{"id":"https://openalex.org/W3085766","doi":null,"title":"Zebrafish : a new model of Parkinson's disease","display_name":"Zebrafish : a new model of Parkinson's disease","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W3085766","mag":"3085766"},"language":"en","primary_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/2214","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/2214","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10451/2214","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086930951","display_name":"Tom\u00e1s Lopes da Fonseca","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tom\u00e1s Ribeiro da Silva Lopes da Fonseca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5086930951"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications","score":0.01720000058412552,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/zebrafish","display_name":"zebrafish","score":0.8569999933242798},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9369999766349792},{"id":"https://openalex.org/keywords/transgenic-models","display_name":"transgenic models","score":0.8109999895095825},{"id":"https://openalex.org/keywords/atp13a2","display_name":"ATP13A2","score":0.8309999704360962},{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/synphilin-1","display_name":"synphilin-1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/glucocerebrosidase","display_name":"glucocerebrosidase","score":0.9950000047683716},{"id":"https://openalex.org/keywords/lewy-bodies","display_name":"Lewy bodies","score":0.7990000247955322},{"id":"https://openalex.org/keywords/gene-homology","display_name":"gene homology","score":0.7910000085830688},{"id":"https://openalex.org/keywords/embryonic-gene-expression","display_name":"embryonic gene expression","score":0.7049999833106995},{"id":"https://openalex.org/keywords/neurodegenerative-disease-models","display_name":"neurodegenerative disease models","score":0.722000002861023}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.9108414053916931},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.8252180814743042},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4424593448638916},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.39756354689598083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3889971971511841},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30052363872528076},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14880311489105225},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1292990744113922},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:repositorio.ulisboa.pt:10451/2214","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/2214","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},{"id":"mag:3085766","doi":null,"is_oa":false,"landing_page_url":"https://repositorio.ul.pt/bitstream/10451/2214/1/596880_Tese.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repositorio.ulisboa.pt:10451/2214","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10451/2214","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"master thesis"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W599063292","https://openalex.org/W1483247593","https://openalex.org/W1489341550","https://openalex.org/W1499500424","https://openalex.org/W1502551601","https://openalex.org/W1529474377","https://openalex.org/W1618912177","https://openalex.org/W1637321639","https://openalex.org/W1844422703","https://openalex.org/W1965778124","https://openalex.org/W1968883761","https://openalex.org/W1970992372","https://openalex.org/W1972062605","https://openalex.org/W1973190490","https://openalex.org/W1979944790","https://openalex.org/W1981704961","https://openalex.org/W1982545542","https://openalex.org/W1991973409","https://openalex.org/W2008116827","https://openalex.org/W2010119513","https://openalex.org/W2013754033","https://openalex.org/W2016134825","https://openalex.org/W2019843148","https://openalex.org/W2021747992","https://openalex.org/W2028796406","https://openalex.org/W2030977705","https://openalex.org/W2034887565","https://openalex.org/W2035333716","https://openalex.org/W2040706104","https://openalex.org/W2042949114","https://openalex.org/W2053188090","https://openalex.org/W2054324553","https://openalex.org/W2065123319","https://openalex.org/W2067302077","https://openalex.org/W2067999317","https://openalex.org/W2068633356","https://openalex.org/W2071010015","https://openalex.org/W2072066672","https://openalex.org/W2080425624","https://openalex.org/W2084970853","https://openalex.org/W2085586303","https://openalex.org/W2114200547","https://openalex.org/W2123184492","https://openalex.org/W2123431154","https://openalex.org/W2130323165","https://openalex.org/W2137015675","https://openalex.org/W2138306686","https://openalex.org/W2141413750","https://openalex.org/W2143168514","https://openalex.org/W2144435948","https://openalex.org/W2145434546","https://openalex.org/W2150656456","https://openalex.org/W2170836605","https://openalex.org/W2461893635","https://openalex.org/W2466055753","https://openalex.org/W2978783401","https://openalex.org/W4247358866","https://openalex.org/W4295994768","https://openalex.org/W4296930794"],"related_works":["https://openalex.org/W6922590701","https://openalex.org/W999454491","https://openalex.org/W4401991460","https://openalex.org/W2259756818","https://openalex.org/W4220990134","https://openalex.org/W2910639281","https://openalex.org/W3156893039","https://openalex.org/W7223335157","https://openalex.org/W7161831749","https://openalex.org/W3041057169"],"abstract_inverted_index":{"Parkinson\u00b4s":[0],"disease":[1,9,55,73,278],"(PD)":[2],"is":[3,74],"the":[4,17,37,45,50,54,72,90,110,115,122,125,158,205,215,231,252,256,274,277,294],"second":[5],"most":[6],"common":[7],"neurodegenerative":[8],"after":[10],"Alzheimer\u2019s":[11],"disease,":[12],"affecting":[13],"around":[14],"2%":[15],"of":[16,49,53,67,92,109,114,121,124,230,236,261,297],"population":[18],"with":[19,28],"more":[20,249,293],"than":[21],"65":[22],"years.":[23],"The":[24,259],"first":[25],"gene":[26,207],"implicated":[27],"PD":[29,189,264,298],"was":[30,42],"SNCA":[31],"that":[32,187],"encodes":[33],"to":[34,86,171,204,251,271,291,300],"alpha-synuclein.":[35,179],"At":[36],"neuronal":[38],"level,":[39],"this":[40,129,262],"protein":[41],"found":[43,186],"in":[44,62,71,94,97,214,243],"Lewy":[46],"Bodies,":[47],"one":[48],"pathologic":[51],"hallmarks":[52,123],"and":[56,64,105,161,196,288,299],"it":[57,155,247],"has":[58,137,156],"been":[59,84,101,138],"identified":[60],"both":[61],"sporadic":[63],"familiar":[65],"cases":[66],"PD.":[68,87],"Its":[69],"role":[70,91],"still":[75],"unclear.":[76],"Besides":[77],"alpha-synuclein,":[78],"other":[79],"15":[80],"genetic":[81],"loci":[82],"have":[83,100],"associated":[85],"To":[88,127],"clarify":[89],"alpha-synuclein":[93],"PD,":[95],"several":[96,147],"vivo":[98],"models":[99,117,132],"developed,":[102],"expressing":[103],"wild-type":[104],"PD-associated":[106],"mutant":[107],"forms":[108],"protein.":[111],"However,":[112],"none":[113],"existing":[116],"fully":[118],"recapitulates":[119],"all":[120,157],"disease.":[126],"circumvent":[128],"limitation,":[130],"new":[131],"must":[133],"be":[134],"developed.":[135],"Zebrafish":[136,174],"widely":[139],"used":[140],"as":[141],"an":[142],"animal":[143],"model":[144,176,266],"for":[145,165,177,304],"studying":[146],"human":[148,178,206],"disorders":[149],"because,":[150],"besides":[151],"being":[152],"a":[153,173,211,227,286],"vertebrate,":[154],"molecular":[159,295],"background":[160],"bioimaging":[162],"characteristics":[163],"suitable":[164],"these":[166,282],"studies.":[167],"Here,":[168],"we":[169,185],"started":[170],"generate":[172],"transgenic":[175,265],"In":[180,233],"addition,":[181],"through":[182],"bioinformatic":[183],"analysis,":[184],"four":[188],"related":[190],"genes":[191],"encoding":[192],"ATP13a2,":[193],"Lrrk2,":[194],"Synphilin-1,":[195],"Glucocerebrosidase,":[197],"display":[198],"high":[199,212],"homology":[200,213],"rates":[201],"when":[202],"compared":[203],"sequences.":[208],"Moreover,":[209],"despite":[210],"entire":[216],"sequence,":[217],"specific":[218],"conserved":[219,228],"domains":[220],"sequences":[221],"are":[222],"also":[223],"highly":[224],"homologous,":[225],"suggesting":[226],"functionality":[229],"genes.":[232],"situ":[234],"hybridization":[235],"ATP13a2":[237],"revealed":[238],"that,":[239],"although":[240],"initially":[241],"expressed":[242],"whole":[244],"embryo\u2019s":[245],"body,":[246],"becomes":[248],"restricted":[250],"brain":[253],"area":[254],"along":[255],"embryonic":[257],"development.":[258],"generation":[260],"novel":[263,287,302],"will":[267,284],"allow":[268],"further":[269],"studies":[270],"better":[272],"understand":[273],"mechanisms":[275],"underlying":[276],"pathology.":[279],"Taken":[280],"together,":[281],"results":[283],"provide":[285],"powerful":[289],"system":[290],"explore":[292],"basis":[296],"open":[301],"avenues":[303],"therapeutic":[305],"intervention.":[306]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
