{"id":"https://openalex.org/W3085723853","doi":"https://doi.org/10.3389/fcell.2020.562662","title":"Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel","display_name":"Identifying Mechanisms of Normal Cognitive Aging Using a Novel Mouse Genetic Reference Panel","publication_year":2020,"publication_date":"2020-09-11","ids":{"openalex":"https://openalex.org/W3085723853","doi":"https://doi.org/10.3389/fcell.2020.562662","mag":"3085723853","pmid":"https://pubmed.ncbi.nlm.nih.gov/33042997"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2020.562662","doi":"https://doi.org/10.3389/fcell.2020.562662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2020.562662","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.562662/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.562662/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011407301","display_name":"Amy R. Dunn","orcid":"https://orcid.org/0000-0001-6437-6099","observed_orcids":["https://orcid.org/0000-0001-6437-6099"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy R. Dunn","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, United States","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017366113","display_name":"Niran Hadad","orcid":"https://orcid.org/0000-0001-8839-7011","observed_orcids":["https://orcid.org/0000-0001-8839-7011"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niran Hadad","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, United States","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039026005","display_name":"Sarah M. Neuner","orcid":"https://orcid.org/0000-0001-5091-401X","observed_orcids":["https://orcid.org/0000-0001-5091-401X"]},"institutions":[{"id":"https://openalex.org/I160606119","display_name":"University of Tennessee Health Science Center","ror":"https://ror.org/0011qv509","country_code":"US","type":"education","lineage":["https://openalex.org/I160606119"]},{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah M. Neuner","raw_affiliation_strings":["Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN, United States","The Jackson Laboratory, Bar Harbor, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, Memphis, TN, United States","institution_ids":["https://openalex.org/I160606119"]},{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, United States","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101811852","display_name":"Jigang Zhang","orcid":"https://orcid.org/0000-0003-4389-449X","observed_orcids":["https://orcid.org/0000-0003-4389-449X"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ji-Gang Zhang","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, United States","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043034121","display_name":"Vivek M. Philip","orcid":"https://orcid.org/0000-0001-5126-707X","observed_orcids":["https://orcid.org/0000-0001-5126-707X"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vivek M. Philip","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, United States","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028690751","display_name":"Logan C. Dumitrescu","orcid":"https://orcid.org/0000-0002-9782-9944","observed_orcids":["https://orcid.org/0000-0002-9782-9944"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Logan Dumitrescu","raw_affiliation_strings":["Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009545818","display_name":"Timothy J. Hohman","orcid":"https://orcid.org/0000-0002-3377-7014","observed_orcids":["https://orcid.org/0000-0002-3377-7014"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy J. Hohman","raw_affiliation_strings":["Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Memory and Alzheimer's Center and Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, United States","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013535951","display_name":"Jeremy H. Herskowitz","orcid":"https://orcid.org/0000-0002-7227-1470","observed_orcids":["https://orcid.org/0000-0002-7227-1470"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy H. Herskowitz","raw_affiliation_strings":["Center for Neurodegeneration and Experimental Therapeutics and Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Neurodegeneration and Experimental Therapeutics and Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054886860","display_name":"Kristen M. S. O\u2019Connell","orcid":"https://orcid.org/0000-0002-4187-747X","observed_orcids":["https://orcid.org/0000-0002-4187-747X"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kristen M. S. O\u2019Connell","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, United States","institution_ids":["https://openalex.org/I4210115256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073164917","display_name":"Catherine Cook Kaczorowski","orcid":"https://orcid.org/0000-0001-5430-0816","observed_orcids":["https://orcid.org/0000-0001-5430-0816"]},"institutions":[{"id":"https://openalex.org/I4210115256","display_name":"Jackson Laboratory","ror":"https://ror.org/021sy4w91","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210115256"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Catherine C. Kaczorowski","raw_affiliation_strings":["The Jackson Laboratory, Bar Harbor, ME, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Jackson Laboratory, Bar Harbor, ME, United States","institution_ids":["https://openalex.org/I4210115256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5073164917"],"corresponding_institution_ids":["https://openalex.org/I4210115256"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":1.3882,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.83678404,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":null,"first_page":"562662","last_page":"562662"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11577","display_name":"Cognitive Abilities and Testing","score":0.5356000065803528,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.19750000536441803,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10448","display_name":"Memory and Neural Mechanisms","score":0.05260000005364418,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cognitive-aging","display_name":"cognitive aging","score":0.843999981880188},{"id":"https://openalex.org/keywords/cognitive-reserve","display_name":"cognitive reserve","score":0.9850000143051147},{"id":"https://openalex.org/keywords/cognitive-resilience","display_name":"cognitive resilience","score":0.9990000128746033},{"id":"https://openalex.org/keywords/genetic-reference-panel","display_name":"genetic reference panel","score":0.7279999852180481},{"id":"https://openalex.org/keywords/working-memory","display_name":"working memory","score":0.7699999809265137},{"id":"https://openalex.org/keywords/contextual-fear-memory","display_name":"contextual fear memory","score":0.949999988079071},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"cognitive decline","score":0.8309999704360962},{"id":"https://openalex.org/keywords/gene-networks","display_name":"gene networks","score":0.7269999980926514},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-seq","score":0.5149999856948853},{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":0.7229999899864197},{"id":"https://openalex.org/keywords/middle-aged-mice","display_name":"middle-aged mice","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.564723789691925},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42055612802505493},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37359726428985596},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3706760108470917},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.33314675092697144}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.3389/fcell.2020.562662","doi":"https://doi.org/10.3389/fcell.2020.562662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2020.562662","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.562662/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:33042997","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33042997","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7517308","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7517308","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:55c45b3c6f334db690a33914c1daf442","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/55c45b3c6f334db690a33914c1daf442","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 8 (2020)","raw_type":"article"},{"id":"pmh:oai:mouseion.jax.org:stfb2020-1197","doi":null,"is_oa":true,"landing_page_url":"https://mouseion.jax.org/stfb2020/197","pdf_url":null,"source":{"id":"https://openalex.org/S4377196421","display_name":"The Mouseion at the JAXlibrary (Jackson Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115256","host_organization_name":"Jackson Laboratory","host_organization_lineage":["https://openalex.org/I4210115256"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Faculty Research 2020","raw_type":"text"}],"best_oa_location":{"id":"doi:10.3389/fcell.2020.562662","doi":"https://doi.org/10.3389/fcell.2020.562662","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2020.562662","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2020.562662/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5699999928474426,"id":"https://metadata.un.org/sdg/1","display_name":"No poverty"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1051361900","display_name":null,"funder_award_id":"R01AG054180","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1859051083","display_name":"Systems Genetics Analysis of Resilience to Alzheimer\u2019s disease","funder_award_id":"R01AG057914","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G1993193384","display_name":null,"funder_award_id":"AG054180","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2091975299","display_name":null,"funder_award_id":"RF1AG059778","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2829851553","display_name":"Identification of Genetic Modifiers of Neuronal Deficits and Memory Failure in Alzheimers Disease","funder_award_id":"F31AG050357","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G3407010745","display_name":null,"funder_award_id":"R01AG057911","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5949076434","display_name":"Mechanisms of an Interaction Between Genetics and Diet in Alzheimer's Disease","funder_award_id":"AARF-18-565506","funder_id":"https://openalex.org/F4320306219","funder_display_name":"Alzheimer's Association"},{"id":"https://openalex.org/G7449923141","display_name":"System Genetics to Identify Modifiers of Alzheimer's Disease","funder_award_id":"A2016397S","funder_id":"https://openalex.org/F4320308990","funder_display_name":"BrightFocus Foundation"},{"id":"https://openalex.org/G7761153988","display_name":null,"funder_award_id":"R01AG054719","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G9000897498","display_name":"Identifying therapeutic targets that confer synaptic resilience to Alzheimer's disease","funder_award_id":"R01AG061800","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320308990","display_name":"BrightFocus Foundation","ror":"https://ror.org/03cvfxv40"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3085723853.pdf","grobid_xml":"https://content.openalex.org/works/W3085723853.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1741693372","https://openalex.org/W1966327575","https://openalex.org/W1972845216","https://openalex.org/W1974750085","https://openalex.org/W1980742033","https://openalex.org/W2006277935","https://openalex.org/W2010754142","https://openalex.org/W2013230506","https://openalex.org/W2024465869","https://openalex.org/W2026017720","https://openalex.org/W2028601946","https://openalex.org/W2038138506","https://openalex.org/W2039454657","https://openalex.org/W2043488532","https://openalex.org/W2044538991","https://openalex.org/W2046364590","https://openalex.org/W2047632093","https://openalex.org/W2078657844","https://openalex.org/W2112658198","https://openalex.org/W2115182824","https://openalex.org/W2118010191","https://openalex.org/W2126824241","https://openalex.org/W2129475546","https://openalex.org/W2140054173","https://openalex.org/W2152280269","https://openalex.org/W2159372535","https://openalex.org/W2165719935","https://openalex.org/W2171195450","https://openalex.org/W2194864295","https://openalex.org/W2199046180","https://openalex.org/W2346626662","https://openalex.org/W2416452882","https://openalex.org/W2466719328","https://openalex.org/W2564662348","https://openalex.org/W2574432813","https://openalex.org/W2615329977","https://openalex.org/W2619734682","https://openalex.org/W2728946616","https://openalex.org/W2755806383","https://openalex.org/W2791355502","https://openalex.org/W2806395345","https://openalex.org/W2809193491","https://openalex.org/W2885764193","https://openalex.org/W2890266409","https://openalex.org/W2891144761","https://openalex.org/W2892344763","https://openalex.org/W2908182575","https://openalex.org/W2921245766","https://openalex.org/W2921670735","https://openalex.org/W2937979781","https://openalex.org/W2940205897","https://openalex.org/W2943810543","https://openalex.org/W2950395494","https://openalex.org/W2967127943","https://openalex.org/W2969546739","https://openalex.org/W6659971437"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Developing":[0],"strategies":[1,71],"to":[2,8,27,68,129,179,189,233,281,332,341],"maintain":[3,48],"cognitive":[4,18,60,74,109,118,134,142,151,186,194,204,207,250,277,297,305,310,346],"health":[5],"is":[6,20,25,99],"critical":[7],"quality":[9],"of":[10,16,90,96,105,117,141,193,220,263,326,337,345],"life":[11,302],"during":[12],"aging.":[13,119],"The":[14],"basis":[15],"healthy":[17],"aging":[19,338],"poorly":[21],"understood;":[22],"thus,":[23],"it":[24],"difficult":[26],"predict":[28],"who":[29],"will":[30],"have":[31,39,80],"normal":[32],"cognition":[33],"later":[34,307],"in":[35,84,133,136,146,169,222,289,301,308],"life.":[36],"Individuals":[37],"may":[38,47,64],"higher":[40],"baseline":[41],"functioning":[42],"(cognitive":[43,54],"reserve)":[44],"and":[45,62,78,93,108,138,157,161,228,237,249,312,348],"others":[46],"or":[49,206,329],"even":[50],"improve":[51],"with":[52,203,243,319],"age":[53],"resilience).":[55],"Understanding":[56],"the":[57,66,91,114,185,190,210,217,257,343],"mechanisms":[58],"underlying":[59],"reserve":[61,77,143,278,298,328,347],"resilience":[63,79,145,280],"hold":[65],"key":[67],"new":[69],"therapeutic":[70],"for":[72,273,334],"maintaining":[73],"health.":[75],"However,":[76],"been":[81],"inconsistently":[82],"defined":[83],"human":[85],"studies.":[86],"Additionally,":[87],"our":[88],"understanding":[89],"molecular":[92,107,218],"cellular":[94,235],"bases":[95],"these":[97,172,223,284],"phenomena":[98],"poor,":[100],"compounded":[101],"by":[102],"a":[103,123,261,270,317],"lack":[104],"longitudinal":[106],"data":[110],"that":[111,240,295],"fully":[112],"capture":[113],"dynamic":[115],"trajectories":[116],"Here,":[120],"we":[121,196,225,255,268,293],"used":[122],"genetically":[124],"diverse":[125],"mouse":[126,339],"population":[127],"(B6-BXDs)":[128],"characterize":[130],"individual":[131],"differences":[132],"abilities":[135],"adulthood":[137],"investigate":[139],"evidence":[140],"and/or":[144,279],"middle-aged":[147,290],"mice.":[148],"We":[149,165],"tested":[150],"function":[152,205,239],"at":[153,209],"two":[154],"ages":[155],"(6mo":[156],"14mo)":[158],"using":[159],"y-maze":[160],"contextual":[162,246],"fear":[163,247],"conditioning.":[164],"observed":[166,288],"heritable":[167],"variation":[168,221],"performance":[170,311],"on":[171,184],"traits":[173,285],"(h2RIx\u0304":[174],"=":[175],"0.51-0.74),":[176],"suggesting":[177],"moderate":[178],"strong":[180],"genetic":[181],"control":[182],"depending":[183],"domain.":[187],"Due":[188],"polygenetic":[191],"nature":[192,344],"function,":[195],"did":[197],"not":[198],"find":[199],"QTLs":[200],"significantly":[201],"associated":[202,242],"decline":[208,314],"genome-wide":[211],"level.":[212],"To":[213],"more":[214],"precisely":[215],"interrogate":[216],"regulation":[219],"traits,":[224],"employed":[226],"RNAseq":[227],"identified":[229],"gene":[230,259],"networks":[231],"related":[232],"transcription/translation,":[234],"metabolism,":[236],"neuronal":[238],"were":[241],"working":[244,264],"memory,":[245,248],"decline.":[251],"Using":[252],"this":[253],"method,":[254],"nominate":[256],"Trio":[258],"as":[260,324],"modulator":[262],"memory":[265],"ability.":[266],"Finally,":[267],"propose":[269],"conceptual":[271],"framework":[272],"identifying":[274],"strains":[275],"exhibiting":[276],"assess":[282],"whether":[283],"can":[286],"be":[287],"B6-BXDs.":[291],"Though":[292],"found":[294],"earlier":[296],"evident":[299],"early":[300],"protects":[303],"against":[304],"impairment":[306],"life,":[309],"age-related":[313],"fell":[315],"along":[316],"continuum,":[318],"no":[320],"clear":[321],"genotypes":[322],"emerging":[323],"exemplars":[325],"exceptional":[327],"resilience\u2014":[330],"leading":[331],"recommendations":[333],"future":[335],"use":[336],"populations":[340],"understand":[342],"resilience.":[349]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4}],"updated_date":"2026-10-15T10:00:46.086208","created_date":"2025-10-10T00:00:00"}