403","pdf_url":null,"source":{"id":"https://openalex.org/S4306401530","display_name":"University of Limerick Institutional Repository (University of Limerick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I230495080","host_organization_name":"University of Limerick","host_organization_lineage":["https://openalex.org/I230495080"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:ulir.ul.ie:10344/10403","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10344/10403","pdf_url":null,"source":{"id":"https://openalex.org/S4306401530","display_name":"University of Limerick Institutional Repository (University of Limerick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I230495080","host_organization_name":"University of Limerick","host_organization_lineage":["https://openalex.org/I230495080"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:http://www.rian.ie/197542/","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10344/10403","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemical Engineering Research and Design;163, pp. 320-326","raw_type":"Journal article"},{"id":"pmh:oai:figshare.com:article/19816936","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Development_of_high-performance_hybrid_ANN-finite_volume_scheme_ANN-FVS_for_simulation_of_pharmaceutical_continuous_granulation/19816936","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"doi:10.34961/15087","doi":"https://doi.org/10.34961/15087","is_oa":true,"landing_page_url":"https://doi.org/10.34961/15087","pdf_url":null,"source":{"id":"https://openalex.org/S4306401530","display_name":"University of Limerick Institutional Repository (University of Limerick)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I230495080","host_organization_name":"University of Limerick","host_organization_lineage":["https://openalex.org/I230495080"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.1016/j.cherd.2020.09.002","doi":"https://doi.org/10.1016/j.cherd.2020.09.002","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cherd.2020.09.002","pdf_url":"https://www.sciencedirect.com/science/article/pii/S026387622030455X/pdf","source":{"id":"https://openalex.org/S166351637","display_name":"Process Safety and Environmental Protection","issn_l":"0263-8762","issn":["0263-8762","0957-5820","1744-3563","1744-3598","1876-4800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","dongbi-c","jufo-1","norway-1","poland-100","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Engineering Research and Design","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G549049203","display_name":"Model Predictive Control of Continuous Pharmaceutical Processes","funder_award_id":"13/IA/1980","funder_id":"https://openalex.org/F4320320847","funder_display_name":"Science Foundation Ireland"}],"funders":[{"id":"https://openalex.org/F4320320834","display_name":"Enterprise Ireland","ror":"https://ror.org/023z51242"},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320338337","display_name":"H2020 Marie Sk\u0142odowska-Curie Actions","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3086255239.pdf","grobid_xml":"https://content.openalex.org/works/W3086255239.grobid-xml"},"referenced_works_count":30,"referenced_works":["https://openalex.org/W219231981","https://openalex.org/W258695830","https://openalex.org/W1975097468","https://openalex.org/W1991679092","https://openalex.org/W1996374282","https://openalex.org/W2055324809","https://openalex.org/W2060923834","https://openalex.org/W2073010988","https://openalex.org/W2087378881","https://openalex.org/W2092504715","https://openalex.org/W2102479906","https://openalex.org/W2112211764","https://openalex.org/W2158858978","https://openalex.org/W2283136666","https://openalex.org/W2609433959","https://openalex.org/W2727451508","https://openalex.org/W2734459323","https://openalex.org/W2769167915","https://openalex.org/W2811073231","https://openalex.org/W2895827033","https://openalex.org/W2898352211","https://openalex.org/W2901187575","https://openalex.org/W2907042851","https://openalex.org/W2922747938","https://openalex.org/W2943892683","https://openalex.org/W2948101451","https://openalex.org/W2987695221","https://openalex.org/W2987807107","https://openalex.org/W3001719837","https://openalex.org/W3008075799"],"related_works":["https://openalex.org/W2584226333","https://openalex.org/W2901187575","https://openalex.org/W1996374282","https://openalex.org/W2948101451","https://openalex.org/W2769167915","https://openalex.org/W3149849234","https://openalex.org/W4365143725","https://openalex.org/W2783563186","https://openalex.org/W3161789844","https://openalex.org/W4398146951"],"abstract_inverted_index":{"A":[0,53],"hybrid":[1],"model":[2,18,24,81,117,159],"was":[3,19,37,62,118],"developed":[4,63,119],"for":[5,26,39,48,64,122,149,173],"simulation":[6],"of":[7,11,28,41,51,66,125,151,170],"continuous":[8],"wet":[9],"granulation":[10,150],"pharmaceutical":[12,174],"formulations":[13],"via":[14],"twin-screw":[15,78,147,171],"granulator.":[16,79],"The":[17,80,132,154],"based":[20,57],"on":[21,58],"population":[22],"balance":[23],"(PBM)":[25],"prediction":[27],"particle":[29],"size":[30,73,96],"distribution,":[31],"while":[32,93],"artificial":[33],"neural":[34],"network":[35],"(ANN)":[36],"used":[38],"estimation":[40],"mean":[42],"residence":[43],"time":[44],"which":[45,165],"is":[46,98,160],"required":[47],"numerical":[49,55],"solution":[50,65],"PBM.":[52],"new":[54],"scheme":[56],"finite":[59],"volume":[60],"approach":[61],"one":[67],"dimensional":[68],"PBM":[69],"to":[70],"predict":[71,167],"granule":[72,95],"distribution":[74,97],"obtained":[75],"in":[76,112],"a":[77,144],"takes":[82],"into":[83],"account":[84],"liquid":[85],"and":[86,90,104,115,120,129,163],"feed":[87],"flow":[88],"rates,":[89],"screw":[91],"speed,":[92],"the":[94,99,109,113,116,158,168],"model's":[100,133],"main":[101,110],"output.":[102],"Aggregation":[103],"breakage":[105],"were":[106,135],"considered":[107],"as":[108],"mechanisms":[111],"process,":[114],"solved":[121],"different":[123],"zones":[124],"extruder,":[126],"i.e.":[127],"conveying":[128],"kneading":[130],"ones.":[131],"predictions":[134],"validated":[136],"through":[137],"comparing":[138],"with":[139],"experimental":[140],"data":[141],"collected":[142],"using":[143],"12":[145],"mm":[146],"extruder":[148],"microcrystalline":[152],"cellulose.":[153],"results":[155],"indicated":[156],"that":[157],"facile,":[161],"robust":[162],"valid,":[164],"can":[166],"performance":[169],"granulator":[172],"formulations.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2020-09-21T00:00:00"}